Standard name
Human Ortholog
Description Cyclin-like component of the RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; forms a kinase-cyclin pair in the RNAPII holoenzyme with Ssn3p; required for both entry into and execution of the meiotic program; involved in glucose repression and telomere maintenance; cyclin homolog 35% identical to human cyclin C
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0.1 0.08 0.15 0.08 0.08 0.09 0.07 0.09 0.05 0.06 0.13 0.17 0.13 0.11 0.1 0.1 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.34 0 0 0.13 0.13 0.35 0.56 0.41 0.71 0.51 0.7 0.43 0 0 0 0 0 0.06 0 0 0 0 0.05 0
Nucleus 0.82 0.9 0.85 0.82 0.75 0.75 0.69 0.73 0.62 0.7 0.66 0.63 0.83 0.81 0.83 0.82 0.8 0.77 0.77 0.73 0.67 0.65 0.54 0.58
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.08 0.09 0.08 0.07
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0.07 0.05 0 0 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.06 0.05
Vac/Vac Membrane 0.06 0.07 0 0 0 0 0 0 0 0 0 0.12 0.05 0 0 0.06 0.06 0.08 0.1 0.14 0.13 0.11 0.15 0.11
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 1 1 2 1 3 1 4 1 2 1 0 0 0 0 0 1 3 1 1 1 5 7
Bud Neck 0 0 3 0 3 2 1 2 1 0 0 1 0 0 0 0 0 0 0 0 1 2 0 2
Bud Site 2 0 0 0 1 4 10 7 5 5 9 6 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 8 3 19 16 43 18 23 22 22 30 14 19 14 35 34 46 31 42 4 0 4 2 3 4
Endoplasmic Reticulum 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 15 10 15 0 0 0 0 0 1
Endosome 2 0 0 2 3 4 0 2 0 0 0 7 1 1 2 5 5 6 2 2 1 1 6 6
Golgi 0 0 0 1 0 0 0 0 0 0 0 0 1 0 0 2 2 2 0 0 1 1 4 0
Mitochondria 69 1 3 25 36 78 154 105 220 176 197 129 0 0 0 12 8 23 3 1 3 2 10 7
Nucleus 163 81 162 155 211 170 191 187 194 244 184 186 90 170 211 347 247 323 168 80 143 104 123 129
Nuclear Periphery 0 0 1 0 1 1 1 0 1 0 0 1 0 0 0 1 0 1 1 0 0 1 1 1
Nucleolus 13 0 1 0 0 2 1 0 1 2 2 2 0 0 0 0 2 2 4 5 17 15 18 15
Peroxisomes 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 1 1 13 10 7 2 4 16 2 10 1 5 2 6 5 7 9 3 7 2 6 8 12 11
Vac/Vac Membrane 11 6 1 0 7 3 4 1 9 8 8 37 5 8 8 25 20 35 21 14 27 17 33 25
Unique Cell Count 200 90 190 189 282 226 276 257 312 347 280 297 109 209 254 421 309 417 219 110 215 161 228 222
Labelled Cell Count 269 92 206 210 314 285 393 343 461 476 417 394 113 220 260 460 334 453 219 110 215 161 228 222


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.0 5.5 4.9 5.2 5.0 4.0 3.8 4.5 3.7 4.0 3.6 4.2 5.8 6.0 5.9 6.6 6.9 6.5 5.5 6.0 6.1
Std Deviation (1e-4) 0.7 1.1 0.8 1.7 1.9 1.1 1.2 1.6 0.8 1.1 0.8 1.0 1.3 1.4 1.4 1.5 1.7 1.6 1.3 1.8 1.7
Intensity Change (Log2) – – – 0.07 0.02 -0.29 -0.39 -0.12 -0.43 -0.3 -0.46 -0.22 0.25 0.3 0.26 0.43 0.49 0.4 0.15 0.29 0.32

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -0.5 1.7 -0.7 -0.6 -0.5 -1.2 -0.5 -2.1 -1.4 0.8 2.0 1.1 0.3 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 2.2
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 4.3 4.3 0 0 0 0 0 0 0 0 0 0 0 0 2.2
Nucleus -0.9 -2.7 -2.5 -4.0 -3.2 -5.5 -3.9 -4.7 -5.4 -0.6 -1.0 -0.6 -0.9 -1.5 -2.2
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole -0.6 -2.3 0 0 0 0 0 0 0 -1.9 -1.9 -2.6 -3.3 -2.1 -4.4
Vacuole 0 0 0 0 0 0 0 0 4.8 0 0 0 3.1 3.2 3.8

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.3919 0.5642 0.398 0.0122 0.0435 0.4186 0.5897 0.7943 0.7015 0.5021 0.1138 0.6051 0.5885 0.0259 0.7709 0.5164 0.6274 0.2324
Actin 0.0098 0.0001 0.0011 0.0002 0.0052 0.0099 0.01 0 0.0028 0 0.0001 0.0005 0.0617 0.0001 0.0161 0.0153 0.003 0.0122
Bud 0.0003 0.0018 0 0.0027 0.0001 0.0001 0.0032 0 0.0048 0 0 0 0.0006 0.0002 0.0005 0.0003 0.0005 0.0001
Bud Neck 0.0017 0.0006 0.0003 0.0005 0.0012 0.0039 0.0056 0.0003 0.0004 0.0001 0.0007 0.001 0.0063 0.0004 0.0015 0.0008 0.0019 0.0016
Bud Periphery 0.0005 0.0002 0 0.0004 0.0003 0.0001 0.0018 0 0.0013 0 0 0.0001 0.0011 0.0001 0.0007 0.0007 0.0014 0.0001
Bud Site 0.0006 0.001 0.0001 0.0001 0.0003 0.0001 0.0027 0.0001 0.0008 0 0 0.0001 0.0095 0.0005 0.0159 0.0005 0.0038 0.0001
Cell Periphery 0.0001 0 0 0 0 0 0.0004 0 0 0 0 0 0.0007 0 0.0007 0.0001 0.0006 0
Cytoplasm 0.0207 0.02 0.0046 0.0097 0.0037 0.0009 0.0086 0.0023 0.002 0.0009 0.0036 0.0005 0.0058 0.0057 0.0113 0.0115 0.0022 0.0028
Cytoplasmic Foci 0.0046 0.0016 0.0002 0.0003 0.0031 0.0005 0.0104 0.0001 0.0013 0 0.0001 0.0004 0.041 0.0024 0.0087 0.0008 0.0009 0.001
Eisosomes 0.0002 0 0 0 0.0001 0 0.0003 0 0 0 0 0 0.002 0 0.0001 0.0001 0.0002 0
Endoplasmic Reticulum 0.0044 0.0007 0.0036 0.0004 0.0019 0.0011 0.0046 0.0002 0.0003 0 0.0001 0.0001 0.0056 0.0004 0.0182 0.0013 0.0014 0.0033
Endosome 0.0238 0.0032 0.0028 0.0003 0.0246 0.0044 0.0144 0.0002 0.0038 0 0.0001 0.0012 0.0246 0.0004 0.0032 0.0085 0.007 0.0062
Golgi 0.0026 0 0.0002 0 0.0031 0.0013 0.0033 0 0.0009 0 0 0.0005 0.0115 0 0.0017 0.006 0.0022 0.0023
Lipid Particles 0.006 0.0001 0.0003 0 0.0157 0.0004 0.0186 0 0.0018 0 0 0.0015 0.0218 0.0001 0.0038 0.0014 0.0058 0.0019
Mitochondria 0.0022 0.0007 0.0003 0.0003 0.0122 0.0004 0.0163 0.0002 0.0012 0.0001 0.0001 0.0019 0.0134 0.0002 0.0014 0.004 0.0045 0.0005
None 0.0344 0.0168 0.0024 0.0185 0.0029 0.0134 0.028 0.0091 0.0073 0.0001 0.0427 0.0065 0.0055 0.002 0.0016 0.0059 0.001 0.0014
Nuclear Periphery 0.0353 0.0127 0.0136 0.0224 0.0279 0.0068 0.0326 0.0089 0.0118 0.0008 0.0062 0.0044 0.0211 0.0075 0.01 0.0067 0.029 0.0137
Nucleolus 0.0101 0.0108 0.0063 0.0069 0.013 0.018 0.0215 0.009 0.0085 0.0048 0.0323 0.0208 0.0079 0.0082 0.0062 0.009 0.022 0.0173
Nucleus 0.8018 0.8996 0.9487 0.9183 0.8429 0.9156 0.7837 0.9476 0.934 0.9899 0.8947 0.9435 0.7137 0.9432 0.86 0.9135 0.8936 0.9152
Peroxisomes 0.0013 0 0 0 0.0058 0.0001 0.0069 0 0.0072 0 0 0.0022 0.0175 0 0.0047 0.0003 0.0005 0.0005
Punctate Nuclear 0.0357 0.0279 0.0148 0.0183 0.0327 0.0224 0.0227 0.0217 0.009 0.0033 0.0189 0.0145 0.0249 0.0283 0.0322 0.0116 0.0106 0.0192
Vacuole 0.0022 0.0016 0.0005 0.0003 0.0013 0.0003 0.0028 0.0002 0.0004 0 0.0001 0.0002 0.0022 0.0002 0.0011 0.0007 0.0049 0.0003
Vacuole Periphery 0.0017 0.0003 0.0003 0.0003 0.0019 0.0002 0.0018 0.0001 0.0003 0 0.0001 0.0002 0.0016 0.0001 0.0004 0.0008 0.0031 0.0003

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 14.1899 13.1923 6.0241 14.1252 10.3028 2.2691 11.7996 11.0803 10.1217 13.1568
Translational Efficiency 0.5295 0.5545 1.031 0.4503 0.4669 4.1802 0.6354 0.4584 0.5392 0.5199

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1227 324 108 1055 1685 2208 893 843 2912 2532 1001 1898

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 659.45 789.03 919.23 856.95 672.20 734.07 854.51 912.51 666.83 741.10 861.49 881.63
Standard Deviation 99.95 95.94 103.60 127.04 79.60 96.61 113.88 130.69 88.97 98.26 114.59 131.60
Intensity Change Log 2 — 0.258817 0.479163 0.377948 — 0.127027 0.346207 0.440950 — 0.193796 0.413580 0.410094

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000463 0.000511 0.001202 0.001012 0.000080 0.000229 0.000542 0.001477 0.000241 0.000265 0.000614 0.001219
Bud Neck 0.001176 0.008000 0.002551 0.016137 0.002743 0.007507 0.004416 0.029663 0.002083 0.007570 0.004215 0.022144
Bud Site 0.000399 0.004660 0.001897 0.011442 0.000996 0.002630 0.000884 0.039583 0.000745 0.002890 0.000993 0.023941
Cell Periphery 0.000126 0.000133 0.000084 0.000170 0.000112 0.000114 0.000106 0.000469 0.000118 0.000116 0.000104 0.000303
Cytoplasm 0.096028 0.024931 0.004455 0.029787 0.064517 0.037783 0.021109 0.047794 0.077794 0.036138 0.019313 0.037785
Cytoplasmic Foci 0.019530 0.002345 0.001036 0.003010 0.010062 0.004743 0.001419 0.013955 0.014052 0.004436 0.001378 0.007871
Eisosomes 0.000036 0.000027 0.000071 0.000030 0.000023 0.000019 0.000032 0.000047 0.000028 0.000020 0.000036 0.000037
Endoplasmic Reticulum 0.001258 0.004351 0.008976 0.009097 0.001201 0.002595 0.005854 0.007961 0.001225 0.002819 0.006190 0.008593
Endosome 0.000789 0.001366 0.000550 0.004734 0.000556 0.001252 0.000493 0.016973 0.000654 0.001267 0.000500 0.010170
Golgi 0.000216 0.000740 0.000100 0.003481 0.000304 0.001005 0.000081 0.014739 0.000267 0.000971 0.000083 0.008481
Lipid Particles 0.003622 0.000869 0.001167 0.001204 0.002184 0.001211 0.000640 0.001637 0.002790 0.001167 0.000697 0.001396
Mitochondria 0.001705 0.001579 0.000743 0.007118 0.001643 0.004186 0.001652 0.006959 0.001669 0.003852 0.001554 0.007047
Mitotic Spindle 0.001104 0.001241 0.000231 0.036447 0.003096 0.006353 0.000642 0.124301 0.002257 0.005698 0.000598 0.075467
None 0.026140 0.007690 0.001875 0.011332 0.010022 0.009649 0.010258 0.009843 0.016814 0.009399 0.009354 0.010671
Nuclear Periphery 0.001162 0.001062 0.000582 0.003062 0.001187 0.001595 0.000777 0.002269 0.001176 0.001527 0.000756 0.002710
Nuclear Periphery Foci 0.000873 0.000466 0.000721 0.002556 0.000424 0.000580 0.000270 0.005348 0.000613 0.000566 0.000319 0.003796
Nucleolus 0.009943 0.007934 0.005722 0.003123 0.007601 0.008677 0.004045 0.008890 0.008588 0.008582 0.004226 0.005685
Nucleus 0.831973 0.926302 0.960781 0.833300 0.891127 0.905383 0.941305 0.609696 0.866202 0.908060 0.943407 0.733986
Peroxisomes 0.001483 0.002746 0.000458 0.001448 0.000751 0.001625 0.000671 0.010036 0.001059 0.001769 0.000648 0.005262
Vacuole 0.001822 0.002480 0.006666 0.017723 0.001230 0.002270 0.004689 0.042961 0.001479 0.002297 0.004903 0.028932
Vacuole Periphery 0.000151 0.000567 0.000133 0.003788 0.000140 0.000594 0.000112 0.005398 0.000145 0.000591 0.000114 0.004503

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -0.30 -2.12 -2.61 -5.46 1.04 -5.43 -13.70 -12.91 -11.77 -8.48 -0.28 -3.95 -9.02 -15.74 -6.87
Bud Neck -3.37 -3.19 -13.06 -6.45 -10.26 -5.26 -3.43 -12.53 -10.54 -10.93 -7.23 -4.70 -17.78 -13.43 -14.20
Bud Site -1.52 -1.22 -6.48 -2.18 -1.80 -2.78 -0.55 -10.46 -9.79 -10.45 -3.63 -1.84 -12.04 -10.17 -11.25
Cell Periphery -0.03 1.08 -1.47 -0.60 -2.40 0.01 0.59 -2.42 -2.47 -2.73 0.31 1.33 -2.86 -2.98 -3.75
Cytoplasm 11.13 17.74 13.21 -0.59 -7.97 6.76 12.19 4.76 -1.17 -6.48 12.04 18.41 13.02 0.77 -6.85
Cytoplasmic Foci 9.29 10.50 10.26 1.11 -0.69 4.23 8.32 2.91 -1.03 -5.24 8.68 13.38 10.02 1.44 -4.83
Eisosomes 2.54 -4.08 -2.88 -4.49 3.20 2.56 -5.20 -14.90 -16.16 -11.52 6.34 -4.07 -13.67 -18.25 -8.25
Endoplasmic Reticulum -5.49 -8.07 -17.14 -7.80 0.57 -7.48 -11.94 -17.34 -14.99 -6.09 -9.26 -13.66 -24.37 -19.55 -5.50
Endosome -0.44 -0.12 -3.98 -1.59 -3.53 -2.33 0.00 -7.78 -6.85 -7.80 -1.99 0.93 -8.72 -6.87 -8.90
Golgi -0.79 1.66 -1.57 -0.79 -1.70 -1.47 1.22 -2.82 -2.24 -3.03 -1.73 1.71 -3.18 -2.06 -3.48
Lipid Particles 6.38 4.50 6.58 -0.05 1.52 3.05 6.12 0.61 -2.99 -7.38 6.12 9.44 5.65 -0.88 -4.43
Mitochondria 0.36 1.72 -2.83 -2.92 -3.54 -3.49 0.12 -2.99 0.27 -2.81 -3.58 0.33 -3.95 -0.59 -3.67
Mitotic Spindle -0.31 0.56 -8.78 -8.65 -8.88 -2.00 1.53 -13.59 -13.21 -13.85 -2.72 1.29 -15.79 -14.91 -16.07
None 6.32 10.14 6.96 -0.30 -5.50 0.60 1.32 2.42 1.84 0.62 5.53 5.83 6.90 1.40 -0.19
Nuclear Periphery 0.52 1.92 -7.61 -8.04 -8.93 -2.32 0.70 -12.20 -9.41 -12.67 -2.25 1.00 -13.15 -10.03 -13.81
Nuclear Periphery Foci 2.39 -0.31 -2.84 -4.84 -1.47 -0.96 1.17 -7.26 -7.13 -7.32 1.00 1.97 -7.93 -8.15 -8.38
Nucleolus 0.76 3.69 0.06 -0.65 -2.83 -1.29 3.03 -5.68 -5.07 -6.91 0.33 5.01 -4.41 -4.38 -7.24
Nucleus -8.69 -9.48 1.92 9.64 10.35 -2.38 -8.30 21.16 22.61 25.46 -7.85 -14.29 16.99 22.24 26.42
Peroxisomes -0.52 3.17 2.03 0.94 -1.17 -2.76 0.86 -3.45 -2.54 -3.61 -1.71 2.21 -2.61 -1.14 -3.59
Vacuole -1.07 -3.47 -10.59 -9.91 -5.38 -3.16 -5.49 -14.67 -14.43 -13.30 -2.78 -6.07 -17.86 -17.46 -14.96
Vacuole Periphery -1.02 -0.52 -2.72 -1.59 -2.68 -3.23 0.96 -3.31 -2.22 -3.36 -3.35 1.22 -4.13 -2.71 -4.19
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Cyclin-like component of the RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; forms a kinase-cyclin pair in the RNAPII holoenzyme with Ssn3p; required for both entry into and execution of the meiotic program; involved in glucose repression and telomere maintenance; cyclin homolog 35% identical to human cyclin C
Localization
Cell Percentages nucleus (87%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Ssn8

Ssn8


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ssn8-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available