Standard name
Human Ortholog
Description Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0.07 0 0 0 0 0 0
Cytoplasm 0.99 0.98 0.97 0.96 0.96 0.93 0.86 0.82 0.8 0.76 0.72 0.75 0.98 0.99 0.99 0.93 0.93 0.96 0.97 0.9 0.95 0.95 0.93 0.96
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0.1 0.08 0.21 0.13 0.32 0.16 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0.05 0 0 0.05 0.1 0.08 0.16 0.07 0.12 0 0 0 0.07 0 0 0 0.05 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0
Bud 0 0 0 0 2 1 0 3 3 6 4 7 0 0 0 0 0 0 1 1 0 0 3 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud Site 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 3 4 0 2 3 3 4 3 7 5 8 1 3 0 12 18 17 0 0 0 0 0 0
Cytoplasm 313 248 248 279 391 369 323 406 313 289 224 291 278 370 365 239 323 232 309 224 241 169 315 299
Endoplasmic Reticulum 1 3 2 1 2 3 4 2 1 1 0 3 2 0 1 4 10 9 0 0 0 0 3 2
Endosome 0 0 0 0 0 0 1 0 0 0 0 0 2 0 1 0 0 0 1 0 0 1 1 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1 0 0 0 0 1 0
Mitochondria 1 0 0 3 1 14 36 39 84 51 100 62 0 0 0 0 1 1 1 1 3 0 0 1
Nucleus 2 7 4 3 2 5 5 12 5 10 4 12 2 3 5 6 5 3 0 7 3 2 3 0
Nuclear Periphery 0 0 0 0 0 0 0 3 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0
Vac/Vac Membrane 1 0 6 15 16 16 19 51 33 60 22 48 2 3 1 17 14 8 0 11 1 0 3 1
Unique Cell Count 315 252 255 291 407 396 374 496 393 379 312 390 284 373 367 258 346 242 319 250 255 179 338 311
Labelled Cell Count 318 261 264 302 416 412 391 521 443 424 360 431 287 379 373 279 372 271 319 250 255 179 338 311


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 10.0 14.0 10.6 9.7 9.3 7.8 7.1 7.5 6.3 6.7 6.0 6.7 11.0 12.5 12.6 22.9 22.7 23.0 11.2 11.8 13.0
Std Deviation (1e-4) 1.7 2.6 1.3 1.4 1.4 1.5 1.4 1.4 1.3 1.5 1.3 1.5 1.9 2.3 1.9 6.2 7.1 6.1 1.9 2.1 2.3
Intensity Change (Log2) – – – -0.13 -0.18 -0.45 -0.58 -0.5 -0.74 -0.65 -0.82 -0.65 0.06 0.25 0.25 1.11 1.1 1.12 0.08 0.16 0.3


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 2.0 2.3 3.0
Cytoplasm -0.9 -0.8 -2.3 -4.6 -6.0 -6.4 -7.2 -8.1 -7.6 0.5 1.9 2.3 -2.4 -2.2 -0.9
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 1.8 2.2
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 3.0 5.1 4.6 7.9 6.1 10.0 6.7 0 0 0 0 0 0
Nucleus 0 0 0 0 0.8 0 0.9 0 1.2 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 1.7 1.1 1.2 1.7 3.9 3.2 5.4 2.6 4.5 0 0 0 2.3 1.1 0.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 7.9371 9.5951 8.5544 7.9827 8.4729 8.265 9.1589 10.4552 9.7842 7.7261 8.7568 9.2842 9.6004 11.3403 10.3981 10.6921 9.7479 10.525
Actin 0.0066 0.001 0.002 0.0003 0.0005 0.0064 0.0042 0.0003 0.0014 0.0004 0.0001 0.0007 0.0085 0.0007 0.0003 0.0003 0.0002 0.0007
Bud 0.0044 0.0036 0.0002 0.0004 0.0275 0.0007 0.0028 0.0024 0.0007 0.0002 0 0.0005 0.003 0.0044 0.0001 0.0007 0.0001 0.0002
Bud Neck 0.0007 0.0004 0.0005 0.0011 0.0019 0.0016 0.0017 0.0002 0.0006 0.0008 0.001 0.0016 0.0005 0.0002 0.0004 0.0004 0.0005 0.001
Bud Periphery 0.0018 0.0007 0.0001 0.0001 0.0038 0.0002 0.0009 0.0003 0.0003 0 0 0.0001 0.0005 0.0004 0 0.0001 0 0
Bud Site 0.0028 0.0073 0.0006 0.0002 0.002 0.0004 0.0067 0.0004 0.0005 0.0001 0 0.0001 0.0014 0.005 0.0001 0.0002 0 0.0001
Cell Periphery 0.0004 0.0001 0 0 0.0001 0 0.0001 0 0 0 0 0 0.0001 0.0001 0 0 0 0
Cytoplasm 0.8846 0.9353 0.9418 0.8954 0.8421 0.9134 0.9086 0.9763 0.9692 0.9512 0.9611 0.939 0.915 0.96 0.9677 0.911 0.8995 0.9471
Cytoplasmic Foci 0.0099 0.0044 0.0048 0.0076 0.0194 0.0063 0.0044 0.0014 0.0038 0.0059 0.0015 0.0051 0.0102 0.0024 0.0013 0.0222 0.0013 0.0028
Eisosomes 0.0004 0 0 0 0 0.0001 0 0 0 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0.0036 0.0012 0.0019 0.0024 0.0022 0.0026 0.0074 0.0009 0.0013 0.0015 0.0015 0.0019 0.003 0.0011 0.0011 0.001 0.004 0.0029
Endosome 0.01 0.0016 0.0052 0.0023 0.0044 0.0075 0.0135 0.0006 0.0008 0.0015 0.0005 0.0019 0.0042 0.001 0.0004 0.0005 0.0016 0.0021
Golgi 0.0019 0.0001 0.0009 0.0001 0.0003 0.0013 0.0012 0 0.0001 0.0001 0 0.0001 0.0007 0.0001 0 0.0001 0 0.0001
Lipid Particles 0.0043 0.0001 0.0002 0 0.0001 0.0023 0.0024 0 0.0001 0 0 0 0.0006 0.0001 0 0.0003 0 0
Mitochondria 0.0044 0.0003 0.0012 0.0003 0.0004 0.0006 0.0006 0.0001 0.0001 0.0002 0.0001 0.0002 0.0007 0.0004 0.0001 0.001 0.0002 0.0002
None 0.0101 0.0032 0.0025 0.0031 0.0035 0.0038 0.006 0.0019 0.002 0.0035 0.0023 0.0042 0.004 0.0013 0.0011 0.0081 0.0012 0.0015
Nuclear Periphery 0.0096 0.0037 0.004 0.0063 0.0048 0.0053 0.0109 0.0013 0.0016 0.0032 0.0019 0.003 0.0054 0.0022 0.0032 0.0058 0.0181 0.0051
Nucleolus 0.0026 0.0002 0 0.0001 0.0008 0.0002 0.0002 0 0 0 0 0.0001 0.0001 0.0009 0 0.0015 0 0
Nucleus 0.0303 0.0323 0.0312 0.074 0.0681 0.0409 0.0237 0.0129 0.0157 0.0292 0.0288 0.0373 0.0379 0.0172 0.0229 0.0373 0.0708 0.034
Peroxisomes 0.0042 0.0001 0.0005 0.0002 0.0003 0.0007 0.0005 0 0.0001 0.0001 0 0.0001 0.0008 0.0001 0 0.0002 0 0.0001
Punctate Nuclear 0.0048 0.0031 0.0012 0.0046 0.0158 0.0042 0.0024 0.0005 0.0014 0.0011 0.0008 0.003 0.0022 0.0017 0.0007 0.0081 0.001 0.0012
Vacuole 0.0019 0.0011 0.0008 0.0013 0.0015 0.0014 0.0013 0.0004 0.0003 0.0007 0.0003 0.0007 0.0009 0.0005 0.0004 0.0009 0.0009 0.0007
Vacuole Periphery 0.0007 0.0002 0.0002 0.0003 0.0003 0.0004 0.0004 0.0001 0.0001 0.0001 0.0001 0.0001 0.0002 0.0001 0.0001 0.0003 0.0004 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 10.8513 7.1477 15.1539 10.4673 12.5882 12.5577 17.035 14.6332 17.2773 14.4531
Translational Efficiency 1.3605 2.4978 0.9319 2.6503 1.6838 2.1685 1.7059 2.232 2.0096 2.0582

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘
Standard name
Human Ortholog
Description Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL1 has a paralog, SOL2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Sol1

Sol1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sol1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available