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Description | 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway; restores resistance to glycolaldehyde by coupling reduction of glycolaldehyde to ethylene glycol and oxidation of NADPH to NADP+; protein abundance increases in response to DNA replication stress; methylglyoxal reductase (NADPH-dependent) is also known as D-lactaldehyde dehydrogenase |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 3 |
Bud | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 1 | 6 | 3 | 19 | 10 | 0 | 1 | 0 | 0 | 0 | 0 | 12 | 5 | 5 | 4 | 12 | 19 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 2 | 1 | 4 | 8 | 7 | 3 | 4 | 4 | 5 | 5 | 0 | 2 | 5 | 12 | 11 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 281 | 203 | 289 | 298 | 452 | 317 | 361 | 347 | 192 | 235 | 225 | 248 | 323 | 548 | 600 | 289 | 324 | 260 | 259 | 181 | 270 | 251 | 422 | 413 |
Endoplasmic Reticulum | 0 | 1 | 0 | 0 | 1 | 4 | 6 | 7 | 3 | 5 | 1 | 0 | 3 | 3 | 3 | 4 | 6 | 4 | 1 | 1 | 1 | 0 | 5 | 3 |
Endosome | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 2 | 0 | 1 | 1 | 3 | 0 | 1 | 1 | 2 | 1 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 2 |
Mitochondria | 4 | 2 | 0 | 1 | 6 | 34 | 54 | 22 | 80 | 57 | 96 | 57 | 0 | 0 | 3 | 2 | 0 | 1 | 0 | 0 | 2 | 2 | 4 | 0 |
Nucleus | 2 | 1 | 0 | 2 | 4 | 4 | 5 | 14 | 2 | 9 | 10 | 9 | 2 | 9 | 3 | 1 | 1 | 2 | 1 | 3 | 2 | 0 | 2 | 1 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2 | 1 |
Nucleolus | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 3 | 5 | 8 |
Vac/Vac Membrane | 0 | 2 | 6 | 7 | 35 | 37 | 85 | 54 | 34 | 68 | 45 | 48 | 11 | 22 | 17 | 25 | 46 | 17 | 6 | 4 | 1 | 8 | 9 | 7 |
Unique Cell Count | 285 | 208 | 295 | 305 | 485 | 376 | 466 | 430 | 278 | 333 | 344 | 353 | 334 | 568 | 621 | 312 | 355 | 279 | 293 | 203 | 292 | 282 | 478 | 475 |
Labelled Cell Count | 287 | 212 | 299 | 309 | 504 | 406 | 520 | 450 | 322 | 386 | 403 | 380 | 340 | 587 | 633 | 334 | 390 | 290 | 293 | 203 | 292 | 282 | 478 | 475 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 7.3 | 10.4 | 8.1 | 8.1 | 8.3 | 7.1 | 7.2 | 7.9 | 6.9 | 7.8 | 7.2 | 8.2 | 12.9 | 13.0 | 13.2 | 19.1 | 21.1 | 20.2 | 7.8 | 8.1 | 8.3 |
Std Deviation (1e-4) | 2.5 | 3.7 | 2.1 | 2.5 | 2.3 | 1.9 | 2.0 | 2.3 | 2.5 | 2.9 | 3.7 | 3.6 | 5.8 | 5.4 | 6.0 | 7.6 | 11.1 | 8.0 | 2.2 | 2.5 | 2.3 |
Intensity Change (Log2) | – | – | – | 0.01 | 0.03 | -0.18 | -0.17 | -0.04 | -0.24 | -0.06 | -0.17 | 0.01 | 0.67 | 0.68 | 0.7 | 1.23 | 1.38 | 1.32 | -0.06 | -0.01 | 0.03 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.8 | 2.4 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.6 | 2.2 | 0 |
Cytoplasm | -0.2 | -3.0 | -5.9 | -7.8 | -7.0 | -9.4 | -9.2 | -10.3 | -9.3 | -1.0 | -1.2 | -1.1 | -3.1 | -3.7 | -2.8 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 5.3 | 6.1 | 3.9 | 9.9 | 7.5 | 9.8 | 7.2 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 3.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0.2 | 3.1 | 4.1 | 6.7 | 5.1 | 4.8 | 7.1 | 5.1 | 5.3 | 1.0 | 1.4 | 0.6 | 3.3 | 5.1 | 2.5 |