Standard name | |
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Human Ortholog | |
Description | Subunit of cleavage factor I; cleavage factor I is a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences; required for genome stability |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
Bud Neck | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 1 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 3 | 7 | 11 | 6 | 14 | 8 | 17 | 21 | 9 | 4 | 3 | 8 | 9 | 15 | 20 | 34 | 19 | 22 | 2 | 2 | 0 | 0 | 0 | 1 |
Endoplasmic Reticulum | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 5 | 3 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 2 | 0 | 2 | 1 | 7 | 41 | 20 | 33 | 53 | 44 | 21 | 36 | 2 | 7 | 7 | 19 | 7 | 20 | 0 | 2 | 0 | 0 | 0 | 0 |
Nucleus | 150 | 209 | 147 | 173 | 216 | 279 | 317 | 351 | 252 | 230 | 115 | 151 | 81 | 149 | 99 | 318 | 234 | 175 | 154 | 205 | 149 | 55 | 117 | 76 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Nucleolus | 13 | 20 | 19 | 25 | 59 | 145 | 138 | 184 | 186 | 189 | 100 | 113 | 18 | 60 | 43 | 23 | 10 | 14 | 4 | 2 | 7 | 5 | 8 | 10 |
Peroxisomes | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 3 | 3 | 3 | 1 | 2 | 2 | 1 | 3 | 3 | 0 | 0 | 3 | 3 | 2 | 2 | 9 | 7 | 7 | 5 | 3 | 7 | 1 | 19 | 23 |
Unique Cell Count | 159 | 220 | 169 | 185 | 257 | 344 | 405 | 481 | 347 | 312 | 156 | 213 | 99 | 187 | 141 | 380 | 266 | 213 | 170 | 224 | 167 | 66 | 149 | 119 |
Labelled Cell Count | 173 | 241 | 182 | 207 | 298 | 475 | 497 | 593 | 504 | 468 | 239 | 314 | 115 | 236 | 173 | 409 | 282 | 245 | 170 | 224 | 167 | 66 | 149 | 119 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 54.6 | 64.6 | 43.2 | 44.0 | 42.2 | 36.6 | 34.8 | 35.3 | 33.8 | 31.1 | 30.4 | 30.4 | 62.2 | 63.6 | 56.6 | 53.8 | 63.1 | 63.1 | 50.5 | 50.9 | 53.8 |
Std Deviation (1e-4) | 15.5 | 25.6 | 18.3 | 16.2 | 18.1 | 13.5 | 18.3 | 15.2 | 14.0 | 11.4 | 11.6 | 15.0 | 29.7 | 26.8 | 31.0 | 24.1 | 26.5 | 27.7 | 18.0 | 19.6 | 20.9 |
Intensity Change (Log2) | – | – | – | 0.03 | -0.03 | -0.24 | -0.31 | -0.29 | -0.35 | -0.47 | -0.51 | -0.51 | 0.53 | 0.56 | 0.39 | 0.32 | 0.55 | 0.55 | 0.23 | 0.24 | 0.32 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -1.4 | -0.5 | -2.4 | -1.2 | -1.1 | -2.2 | -3.1 | -2.0 | -1.2 | 0.8 | 0.5 | 2.2 | 1.0 | 0.3 | 1.3 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 4.1 | 2.1 | 2.8 | 4.9 | 4.6 | 4.3 | 5.1 | 0 | 0 | 0 | 2.2 | 0 | 3.4 |
Nucleus | 2.1 | -0.8 | -1.7 | -2.4 | -3.7 | -3.7 | -3.4 | -3.0 | -3.8 | -1.1 | -1.8 | -3.6 | -1.0 | 0.3 | -1.3 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0.6 | 3.1 | 7.1 | 5.6 | 6.5 | 9.2 | 10.4 | 9.9 | 8.5 | 1.6 | 4.7 | 4.2 | -2.1 | -3.0 | -1.6 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 23.9906 | 61.0916 | 55.822 | 49.1246 | 48.7254 | 52.7928 | 54.0228 | 57.4017 | 51.4978 | 49.6709 | 48.4401 | 48.3967 | 61.6268 | 65.7784 | 62.3595 | 61.9401 | 58.684 | 60.2761 |
Actin | 0.0002 | 0 | 0 | 0 | 0.0001 | 0 | 0.0004 | 0 | 0.0014 | 0 | 0.0074 | 0 | 0.0277 | 0 | 0.0091 | 0 | 0.0053 | 0.0034 |
Bud | 0 | 0 | 0 | 0 | 0.0002 | 0 | 0.0007 | 0 | 0.0002 | 0.0008 | 0.0005 | 0.0002 | 0.0009 | 0 | 0.0004 | 0 | 0.0001 | 0 |
Bud Neck | 0.0001 | 0 | 0 | 0 | 0.0002 | 0 | 0.0002 | 0 | 0.0004 | 0 | 0.0001 | 0.0002 | 0.0003 | 0 | 0.0002 | 0 | 0.0001 | 0.0001 |
Bud Periphery | 0 | 0 | 0 | 0 | 0.0005 | 0 | 0.0006 | 0 | 0.0002 | 0.0003 | 0.0005 | 0.0001 | 0.0005 | 0 | 0.0003 | 0 | 0.0001 | 0 |
Bud Site | 0.0001 | 0 | 0 | 0 | 0.0001 | 0 | 0.0007 | 0 | 0.0055 | 0.0003 | 0.0002 | 0 | 0.0013 | 0 | 0.0008 | 0 | 0.0008 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0.0022 | 0 | 0.0024 | 0 | 0.0001 | 0.0005 | 0.0005 | 0.0005 | 0.0003 | 0 | 0.0002 | 0.0001 | 0.0001 | 0.0001 |
Cytoplasm | 0.0131 | 0 | 0 | 0 | 0 | 0 | 0.0019 | 0 | 0.0019 | 0.0002 | 0.001 | 0.0015 | 0.0004 | 0 | 0.0009 | 0 | 0.0001 | 0.0001 |
Cytoplasmic Foci | 0 | 0 | 0 | 0 | 0 | 0 | 0.0013 | 0 | 0.0118 | 0.0035 | 0.0004 | 0.0215 | 0.0036 | 0 | 0.0028 | 0 | 0.0126 | 0.0009 |
Eisosomes | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0.0001 | 0.0001 | 0 | 0.0003 | 0 | 0 | 0 | 0.0001 | 0 |
Endoplasmic Reticulum | 0.0012 | 0 | 0 | 0 | 0 | 0 | 0.0005 | 0 | 0.0004 | 0 | 0.0006 | 0 | 0.0005 | 0 | 0.0001 | 0 | 0 | 0.0001 |
Endosome | 0.0008 | 0 | 0 | 0 | 0.0001 | 0 | 0.0023 | 0 | 0.0065 | 0 | 0.003 | 0 | 0.0059 | 0 | 0.0042 | 0 | 0.002 | 0.0013 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0.0022 | 0 | 0.0004 | 0 | 0.013 | 0 | 0.0074 | 0 | 0.0031 | 0.0012 |
Lipid Particles | 0 | 0 | 0 | 0 | 0.0002 | 0 | 0.0011 | 0 | 0.0037 | 0.0003 | 0.0003 | 0.0014 | 0.0045 | 0 | 0.0008 | 0 | 0.0159 | 0.005 |
Mitochondria | 0.0021 | 0.0008 | 0.0006 | 0.0004 | 0.0605 | 0.0005 | 0.0091 | 0.0006 | 0.0022 | 0.0421 | 0.0244 | 0.0014 | 0.0227 | 0.0005 | 0.0063 | 0.0017 | 0.0064 | 0.0008 |
None | 0.0011 | 0 | 0 | 0 | 0.0001 | 0 | 0.0012 | 0 | 0.0006 | 0.0012 | 0.0009 | 0.0015 | 0.0011 | 0 | 0.0005 | 0 | 0.0003 | 0.0001 |
Nuclear Periphery | 0.0643 | 0.001 | 0.0002 | 0.0005 | 0.0001 | 0.0001 | 0.035 | 0.0006 | 0.0013 | 0.0002 | 0.0572 | 0.0012 | 0.0004 | 0.0003 | 0.0004 | 0.0003 | 0.0002 | 0.0009 |
Nucleolus | 0.0132 | 0.022 | 0.0123 | 0.0191 | 0.4766 | 0.059 | 0.1068 | 0.0185 | 0.0413 | 0.0251 | 0.3812 | 0.0533 | 0.041 | 0.0225 | 0.0183 | 0.0396 | 0.1932 | 0.039 |
Nucleus | 0.8998 | 0.9759 | 0.9869 | 0.9798 | 0.4486 | 0.9401 | 0.8095 | 0.9801 | 0.9125 | 0.921 | 0.5097 | 0.9152 | 0.8707 | 0.9766 | 0.9437 | 0.9576 | 0.6797 | 0.9429 |
Peroxisomes | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0.0002 | 0 | 0.0016 | 0.001 | 0.0006 | 0.0002 | 0.0032 | 0 | 0.0016 | 0 | 0.0791 | 0.0026 |
Punctate Nuclear | 0.0009 | 0 | 0 | 0 | 0 | 0 | 0.0008 | 0 | 0.0055 | 0 | 0.0069 | 0.0003 | 0.0003 | 0.0001 | 0.0002 | 0 | 0.0005 | 0.0011 |
Vacuole | 0.0016 | 0 | 0 | 0 | 0.0035 | 0.0001 | 0.0124 | 0 | 0.0006 | 0.0012 | 0.0008 | 0.0008 | 0.0008 | 0 | 0.0009 | 0.0001 | 0.0001 | 0.0001 |
Vacuole Periphery | 0.0012 | 0.0001 | 0 | 0.0001 | 0.0067 | 0.0001 | 0.0126 | 0.0001 | 0.0002 | 0.0021 | 0.0032 | 0.0006 | 0.0008 | 0 | 0.0008 | 0.0004 | 0.0003 | 0.0002 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 142.652 | 118.611 | 74.7895 | 84.2152 | 98.4939 | 131.2359 | 73.3235 | 91.8472 | 76.622 | 114.1451 |
Translational Efficiency | 2.2521 | 2.584 | 2.3989 | 1.9406 | 2.6462 | 2.662 | 2.315 | 1.698 | 2.1569 | 2.144 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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