Standard name
Description Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0.09 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0.06 0.05 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.11 0.11 0.32 0.27 0.2 0.17 0.17 0.16 0.09 0.11 0.1 0.1 0.15 0.2 0.26 0.08 0.13 0.15 0 0.05 0.09 0.08 0.12 0.13
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.07 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.4 0.43 0.07 0.18 0.11 0.56 0.54 0.39 0.68 0.73 0.77 0.59 0.2 0.11 0.06 0.05 0 0.08 0 0.06 0.05 0.06 0.08 0.08
Nucleus 0.53 0.55 0.56 0.48 0.62 0.45 0.5 0.54 0.53 0.49 0.53 0.57 0.56 0.59 0.54 0.71 0.69 0.67 0.47 0.55 0.38 0.34 0.24 0.25
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0.12 0.09 0 0.06 0.07 0 0.05 0.05 0.05 0 0 0 0 0 0 0.1 0 0.06 0 0.06 0.07
Vac/Vac Membrane 0.14 0.21 0 0 0 0 0 0 0 0 0 0 0.15 0.14 0.17 0.11 0.15 0.16 0.17 0.23 0.3 0.39 0.39 0.34
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0
Bud 1 1 1 1 1 4 12 2 7 9 7 7 0 0 0 1 0 0 2 1 3 2 3 3
Bud Neck 1 0 19 8 13 4 11 16 3 6 3 5 0 0 0 0 0 0 0 0 2 0 1 2
Bud Site 0 0 1 1 3 6 6 7 10 14 14 16 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
Cytoplasm 15 14 69 49 57 53 79 80 32 42 25 32 20 31 42 10 18 14 8 7 34 8 21 23
Endoplasmic Reticulum 0 0 2 0 1 0 1 0 1 1 0 0 2 0 2 6 10 4 0 0 1 1 1 2
Endosome 2 1 0 3 4 0 3 2 0 1 1 1 3 1 4 5 4 0 7 2 8 0 3 1
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 3 0 1 1 0 0 0 0 0
Mitochondria 55 55 15 33 30 174 244 194 240 287 186 189 26 17 10 7 3 7 7 8 16 6 14 13
Nucleus 73 70 122 86 174 140 229 271 186 195 128 182 75 91 87 94 94 61 92 87 139 36 43 46
Nuclear Periphery 0 0 0 0 1 0 0 0 0 2 0 0 0 0 0 1 1 0 3 0 2 0 0 0
Nucleolus 0 0 0 0 0 1 4 3 3 3 3 1 0 0 0 1 0 0 8 3 5 2 2 5
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1
SpindlePole 0 1 5 21 26 7 27 35 12 20 11 17 0 0 2 3 2 1 20 4 22 3 10 12
Vac/Vac Membrane 19 27 8 4 7 7 7 16 5 5 0 6 20 21 27 15 21 15 32 36 110 42 71 62
Unique Cell Count 137 127 219 181 281 309 454 502 354 395 242 318 133 153 161 132 136 91 196 158 369 108 182 181
Labelled Cell Count 166 169 242 206 317 396 624 626 499 585 378 456 146 161 175 148 153 103 196 158 369 108 182 181


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.1 3.9 4.7 4.3 4.8 3.7 4.0 4.4 3.5 3.4 3.2 3.8 4.3 4.5 4.6 6.8 6.7 6.5 4.0 4.4 4.6
Std Deviation (1e-4) 0.9 0.7 0.9 0.9 1.0 1.0 1.1 1.3 1.0 1.0 0.7 0.8 0.9 1.1 1.4 1.6 1.2 1.4 1.3 2.2 2.0
Intensity Change (Log2) -0.14 0.02 -0.36 -0.22 -0.1 -0.42 -0.44 -0.55 -0.31 -0.12 -0.07 -0.03 0.53 0.52 0.47 -0.21 -0.08 -0.02


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin
Bud 0 0 0
Bud Neck 0 0 0
Bud Site 0 0 0
Cell Periphery 0 0 0
Cyto
Endoplasmic Reticulum 0 0 0
Endosome 0 0 0
Golgi 0 0 0
Mitochondria 0 0 0
Nuclear Periphery 0 0 0
Nuc
Nucleolus 0 0 0
Peroxisomes 0 0 0
SpindlePole 0 0 0
Vac
Cortical Patches 0 0 0
Cytoplasm 0 0 0
Nucleus 0 0 0
Vacuole 2.8 3.9 3.9