Standard name | |
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Human Ortholog | |
Description | Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Bud | 1 | 1 | 1 | 1 | 1 | 4 | 12 | 2 | 7 | 9 | 7 | 7 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 3 | 2 | 3 | 3 |
Bud Neck | 1 | 0 | 19 | 8 | 13 | 4 | 11 | 16 | 3 | 6 | 3 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 2 |
Bud Site | 0 | 0 | 1 | 1 | 3 | 6 | 6 | 7 | 10 | 14 | 14 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 15 | 14 | 69 | 49 | 57 | 53 | 79 | 80 | 32 | 42 | 25 | 32 | 20 | 31 | 42 | 10 | 18 | 14 | 8 | 7 | 34 | 8 | 21 | 23 |
Endoplasmic Reticulum | 0 | 0 | 2 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 2 | 6 | 10 | 4 | 0 | 0 | 1 | 1 | 1 | 2 |
Endosome | 2 | 1 | 0 | 3 | 4 | 0 | 3 | 2 | 0 | 1 | 1 | 1 | 3 | 1 | 4 | 5 | 4 | 0 | 7 | 2 | 8 | 0 | 3 | 1 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 55 | 55 | 15 | 33 | 30 | 174 | 244 | 194 | 240 | 287 | 186 | 189 | 26 | 17 | 10 | 7 | 3 | 7 | 7 | 8 | 16 | 6 | 14 | 13 |
Nucleus | 73 | 70 | 122 | 86 | 174 | 140 | 229 | 271 | 186 | 195 | 128 | 182 | 75 | 91 | 87 | 94 | 94 | 61 | 92 | 87 | 139 | 36 | 43 | 46 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 3 | 0 | 2 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 3 | 3 | 3 | 3 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 8 | 3 | 5 | 2 | 2 | 5 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
SpindlePole | 0 | 1 | 5 | 21 | 26 | 7 | 27 | 35 | 12 | 20 | 11 | 17 | 0 | 0 | 2 | 3 | 2 | 1 | 20 | 4 | 22 | 3 | 10 | 12 |
Vac/Vac Membrane | 19 | 27 | 8 | 4 | 7 | 7 | 7 | 16 | 5 | 5 | 0 | 6 | 20 | 21 | 27 | 15 | 21 | 15 | 32 | 36 | 110 | 42 | 71 | 62 |
Unique Cell Count | 137 | 127 | 219 | 181 | 281 | 309 | 454 | 502 | 354 | 395 | 242 | 318 | 133 | 153 | 161 | 132 | 136 | 91 | 196 | 158 | 369 | 108 | 182 | 181 |
Labelled Cell Count | 166 | 169 | 242 | 206 | 317 | 396 | 624 | 626 | 499 | 585 | 378 | 456 | 146 | 161 | 175 | 148 | 153 | 103 | 196 | 158 | 369 | 108 | 182 | 181 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 4.1 | 3.9 | 4.7 | 4.3 | 4.8 | 3.7 | 4.0 | 4.4 | 3.5 | 3.4 | 3.2 | 3.8 | 4.3 | 4.5 | 4.6 | 6.8 | 6.7 | 6.5 | 4.0 | 4.4 | 4.6 |
Std Deviation (1e-4) | 0.9 | 0.7 | 0.9 | 0.9 | 1.0 | 1.0 | 1.1 | 1.3 | 1.0 | 1.0 | 0.7 | 0.8 | 0.9 | 1.1 | 1.4 | 1.6 | 1.2 | 1.4 | 1.3 | 2.2 | 2.0 |
Intensity Change (Log2) | – | – | – | -0.14 | 0.02 | -0.36 | -0.22 | -0.1 | -0.42 | -0.44 | -0.55 | -0.31 | -0.12 | -0.07 | -0.03 | 0.53 | 0.52 | 0.47 | -0.21 | -0.08 | -0.02 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | 2.8 | 3.9 | 3.9 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 2.4443 | 1.9623 | 2.051 | 1.4612 | 2.0443 | 2.3362 | -0.2183 | -0.3254 | -0.4875 | -0.2184 | -0.805 | -0.5126 | -0.8297 | -0.8864 | -1.1178 | -0.7893 | -1.1378 | -1.1884 |
Actin | 0.0398 | 0.0008 | 0.0059 | 0.0044 | 0.0232 | 0.0034 | 0.0347 | 0.0004 | 0.0146 | 0.0152 | 0.0023 | 0.0006 | 0.0262 | 0.0005 | 0.0124 | 0.023 | 0.053 | 0.0042 |
Bud | 0.0011 | 0.0006 | 0.0008 | 0.0002 | 0.0003 | 0.0003 | 0.0009 | 0.0002 | 0.0003 | 0.0003 | 0.0002 | 0.0001 | 0.0003 | 0.0003 | 0.0004 | 0.0012 | 0.0022 | 0.0001 |
Bud Neck | 0.0085 | 0.0013 | 0.0019 | 0.0015 | 0.0031 | 0.0127 | 0.017 | 0.002 | 0.0022 | 0.0015 | 0.0014 | 0.0094 | 0.0019 | 0.001 | 0.0091 | 0.001 | 0.0016 | 0.0042 |
Bud Periphery | 0.0019 | 0.0011 | 0.0009 | 0.0002 | 0.0004 | 0.0012 | 0.0019 | 0.0002 | 0.0004 | 0.0005 | 0.0008 | 0.0002 | 0.0003 | 0.0002 | 0.0005 | 0.0023 | 0.0035 | 0.0001 |
Bud Site | 0.01 | 0.0031 | 0.0059 | 0.0016 | 0.0008 | 0.0008 | 0.0067 | 0.0056 | 0.0066 | 0.0009 | 0.0004 | 0.0003 | 0.002 | 0.0041 | 0.0031 | 0.0051 | 0.0068 | 0.0003 |
Cell Periphery | 0.0006 | 0.0002 | 0.0002 | 0.0001 | 0.0004 | 0.0002 | 0.0004 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0002 | 0.0001 | 0.0001 | 0.0002 | 0.0004 | 0 |
Cytoplasm | 0.0874 | 0.0888 | 0.0499 | 0.0214 | 0.1023 | 0.0656 | 0.0565 | 0.08 | 0.0655 | 0.0241 | 0.0356 | 0.0656 | 0.0939 | 0.0811 | 0.0622 | 0.0584 | 0.0196 | 0.0642 |
Cytoplasmic Foci | 0.0228 | 0.0041 | 0.0047 | 0.0247 | 0.0168 | 0.0053 | 0.0508 | 0.0102 | 0.0093 | 0.0157 | 0.0024 | 0.0063 | 0.017 | 0.008 | 0.0124 | 0.0211 | 0.0132 | 0.0112 |
Eisosomes | 0.0008 | 0.0001 | 0.0002 | 0.0001 | 0.0002 | 0.0001 | 0.0004 | 0.0001 | 0.0003 | 0.0002 | 0.0001 | 0 | 0.0002 | 0.0001 | 0.0002 | 0.0002 | 0.0005 | 0.0001 |
Endoplasmic Reticulum | 0.0075 | 0.0043 | 0.0024 | 0.0024 | 0.0087 | 0.0024 | 0.0076 | 0.0051 | 0.0065 | 0.0024 | 0.0025 | 0.0017 | 0.0055 | 0.0056 | 0.0043 | 0.0058 | 0.0018 | 0.0014 |
Endosome | 0.0265 | 0.007 | 0.0119 | 0.0136 | 0.038 | 0.0031 | 0.0438 | 0.0059 | 0.0212 | 0.0271 | 0.0096 | 0.0066 | 0.0186 | 0.0061 | 0.0105 | 0.0127 | 0.0132 | 0.0054 |
Golgi | 0.0165 | 0.0005 | 0.0045 | 0.0047 | 0.027 | 0.0014 | 0.0125 | 0.0003 | 0.0034 | 0.0064 | 0.0012 | 0.0017 | 0.0054 | 0.0003 | 0.0091 | 0.015 | 0.0129 | 0.0016 |
Lipid Particles | 0.0334 | 0.0009 | 0.003 | 0.0168 | 0.016 | 0.0054 | 0.0225 | 0.001 | 0.0032 | 0.0173 | 0.0043 | 0.0055 | 0.0109 | 0.0024 | 0.0038 | 0.0133 | 0.0124 | 0.0062 |
Mitochondria | 0.0295 | 0.0152 | 0.0219 | 0.019 | 0.0325 | 0.0177 | 0.0137 | 0.0006 | 0.003 | 0.0041 | 0.0054 | 0.0058 | 0.0017 | 0.0007 | 0.004 | 0.008 | 0.0122 | 0.0007 |
None | 0.0896 | 0.1505 | 0.185 | 0.1414 | 0.1533 | 0.1864 | 0.0975 | 0.1262 | 0.1141 | 0.0767 | 0.056 | 0.0659 | 0.1402 | 0.2107 | 0.1487 | 0.2549 | 0.1263 | 0.1439 |
Nuclear Periphery | 0.0298 | 0.0153 | 0.0198 | 0.0314 | 0.0491 | 0.0103 | 0.0427 | 0.0371 | 0.0443 | 0.0698 | 0.0654 | 0.0154 | 0.0225 | 0.0339 | 0.0326 | 0.0183 | 0.0252 | 0.0128 |
Nucleolus | 0.0119 | 0.0207 | 0.0112 | 0.0101 | 0.013 | 0.0193 | 0.0089 | 0.0106 | 0.0087 | 0.006 | 0.0141 | 0.0141 | 0.0057 | 0.0148 | 0.0059 | 0.0066 | 0.0086 | 0.0125 |
Nucleus | 0.4977 | 0.6137 | 0.5925 | 0.5351 | 0.4096 | 0.5655 | 0.4828 | 0.6195 | 0.6331 | 0.6578 | 0.6662 | 0.6981 | 0.5311 | 0.5642 | 0.5875 | 0.4806 | 0.5219 | 0.6621 |
Peroxisomes | 0.0169 | 0.0014 | 0.0049 | 0.0378 | 0.0279 | 0.0052 | 0.0131 | 0.0004 | 0.0022 | 0.0327 | 0.0005 | 0.0013 | 0.0138 | 0.0002 | 0.0027 | 0.0176 | 0.0095 | 0.0046 |
Punctate Nuclear | 0.0617 | 0.065 | 0.0691 | 0.1314 | 0.0688 | 0.0915 | 0.073 | 0.0903 | 0.0559 | 0.0354 | 0.1258 | 0.0994 | 0.0993 | 0.0631 | 0.0883 | 0.0529 | 0.1519 | 0.0629 |
Vacuole | 0.0041 | 0.0046 | 0.0026 | 0.0015 | 0.0064 | 0.0019 | 0.007 | 0.0035 | 0.0035 | 0.0041 | 0.0024 | 0.0014 | 0.0026 | 0.0021 | 0.0017 | 0.0012 | 0.0021 | 0.0013 |
Vacuole Periphery | 0.0022 | 0.0008 | 0.0009 | 0.0006 | 0.0022 | 0.0004 | 0.0056 | 0.0007 | 0.0015 | 0.0018 | 0.0032 | 0.0005 | 0.0006 | 0.0005 | 0.0006 | 0.0006 | 0.0011 | 0.0003 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 6.8027 | 7.7029 | 8.4234 | 8.3119 | 6.468 | 5.8924 | 10.0429 | 10.0983 | 9.4593 | 8.8488 |
Translational Efficiency | – | – | – | – | – | – | – | – | – | – |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | – |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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