Standard name
Human Ortholog
Description Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.06 0 0 0 0.06 0 0 – 0 0 0 0 0.07 0.12 0.13 0.08 0.06 0.05 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.19 0 – 0.14 0.09 0.16 0.09 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.88 0.95 0.94 0.96 0.92 0.85 0.91 – 0.85 0.85 0.79 0.83 0.92 0.85 0.83 0.83 0.84 0.85 0.88 0.94 0.9 0.85 0.78 0.73
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.06 0 0 0 0 0.08 0.05 – 0.15 0.13 0.2 0.17 0 0 0 0 0 0 0 0 0 0 0.07 0.09
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0.1 0.1 0 0 0 0.08 0.11 0.13
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 1 0 0 – 0 0 0 0 0 0 0 0 0 0 1 1 0 0 2 1
Bud 0 0 0 0 1 2 1 – 3 1 0 1 0 0 1 0 0 0 4 5 2 1 2 7
Bud Neck 0 0 0 0 0 1 0 – 1 1 0 3 0 0 0 0 0 0 0 0 0 0 0 1
Bud Site 0 0 0 0 0 5 1 – 3 5 10 13 0 3 1 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
Cytoplasm 15 9 8 12 18 14 13 – 8 14 10 9 57 130 152 8 4 4 0 0 1 1 2 3
Endoplasmic Reticulum 1 4 0 0 0 0 0 – 0 0 0 0 2 2 1 3 0 1 0 2 0 0 1 2
Endosome 2 1 0 0 1 0 1 – 0 0 0 1 1 7 10 1 0 0 4 4 0 3 6 4
Golgi 0 0 0 0 1 0 0 – 0 0 0 0 0 0 0 1 0 0 3 3 0 2 2 4
Mitochondria 5 25 1 0 0 64 5 – 50 37 71 46 0 0 0 1 0 0 2 7 2 3 10 4
Nucleus 206 848 193 269 295 282 300 – 297 349 361 416 733 935 951 83 53 62 215 863 195 439 642 625
Nuclear Periphery 1 0 0 0 0 1 5 – 2 0 2 4 1 3 3 1 0 0 0 0 0 0 2 2
Nucleolus 13 13 4 4 6 25 15 – 54 53 93 85 10 12 25 2 0 0 3 4 3 23 57 72
Peroxisomes 1 0 0 0 0 0 0 – 0 0 0 0 1 10 13 0 0 0 1 0 0 0 0 0
SpindlePole 1 0 1 0 1 2 2 – 0 1 3 2 3 19 23 0 0 0 1 2 0 2 3 8
Vac/Vac Membrane 4 14 1 1 5 2 5 – 0 4 5 7 1 3 15 5 6 7 4 23 5 39 88 106
Unique Cell Count 234 888 205 280 321 332 329 350 410 455 503 796 1101 1150 100 63 73 245 921 217 518 826 851
Labelled Cell Count 249 914 208 286 329 398 348 418 465 555 587 809 1124 1196 105 63 74 245 921 217 518 826 851


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.8 7.7 7.9 7.7 8.3 5.5 7.0 – 6.0 6.6 6.1 6.6 8.8 8.7 9.1 10.5 11.6 10.7 7.8 8.0 8.1
Std Deviation (1e-4) 2.8 1.5 1.3 1.3 1.8 1.7 1.6 – 1.2 1.4 1.3 1.6 1.9 2.2 2.4 3.0 3.2 2.9 1.4 1.6 1.7
Intensity Change (Log2) – – – -0.03 0.07 -0.53 -0.18 – -0.41 -0.25 -0.36 -0.25 0.16 0.15 0.2 0.41 0.56 0.44 -0.01 0.02 0.04

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.2 0.9 0.2 0 – -1.1 -0.3 -1.2 0 1.7 3.4 3.8 1.5 0 0
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 6.5 0 – 5.4 4.1 5.8 4.2 0 0 0 0 0 0
Nucleus 1.0 -1.0 -3.2 -1.2 – -3.3 -3.3 -4.8 -4.0 -1.0 -3.5 -4.2 -3.1 -2.5 -2.5
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 2.8 1.6 – 5.0 4.4 6.2 5.4 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.7129 3.6508 3.4526 3.0602 3.6193 3.3035 5.9524 6.1344 5.9507 5.5786 5.7579 6.0402 7.8625 7.6298 8.0091 7.6894 8.0778 8.1095
Actin 0.0254 0 0.0086 0.0004 0.0153 0.0002 0 0 0 0 0 0 0.0001 0 0 0 0 0
Bud 0.0004 0 0.0005 0 0.0008 0 0 0 0 0 0 0 0.0001 0 0 0 0.0001 0
Bud Neck 0.0019 0 0.0038 0.0001 0.0017 0.0005 0 0 0 0 0.0003 0.0002 0.0005 0 0 0 0.0008 0.0003
Bud Periphery 0.0008 0 0.0008 0 0.0011 0.0001 0 0 0 0 0 0 0.0003 0 0 0 0.0002 0
Bud Site 0.0013 0 0.0029 0.0001 0.0056 0 0 0 0 0 0 0 0.0001 0 0 0 0.0001 0
Cell Periphery 0.0003 0 0.0002 0 0.0004 0 0 0 0 0 0 0 0.0001 0 0 0 0.0001 0
Cytoplasm 0.0034 0 0.0009 0.0006 0.0056 0.0002 0.0045 0 0 0 0.0001 0 0.0003 0 0 0 0 0
Cytoplasmic Foci 0.0144 0 0.0047 0.0493 0.0023 0.0024 0.0001 0 0 0 0 0 0.0004 0 0 0 0 0
Eisosomes 0.0002 0 0.0001 0 0.0002 0 0 0 0 0 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0.0022 0 0.0007 0 0.0087 0.0003 0.0001 0 0 0 0 0 0.0002 0 0 0 0 0
Endosome 0.0119 0 0.0083 0.001 0.0243 0.0015 0.0001 0 0 0 0.0001 0 0.0004 0 0 0 0 0
Golgi 0.0063 0 0.0035 0.0007 0.0026 0.0003 0 0 0 0 0 0 0 0 0 0 0 0
Lipid Particles 0.0094 0 0.0042 0.0015 0.0022 0.0008 0 0 0 0 0 0 0.0003 0 0 0 0 0
Mitochondria 0.0056 0 0.0029 0.0001 0.0057 0.0002 0.0002 0 0 0 0.0001 0 0.0009 0.0001 0 0.0001 0.0003 0.0001
None 0.0075 0 0.0011 0.0007 0.0046 0.0001 0.0003 0 0 0 0 0 0.0002 0 0 0 0 0
Nuclear Periphery 0.0183 0.0007 0.0052 0.0004 0.0703 0.0078 0.0001 0.0008 0.0003 0.0001 0.0072 0.0005 0.004 0.0005 0.0001 0.0002 0.0003 0.0001
Nucleolus 0.0223 0.0077 0.0103 0.0051 0.036 0.0286 0.0082 0.007 0.0038 0.0031 0.0281 0.0236 0.0166 0.0119 0.0041 0.0075 0.0508 0.0192
Nucleus 0.8532 0.9898 0.9319 0.9276 0.7979 0.9529 0.9855 0.9907 0.9958 0.9966 0.9608 0.9753 0.9604 0.9872 0.9957 0.9922 0.9462 0.9803
Peroxisomes 0.0044 0 0.0014 0.0064 0.0005 0.0004 0 0 0 0 0 0 0 0 0 0 0 0
Punctate Nuclear 0.0055 0.0017 0.0068 0.0059 0.0067 0.0034 0.0005 0.0013 0 0.0001 0.003 0.0002 0.0146 0.0001 0 0.0001 0.0003 0.0001
Vacuole 0.0034 0 0.0009 0 0.0037 0.0002 0.0001 0 0 0 0.0001 0 0.0004 0.0001 0 0 0.0005 0
Vacuole Periphery 0.0019 0 0.0004 0 0.0038 0.0002 0 0 0 0 0.0001 0 0.0002 0.0001 0 0 0.0001 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 20.4334 20.8757 5.1636 13.4623 15.1388 13.6147 14.9511 13.6525 21.0696 14.4846
Translational Efficiency 1.0033 1.1449 3.5429 1.2462 1.0771 1.1449 1.2354 1.1784 0.9737 1.3905

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1693 825 557 118 2058 1604 1537 1420 3751 2429 2094 1538

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 811.39 955.24 975.89 1165.98 842.26 924.85 1061.88 1020.36 828.33 935.17 1039.01 1031.53
Standard Deviation 132.07 171.42 166.41 164.06 121.40 135.07 163.64 165.04 127.26 149.12 168.72 169.45
Intensity Change Log 2 — 0.235468 0.266323 0.523076 — 0.134954 0.334283 0.276741 — 0.185148 0.301337 0.402864

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000253 0.000620 0.000669 0.000834 0.000220 0.000370 0.000639 0.000816 0.000235 0.000455 0.000647 0.000817
Bud Neck 0.003974 0.013289 0.006601 0.012049 0.005171 0.009599 0.016773 0.024338 0.004631 0.010853 0.014068 0.023395
Bud Site 0.000517 0.001328 0.001406 0.001681 0.000537 0.001640 0.000927 0.003451 0.000528 0.001534 0.001054 0.003315
Cell Periphery 0.000187 0.000173 0.000092 0.000066 0.000129 0.000153 0.000066 0.000144 0.000155 0.000159 0.000073 0.000138
Cytoplasm 0.001016 0.001617 0.002235 0.000342 0.000333 0.001154 0.000301 0.007249 0.000641 0.001311 0.000815 0.006719
Cytoplasmic Foci 0.000317 0.000239 0.000107 0.000061 0.000087 0.000314 0.000008 0.001086 0.000191 0.000288 0.000034 0.001008
Eisosomes 0.000033 0.000041 0.000040 0.000041 0.000037 0.000037 0.000047 0.000037 0.000035 0.000038 0.000045 0.000038
Endoplasmic Reticulum 0.004947 0.004787 0.003418 0.002530 0.004635 0.005332 0.002672 0.003870 0.004776 0.005147 0.002871 0.003767
Endosome 0.000219 0.000260 0.000124 0.000118 0.000328 0.000494 0.000076 0.002463 0.000279 0.000414 0.000089 0.002283
Golgi 0.000081 0.000124 0.000054 0.000069 0.000061 0.000536 0.000048 0.001475 0.000070 0.000396 0.000050 0.001367
Lipid Particles 0.000045 0.000038 0.000061 0.000041 0.000108 0.000077 0.000018 0.000325 0.000079 0.000064 0.000030 0.000303
Mitochondria 0.000382 0.001266 0.000685 0.001438 0.000898 0.002692 0.001080 0.002647 0.000665 0.002208 0.000975 0.002554
Mitotic Spindle 0.000632 0.002473 0.000284 0.009446 0.000439 0.003334 0.000887 0.014674 0.000526 0.003041 0.000726 0.014273
None 0.003837 0.006417 0.004259 0.001120 0.001618 0.002582 0.001265 0.007747 0.002620 0.003884 0.002062 0.007239
Nuclear Periphery 0.000150 0.000296 0.000136 0.000257 0.000166 0.000362 0.000173 0.002125 0.000159 0.000339 0.000163 0.001982
Nuclear Periphery Foci 0.000271 0.000108 0.000122 0.000124 0.000045 0.000184 0.000023 0.002726 0.000147 0.000158 0.000049 0.002527
Nucleolus 0.011379 0.016795 0.010842 0.005204 0.013334 0.012242 0.009494 0.008499 0.012451 0.013789 0.009852 0.008246
Nucleus 0.971084 0.947705 0.967349 0.963213 0.970847 0.956466 0.964530 0.909803 0.970954 0.953490 0.965280 0.913900
Peroxisomes 0.000214 0.000323 0.000363 0.000275 0.000146 0.000248 0.000228 0.000663 0.000177 0.000273 0.000264 0.000633
Vacuole 0.000370 0.001404 0.001072 0.000956 0.000682 0.001251 0.000460 0.004358 0.000541 0.001303 0.000623 0.004097
Vacuole Periphery 0.000092 0.000696 0.000080 0.000135 0.000181 0.000935 0.000286 0.001506 0.000141 0.000854 0.000231 0.001400

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -9.57 -12.37 -7.36 -2.59 -2.24 -4.18 -19.05 -13.42 -9.38 -3.79 -8.38 -23.04 -14.31 -8.68 -4.25
Bud Neck -8.81 -5.05 -5.71 -0.22 -4.02 -5.42 -16.31 -14.91 -10.52 -4.68 -9.76 -17.41 -15.94 -9.95 -6.84
Bud Site -3.42 -1.33 -2.47 -0.96 -0.85 -2.28 -4.19 -6.74 -3.06 -5.66 -3.19 -3.31 -7.11 -3.66 -5.22
Cell Periphery 0.19 1.59 1.76 1.90 0.49 -0.86 3.90 -0.02 0.94 -5.75 -0.11 2.90 1.03 1.47 -4.98
Cytoplasm -0.12 -0.81 1.88 1.95 2.51 -1.76 0.12 -5.34 -4.27 -5.35 -1.15 0.12 -4.84 -4.26 -4.91
Cytoplasmic Foci 0.17 0.93 1.17 0.91 0.81 -1.32 1.72 -2.20 -1.36 -2.53 -0.56 1.55 -1.71 -1.36 -2.44
Eisosomes -2.40 -2.70 -2.49 -0.56 -0.60 -0.01 -4.93 -0.12 -0.11 3.59 -1.44 -6.10 -0.81 0.18 3.12
Endoplasmic Reticulum 0.25 4.98 6.35 5.54 2.69 -2.04 8.40 1.29 2.82 -4.21 -1.50 10.25 2.26 3.19 -3.57
Endosome -0.48 1.62 1.47 1.94 0.17 -0.95 1.90 -2.74 -2.44 -3.26 -1.20 2.47 -2.84 -2.56 -3.25
Golgi -0.60 0.73 0.25 0.91 -0.91 -1.33 0.03 -2.10 -0.89 -2.11 -1.37 0.54 -2.08 -1.18 -2.11
Lipid Particles 0.47 -0.86 0.48 0.13 1.46 0.34 1.06 -1.33 -1.91 -2.55 0.31 1.06 -1.74 -2.05 -2.44
Mitochondria -4.43 -5.75 -5.69 -0.94 -4.23 -1.98 -0.79 -3.18 0.11 -4.01 -2.68 -1.83 -4.79 -0.47 -4.55
Mitotic Spindle -1.23 0.55 -0.96 -0.69 -1.01 -2.37 -0.91 -5.95 -4.13 -5.58 -2.62 -0.58 -5.96 -4.42 -5.77
None -1.19 -0.14 2.79 2.43 1.74 -1.97 1.11 -4.82 -3.63 -5.20 -1.57 1.15 -3.64 -2.05 -4.17
Nuclear Periphery -3.55 0.25 -1.87 0.21 -1.94 -2.56 -2.27 -4.60 -3.99 -4.45 -3.53 -2.36 -4.65 -4.06 -4.53
Nuclear Periphery Foci 1.07 1.04 1.07 0.20 0.25 -2.20 1.22 -2.76 -2.56 -2.78 0.01 1.40 -2.57 -2.59 -2.75
Nucleolus -3.62 0.50 4.95 6.83 3.85 0.77 2.45 3.22 2.40 0.82 -1.65 2.24 3.42 4.47 1.35
Nucleus 5.75 1.02 1.01 -1.58 0.63 4.49 4.75 11.78 8.01 9.82 6.88 4.65 11.87 7.48 10.08
Peroxisomes -1.82 -2.42 -0.67 0.80 1.18 -1.68 -3.94 -1.24 -0.88 -0.89 -2.09 -3.42 -1.15 -0.78 -0.78
Vacuole -1.99 -1.82 -2.30 0.82 0.47 -1.30 0.27 -3.95 -3.41 -4.17 -2.34 -0.95 -4.18 -3.35 -4.01
Vacuole Periphery -1.87 1.17 -0.79 1.74 -1.05 -1.72 -0.43 -2.42 -0.32 -2.03 -2.32 -0.54 -2.55 -0.40 -2.20
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication
Localization
Cell Percentages nucleus (100%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-4

Syc1

Syc1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Syc1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available