Standard name
Human Ortholog
Description Subunit of UAF (upstream activation factor) complex; UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; targeting factor for the UAF that facilitates activation of many rDNA genes; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0.06 0 – 0 0 0.08 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0.08 0.11 0.14 0.16 0.09 – 0.13 0.1 0.07 0.07 0 0 0.05 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0.07 0 – 0 0.09 0.1 0.07 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0.09 0.1 0.14 0.15 – 0.06 0.1 0.07 0.06 0.09 0.17 0.25 0.44 0.34 0.32 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0.19 0.19 0 0.05 0.05 0 0 – 0 0 0 0 0.2 0.21 0.21 0.14 0.17 0.12 0.16 0.09 0.11 0.11 0.13 0.14
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.22 0.22 0 0 0 0.23 0.08 – 0.23 0.25 0.3 0.23 0 0 0 0.12 0.1 0.11 0 0 0 0 0 0
Nucleus 0.15 0.2 0.15 0.18 0.08 0.09 0.12 – 0.07 0.09 0.09 0.05 0.14 0.09 0.08 0.14 0.14 0.15 0 0.08 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.49 0.29 0.16 0.13 0.08 0.11 0.07 – 0.16 0.16 0.12 0.16 0.4 0.34 0.28 0.21 0.25 0.32 0.27 0.38 0.33 0.22 0.13 0.11
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0
SpindlePole 0.35 0.44 0.8 0.78 0.77 0.52 0.69 – 0.65 0.66 0.63 0.68 0.58 0.59 0.5 0.33 0.44 0.37 0.4 0.3 0.44 0.51 0.6 0.58
Vac/Vac Membrane 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.06 0.08 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 1 2 0 0 – 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 2 0 1 3 3 7 6 – 9 12 22 15 0 0 1 2 0 0 3 4 0 1 2 1
Bud Neck 7 0 8 16 42 18 24 – 27 29 19 26 8 7 11 0 1 3 2 2 1 3 1 6
Bud Site 4 1 0 6 0 8 7 – 7 27 27 25 1 1 0 3 0 3 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 4 7 3 14 28 16 39 – 12 29 19 22 16 46 54 70 39 43 0 3 0 2 3 5
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 1 0 0 6 3 4 0 0 0 0 2 0
Endosome 35 35 1 8 14 0 10 – 3 3 5 14 37 57 45 23 20 17 36 21 15 18 29 27
Golgi 0 0 0 1 0 0 0 – 0 0 0 0 0 0 0 0 0 0 4 0 0 2 6 1
Mitochondria 41 40 3 3 4 27 21 – 48 72 85 81 4 5 3 19 12 15 5 2 0 1 2 3
Nucleus 29 37 15 28 24 10 32 – 15 25 26 17 25 24 18 22 16 21 7 18 4 2 3 2
Nuclear Periphery 2 1 2 0 0 0 0 – 1 0 0 0 4 0 1 3 1 0 3 0 0 0 0 0
Nucleolus 93 54 16 20 22 13 19 – 33 46 35 55 72 95 61 34 29 43 60 91 45 38 30 21
Peroxisomes 4 6 0 4 0 0 1 – 2 2 0 8 2 10 11 1 0 2 0 1 1 0 0 0
SpindlePole 66 81 82 118 222 60 180 – 136 193 176 236 105 164 108 53 51 50 87 71 60 87 134 112
Vac/Vac Membrane 2 5 1 1 2 1 1 – 2 1 2 1 1 1 0 7 7 11 4 10 1 3 4 5
Unique Cell Count 189 184 103 152 290 116 261 210 293 280 347 181 277 217 160 115 136 222 238 138 172 226 195
Labelled Cell Count 289 267 132 223 363 160 340 295 439 417 500 276 410 313 243 179 212 222 238 138 172 226 195


Nucleolus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.5 5.0 4.9 5.0 5.6 3.7 4.7 – 4.1 4.0 3.8 4.0 5.2 5.4 5.4 7.1 6.8 7.0 4.9 5.1 5.1
Std Deviation (1e-4) 1.0 0.9 0.9 1.5 1.4 1.3 1.8 – 1.3 1.2 1.0 1.1 0.9 1.6 1.7 2.1 1.8 1.8 1.7 1.6 1.6
Intensity Change (Log2) – – – 0.03 0.19 -0.41 -0.06 – -0.27 -0.29 -0.36 -0.29 0.1 0.14 0.15 0.54 0.48 0.53 -0.0 0.06 0.06

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0.7 1.8 0 0 – 0 0 0 0 -1.2 0 -1.0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm 2.0 2.2 2.9 3.2 – 0 2.2 1.4 1.3 1.9 3.5 4.8 7.2 5.8 5.6
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 4.6 4.7 4.7 3.7 4.1 3.3
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 – 0 0 0 0 0 0 0 2.6 2.2 2.4
Nucleus 0.8 -1.8 -1.4 -0.6 – -2.1 -1.7 -1.5 -3.4 -0.2 -1.7 -1.7 -0.2 -0.1 0.2
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus -0.5 -2.3 0 0 – 0 0 0 0 4.2 3.6 2.5 1.2 1.8 2.9
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole -0.4 -0.6 0 0 – 0 0 0 0 -3.7 -3.7 -5.1 -7.4 -5.3 -6.6
Vacuole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 2.5

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -0.8113 -0.5327 -0.3854 -0.9445 -1.0488 -0.6889 1.4785 1.1263 0.8426 1.2412 0.4554 0.9538 1.8625 2.1981 1.8041 1.9589 1.6934 1.7755
Actin 0.0368 0.0003 0.0124 0.004 0.0049 0.0009 0.0253 0.0027 0.0142 0.0212 0.0018 0.0009 0.0079 0.0001 0.0018 0.0001 0.0007 0.0002
Bud 0.0003 0.0003 0.0002 0.0005 0.0004 0.0001 0.0022 0.0006 0.0005 0.0008 0.0005 0.0002 0.0003 0.0001 0.0001 0.0002 0.0001 0.0001
Bud Neck 0.0039 0.0076 0.0077 0.0045 0.0083 0.0041 0.0063 0.0076 0.0096 0.0212 0.0855 0.0145 0.0094 0.004 0.0064 0.0215 0.0054 0.0086
Bud Periphery 0.0003 0.0006 0.0003 0.0007 0.0006 0.0001 0.0054 0.0008 0.0007 0.001 0.001 0.0005 0.0006 0.0002 0.0002 0.0004 0.0006 0.0003
Bud Site 0.0023 0.0051 0.0025 0.0017 0.0154 0.0005 0.0037 0.0151 0.0037 0.0113 0.0051 0.0021 0.0057 0.0015 0.0078 0.0024 0.0006 0.0008
Cell Periphery 0.0003 0.0008 0.0005 0.0003 0.0003 0.0001 0.0006 0.0006 0.0006 0.001 0.0003 0.0003 0.0007 0.0001 0.0005 0.0008 0.0002 0.0003
Cytoplasm 0.0028 0.0039 0.0028 0.0332 0.0008 0.0014 0.01 0.0029 0.0084 0.0127 0.0099 0.0014 0.0039 0.0002 0.0008 0.0012 0.0003 0.001
Cytoplasmic Foci 0.0945 0.0579 0.05 0.0371 0.0537 0.0366 0.0496 0.0372 0.0375 0.0342 0.0189 0.0221 0.0535 0.0153 0.0268 0.0424 0.0278 0.0233
Eisosomes 0.0002 0.0002 0.0003 0.0001 0.0002 0 0.0003 0.0001 0.0001 0.0001 0.0001 0 0.0004 0 0.0001 0.0001 0.0001 0.0001
Endoplasmic Reticulum 0.0009 0.0007 0.0011 0.0013 0.0003 0.0001 0.0016 0.0021 0.0009 0.006 0.0023 0.0006 0.0008 0.0001 0.0002 0.0002 0.0001 0.0054
Endosome 0.0223 0.0197 0.0245 0.0361 0.0096 0.0052 0.0549 0.0196 0.0184 0.0328 0.0172 0.0184 0.0162 0.0017 0.0106 0.0077 0.0055 0.0041
Golgi 0.0106 0.0052 0.02 0.0135 0.0073 0.0037 0.0333 0.0091 0.0109 0.0298 0.0091 0.0052 0.007 0.0014 0.0033 0.0025 0.0051 0.0025
Lipid Particles 0.2063 0.1714 0.1615 0.0843 0.1665 0.1145 0.1139 0.081 0.0888 0.1021 0.0598 0.0686 0.1564 0.0383 0.089 0.0847 0.1661 0.0717
Mitochondria 0.0016 0.0013 0.0194 0.0582 0.0034 0.0002 0.0389 0.0054 0.0031 0.0073 0.027 0.0007 0.0055 0.0002 0.0004 0.0012 0.0094 0.0003
None 0.0042 0.0133 0.0258 0.0232 0.0034 0.0009 0.038 0.0132 0.0024 0.0008 0.0046 0.0005 0.0164 0.0021 0.0015 0.0027 0.0009 0.0148
Nuclear Periphery 0.003 0.0035 0.013 0.0031 0.0022 0.004 0.0052 0.0022 0.0078 0.0036 0.0129 0.0063 0.0053 0.0019 0.0017 0.0004 0.0042 0.0025
Nucleolus 0.2123 0.3674 0.3702 0.4699 0.0894 0.2048 0.2101 0.4809 0.5185 0.489 0.2583 0.3255 0.2358 0.4321 0.4809 0.4515 0.2416 0.2111
Nucleus 0.0188 0.0353 0.0256 0.0358 0.0075 0.028 0.0505 0.0752 0.073 0.0399 0.0738 0.0283 0.0365 0.034 0.0443 0.0295 0.027 0.0209
Peroxisomes 0.0289 0.0074 0.0149 0.0056 0.0434 0.0099 0.0191 0.0071 0.0044 0.0048 0.0042 0.0065 0.0201 0.0027 0.0082 0.017 0.0472 0.0058
Punctate Nuclear 0.3468 0.2868 0.2431 0.1778 0.5802 0.5838 0.3134 0.2247 0.1858 0.1677 0.4017 0.4937 0.4136 0.4632 0.3104 0.3286 0.455 0.6245
Vacuole 0.0025 0.0103 0.0033 0.0054 0.0018 0.0008 0.0135 0.0109 0.0096 0.0117 0.0042 0.0031 0.0035 0.0007 0.0045 0.0046 0.0013 0.0016
Vacuole Periphery 0.0005 0.0009 0.001 0.0037 0.0005 0.0002 0.0041 0.001 0.0013 0.0012 0.0017 0.0005 0.0004 0.0001 0.0002 0.0003 0.0006 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 5.6214 4.3073 2.1308 9.3071 10.412 3.2105 9.4361 6.3687 10.4847 9.3928
Translational Efficiency 1.7034 2.3437 3.8698 1.0842 0.8862 3.1214 1.4302 1.5247 0.773 1.0627

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2058 949 1992 1622 1896 2180 157 1837 3954 3129 2149 3459

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 610.03 763.11 848.24 873.96 679.15 761.74 973.97 886.17 643.17 762.16 857.43 880.44
Standard Deviation 77.19 99.19 102.24 119.84 81.69 98.89 111.67 117.79 86.57 98.98 108.04 118.91
Intensity Change Log 2 — 0.323011 0.475592 0.518687 — 0.165568 0.520147 0.383853 — 0.242214 0.499236 0.449228

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000209 0.000711 0.000404 0.000495 0.000179 0.000335 0.001118 0.000661 0.000195 0.000449 0.000456 0.000583
Bud Neck 0.008495 0.015077 0.012819 0.026892 0.006081 0.018911 0.011676 0.027290 0.007337 0.017748 0.012736 0.027103
Bud Site 0.002064 0.006775 0.002885 0.017390 0.001266 0.006218 0.003684 0.019057 0.001681 0.006387 0.002944 0.018275
Cell Periphery 0.000304 0.000153 0.000055 0.000130 0.000121 0.000216 0.000092 0.000475 0.000217 0.000197 0.000058 0.000313
Cytoplasm 0.035197 0.030336 0.007077 0.040778 0.031800 0.069782 0.003191 0.036338 0.033568 0.057819 0.006793 0.038420
Cytoplasmic Foci 0.135295 0.066101 0.001281 0.003097 0.057845 0.054509 0.001713 0.007300 0.098157 0.058025 0.001313 0.005329
Eisosomes 0.000166 0.000133 0.000056 0.000066 0.000128 0.000116 0.000167 0.000066 0.000148 0.000121 0.000064 0.000066
Endoplasmic Reticulum 0.002038 0.003087 0.001986 0.002701 0.001111 0.001516 0.006294 0.002449 0.001593 0.001992 0.002301 0.002567
Endosome 0.016092 0.033398 0.002685 0.009632 0.018431 0.026939 0.004277 0.013736 0.017214 0.028898 0.002802 0.011811
Golgi 0.023973 0.014775 0.001123 0.002842 0.006449 0.009404 0.001612 0.004674 0.015570 0.011033 0.001158 0.003815
Lipid Particles 0.143979 0.022258 0.000692 0.001788 0.044094 0.017631 0.002671 0.001322 0.096083 0.019034 0.000837 0.001541
Mitochondria 0.035730 0.013725 0.001560 0.004171 0.007028 0.018740 0.001038 0.004715 0.021967 0.017219 0.001522 0.004460
Mitotic Spindle 0.056894 0.346075 0.245007 0.483668 0.061113 0.104845 0.148277 0.459866 0.058917 0.178008 0.237941 0.471027
None 0.029451 0.009655 0.002804 0.003575 0.014175 0.026876 0.002665 0.005094 0.022125 0.021653 0.002794 0.004382
Nuclear Periphery 0.004330 0.002386 0.001797 0.005719 0.002741 0.002352 0.002918 0.002517 0.003568 0.002362 0.001879 0.004019
Nuclear Periphery Foci 0.074890 0.095210 0.037543 0.040134 0.103084 0.033957 0.065689 0.021524 0.088409 0.052535 0.039600 0.030251
Nucleolus 0.338435 0.222716 0.489466 0.236975 0.537451 0.417304 0.456903 0.263017 0.433866 0.358287 0.487087 0.250805
Nucleus 0.067491 0.080674 0.186185 0.097692 0.091349 0.163442 0.268318 0.102612 0.078931 0.138339 0.192186 0.100305
Peroxisomes 0.021485 0.024483 0.001908 0.002926 0.013126 0.016571 0.009000 0.004233 0.017477 0.018971 0.002426 0.003620
Vacuole 0.002146 0.009032 0.001801 0.015577 0.001647 0.008159 0.008163 0.017775 0.001907 0.008424 0.002266 0.016744
Vacuole Periphery 0.001336 0.003241 0.000863 0.003753 0.000782 0.002176 0.000534 0.005280 0.001070 0.002499 0.000839 0.004564

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -9.54 -9.48 -10.38 1.92 -2.53 -3.28 -7.98 -7.15 -3.90 5.19 -6.93 -13.61 -11.12 -3.37 -0.75
Bud Neck -5.99 -10.21 -18.42 -11.36 -11.44 -14.08 -5.28 -21.21 -10.62 -6.92 -14.47 -12.97 -27.91 -15.19 -14.95
Bud Site -6.96 -6.99 -12.84 -8.54 -10.36 -6.52 -4.40 -13.36 -9.62 -3.80 -8.58 -9.29 -18.46 -12.92 -13.83
Cell Periphery 5.21 9.97 7.57 4.46 -2.76 -6.27 -2.28 -0.70 0.06 -0.32 1.19 10.92 0.99 0.69 -1.35
Cytoplasm 0.72 11.50 -1.67 -2.01 -10.05 -8.95 7.85 -1.81 6.97 -9.04 -7.70 13.11 -2.33 5.19 -13.18
Cytoplasmic Foci 13.05 32.58 31.72 14.48 -6.47 1.28 19.65 19.04 20.14 -2.70 11.88 37.89 36.05 25.11 -8.66
Eisosomes 4.58 31.65 23.69 12.72 -3.64 4.06 -4.24 17.05 12.87 7.26 8.17 25.90 29.07 18.03 0.06
Endoplasmic Reticulum -3.88 -1.93 -4.16 -0.42 -4.72 -3.56 -8.83 -11.55 -8.51 6.66 -2.75 -6.96 -8.05 -8.44 -1.21
Endosome -6.75 13.28 3.19 8.40 -12.31 -4.31 4.72 2.51 7.21 -3.20 -7.64 15.63 3.88 10.87 -16.03
Golgi 4.63 15.77 14.85 10.51 -1.05 -2.41 8.08 6.35 7.44 -0.26 4.74 18.07 15.87 12.35 -2.49
Lipid Particles 23.56 30.17 29.95 9.96 -5.95 8.21 14.54 16.26 12.30 3.69 24.55 32.83 32.58 15.74 -4.87
Mitochondria 9.17 18.29 17.55 6.55 -3.55 -6.66 7.06 3.87 9.23 -4.64 3.48 18.92 17.23 11.27 -4.95
Mitotic Spindle -23.35 -27.32 -40.31 -8.69 -15.05 -8.00 -5.44 -38.36 -31.66 -9.57 -20.87 -28.02 -55.72 -32.09 -18.00
None 10.19 16.34 15.93 6.44 -2.06 -5.22 9.32 8.60 12.99 -2.11 1.58 19.16 17.79 14.52 -3.77
Nuclear Periphery 3.94 4.43 -1.50 -4.99 -5.38 0.97 -0.80 -2.89 -3.93 -0.47 3.98 4.13 -2.28 -6.24 -6.38
Nuclear Periphery Foci -2.38 10.36 12.72 11.01 3.07 13.93 1.77 18.39 5.59 5.62 10.27 14.48 22.31 10.86 6.53
Nucleolus 9.56 -12.52 11.01 0.32 23.44 9.87 6.75 25.01 15.43 4.53 7.75 -2.64 24.34 15.10 24.38
Nucleus -3.63 -20.19 -8.26 -3.68 10.23 -13.11 -8.04 -6.19 6.47 6.38 -14.68 -21.13 -10.29 4.73 12.39
Peroxisomes -1.78 23.24 20.30 12.77 -4.36 -2.64 2.69 12.62 12.76 4.45 -1.52 26.82 23.51 18.03 -4.32
Vacuole -4.83 -2.78 -11.88 -9.47 -11.41 -7.00 -3.65 -11.41 -8.54 0.73 -8.25 -4.94 -16.32 -12.89 -13.40
Vacuole Periphery -2.28 2.05 -0.84 1.34 -1.80 -4.72 -1.09 -3.17 -0.90 -2.93 -4.44 1.08 -2.87 0.26 -3.31
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit of UAF (upstream activation factor) complex; UAF is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; targeting factor for the UAF that facilitates activation of many rDNA genes; deletion decreases cellular growth rate; UAF30 has a paralog, TRI1, that arose from the whole genome duplication
Localization
Cell Percentages nucleolus (53%)
Cell Cycle Regulation No
Subcompartmental Group nucleolus-1

Uaf30

Uaf30


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Uaf30-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available