Standard name | |
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Human Ortholog | |
Description | GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress; GYP5 has a paralog, GYL1, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 40 | 35 | 10 | 14 | 13 | 22 | 17 | 15 | 9 | – | 5 | 5 | 6 | 0 | 1 | 22 | 18 | 21 | 44 | 41 | 27 | 25 | 68 | 57 |
Bud | 19 | 19 | 3 | 8 | 14 | 23 | 19 | 23 | 6 | – | 19 | 15 | 7 | 2 | 6 | 5 | 0 | 2 | 35 | 34 | 10 | 27 | 125 | 94 |
Bud Neck | 0 | 3 | 7 | 2 | 2 | 2 | 2 | 10 | 4 | – | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 35 | 48 | 15 | 23 | 35 | 32 |
Bud Site | 16 | 17 | 6 | 7 | 10 | 12 | 10 | 6 | 2 | – | 3 | 2 | 4 | 0 | 1 | 6 | 1 | 3 | – | – | – | – | – | – |
Cell Periphery | 3 | 7 | 8 | 10 | 8 | 1 | 4 | 6 | 11 | – | 8 | 11 | 13 | 19 | 20 | 17 | 18 | 22 | 1 | 3 | 3 | 1 | 3 | 4 |
Cytoplasm | 178 | 192 | 212 | 173 | 201 | 213 | 309 | 291 | 224 | – | 173 | 165 | 308 | 368 | 428 | 224 | 153 | 189 | 117 | 132 | 133 | 40 | 108 | 127 |
Endoplasmic Reticulum | 7 | 8 | 4 | 4 | 1 | 3 | 6 | 5 | 0 | – | 2 | 2 | 2 | 1 | 1 | 15 | 11 | 11 | 6 | 3 | 3 | 4 | 9 | 8 |
Endosome | 3 | 19 | 0 | 2 | 1 | 1 | 4 | 2 | 4 | – | 0 | 2 | 7 | 3 | 4 | 11 | 6 | 3 | 17 | 18 | 7 | 7 | 13 | 11 |
Golgi | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 5 | 0 | 2 | 1 | 0 | 2 | 3 |
Mitochondria | 6 | 9 | 0 | 2 | 2 | 29 | 49 | 33 | 69 | – | 106 | 69 | 5 | 1 | 0 | 11 | 3 | 4 | 10 | 20 | 29 | 15 | 31 | 20 |
Nucleus | 1 | 0 | 1 | 1 | 3 | 1 | 4 | 6 | 2 | – | 2 | 2 | 0 | 0 | 2 | 4 | 1 | 3 | 2 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | – | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 2 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Peroxisomes | 10 | 29 | 0 | 5 | 2 | 4 | 3 | 2 | 0 | – | 0 | 2 | 11 | 0 | 3 | 6 | 3 | 2 | 0 | 0 | 0 | 3 | 6 | 3 |
SpindlePole | 12 | 22 | 21 | 21 | 28 | 11 | 20 | 30 | 6 | – | 6 | 12 | 8 | 1 | 2 | 13 | 10 | 8 | 8 | 15 | 18 | 6 | 26 | 22 |
Vac/Vac Membrane | 0 | 5 | 3 | 0 | 2 | 1 | 3 | 7 | 8 | – | 3 | 4 | 1 | 0 | 2 | 40 | 14 | 23 | 3 | 7 | 6 | 8 | 12 | 9 |
Unique Cell Count | 245 | 289 | 248 | 214 | 243 | 279 | 386 | 374 | 296 | 260 | 242 | 333 | 373 | 443 | 312 | 207 | 241 | 291 | 333 | 268 | 168 | 450 | 400 | |
Labelled Cell Count | 295 | 368 | 275 | 249 | 287 | 324 | 450 | 436 | 346 | 331 | 293 | 373 | 395 | 471 | 378 | 238 | 296 | 291 | 333 | 268 | 168 | 450 | 400 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 5.5 | 5.9 | 6.5 | 5.8 | 6.5 | 4.9 | 5.5 | 5.6 | 5.0 | – | 4.4 | 5.1 | 5.8 | 6.0 | 6.1 | 9.5 | 10.3 | 9.7 | 5.4 | 5.4 | 5.9 |
Std Deviation (1e-4) | 0.8 | 0.8 | 3.2 | 2.1 | 2.0 | 0.9 | 1.6 | 1.6 | 2.2 | – | 1.3 | 1.4 | 1.1 | 1.2 | 1.6 | 1.6 | 1.6 | 1.7 | 1.3 | 1.4 | 1.7 |
Intensity Change (Log2) | – | – | – | -0.18 | -0.0 | -0.42 | -0.25 | -0.22 | -0.39 | – | -0.56 | -0.35 | -0.18 | -0.12 | -0.09 | 0.53 | 0.65 | 0.57 | -0.28 | -0.27 | -0.15 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 1.2 | 0.7 | 1.8 | 0.2 | 0 | -0.6 | – | 0 | -1.3 | -1.6 | 0 | 0 | 1.5 | 2.1 | 2.1 |
Bud | 1.8 | 2.8 | 3.7 | 2.5 | 3.0 | 0 | – | 0 | 2.9 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | -0.1 | -1.2 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0.6 | 1.1 | 1.2 | 0.1 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | -0.4 | 0 | 0 |
Cell Periphery | 0.8 | 0 | 0 | 0 | -1.3 | 0.3 | – | 0 | 0.8 | 0.4 | 1.1 | 0.8 | 1.3 | 2.5 | 2.7 |
Cytoplasm | -1.3 | -0.8 | -2.7 | -1.7 | -2.4 | -2.9 | – | -5.0 | -4.5 | 2.7 | 6.5 | 5.4 | -3.9 | -3.1 | -2.0 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 2.1 | 2.2 | 1.9 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 5.2 | 5.8 | 4.8 | 8.1 | – | 0 | 9.1 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0.5 | 1.1 | -2.2 | -1.6 | -0.2 | -3.4 | – | 0 | -1.5 | -3.3 | -5.4 | -5.6 | -2.1 | -1.5 | -2.4 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 1.2 | – | 0 | 0 | 0 | 0 | 0 | 5.1 | 3.1 | 4.1 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 2.1081 | 2.999 | 2.4242 | 2.7227 | 1.9248 | 2.4565 | 1.8439 | 2.0791 | 1.8379 | 1.4922 | 1.9289 | 1.7796 | 1.7884 | 1.6159 | 1.4484 | 1.3861 | 1.3294 | 1.4831 |
Actin | 0.0635 | 0.01 | 0.0696 | 0.0279 | 0.0454 | 0.0252 | 0.0751 | 0.0159 | 0.0437 | 0.0169 | 0.0365 | 0.0304 | 0.0274 | 0.0167 | 0.0334 | 0.0079 | 0.0463 | 0.0204 |
Bud | 0.0222 | 0.0506 | 0.0583 | 0.0134 | 0.0086 | 0.006 | 0.025 | 0.0298 | 0.0725 | 0.0336 | 0.0167 | 0.017 | 0.0196 | 0.0455 | 0.0977 | 0.024 | 0.0407 | 0.0199 |
Bud Neck | 0.0192 | 0.0103 | 0.0132 | 0.0014 | 0.0135 | 0.3573 | 0.0284 | 0.0048 | 0.0112 | 0.0274 | 0.0021 | 0.3448 | 0.032 | 0.0033 | 0.0076 | 0.0012 | 0.0422 | 0.3571 |
Bud Periphery | 0.0239 | 0.0396 | 0.0683 | 0.0686 | 0.0086 | 0.0025 | 0.038 | 0.0259 | 0.0955 | 0.0725 | 0.0455 | 0.0181 | 0.0215 | 0.0248 | 0.1067 | 0.0341 | 0.0701 | 0.0204 |
Bud Site | 0.0876 | 0.3449 | 0.0435 | 0.0038 | 0.0252 | 0.0021 | 0.0818 | 0.2196 | 0.0771 | 0.0219 | 0.0081 | 0.0126 | 0.1085 | 0.2754 | 0.0532 | 0.0065 | 0.02 | 0.0102 |
Cell Periphery | 0.0051 | 0.0031 | 0.004 | 0.0023 | 0.0027 | 0.0018 | 0.0025 | 0.0024 | 0.0015 | 0.0016 | 0.0007 | 0.0013 | 0.002 | 0.0026 | 0.0015 | 0.0011 | 0.0023 | 0.0013 |
Cytoplasm | 0.3099 | 0.3616 | 0.3504 | 0.4072 | 0.3801 | 0.3702 | 0.3968 | 0.469 | 0.4379 | 0.549 | 0.4207 | 0.3492 | 0.3762 | 0.3611 | 0.3559 | 0.6486 | 0.3266 | 0.2931 |
Cytoplasmic Foci | 0.1113 | 0.0467 | 0.0744 | 0.0812 | 0.0714 | 0.0696 | 0.085 | 0.0552 | 0.0445 | 0.0479 | 0.0475 | 0.1054 | 0.1223 | 0.069 | 0.0412 | 0.0195 | 0.0765 | 0.0942 |
Eisosomes | 0.0019 | 0.0001 | 0.001 | 0.0003 | 0.0009 | 0.0003 | 0.0006 | 0.0001 | 0.0003 | 0.0001 | 0.0003 | 0.0001 | 0.0004 | 0.0002 | 0.0003 | 0.0001 | 0.0003 | 0.0002 |
Endoplasmic Reticulum | 0.0046 | 0.0013 | 0.0033 | 0.0055 | 0.0051 | 0.0024 | 0.0056 | 0.0019 | 0.0036 | 0.0027 | 0.0046 | 0.0017 | 0.0066 | 0.0017 | 0.0041 | 0.0031 | 0.0068 | 0.0013 |
Endosome | 0.0179 | 0.012 | 0.0221 | 0.0274 | 0.0331 | 0.0049 | 0.0321 | 0.0099 | 0.0188 | 0.0096 | 0.0387 | 0.0123 | 0.0342 | 0.0081 | 0.0187 | 0.0136 | 0.0391 | 0.0052 |
Golgi | 0.0097 | 0.0023 | 0.0061 | 0.0064 | 0.0068 | 0.0034 | 0.0171 | 0.0028 | 0.007 | 0.0039 | 0.0255 | 0.0053 | 0.0123 | 0.002 | 0.0073 | 0.0028 | 0.0135 | 0.003 |
Lipid Particles | 0.0092 | 0.0013 | 0.006 | 0.0123 | 0.0076 | 0.0039 | 0.0252 | 0.0007 | 0.0044 | 0.0013 | 0.0194 | 0.0008 | 0.008 | 0.0006 | 0.0039 | 0.0003 | 0.0153 | 0.0011 |
Mitochondria | 0.0033 | 0.0016 | 0.0074 | 0.0082 | 0.0028 | 0.0009 | 0.0121 | 0.0014 | 0.0054 | 0.0043 | 0.0293 | 0.0048 | 0.0088 | 0.0014 | 0.0111 | 0.0027 | 0.0173 | 0.0032 |
None | 0.2703 | 0.0963 | 0.2351 | 0.2874 | 0.3536 | 0.1347 | 0.1183 | 0.1312 | 0.145 | 0.1761 | 0.2729 | 0.0768 | 0.1474 | 0.1567 | 0.1979 | 0.2085 | 0.2079 | 0.134 |
Nuclear Periphery | 0.0011 | 0.0003 | 0.0011 | 0.0013 | 0.0046 | 0.0002 | 0.007 | 0.0006 | 0.0014 | 0.001 | 0.0029 | 0.0006 | 0.0121 | 0.0012 | 0.005 | 0.0025 | 0.0053 | 0.0011 |
Nucleolus | 0.0008 | 0.0009 | 0.0008 | 0.0005 | 0.0008 | 0.0004 | 0.0009 | 0.0013 | 0.001 | 0.0024 | 0.0005 | 0.0005 | 0.0022 | 0.0014 | 0.0016 | 0.0008 | 0.0009 | 0.0014 |
Nucleus | 0.001 | 0.001 | 0.0014 | 0.0017 | 0.0024 | 0.0014 | 0.004 | 0.0039 | 0.0033 | 0.0037 | 0.0044 | 0.0021 | 0.0125 | 0.0059 | 0.0156 | 0.0069 | 0.0065 | 0.0047 |
Peroxisomes | 0.0299 | 0.001 | 0.0228 | 0.0247 | 0.0148 | 0.0083 | 0.03 | 0.0086 | 0.0155 | 0.0054 | 0.0094 | 0.0102 | 0.0279 | 0.0069 | 0.0187 | 0.0013 | 0.0314 | 0.0138 |
Punctate Nuclear | 0.0046 | 0.0128 | 0.0052 | 0.0033 | 0.0062 | 0.0034 | 0.0037 | 0.0035 | 0.0044 | 0.0118 | 0.003 | 0.0027 | 0.0099 | 0.0121 | 0.0098 | 0.0035 | 0.0243 | 0.0119 |
Vacuole | 0.0027 | 0.0023 | 0.0053 | 0.0142 | 0.005 | 0.0009 | 0.0095 | 0.01 | 0.005 | 0.0061 | 0.0096 | 0.0031 | 0.0066 | 0.0033 | 0.006 | 0.0092 | 0.0055 | 0.0021 |
Vacuole Periphery | 0.0003 | 0.0002 | 0.0006 | 0.0011 | 0.0009 | 0.0001 | 0.0014 | 0.0012 | 0.0009 | 0.0009 | 0.0017 | 0.0004 | 0.0017 | 0.0004 | 0.0027 | 0.002 | 0.0013 | 0.0004 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 14.3833 | 4.7758 | 16.0835 | 18.1279 | 10.3899 | 13.5539 | 12.9076 | 20.808 | 24.0133 | 17.1072 |
Translational Efficiency | 2.0122 | 4.3817 | 1.6205 | 2.0017 | 2.202 | 2.1876 | 1.6401 | 1.2727 | 1.4236 | 1.5047 |
Dataset | Hit |
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Protein Abundance | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |