Standard name
Human Ortholog
Description Constituent of 66S pre-ribosomal particles; has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0.05 0 0 0.05 0 0.06 0 0 0 0.07 0.11 0.1 0.06 0.06 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0.05 0 0 0 0 0.06 0 0 0 0 0 0.06 0 0 0.05 0.06 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0.12 0 0.13 0 0 0.06 0 0.09 0.06 0.06 0 0 0 0 0 0
Nucleus 0.63 0.61 0.52 0.05 0 0 0.09 0.1 0.12 0.14 0.16 0.21 0.12 0 0 0.11 0.09 0.16 0.51 0.6 0.47 0.55 0.29 0.16
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.21 0.22 0.24 0.86 0.83 0.8 0.75 0.73 0.77 0.69 0.73 0.65 0.74 0.84 0.82 0.55 0.58 0.52 0.38 0.26 0.41 0.33 0.45 0.44
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.07
Vac/Vac Membrane 0.19 0.23 0.21 0.06 0.07 0.12 0.12 0.13 0.06 0.12 0.13 0.1 0.11 0.06 0 0.2 0.28 0.24 0.06 0.08 0.06 0.08 0.13 0.2
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 1 1 1 0 1 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 2 2 0 2 4 6
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 2 3 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 1 1 0 0 0 1 4 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 5 6 9 11 7 11 19 8 15 3 6 1 17 36 11 10 11 0 2 0 0 0 1
Endoplasmic Reticulum 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 5 5 6 0 0 0 0 0 1
Endosome 0 1 2 3 7 11 15 5 3 6 2 5 1 2 5 2 3 0 0 0 1 1 9 9
Golgi 0 1 8 4 9 5 6 22 3 6 0 2 2 15 6 5 8 11 0 0 0 0 3 3
Mitochondria 0 0 0 8 6 9 13 3 26 10 16 9 2 16 12 10 9 10 0 0 0 0 0 5
Nucleus 44 69 86 12 7 12 29 40 25 36 20 45 8 4 3 12 14 28 64 96 117 121 84 53
Nuclear Periphery 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 0 6 0 1 3
Nucleolus 15 25 40 191 200 217 250 285 162 173 91 136 49 211 276 63 91 90 47 42 104 72 131 146
Peroxisomes 0 0 0 1 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 1 10 12 7 9 1 2 0 4 0 1 12 0 0 0 2 0 3 1 16 21
Vac/Vac Membrane 13 26 35 14 17 34 41 52 13 29 16 21 7 14 13 23 43 42 7 13 14 17 38 67
Unique Cell Count 70 113 164 222 242 272 333 393 210 249 125 210 66 250 336 114 156 174 126 161 252 221 295 330
Labelled Cell Count 72 127 177 243 268 309 375 436 243 278 149 232 70 285 367 131 183 198 126 161 252 221 295 330


Nucleolus, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 41.6 32.6 37.8 38.4 33.5 30.3 27.9 28.1 25.2 26.2 24.5 24.9 41.6 39.6 36.9 31.0 37.5 41.7 46.4 45.2 42.0
Std Deviation (1e-4) 11.0 10.1 10.8 11.8 10.5 8.5 8.2 7.9 7.6 7.8 8.4 7.7 12.0 12.6 14.6 12.7 14.6 16.5 15.8 13.8 16.5
Intensity Change (Log2) – – – 0.02 -0.17 -0.32 -0.44 -0.43 -0.58 -0.53 -0.62 -0.6 0.14 0.07 -0.03 -0.29 -0.01 0.14 0.3 0.26 0.15

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000204060WT3HU80HU120HU1600204060WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30204060WT1AF100AF140AF1800204060
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.2 0.4 0 -0.2 0.6 0.1 1.1 0 -0.4 0 1.4 2.7 2.1 1.1 1.1
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 1.9 0 0 0 0 0 0 0 0 0 0 0
Golgi -1.7 -0.6 0 0 0.3 0 -1.4 0 0 0 0.5 0 -0.2 0.1 0.6
Mitochondria 0 0 0 0 0 4.7 0 4.7 0 0 3.3 0 0 0 0
Nucleus -10.5 -11.7 -11.6 -10.9 -10.9 -8.5 -8.3 -6.4 -6.2 -5.6 -12.3 -14.1 -7.2 -8.4 -7.1
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 12.2 11.7 11.4 10.8 10.5 10.2 9.0 8.2 7.8 7.0 12.2 12.6 5.2 6.2 5.2
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -4.4 -4.2 -2.5 -2.6 -2.4 -4.3 -2.7 -1.9 -3.1 -1.9 -4.8 -6.2 -0.2 1.3 0.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 37.7572 43.2088 38.7264 33.8092 38.4079 39.2132 32.9034 46.8859 38.2564 34.9174 34.3236 40.5921 37.0999 45.2592 39.0264 37.9545 36.1563 41.1705
Actin 0.0075 0 0.0047 0.0003 0.0004 0.0002 0.0055 0.0002 0.0103 0.0007 0.0014 0.0002 0.0105 0 0.0112 0.0012 0.0002 0.0001
Bud 0.0002 0.0001 0.0001 0.0001 0.0001 0.0001 0.0004 0.0001 0.0002 0.0005 0.0004 0.0001 0.0002 0 0.0003 0.0002 0.0001 0.0001
Bud Neck 0.0002 0.0003 0.0002 0.0002 0.0004 0.0005 0.0005 0.0002 0.0002 0.0003 0.0003 0.0004 0.0013 0.0001 0.0002 0.0002 0.0002 0.0004
Bud Periphery 0.0003 0.0001 0.0001 0.0001 0.0002 0.0003 0.0005 0.0001 0.0003 0.0008 0.0007 0.0004 0.0002 0.0001 0.0003 0.0003 0.0003 0.0002
Bud Site 0.0007 0.0001 0.0007 0.0003 0.0001 0.0001 0.0066 0.0001 0.0006 0.0004 0.0007 0.0001 0.0008 0 0.0025 0.0003 0.0001 0
Cell Periphery 0.0007 0.0007 0.0005 0.0005 0.0006 0.0004 0.0004 0.0002 0.0003 0.0003 0.0003 0.0005 0.0004 0.0002 0.0005 0.0003 0.0007 0.0002
Cytoplasm 0.002 0.0002 0.0008 0.0016 0.0002 0.0001 0.0111 0.0001 0.0023 0.001 0.0018 0.0001 0.0072 0 0.0059 0.0005 0.0038 0.0001
Cytoplasmic Foci 0.0101 0.0001 0.004 0.0492 0 0.0038 0.0103 0 0.0039 0.0002 0.0002 0 0.0156 0 0.0099 0.0032 0.0455 0
Eisosomes 0.0001 0 0 0.0001 0 0 0.0001 0 0.0001 0 0.0001 0 0.0001 0 0.0001 0.0001 0 0
Endoplasmic Reticulum 0.0012 0.0001 0.0004 0.0002 0.0001 0.0001 0.0023 0 0.0024 0.0001 0.0004 0.0002 0.0011 0 0.0005 0.0001 0.0002 0
Endosome 0.0103 0.0001 0.0029 0.0136 0.0001 0.0018 0.0152 0 0.0146 0.0003 0.002 0.0002 0.0042 0 0.0068 0.0023 0.001 0
Golgi 0.0017 0 0.0027 0.0028 0 0.0006 0.0041 0 0.0055 0 0.0002 0 0.0018 0 0.0027 0.0024 0.0002 0
Lipid Particles 0.0055 0.0003 0.0011 0.014 0.0001 0.0024 0.0114 0.0001 0.0022 0.0001 0.0005 0.0001 0.0104 0 0.0039 0.027 0.0076 0
Mitochondria 0.0043 0.0003 0.0013 0.0048 0.001 0.0011 0.0054 0.0012 0.0025 0.0038 0.0129 0.0014 0.0034 0.0008 0.0221 0.0096 0.003 0.0024
None 0.0025 0 0.0002 0.0039 0.0001 0 0.0117 0.0001 0.0012 0.0002 0.0007 0 0.0023 0 0.0016 0.0003 0.0039 0
Nuclear Periphery 0.027 0.0126 0.004 0.0598 0.0731 0.0429 0.0451 0.0425 0.0119 0.0311 0.0839 0.0499 0.0154 0.0045 0.0025 0.0213 0.0476 0.0045
Nucleolus 0.5849 0.5505 0.7167 0.5677 0.3416 0.5669 0.2764 0.4556 0.5122 0.2737 0.1509 0.4004 0.4184 0.4385 0.5723 0.5916 0.3522 0.4517
Nucleus 0.3205 0.4269 0.2555 0.2685 0.5734 0.3702 0.534 0.4961 0.4073 0.6705 0.7276 0.5355 0.4893 0.549 0.35 0.2986 0.5085 0.5371
Peroxisomes 0.0007 0 0.0002 0.0014 0 0.0006 0.0046 0 0.0003 0 0.0001 0 0.0026 0 0.0016 0.0304 0.0004 0
Punctate Nuclear 0.01 0.0021 0.0011 0.0034 0.001 0.001 0.0406 0.0006 0.019 0.0105 0.0034 0.0002 0.0118 0.0002 0.0012 0.0036 0.0072 0.0002
Vacuole 0.0038 0.0043 0.0017 0.003 0.002 0.0016 0.0064 0.0005 0.0011 0.0021 0.0031 0.0019 0.0013 0.0014 0.0021 0.002 0.0033 0.0007
Vacuole Periphery 0.0057 0.0011 0.0012 0.0044 0.0055 0.0053 0.0075 0.0023 0.0017 0.0031 0.0084 0.0085 0.0018 0.005 0.0019 0.0046 0.0139 0.0021

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 219.0362 187.1174 145.7917 172.6736 149.2644 134.487 147.3012 143.655 133.5478 171.6951
Translational Efficiency 1.2235 1.2952 1.4962 1.3029 1.4138 1.6397 1.5001 1.1173 1.1671 1.1907

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1350 1084 1178 1903 1995 1999 1455 1786 3345 3083 2633 3689

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1598.14 2599.52 4085.30 3908.11 2036.78 2469.07 3593.83 3727.52 1859.75 2514.94 3813.71 3820.68
Standard Deviation 417.24 640.46 873.14 998.55 479.23 649.49 880.68 914.76 503.53 649.33 910.71 963.14
Intensity Change Log 2 — 0.701851 1.354048 1.290077 — 0.277678 0.819232 0.871926 — 0.479661 1.079019 1.070824

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001053 0.000967 0.001739 0.000870 0.000710 0.000720 0.001355 0.001224 0.000849 0.000807 0.001527 0.001042
Bud Neck 0.015235 0.019591 0.026154 0.024646 0.016247 0.016578 0.026099 0.017001 0.015838 0.017638 0.026123 0.020945
Bud Site 0.000857 0.000912 0.001231 0.003542 0.001191 0.001512 0.001826 0.001048 0.001056 0.001301 0.001560 0.002334
Cell Periphery 0.000137 0.000077 0.000164 0.000237 0.000094 0.000105 0.000194 0.000130 0.000111 0.000095 0.000181 0.000185
Cytoplasm 0.002010 0.000488 0.001215 0.003270 0.000995 0.001871 0.003130 0.001068 0.001405 0.001385 0.002273 0.002204
Cytoplasmic Foci 0.000146 0.000528 0.001932 0.004641 0.000937 0.000840 0.005003 0.002167 0.000618 0.000730 0.003629 0.003443
Eisosomes 0.000036 0.000035 0.000039 0.000036 0.000036 0.000030 0.000038 0.000037 0.000036 0.000032 0.000038 0.000036
Endoplasmic Reticulum 0.001833 0.000509 0.000448 0.000411 0.000651 0.000625 0.000385 0.000361 0.001128 0.000584 0.000413 0.000387
Endosome 0.000200 0.000113 0.000123 0.001778 0.000195 0.000267 0.001254 0.000187 0.000197 0.000213 0.000748 0.001008
Golgi 0.000121 0.000232 0.000561 0.001771 0.000292 0.000326 0.000739 0.000778 0.000223 0.000293 0.000659 0.001290
Lipid Particles 0.000028 0.000045 0.000054 0.000223 0.000031 0.000079 0.000073 0.000066 0.000030 0.000067 0.000065 0.000147
Mitochondria 0.002351 0.002916 0.007088 0.006446 0.002380 0.002160 0.005777 0.005680 0.002368 0.002426 0.006364 0.006075
Mitotic Spindle 0.000509 0.000974 0.003000 0.036584 0.005059 0.000780 0.007620 0.008968 0.003223 0.000848 0.005553 0.023214
None 0.004590 0.001020 0.001134 0.001769 0.001284 0.002435 0.002137 0.001198 0.002618 0.001937 0.001688 0.001492
Nuclear Periphery 0.002366 0.001443 0.021951 0.032029 0.002917 0.002406 0.012226 0.047442 0.002695 0.002068 0.016577 0.039491
Nuclear Periphery Foci 0.000845 0.000669 0.002748 0.012353 0.001316 0.001216 0.001789 0.010805 0.001126 0.001024 0.002218 0.011603
Nucleolus 0.228240 0.372629 0.412892 0.488837 0.384013 0.309569 0.394444 0.527693 0.321145 0.331741 0.402698 0.507649
Nucleus 0.736454 0.591190 0.502778 0.349292 0.575408 0.653713 0.522640 0.354200 0.640404 0.631730 0.513754 0.351668
Peroxisomes 0.001029 0.002767 0.006236 0.007267 0.004063 0.001345 0.006212 0.007402 0.002839 0.001845 0.006223 0.007333
Vacuole 0.000825 0.000980 0.001762 0.005333 0.000719 0.001149 0.002048 0.002101 0.000762 0.001090 0.001920 0.003768
Vacuole Periphery 0.001135 0.001916 0.006754 0.018667 0.001461 0.002272 0.005011 0.010443 0.001329 0.002147 0.005790 0.014685

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.37 -12.03 3.57 1.88 16.00 -0.04 -17.98 -14.11 -13.88 3.43 1.65 -20.95 -7.99 -9.56 14.30
Bud Neck -4.22 -10.49 -14.53 -8.88 -2.75 -0.76 -12.43 -4.27 -3.52 8.67 -3.19 -16.14 -13.74 -10.18 3.94
Bud Site -0.90 -4.53 -11.04 -10.84 -8.58 -0.43 -9.21 -3.01 -0.70 5.32 -0.62 -9.88 -11.05 -6.02 -4.60
Cell Periphery 2.79 -2.82 -5.33 -8.44 -3.70 -0.47 -6.55 -4.13 -2.56 4.18 1.15 -7.09 -7.04 -7.67 -0.27
Cytoplasm 2.70 1.43 -2.28 -7.83 -5.89 -2.44 -4.61 -1.55 1.09 3.40 0.13 -2.44 -3.39 -3.75 -0.86
Cytoplasmic Foci -4.29 -6.51 -8.16 -7.67 -5.11 0.33 -5.00 -4.46 -4.05 3.06 -0.52 -6.28 -9.08 -8.33 -0.25
Eisosomes 0.15 -2.40 -1.41 -1.71 1.27 4.70 -3.99 -1.73 -5.43 2.01 3.73 -4.51 -2.21 -5.71 2.41
Endoplasmic Reticulum 8.12 8.79 9.08 2.09 0.75 0.92 7.47 8.97 8.41 2.08 7.78 10.48 11.04 6.67 1.41
Endosome 2.58 2.87 -3.10 -3.31 -3.28 -1.10 -1.52 0.19 1.21 1.53 -0.41 -1.40 -3.07 -2.93 -0.77
Golgi -4.39 -15.53 -17.08 -15.28 -11.61 -0.27 -4.80 -13.96 -4.90 -0.46 -1.11 -8.30 -20.24 -12.31 -7.89
Lipid Particles -1.71 -3.82 -4.90 -4.18 -3.94 -1.31 -4.79 -4.69 -0.20 0.74 -1.67 -6.05 -5.77 -3.10 -3.40
Mitochondria -3.10 -17.60 -15.08 -11.45 1.47 1.64 -15.64 -13.81 -15.30 0.76 -0.74 -23.35 -20.22 -19.41 1.29
Mitotic Spindle -0.45 -3.05 -13.45 -13.45 -10.18 4.50 -2.27 -3.49 -7.15 -0.80 3.86 -3.44 -12.80 -15.14 -8.80
None 3.19 2.98 2.12 -7.18 -6.67 -2.31 -4.77 -0.31 2.20 4.29 1.27 1.71 1.81 0.42 0.28
Nuclear Periphery 2.12 -8.72 -11.55 -12.21 -1.64 0.68 -4.90 -12.73 -12.92 -9.85 1.28 -9.76 -16.88 -17.28 -8.88
Nuclear Periphery Foci 0.57 -4.95 -9.08 -9.44 -7.13 -0.03 -0.76 -10.75 -9.93 -10.09 0.11 -3.81 -13.78 -13.14 -12.04
Nucleolus -11.94 -15.00 -22.57 -7.22 -4.76 7.85 2.29 -12.80 -20.43 -13.68 -1.27 -7.05 -22.24 -20.23 -13.07
Nucleus 12.21 19.96 37.19 19.13 12.00 -8.24 3.01 21.42 29.75 15.89 1.11 14.09 38.29 35.97 19.89
Peroxisomes -9.43 -10.52 -19.76 -13.04 -1.94 9.43 -5.48 -8.07 -17.46 -1.56 5.28 -10.40 -16.39 -22.83 -2.46
Vacuole -1.19 -5.62 -12.18 -10.72 -9.15 -1.89 -5.05 -10.39 -4.70 1.05 -2.20 -6.78 -14.82 -11.38 -5.72
Vacuole Periphery -2.99 -8.96 -12.52 -11.65 -6.90 -1.84 -4.86 -13.06 -10.32 -6.84 -2.80 -9.43 -17.06 -14.84 -9.65
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Constituent of 66S pre-ribosomal particles; has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits
Localization
Cell Percentages nucleus (83%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-5

Tif6

Tif6


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Tif6-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available