Standard name
Human Ortholog
Description Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.16 0.3 0.26 0.27 0.25 0.21 0.27 0.24 0.25 0.32 0.23 0.28 0.17 0.09 0.08 0.09 0.06 0.09 0 0 0 0 0 0
Bud 0.05 0 0 0 0 0 0 0.08 0.11 0 0.07 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0.73 0.79 0.71 0.61 0.56 0.4 0.48 0.42 0.51 0.5 0.52 0.49 0.78 0.77 0.8 0.76 0.72 0.7 0.62 0.73 0.71 0.73 0.8 0.83
Cytoplasm 0.15 0.11 0.11 0.27 0.22 0.33 0.27 0.28 0.32 0.26 0.24 0.26 0.17 0.15 0.17 0.2 0.23 0.29 0 0 0 0 0 0
Endoplasmic Reticulum 0.19 0.16 0.23 0.19 0.32 0.26 0.2 0.15 0.06 0.1 0.07 0.09 0.14 0.2 0.14 0 0 0 0.26 0.17 0.21 0.19 0.1 0.06
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0.05 0.15 0.08 0.2 0.21 0.28 0.33 0.35 0.42 0.46 0 0 0 0.1 0.09 0.08 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 51 119 65 52 62 67 96 114 79 117 80 107 119 74 68 29 17 22 5 11 9 9 13 8
Bud 15 13 10 8 7 14 13 38 34 15 24 21 14 8 8 4 6 2 4 3 0 1 3 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 4 4 2 1 4 6
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 229 316 179 120 141 125 168 198 165 183 177 187 537 601 651 245 194 180 220 349 204 251 351 344
Cytoplasm 46 44 28 53 55 104 95 133 102 93 81 98 119 120 142 65 62 74 14 13 4 6 11 10
Endoplasmic Reticulum 61 64 58 38 80 80 69 72 20 38 23 35 99 156 111 5 8 4 92 81 60 65 42 26
Endosome 0 0 0 0 0 1 0 0 0 0 0 0 2 0 0 0 0 1 0 0 0 0 1 0
Golgi 0 1 1 0 0 0 0 1 0 0 0 0 2 0 0 3 0 0 2 0 0 0 1 1
Mitochondria 8 12 13 29 20 64 75 129 106 126 144 173 2 0 0 33 23 21 2 5 4 3 1 6
Nucleus 0 0 1 0 2 0 1 1 0 1 1 3 1 0 2 1 1 1 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 4 0 4 3 6 0 0 0 1 1 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 1 0 1 1 1 1 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 2 0 0 0 0 1 0 0 0 1 3 1 4 1 0 1 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 1 0 1 1 1 3 6 0 3 4 0 4 2 1 1 2 2
Unique Cell Count 313 401 252 196 251 313 352 468 321 363 342 380 690 784 813 321 270 258 354 477 290 345 439 415
Labelled Cell Count 410 570 357 301 368 456 518 693 506 579 535 633 901 966 986 390 316 306 354 477 290 345 439 415


Cell Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 14.1 16.5 11.8 10.8 11.1 10.0 10.4 10.6 10.1 9.5 10.0 9.8 13.6 13.7 13.9 11.5 13.1 15.0 13.7 12.9 12.4
Std Deviation (1e-4) 3.3 4.4 3.0 2.8 2.5 2.5 2.3 2.4 2.1 1.9 2.2 2.1 3.1 2.7 2.7 2.3 3.2 3.3 3.2 2.5 2.2
Intensity Change (Log2) – – – -0.13 -0.08 -0.24 -0.18 -0.15 -0.22 -0.32 -0.24 -0.26 0.21 0.21 0.24 -0.03 0.15 0.34 0.21 0.13 0.07

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0.2 -0.3 -1.2 0.4 -0.4 -0.3 1.7 -0.7 0.7 -2.9 -6.6 -7.3 -5.4 -6.1 -5.2
Bud 0.1 -0.7 0.3 -0.2 2.1 3.0 0.1 1.6 0.9 -1.7 0 0 -2.1 -1.2 -2.4
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -2.2 -3.5 -7.4 -5.7 -7.4 -4.8 -5.1 -4.7 -5.4 2.2 1.8 3.0 1.4 0.2 -0.3
Cytoplasm 4.3 3.3 6.2 4.8 5.3 5.9 4.5 3.9 4.5 2.3 1.7 2.4 2.9 3.6 5.0
Endoplasmic Reticulum -0.9 2.2 0.7 -1.0 -2.5 -5.8 -4.2 -5.7 -4.8 -3.2 -1.1 -3.6 -8.2 -6.9 -7.4
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 3.5 1.3 5.3 5.5 7.2 8.2 8.6 10.1 10.9 0 0 0 2.2 1.5 1.3
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 12.025 15.5008 13.325 13.305 12.8596 15.3362 13.2156 15.9845 13.7492 13.8438 15.3038 15.593 16.9913 17.074 16.5754 16.4595 17.409 18.9239
Actin 0.0259 0.0013 0.029 0.0513 0.0004 0.0007 0.0521 0.0073 0.0002 0 0.0023 0.0001 0.0255 0.0002 0.0001 0.0001 0 0.0001
Bud 0.0024 0.0004 0.0018 0.001 0.0002 0.0005 0.001 0.0003 0.0001 0.0001 0.0002 0.0001 0.0003 0.0001 0.0001 0.0001 0 0.0001
Bud Neck 0.0014 0.0005 0.0008 0.0013 0.0001 0.0006 0.0038 0.0003 0.0005 0.0003 0.0004 0.0011 0.0003 0.0005 0.0003 0.0016 0.0003 0.0004
Bud Periphery 0.0118 0.0025 0.0092 0.0046 0.0049 0.0107 0.004 0.0012 0.0019 0.0026 0.0012 0.0033 0.0013 0.001 0.0014 0.0037 0.0013 0.0037
Bud Site 0.008 0.018 0.0063 0.0039 0.0001 0.0002 0.0126 0.018 0.0137 0.0003 0.0005 0.0001 0.0017 0.0384 0.0016 0.0003 0.0001 0.0001
Cell Periphery 0.622 0.8303 0.8179 0.6223 0.7064 0.7526 0.6365 0.8278 0.8901 0.7798 0.6397 0.7898 0.7657 0.8132 0.8727 0.5343 0.7052 0.8364
Cytoplasm 0.042 0.0715 0.0487 0.0679 0.014 0.0249 0.0245 0.0392 0.0241 0.0145 0.0219 0.0199 0.0119 0.0399 0.0276 0.0203 0.0292 0.0123
Cytoplasmic Foci 0.0198 0.0001 0.0014 0.0031 0.0001 0 0.0075 0.0001 0 0 0.0069 0 0.0006 0 0 0 0 0
Eisosomes 0.004 0.001 0.0007 0.0031 0.0082 0.0006 0.0059 0.0004 0.0018 0.0003 0.0008 0.0003 0.0006 0.0005 0.0015 0.0006 0.0004 0.0004
Endoplasmic Reticulum 0.0934 0.0633 0.0529 0.2113 0.2446 0.1735 0.1738 0.0972 0.0573 0.1867 0.2552 0.1758 0.1648 0.0945 0.085 0.4271 0.2537 0.1366
Endosome 0.0305 0.0001 0.0013 0.0051 0.0003 0.0003 0.0104 0 0 0 0.0153 0 0.0012 0 0 0 0 0
Golgi 0.0114 0.0002 0.0009 0.0091 0.0004 0.0002 0.0039 0.0001 0.0001 0 0.0344 0.0001 0.0015 0 0 0.0001 0.0001 0
Lipid Particles 0.0038 0.0009 0.0007 0.0019 0.0019 0.0012 0.008 0.0003 0.0009 0.0014 0.003 0.0008 0.0014 0.0007 0.0005 0.0012 0.0014 0.0005
Mitochondria 0.0126 0.0004 0.0006 0.0024 0.0063 0.0203 0.0031 0.0001 0 0 0.0074 0.0001 0.0015 0 0 0 0 0
None 0.0032 0.0002 0.0006 0.0003 0.001 0.0001 0.0068 0.0001 0.0001 0 0.0001 0.0001 0.0006 0.0001 0.0001 0.0001 0 0
Nuclear Periphery 0.0367 0.0021 0.0071 0.0036 0.0027 0.003 0.0161 0.0029 0.0024 0.005 0.0027 0.0022 0.0074 0.0042 0.0027 0.004 0.0031 0.0028
Nucleolus 0.0009 0 0.0004 0 0.0001 0 0.0006 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.0343 0.0002 0.0051 0.0003 0.0002 0.0002 0.0034 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001
Peroxisomes 0.01 0 0.0037 0.0005 0 0 0.0082 0 0 0 0.0021 0 0.0005 0 0 0 0 0
Punctate Nuclear 0.0054 0 0.003 0.0001 0 0 0.0035 0 0 0 0.0001 0 0.0001 0 0 0 0 0
Vacuole 0.0173 0.0069 0.0076 0.0066 0.0078 0.0099 0.0129 0.0045 0.0067 0.0088 0.0056 0.0061 0.0129 0.0066 0.0062 0.0062 0.005 0.0064
Vacuole Periphery 0.0032 0.0001 0.0003 0.0002 0.0004 0.0005 0.0015 0 0 0 0.0003 0.0001 0.0001 0 0 0.0001 0.0001 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 6.1989 22.1658 73.6241 51.0242 9.568 12.981 42.0221 72.931 61.757 17.6082
Translational Efficiency 0.9658 1.663 1.2954 1.562 1.5834 0.7289 1.2601 1.2408 1.1479 1.1192

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
134 1114 210 353 1849 1372 1577 1518 1983 2486 1787 1871

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1383.84 1297.58 2296.03 2506.92 1109.84 1241.18 1939.89 2292.92 1128.36 1266.45 1981.74 2333.30
Standard Deviation 214.60 222.17 354.23 452.51 187.43 203.86 360.70 492.48 201.49 214.11 377.78 492.36
Intensity Change Log 2 — -0.092854 0.730464 0.857239 — 0.161361 0.805623 1.046834 — 0.025848 0.764399 0.944710

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.010728 0.002276 0.001943 0.002089 0.001504 0.001505 0.000826 0.003006 0.002127 0.001850 0.000958 0.002833
Bud Neck 0.006755 0.003066 0.003980 0.002353 0.002327 0.002458 0.001063 0.000958 0.002626 0.002730 0.001406 0.001221
Bud Site 0.075033 0.036262 0.011936 0.017985 0.018170 0.022699 0.006837 0.010794 0.022013 0.028777 0.007436 0.012150
Cell Periphery 0.390787 0.803336 0.886680 0.849307 0.774802 0.803787 0.931338 0.895604 0.748852 0.803585 0.926090 0.886869
Cytoplasm 0.194319 0.033062 0.002025 0.013508 0.065266 0.031774 0.002625 0.002812 0.073986 0.032351 0.002555 0.004830
Cytoplasmic Foci 0.018755 0.001750 0.000226 0.000480 0.003166 0.002675 0.000222 0.000386 0.004220 0.002261 0.000222 0.000404
Eisosomes 0.001280 0.000606 0.003320 0.001722 0.000757 0.000480 0.001214 0.000785 0.000792 0.000536 0.001462 0.000961
Endoplasmic Reticulum 0.124159 0.090956 0.027920 0.018733 0.089054 0.096244 0.011489 0.023247 0.091426 0.093874 0.013420 0.022395
Endosome 0.009291 0.001912 0.001254 0.001134 0.002028 0.002259 0.000676 0.001717 0.002518 0.002104 0.000744 0.001607
Golgi 0.009799 0.001483 0.005548 0.005057 0.001123 0.000986 0.001044 0.004268 0.001710 0.001209 0.001573 0.004417
Lipid Particles 0.035680 0.001727 0.001457 0.028279 0.002490 0.001361 0.000890 0.002895 0.004733 0.001525 0.000957 0.007684
Mitochondria 0.000595 0.001205 0.000670 0.000372 0.001980 0.002075 0.000468 0.001432 0.001886 0.001685 0.000492 0.001232
Mitotic Spindle 0.001411 0.000922 0.001478 0.001662 0.000895 0.000772 0.000804 0.001495 0.000930 0.000839 0.000883 0.001526
None 0.000033 0.000046 0.000051 0.000077 0.000104 0.000048 0.000030 0.000078 0.000099 0.000047 0.000032 0.000077
Nuclear Periphery 0.001616 0.003311 0.004693 0.005687 0.005062 0.004603 0.005170 0.011989 0.004829 0.004024 0.005114 0.010800
Nuclear Periphery Foci 0.004652 0.001063 0.000912 0.001315 0.000869 0.000731 0.000487 0.000766 0.001125 0.000880 0.000537 0.000870
Nucleolus 0.000027 0.000050 0.000099 0.000065 0.000097 0.000084 0.000097 0.000143 0.000093 0.000069 0.000097 0.000129
Nucleus 0.001716 0.000420 0.000321 0.000917 0.000745 0.000443 0.000287 0.000356 0.000811 0.000433 0.000291 0.000462
Peroxisomes 0.001761 0.002678 0.000032 0.001009 0.010843 0.006239 0.000220 0.000455 0.010229 0.004643 0.000198 0.000559
Vacuole 0.102447 0.011885 0.036791 0.042518 0.016101 0.015236 0.030257 0.031291 0.021936 0.013734 0.031025 0.033410
Vacuole Periphery 0.009156 0.001984 0.008663 0.005730 0.002617 0.003540 0.003956 0.005524 0.003059 0.002843 0.004509 0.005563

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 3.91 3.94 3.95 0.31 -0.21 -0.00 2.17 -1.79 -1.77 -2.67 0.79 3.51 -1.00 -1.46 -2.79
Bud Neck 4.17 2.85 4.87 1.30 2.43 -0.36 5.67 4.67 4.04 0.44 -0.33 5.42 5.14 5.02 0.85
Bud Site 2.90 4.70 4.22 3.62 -1.37 -1.55 6.22 3.21 4.08 -2.28 -2.45 7.44 4.26 6.48 -2.96
Cell Periphery -12.66 -14.95 -13.75 -3.50 2.68 -3.19 -23.89 -16.35 -11.30 7.17 -6.73 -25.74 -18.32 -12.69 8.30
Cytoplasm 7.72 9.26 8.64 4.79 -3.68 8.16 18.89 18.90 11.40 -0.33 10.68 20.59 19.76 13.81 -2.70
Cytoplasmic Foci 3.36 3.64 3.59 5.00 -1.60 1.01 9.12 8.41 6.04 -2.23 3.86 8.37 7.93 7.94 -2.70
Eisosomes 2.76 -2.92 -1.47 -5.41 2.30 4.54 -4.10 -0.42 -5.38 3.92 4.61 -5.23 -2.34 -7.23 3.84
Endoplasmic Reticulum 1.42 4.34 4.80 10.72 1.60 -1.13 19.29 15.25 13.49 -5.19 -0.48 19.28 16.28 17.20 -4.34
Endosome 3.03 3.30 3.35 4.05 0.57 -1.41 16.36 0.68 1.15 -2.36 2.02 9.57 2.23 1.31 -2.40
Golgi 1.88 0.92 1.01 -2.58 0.29 1.25 0.73 -4.26 -4.46 -4.39 1.55 0.39 -3.80 -4.91 -4.31
Lipid Particles 3.84 3.86 0.73 -5.21 -5.23 2.68 3.69 -0.56 -2.55 -3.30 4.30 5.07 -2.24 -5.56 -6.08
Mitochondria -1.50 -0.30 0.91 2.34 1.57 -0.14 2.78 0.79 1.10 -2.34 0.35 2.75 1.06 1.03 -2.21
Mitotic Spindle 0.77 -0.13 -0.43 -5.42 -0.98 2.17 1.75 -7.85 -9.82 -9.85 1.40 0.71 -7.40 -10.77 -9.89
None -1.33 -1.65 -3.21 -2.54 -1.89 3.40 4.68 0.77 -1.14 -1.80 3.46 4.52 0.75 -1.42 -2.07
Nuclear Periphery -3.08 -3.18 -5.73 -3.98 -1.00 1.07 -0.25 -9.64 -10.14 -9.29 2.32 -0.70 -9.79 -11.56 -9.10
Nuclear Periphery Foci 5.21 5.54 4.96 -1.13 -2.51 1.75 4.89 1.20 -0.57 -4.65 2.16 6.66 2.76 0.09 -5.90
Nucleolus -4.53 -5.47 -5.87 -2.85 2.56 2.63 0.09 -0.90 -1.15 -0.90 6.28 -1.07 -0.86 -1.43 -0.75
Nucleus 5.01 5.23 2.66 -3.03 -3.38 8.25 11.20 7.17 1.77 -1.37 9.99 12.30 5.86 -0.69 -3.24
Peroxisomes -1.83 4.39 0.79 1.84 -1.15 5.01 14.62 14.15 10.06 -2.09 7.33 14.76 13.75 10.46 -1.96
Vacuole 6.11 4.34 4.06 -10.08 -1.09 0.73 -8.61 -9.44 -9.80 -0.53 5.62 -4.58 -6.00 -14.10 -1.29
Vacuole Periphery 1.40 0.07 0.64 -4.13 1.88 -1.61 -4.42 -8.35 -3.59 -5.88 0.40 -3.14 -5.17 -7.21 -3.33
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; specific for spermine; localizes to the plasma membrane; TPO3 has a paralog, TPO2, that arose from the whole genome duplication
Localization
Cell Percentages cell periphery (72%), ER (9%), mixed (17%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Tpo3

Tpo3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Tpo3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available