Standard name
Description Subunit of inner ring of nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; interacts with genomic regions that contain ribosomal protein and subtelomeric genes, where it functions in nucleosome positioning and as a repressor of transcription; both Nup170p and NUP157p are similar to human Nup155p; NUP170 has a paralog, NUP157, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 0.11 0.1 0.14 0.07 0.12 0.17 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0 0 0.06 0.05 0 0 0 0 0 0.06 0.08
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.06 0.14 0.17 0.22 0.58 0.58 0.56 0.68 0.65 0.62 0.62 0 0 0 0.08 0.12 0.07 0 0 0 0.12 0.18 0.13
Nucleus 0 0 0 0 0 0 0 0.05 0 0.06 0.05 0 0.05 0.05 0 0.05 0.09 0 0 0 0 0 0 0
Nuclear Periphery 0.78 0.81 0.8 0.81 0.71 0.54 0.53 0.45 0.49 0.45 0.46 0.55 0.76 0.76 0.69 0.6 0.53 0.41 0.85 0.84 0.86 0.73 0.62 0.62
Nucleolus 0.06 0.07 0.12 0.25 0.18 0.26 0.26 0.26 0.27 0.29 0.29 0.3 0.08 0.08 0.09 0.11 0.14 0.21 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.43 0.33 0.24 0.14 0.19 0.09 0.07 0.06 0.07 0 0.05 0 0.21 0.23 0.27 0.31 0.29 0.38 0 0.06 0 0 0.05 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 1 0 0 1 0 0 1 1 0 0 0 1 2 1 2 3
Bud 0 1 0 0 0 1 4 5 3 1 2 3 0 0 0 1 2 0 2 3 1 1 4 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 0 0 1 0 0 0 0 0
Bud Site 0 0 1 0 1 5 7 5 14 7 10 6 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 6 6 8 7 10 8 16 10 1 6 5 7 15 15 21 18 30 16 0 0 0 0 1 1
Endoplasmic Reticulum 0 4 0 0 0 3 2 1 2 1 1 0 0 1 1 7 6 1 0 0 2 1 3 3
Endosome 2 0 15 2 20 6 9 11 5 0 5 6 4 4 2 16 13 2 7 7 11 11 26 41
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 0 6 2 1 11 10 10
Mitochondria 17 27 49 40 81 263 373 380 306 355 255 301 1 1 1 21 29 6 12 17 14 39 72 66
Nucleus 11 19 7 8 10 14 24 34 20 33 19 14 7 7 3 13 21 4 3 8 1 5 0 5
Nuclear Periphery 296 380 271 188 261 247 341 309 218 245 190 264 107 110 104 154 130 38 368 435 328 248 255 322
Nucleolus 24 31 41 58 68 119 167 178 123 158 121 144 11 11 13 28 35 19 7 8 6 2 4 7
Peroxisomes 0 0 0 0 0 0 1 1 5 3 0 1 0 0 0 1 0 0 0 0 0 3 6 12
SpindlePole 0 0 2 0 3 4 7 6 4 8 5 5 3 3 6 5 2 1 1 1 2 2 1 9
Vac/Vac Membrane 162 154 81 32 71 39 48 41 31 23 22 19 30 33 41 79 71 35 17 29 4 8 20 20
Unique Cell Count 380 469 338 232 369 455 643 680 449 544 411 484 141 144 150 258 246 92 433 521 382 339 413 516
Labelled Cell Count 518 623 475 335 525 709 999 981 733 840 635 772 178 185 195 344 340 122 433 521 382 339 413 516


Nuclear Periphery

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 11.7 12.2 9.1 8.8 8.1 6.7 6.3 6.4 6.3 6.1 6.7 6.3 10.0 10.0 9.9 8.4 8.8 10.8 11.0 11.4 11.7
Std Deviation (1e-4) 2.2 3.3 2.3 2.2 2.1 2.0 1.9 1.6 1.8 1.8 2.2 1.7 2.7 2.7 2.8 1.8 2.1 2.5 2.3 2.2 2.2
Intensity Change (Log2) – – – -0.05 -0.17 -0.45 -0.54 -0.51 -0.54 -0.58 -0.45 -0.53 0.13 0.13 0.11 -0.11 -0.05 0.24 0.27 0.32 0.35


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 2.9 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.5 0.3 -0.6 0.1 -1.0 0 -1.5 -1.2 -1.0 3.9 3.8 5.0 2.7 4.8 5.6
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome -2.5 0.6 -2.7 -2.9 -2.7 -2.9 -5.0 -2.7 -2.9 -0.8 -0.9 -1.7 1.0 0.5 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.9 2.6 12.3 13.1 12.6 15.0 14.7 13.2 13.6 -4.5 -4.5 -4.6 -2.4 -1.0 -2.0
Nucleus 1.0 0.6 0.9 1.4 2.2 1.8 2.8 1.9 0.7 0 0 0 2.0 3.6 0
Nuclear Periphery 0.3 -2.9 -7.6 -8.3 -10.5 -9.1 -10.3 -9.5 -7.6 -1.0 -0.9 -2.6 -5.5 -7.0 -7.4
Nucleolus 4.0 2.3 4.9 5.0 5.1 5.2 5.8 5.7 6.0 -1.4 -1.5 -1.1 -0.5 0.7 2.1
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole -3.0 -1.5 -6.0 -7.3 -8.3 -6.8 -8.8 -7.4 -8.6 -0.6 -0.2 0.8 1.8 1.3 2.7


Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Nup170-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available