Standard name
Human Ortholog
Description One of two mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth; see also PTH1
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.12 0.08 0 0 0 0 0 0.07 0.06
Bud 0 0 0 0 0 0 0 – 0.06 0.06 0.07 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.07 0.07 0 0 0 – 0 0 0 0 0 0 0 0.06 0.19 0 0 0 0 0 0 0
Cytoplasm 0 0.12 0.2 0.15 0.17 0.09 0.1 – 0.09 0 0.05 0.05 0.13 0.26 0.34 0.1 0 0.16 0 0 0 0 0 0
Endoplasmic Reticulum 0 0.11 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.11 0.05 0 0 0 0 0 0
Endosome 0.07 0 0.16 0.24 0.26 0 0.21 – 0 0.06 0 0 0.16 0.15 0.24 0 0 0.05 0.11 0.06 0.05 0.08 0.09 0.11
Golgi 0 0 0.07 0 0 0 0 – 0 0 0 0 0 0 0 0.33 0.49 0.29 0.06 0.06 0 0 0.05 0.05
Mitochondria 0.84 0.78 0.45 0.61 0.35 0.79 0.6 – 0.81 0.84 0.88 0.88 0.62 0.46 0.32 0.15 0.08 0 0.69 0.7 0.76 0.71 0.59 0.52
Nucleus 0 0 0 0 0 0.05 0 – 0 0 0 0 0 0 0 0 0 0.11 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.08 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Peroxisomes 0 0 0.1 0.15 0.09 0 0 – 0 0 0 0 0 0 0.15 0 0 0 0 0 0 0 0 0.08
SpindlePole 0 0 0.09 0.1 0.14 0.05 0.08 – 0 0.1 0.06 0.05 0 0.06 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.2 0.12 0.13 0.11 0.21 0.17 0.19 – 0.12 0.11 0.05 0.05 0.1 0.2 0.15 0.27 0.27 0.24 0 0.07 0 0 0 0.05
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 3 0 0 0 0 0 – 0 0 1 0 6 2 0 6 3 0 3 6 4 5 24 21
Bud 1 4 3 4 3 3 9 – 12 15 22 15 8 2 3 1 0 0 0 3 0 1 5 5
Bud Neck 0 0 0 0 0 0 0 – 0 0 1 0 0 0 0 0 0 0 0 2 0 1 9 7
Bud Site 1 1 0 1 0 2 2 – 2 6 6 9 0 0 0 0 0 1 – – – – – –
Cell Periphery 6 11 6 11 3 1 6 – 5 4 1 2 6 4 3 3 7 1 0 1 0 1 1 0
Cytoplasm 6 31 17 24 26 14 25 – 20 10 16 18 34 77 138 5 1 6 0 2 4 1 5 4
Endoplasmic Reticulum 5 27 0 0 0 0 0 – 1 2 2 3 10 2 1 2 4 2 1 3 1 2 3 8
Endosome 16 2 14 39 39 6 53 – 6 14 13 8 42 46 96 2 1 2 28 19 6 24 35 42
Golgi 7 7 6 0 4 0 0 – 0 0 0 1 4 2 5 16 18 11 15 19 5 9 18 19
Mitochondria 206 200 39 101 53 121 156 – 175 210 290 299 163 139 129 7 3 1 181 209 109 205 221 199
Nucleus 0 2 0 1 2 7 9 – 4 2 6 6 4 4 2 1 1 4 0 0 0 0 1 1
Nuclear Periphery 7 3 0 0 0 0 3 – 5 1 4 2 1 0 0 0 1 3 2 2 0 2 1 5
Nucleolus 2 1 0 1 0 5 7 – 3 3 14 6 1 0 1 1 2 0 1 0 0 0 2 3
Peroxisomes 4 1 9 25 14 1 11 – 7 8 3 2 8 8 61 0 0 1 10 5 4 12 16 29
SpindlePole 3 2 8 16 21 8 21 – 7 25 20 17 8 18 7 1 1 1 3 1 0 3 6 10
Vac/Vac Membrane 48 30 11 18 32 26 48 – 26 27 18 17 27 61 60 13 10 9 8 20 1 9 13 18
Unique Cell Count 244 255 87 165 151 154 258 216 250 328 340 264 299 408 48 37 38 264 301 143 288 375 384
Labelled Cell Count 313 325 113 241 197 194 350 273 327 417 405 322 365 506 58 52 42 264 301 143 288 375 384


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.3 5.3 6.8 6.1 7.0 5.1 6.0 – 5.3 5.4 5.3 5.5 5.6 6.3 6.1 8.0 8.7 8.3 5.2 5.3 5.6
Std Deviation (1e-4) 0.9 0.9 2.4 2.0 5.2 2.4 2.0 – 1.6 1.4 1.3 1.5 1.1 2.8 1.5 1.7 1.5 1.8 1.7 1.7 2.2
Intensity Change (Log2) – – – -0.16 0.03 -0.43 -0.19 – -0.36 -0.35 -0.37 -0.31 -0.28 -0.11 -0.16 0.24 0.35 0.28 -0.39 -0.37 -0.28

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 1.1 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery -0.1 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm -1.0 -0.4 -2.3 -2.4 – -2.5 -4.6 -4.5 -4.3 -1.5 1.2 2.6 -1.4 -2.4 -0.5
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 1.4 1.7 -3.3 0.9 – -4.2 -3.1 -4.1 0 0 -0.2 1.5 -2.1 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 4.0 5.4 3.3
Mitochondria 2.5 -1.5 5.3 2.5 – 6.3 7.2 8.9 8.8 2.8 0.3 -2.4 -3.5 -4.0 -4.7
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 1.1 -0.3 0 -2.1 – 0 0 0 0 0 0 1.1 0 0 0
SpindlePole 0.1 1.1 -1.2 -0.3 – 0 0.2 -1.0 -1.5 0 -1.0 0 0 0 0
Vacuole -0.4 1.7 0.9 1.3 – -0.1 -0.5 -2.3 -2.6 -0.6 1.6 0.5 2.1 2.0 1.5

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 0.8769 0.861 0.6702 0.585 0.2835 0.8103 2.8328 2.3099 2.6637 2.3587 2.5379 2.5133 4.519 4.6134 4.1172 4.5599 3.6952 4.4764
Actin 0.0251 0.0089 0.008 0.0058 0.0126 0.0029 0.0384 0.0097 0.0218 0.023 0.0053 0.004 0.0344 0.04 0.0258 0.0614 0.0374 0.0047
Bud 0.0014 0.0127 0.0105 0.0019 0.001 0.0045 0.0016 0.0029 0.003 0.0066 0.002 0.0017 0.0021 0.0039 0.0026 0.0021 0.0005 0.0016
Bud Neck 0.002 0.0017 0.0052 0.0127 0.001 0.0013 0.0018 0.0013 0.0021 0.0013 0.0011 0.0023 0.0027 0.0016 0.0032 0.0007 0.0015 0.0011
Bud Periphery 0.0017 0.0106 0.0077 0.0043 0.0026 0.0032 0.0023 0.0043 0.006 0.0107 0.0031 0.0046 0.0025 0.0147 0.0051 0.0067 0.0009 0.0063
Bud Site 0.006 0.0364 0.0106 0.0075 0.0018 0.0009 0.0132 0.0353 0.0118 0.007 0.0038 0.0012 0.0246 0.0501 0.0083 0.0011 0.0026 0.0008
Cell Periphery 0.0008 0.0017 0.0023 0.0008 0.0006 0.0009 0.0008 0.001 0.0013 0.0007 0.0005 0.001 0.0022 0.0065 0.001 0.0004 0.0003 0.0018
Cytoplasm 0.014 0.0109 0.0142 0.012 0.0049 0.0147 0.0173 0.0131 0.017 0.0224 0.0317 0.0116 0.0271 0.0174 0.0224 0.0065 0.0019 0.0144
Cytoplasmic Foci 0.0434 0.0535 0.0475 0.0681 0.0509 0.0433 0.0424 0.0515 0.0411 0.0376 0.0419 0.027 0.0491 0.0439 0.0308 0.0195 0.0349 0.0515
Eisosomes 0.0009 0.0003 0.0005 0.0003 0.0002 0.0003 0.0008 0.0002 0.0004 0.0004 0.0002 0.0002 0.0034 0.0021 0.0009 0.0004 0.0005 0.0004
Endoplasmic Reticulum 0.0031 0.0009 0.0025 0.0009 0.0008 0.0018 0.0052 0.0032 0.0029 0.0252 0.0031 0.0018 0.0119 0.0017 0.0114 0.0011 0.0017 0.0042
Endosome 0.1685 0.0811 0.1151 0.1348 0.0934 0.0726 0.1461 0.1794 0.1205 0.0886 0.2039 0.1059 0.0447 0.1213 0.1138 0.1326 0.0937 0.0965
Golgi 0.0685 0.0868 0.054 0.0704 0.0577 0.0639 0.078 0.0947 0.0736 0.0792 0.0985 0.0661 0.0393 0.0886 0.0758 0.0725 0.0828 0.0599
Lipid Particles 0.0365 0.0154 0.0143 0.0133 0.0075 0.0132 0.0251 0.0125 0.0103 0.0216 0.0361 0.0094 0.0847 0.0043 0.0118 0.0016 0.0504 0.0219
Mitochondria 0.543 0.6104 0.6211 0.565 0.7212 0.7135 0.5383 0.522 0.6309 0.6064 0.4796 0.7315 0.5318 0.5468 0.5854 0.6703 0.6144 0.6831
None 0.0159 0.0196 0.0335 0.0127 0.0005 0.0088 0.0075 0.0063 0.0012 0.0051 0.0058 0.0014 0.0506 0.0242 0.0508 0.0008 0.0005 0.0048
Nuclear Periphery 0.0047 0.0003 0.0031 0.0007 0.0004 0.0009 0.0118 0.0018 0.0022 0.0087 0.0264 0.002 0.0193 0.0003 0.0047 0.0005 0.0015 0.0013
Nucleolus 0.0042 0.001 0.0019 0.0087 0.0002 0.0009 0.0046 0.0009 0.0008 0.0004 0.0022 0.0003 0.0029 0.0006 0.0004 0.0002 0.0001 0.0004
Nucleus 0.0067 0.0009 0.0021 0.0088 0.0002 0.0013 0.0093 0.0013 0.0014 0.0014 0.0069 0.0006 0.0139 0.0006 0.0014 0.0003 0.0002 0.0007
Peroxisomes 0.0235 0.0359 0.0233 0.0346 0.0344 0.0365 0.0122 0.0206 0.0217 0.0324 0.0209 0.0123 0.0331 0.0212 0.0175 0.0086 0.0693 0.0177
Punctate Nuclear 0.0054 0.0003 0.0023 0.0057 0.0002 0.0026 0.0144 0.0004 0.0007 0.0013 0.0027 0.0008 0.0103 0.0002 0.0019 0.0002 0.0006 0.0027
Vacuole 0.016 0.0072 0.0129 0.022 0.004 0.0067 0.0185 0.0266 0.0201 0.0116 0.0115 0.0076 0.0064 0.0071 0.0149 0.0072 0.0015 0.0139
Vacuole Periphery 0.009 0.0037 0.0075 0.0088 0.0037 0.0056 0.0104 0.0113 0.0091 0.0084 0.0128 0.0069 0.0032 0.0028 0.0099 0.0053 0.0027 0.0103

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 55.4342 47.195 46.6943 45.5339 54.7603 43.971 41.3563 37.5748 45.672 47.5288
Translational Efficiency 0.9369 0.9661 0.9639 1.0521 0.6968 0.9674 1.0713 1.0902 0.9854 0.9245

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
177 875 142 2861 1676 2491 1733 2530 1853 3366 1875 5391

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 642.09 781.52 1021.94 1047.80 684.00 822.38 862.79 1095.33 680.00 811.76 874.84 1070.11
Standard Deviation 86.73 117.16 118.10 173.93 80.87 111.47 160.52 167.21 82.37 114.39 163.23 172.45
Intensity Change Log 2 — 0.283507 0.670463 0.706516 — 0.265809 0.335013 0.679297 — 0.274406 0.507179 0.692541

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000892 0.003148 0.012236 0.011234 0.000994 0.000840 0.005231 0.002192 0.000984 0.001440 0.005762 0.006990
Bud Neck 0.042293 0.016739 0.016153 0.001871 0.020601 0.010571 0.007172 0.001990 0.022673 0.012175 0.007852 0.001927
Bud Site 0.032428 0.049807 0.077687 0.059882 0.025160 0.021102 0.113297 0.057388 0.025854 0.028564 0.110600 0.058711
Cell Periphery 0.002922 0.000730 0.000433 0.004274 0.000371 0.000366 0.001511 0.000554 0.000614 0.000461 0.001429 0.002528
Cytoplasm 0.089133 0.021942 0.031920 0.014208 0.044098 0.010841 0.026831 0.020054 0.048400 0.013726 0.027217 0.016951
Cytoplasmic Foci 0.165761 0.108415 0.146659 0.012469 0.145648 0.054632 0.055390 0.032690 0.147569 0.068613 0.062302 0.021959
Eisosomes 0.000695 0.000161 0.000175 0.000136 0.000188 0.000083 0.000107 0.000058 0.000236 0.000103 0.000113 0.000100
Endoplasmic Reticulum 0.002431 0.001414 0.006372 0.001933 0.002634 0.000809 0.003085 0.000776 0.002614 0.000966 0.003334 0.001390
Endosome 0.043419 0.121414 0.143087 0.024101 0.083983 0.094204 0.086365 0.050237 0.080108 0.101277 0.090661 0.036367
Golgi 0.054362 0.147518 0.124344 0.072306 0.092124 0.121627 0.102806 0.147943 0.088517 0.128357 0.104438 0.107802
Lipid Particles 0.027178 0.004043 0.012665 0.000167 0.012213 0.003960 0.001085 0.000187 0.013642 0.003982 0.001962 0.000176
Mitochondria 0.400959 0.385375 0.089097 0.737566 0.469043 0.584983 0.365683 0.528450 0.462540 0.533094 0.344737 0.639428
Mitotic Spindle 0.001762 0.017409 0.083874 0.010879 0.007866 0.012205 0.042851 0.041038 0.007283 0.013558 0.045957 0.025032
None 0.001398 0.000606 0.000379 0.000606 0.001043 0.001081 0.001072 0.000548 0.001077 0.000957 0.001019 0.000578
Nuclear Periphery 0.000837 0.000155 0.001399 0.000040 0.000530 0.000133 0.000329 0.000222 0.000559 0.000139 0.000410 0.000125
Nuclear Periphery Foci 0.000312 0.000412 0.003790 0.000057 0.000406 0.000422 0.000822 0.000305 0.000397 0.000420 0.001047 0.000173
Nucleolus 0.002268 0.002613 0.009539 0.000031 0.001293 0.000695 0.001930 0.000082 0.001386 0.001194 0.002506 0.000055
Nucleus 0.045104 0.007036 0.014765 0.000125 0.007520 0.002272 0.003715 0.000306 0.011110 0.003511 0.004552 0.000210
Peroxisomes 0.049665 0.050342 0.084092 0.005023 0.032835 0.017063 0.021093 0.005199 0.034442 0.025714 0.025864 0.005106
Vacuole 0.021372 0.037086 0.091303 0.017851 0.030468 0.037721 0.089874 0.050873 0.029599 0.037556 0.089982 0.033348
Vacuole Periphery 0.014808 0.023634 0.050032 0.025243 0.020982 0.024390 0.069750 0.058909 0.020393 0.024193 0.068257 0.041043

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.99 -3.84 -8.87 -6.26 0.33 0.59 -5.51 -3.58 -3.90 3.75 -1.66 -6.40 -9.57 -8.58 -1.28
Bud Neck 3.31 3.23 5.43 7.35 4.56 5.65 8.30 12.26 9.10 8.94 5.92 8.95 13.37 11.69 10.08
Bud Site -2.15 -3.62 -3.66 -2.21 1.68 1.83 -18.98 -10.35 -12.44 11.06 -1.22 -19.23 -13.12 -13.01 11.61
Cell Periphery 2.17 2.47 -1.23 -7.40 -8.14 0.08 -4.24 -3.79 -3.67 3.55 1.40 -3.05 -7.10 -8.18 -3.16
Cytoplasm 5.38 3.60 6.14 3.25 2.36 11.62 5.01 7.95 -6.00 3.17 12.00 6.13 11.01 -2.65 5.42
Cytoplasmic Foci 3.96 1.22 11.26 21.04 12.72 20.48 20.00 26.66 10.21 9.74 18.31 19.38 31.79 24.16 18.49
Eisosomes 5.35 5.10 5.61 2.11 1.86 7.96 5.87 10.03 6.48 9.31 8.46 7.68 8.60 0.69 2.06
Endoplasmic Reticulum 1.40 -2.59 0.70 -1.71 3.18 3.39 -0.79 3.68 0.14 6.49 3.41 -1.35 2.58 -2.17 5.42
Endosome -9.78 -7.60 3.12 18.75 10.32 -2.42 -0.52 9.43 13.96 11.59 -5.49 -2.56 14.01 25.01 19.31
Golgi -9.09 -4.12 -2.11 11.12 3.41 -6.10 -2.05 -10.44 -4.91 -8.24 -9.05 -3.20 -4.78 5.31 -0.90
Lipid Particles 3.70 1.98 4.36 6.05 3.63 6.00 9.23 10.10 6.20 5.00 7.16 9.14 10.94 7.91 5.65
Mitochondria 0.54 10.39 -12.15 -27.84 -46.29 -10.95 8.98 -5.42 5.97 -15.35 -7.12 10.68 -19.08 -14.22 -32.95
Mitotic Spindle -8.43 -6.38 -10.36 3.44 5.66 -3.46 -12.91 -14.69 -12.55 0.50 -5.58 -14.35 -13.49 -8.42 7.42
None 1.12 1.48 1.17 0.21 -2.29 -0.12 -0.02 3.49 1.91 1.91 0.44 0.26 3.41 1.84 1.73
Nuclear Periphery 2.34 -1.11 2.76 2.91 3.25 2.63 1.19 1.96 -1.57 1.19 3.02 0.93 3.11 0.46 3.53
Nuclear Periphery Foci -0.84 -2.98 2.82 4.74 3.19 -0.07 -2.81 0.88 0.47 3.53 -0.14 -4.02 2.71 1.41 5.74
Nucleolus -0.39 -1.50 3.30 3.05 2.01 2.16 -1.01 5.18 5.25 3.26 0.46 -1.62 6.02 4.84 3.86
Nucleus 3.43 2.54 4.12 3.85 3.96 4.70 2.86 7.33 3.77 4.95 4.97 3.94 7.84 5.45 6.21
Peroxisomes -0.11 -2.34 6.15 12.00 6.30 6.34 4.24 12.25 8.86 8.75 3.50 3.08 13.78 14.70 10.74
Vacuole -3.51 -6.76 1.02 6.22 7.40 -2.98 -16.96 -8.10 -5.32 10.66 -3.68 -18.21 -2.11 2.09 18.00
Vacuole Periphery -2.77 -3.92 -3.71 -0.76 2.81 -2.31 -16.35 -15.85 -14.67 3.03 -2.81 -16.87 -13.04 -11.22 9.28
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description One of two mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth; see also PTH1
Localization
Cell Percentages mitochondrion (80%)
Cell Cycle Regulation No
Subcompartmental Group mito-1

Pth2

Pth2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pth2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available