Standard name
Description Copper-binding protein of mitochondrial inner membrane; required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; similar to thioredoxins; SCO1 has a paralog, SCO2, that arose from the whole genome duplication

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0.11 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0.05 0 0 0 0 0 0
Cytoplasm 0.05 0 0 0 0.05 0.05 0 0 0 0 0.05 0.07 0.11 0.11 0.05 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0.08 0.07 0 0.05 0.09 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0.08 0.12 0.31 0.05 0.44 0.06 0.05 0.08 0.06 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0.15 0.14 0.08 0.26 0 0 0 0.05 0.05 0
Mitochondria 0.82 0.93 0.94 0.92 0.95 0.91 0.94 0.95 0.94 0.98 0.97 0.5 0.39 0.18 0.16 0 0.73 0.83 0.73 0.7 0.71
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.11 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.16 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0.05 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0 0 0 0 0.06 0.05 0
SpindlePole 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0.07 0.05 0 0 0 0 0 0
Vac/Vac Membrane 0.19 0.07 0 0.1 0 0.08 0.06 0.05 0.07 0 0.05 0.18 0.22 0.3 0.11 0 0.07 0 0 0.06 0.06
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 0 0 0 0 0 0 0 0 0 0 9 3 1 2 0 6 2 3 5 7
Bud 3 1 2 14 6 11 5 6 7 4 7 1 1 4 1 0 2 2 1 0 1
Bud Neck 0 0 0 0 1 0 0 0 0 0 0 1 0 0 0 0 3 0 1 2 2
Bud Site 0 0 0 0 3 5 5 4 7 2 0 0 0 0 1
Cell Periphery 13 2 4 0 2 1 1 0 1 3 2 3 7 6 1 0 0 0 0 0 1
Cytoplasm 18 7 7 14 11 14 10 7 10 4 12 9 13 19 1 0 2 0 0 0 0
Endoplasmic Reticulum 9 4 2 2 8 0 4 1 1 3 1 10 8 7 1 0 1 1 0 1 3
Endosome 16 4 2 12 1 1 5 0 1 0 0 10 14 52 1 0 25 9 16 14 9
Golgi 7 0 0 0 0 0 0 0 0 0 0 18 16 14 5 0 16 2 9 12 7
Mitochondria 291 163 172 304 204 250 279 190 306 174 218 61 46 30 3 0 296 143 153 159 158
Nucleus 2 1 0 4 2 6 4 3 4 1 1 1 1 1 2 0 1 0 0 0 0
Nuclear Periphery 2 1 0 1 9 4 5 4 13 8 7 0 0 0 1 0 3 1 0 1 2
Nucleolus 0 0 1 3 3 5 4 3 16 2 6 1 0 2 1 0 1 0 0 0 0
Peroxisomes 13 4 3 10 0 4 0 1 2 2 1 5 3 15 0 0 10 6 11 12 9
SpindlePole 8 2 2 4 2 6 8 3 15 3 4 4 2 11 1 0 1 0 0 1 1
Vac/Vac Membrane 68 12 5 34 8 22 17 10 22 3 11 22 26 50 2 0 28 2 6 13 12
Unique Cell Count 357 175 183 329 214 274 297 200 325 178 225 121 118 166 19 2 405 174 211 229 223
Labelled Cell Count 451 201 200 402 260 329 347 232 405 209 270 155 140 212 23 2 405 174 211 229 223


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.3 4.3 4.1 4.3 4.0 4.2 3.8 3.7 3.3 3.5 3.6 6.4 6.1 6.4 6.6 6.7 6.9 7.0
Std Deviation (1e-4) 0.8 0.9 1.4 1.2 0.9 3.2 1.0 1.1 0.7 1.1 0.9 1.0 0.7 1.0 1.2 1.1 1.3 1.5
Intensity Change (Log2) -0.06 -0.01 -0.09 -0.01 -0.18 -0.23 -0.36 -0.28 -0.26 0.58 0.52 0.59 0.62 0.65 0.69 0.72


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -0.1 0.1 0.5 0.5 -0.4 -0.3 -0.5 -0.9 0.6 1.3 2.3 2.6 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 2.4 0 1.0 0
Endosome 0 0 0 0 0 0 0 0 0 2.4 3.3 7.2 0
Golgi 0 0 0 0 0 0 0 0 0 5.3 5.0 3.9 0
Mitochondria 0 0 0 0 0 0 0 0 0 -8.4 -10.1 -14.0 -9.1
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 2.7 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 2.6 0
Vacuole -1.8 1.3 -1.4 0.5 -0.5 -0.8 0 -2.4 -0.8 3.0 3.8 5.6 0


Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sco1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available