Standard name
Human Ortholog
Description Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated S/T residues N-terminal to proline; regulates phosphorylation of RNAPII large subunit (Rpo21p) C-terminal domain (CTD) at Ser7; associates with phospho-Ser5 form of RNAPII in vivo; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription, trimethylation of histone H3; human ortholog PIN1 can complement yeast null and ts mutants
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.06 0.06
Bud Neck 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.06 – 0 0.05 0.05 0.06 0.09 – 0.05 0.06 0.06 0.05 0.1 0.24 0.32 0.11 0.13 0.18 0 0 0 0 0.05 0.08
Endoplasmic Reticulum 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Endosome 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0.05 0.05
Golgi 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.08 0.13 0 0 0 0 0 0
Mitochondria 0 – 0 0 0 0.08 0 – 0.09 0 0.08 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.5 – 0.29 0.76 0.74 0.55 0.71 – 0.65 0.6 0.67 0.68 0.45 0.27 0.18 0.48 0.41 0.3 0.69 0.8 0.63 0.54 0.42 0.43
Nuclear Periphery 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.44 – 0.47 0 0 0.09 0 – 0.09 0.12 0.11 0.1 0.05 0 0 0 0 0 0.22 0.08 0.21 0.18 0.17 0.12
Peroxisomes 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.09
Vac/Vac Membrane 0.17 – 0.29 0.19 0.22 0.31 0.23 – 0.2 0.27 0.16 0.17 0.41 0.5 0.52 0.4 0.47 0.46 0 0 0.06 0.09 0.11 0.1
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 – 0 0 0 0 0 – 0 1 0 2 0 0 0 1 0 0 0 0 0 0 0 0
Bud 0 – 0 0 0 2 1 – 3 3 3 3 0 1 0 1 0 0 1 1 0 21 46 35
Bud Neck 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 9
Bud Site 0 – 0 0 0 0 0 – 4 4 3 3 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 2 – 0 11 21 13 33 – 13 21 13 17 30 104 175 17 17 27 0 1 0 10 36 43
Endoplasmic Reticulum 0 – 0 0 0 0 0 – 0 0 0 0 0 1 0 5 5 8 0 0 0 1 4 5
Endosome 0 – 0 5 1 2 3 – 4 6 3 4 7 4 18 3 1 1 1 0 2 11 35 26
Golgi 0 – 0 0 5 0 4 – 0 1 0 0 10 18 17 6 10 19 0 0 0 0 1 3
Mitochondria 0 – 0 0 2 18 1 – 24 13 19 21 1 0 0 1 1 1 0 0 0 1 1 0
Nucleus 18 – 5 156 288 119 273 – 183 205 155 244 133 113 97 72 54 44 50 55 30 188 303 244
Nuclear Periphery 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 1 10 6
Nucleolus 16 – 8 0 7 19 9 – 24 42 26 37 15 6 4 1 2 6 16 5 10 64 126 70
Peroxisomes 0 – 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 – 0 0 1 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 1 14 59 49
Vac/Vac Membrane 6 – 5 38 84 66 89 – 56 93 36 61 119 214 289 60 63 68 0 2 2 30 78 58
Unique Cell Count 36 17 204 389 216 387 282 344 231 359 293 426 552 151 133 149 73 70 49 352 724 568
Labelled Cell Count 42 18 210 409 239 413 311 389 258 392 315 461 600 167 153 174 73 70 49 352 724 568


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 10.4 – 8.9 11.8 12.4 8.0 11.3 – 9.5 10.2 9.5 9.9 14.8 14.7 14.8 18.2 19.8 19.5 12.2 12.4 12.8
Std Deviation (1e-4) 2.5 – 1.3 2.1 1.9 2.0 2.2 – 1.9 1.9 1.8 2.0 2.3 2.2 2.2 4.4 4.7 5.7 1.7 1.9 2.0
Intensity Change (Log2) – – – 0.41 0.49 -0.15 0.35 – 0.1 0.2 0.11 0.16 0.74 0.73 0.74 1.04 1.16 1.14 0.46 0.48 0.53

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP70001020WT3HU80HU120HU16001020WT3rpd3Δ_1rpd3Δ_2rpd3Δ_301020WT1AF100AF140AF18001020
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 – 0 0 0 0 0 0 2.8 0 0 0
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleus 4.2 4.0 2.0 3.6 – 2.9 2.5 3.1 3.3 1.3 0 0 1.4 0.9 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0.1 0 – 0 0 0 0 0.9 1.7 1.9 0.8 1.4 1.3

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 7.4128 8.3845 7.9062 7.1942 7.4512 7.5831 7.8478 10.7195 8.9789 9.2889 8.6335 9.4461 9.2871 11.9752 10.0649 10.5739 9.8481 10.4116
Actin 0.0143 0 0.0001 0 0 0.0005 0.0222 0 0.0013 0 0.0001 0 0.0108 0 0.0046 0.0077 0 0.0025
Bud 0.0002 0.0002 0.0007 0 0 0.0001 0.0002 0 0.0004 0.0001 0.0001 0.0001 0.0002 0 0.0002 0.0002 0 0.0001
Bud Neck 0.0007 0.0002 0.0002 0.0001 0.0005 0.0021 0.0007 0.0001 0.0004 0.0002 0.0009 0.0024 0.0002 0.0001 0.0006 0.0003 0.0007 0.0016
Bud Periphery 0.0001 0 0.0001 0 0 0.0001 0.0003 0 0.0009 0 0.0001 0.0001 0.0002 0 0.0006 0.0007 0 0.0001
Bud Site 0.0003 0.0001 0.0006 0 0.0001 0.0001 0.001 0.0001 0.0055 0.0001 0.0003 0.0001 0.0004 0.0001 0.0004 0.0004 0.0001 0.0001
Cell Periphery 0 0 0 0 0 0 0.0001 0 0.0004 0 0 0 0.0001 0 0.0002 0.0002 0 0
Cytoplasm 0.0037 0.0024 0.0043 0.0003 0.0166 0.0017 0.0044 0.0115 0.0002 0.0004 0.0005 0.0019 0.0032 0.0058 0.0021 0.0004 0.0005 0.0003
Cytoplasmic Foci 0.0045 0.0004 0.0026 0 0.0001 0.0004 0.0055 0 0 0 0 0 0.024 0 0.0071 0.004 0.0013 0.0003
Eisosomes 0.0001 0 0 0 0 0 0.0004 0 0.0001 0 0 0 0.0001 0 0.0001 0.0002 0 0
Endoplasmic Reticulum 0.0011 0 0 0 0.0004 0.0004 0.0018 0 0.0002 0 0.0001 0.0001 0.0005 0 0.0004 0.0008 0 0.0002
Endosome 0.0047 0 0 0 0.0004 0.0008 0.0053 0 0.0002 0 0.0001 0 0.0049 0 0.0051 0.0038 0.0003 0.0018
Golgi 0.0008 0 0 0 0 0.0001 0.0022 0 0.0001 0 0 0 0.0015 0 0.0017 0.0022 0 0.0017
Lipid Particles 0.003 0 0 0 0 0.0001 0.0069 0 0.0001 0 0 0 0.0081 0 0.0017 0.0121 0.0003 0.0011
Mitochondria 0.0006 0.0001 0.0008 0.0001 0.0002 0.0002 0.0097 0.0001 0.0005 0.0001 0.0002 0 0.0046 0.0001 0.0071 0.0147 0.0001 0.0002
None 0.0018 0.0002 0.0018 0 0.0003 0.0004 0.0034 0 0.0001 0 0 0 0.0095 0 0.004 0.0003 0.0001 0
Nuclear Periphery 0.0064 0.0016 0.0017 0.0027 0.0065 0.005 0.0058 0.001 0.0009 0.0009 0.0026 0.0015 0.0041 0.0006 0.0012 0.0033 0.0014 0.0006
Nucleolus 0.0076 0.0057 0.0075 0.0021 0.0078 0.0186 0.0085 0.0046 0.003 0.003 0.0149 0.0084 0.0064 0.0062 0.0048 0.0053 0.0199 0.0092
Nucleus 0.8959 0.9745 0.9351 0.9943 0.9635 0.917 0.904 0.9822 0.9847 0.9949 0.9778 0.9841 0.8963 0.9859 0.9496 0.9111 0.9279 0.9794
Peroxisomes 0.0078 0 0 0 0 0 0.0085 0 0.0001 0 0 0 0.004 0 0.0048 0.0012 0 0.0002
Punctate Nuclear 0.0456 0.0145 0.0443 0.0002 0.0028 0.0519 0.0079 0.0002 0.0001 0.0003 0.002 0.0006 0.019 0.001 0.0016 0.0293 0.0471 0.0005
Vacuole 0.0006 0.0001 0.0001 0.0001 0.0006 0.0003 0.0006 0.0001 0.0007 0 0.0003 0.0007 0.0009 0 0.0016 0.0009 0.0001 0.0001
Vacuole Periphery 0.0002 0 0 0 0.0001 0.0002 0.0006 0 0.0001 0 0.0001 0.0001 0.0008 0 0.0004 0.001 0 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 108.6197 134.5932 112.7149 99.3244 79.4784 135.4308 123.9365 122.0288 134.2453 101.5444
Translational Efficiency 1.1392 1.0229 1.1689 1.7788 1.761 1.1488 1.1523 1.9236 1.3394 1.363

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1124 621 2551 1207 590 2079 2295 1261 1714 2700 4846 2468

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1030.55 1321.15 1462.06 1414.12 912.02 1211.48 1368.22 1334.21 989.75 1236.70 1417.62 1373.29
Standard Deviation 158.17 196.20 209.89 220.41 168.02 173.85 199.96 264.73 171.16 185.09 210.53 247.31
Intensity Change Log 2 — 0.358380 0.504588 0.456490 — 0.409633 0.585163 0.548848 — 0.382670 0.542978 0.500589

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000940 0.001213 0.000559 0.000990 0.001849 0.000525 0.000740 0.001033 0.001253 0.000683 0.000645 0.001012
Bud Neck 0.013046 0.040598 0.029908 0.022376 0.010095 0.032170 0.025444 0.014643 0.012031 0.034109 0.027794 0.018425
Bud Site 0.001887 0.003435 0.002005 0.006013 0.003610 0.002945 0.002133 0.008012 0.002480 0.003058 0.002065 0.007035
Cell Periphery 0.000131 0.000130 0.000106 0.000207 0.000449 0.000092 0.000111 0.000269 0.000241 0.000101 0.000108 0.000238
Cytoplasm 0.006984 0.008833 0.007659 0.037499 0.038664 0.011465 0.008044 0.163849 0.017889 0.010860 0.007842 0.102056
Cytoplasmic Foci 0.000281 0.000759 0.000047 0.001782 0.001512 0.000676 0.000064 0.008583 0.000705 0.000695 0.000055 0.005257
Eisosomes 0.000031 0.000028 0.000020 0.000022 0.000033 0.000018 0.000021 0.000027 0.000032 0.000021 0.000021 0.000025
Endoplasmic Reticulum 0.004117 0.003413 0.001339 0.001790 0.005969 0.002152 0.001443 0.002725 0.004755 0.002442 0.001388 0.002268
Endosome 0.000296 0.000886 0.000102 0.001641 0.000714 0.000679 0.000104 0.006206 0.000439 0.000726 0.000103 0.003973
Golgi 0.000150 0.000292 0.000076 0.002189 0.000853 0.000458 0.000082 0.007894 0.000392 0.000420 0.000079 0.005104
Lipid Particles 0.000112 0.000192 0.000036 0.000147 0.000780 0.000090 0.000052 0.000873 0.000342 0.000114 0.000043 0.000518
Mitochondria 0.002665 0.001808 0.001978 0.003080 0.001516 0.001513 0.001671 0.006325 0.002270 0.001581 0.001833 0.004738
Mitotic Spindle 0.004652 0.011208 0.005159 0.028142 0.000967 0.010067 0.005506 0.059728 0.003383 0.010330 0.005324 0.044280
None 0.004626 0.003326 0.003767 0.009566 0.014933 0.005017 0.004357 0.018476 0.008174 0.004628 0.004046 0.014118
Nuclear Periphery 0.000280 0.000538 0.000595 0.001711 0.000437 0.000452 0.000460 0.001256 0.000334 0.000471 0.000531 0.001478
Nuclear Periphery Foci 0.000674 0.000402 0.000042 0.001670 0.002807 0.000287 0.000094 0.001554 0.001408 0.000313 0.000067 0.001611
Nucleolus 0.019466 0.015570 0.002275 0.001162 0.016602 0.011288 0.002394 0.001729 0.018480 0.012273 0.002331 0.001452
Nucleus 0.938133 0.904913 0.943510 0.874160 0.894555 0.917582 0.946127 0.668436 0.923132 0.914668 0.944749 0.769047
Peroxisomes 0.000358 0.000464 0.000057 0.000119 0.000796 0.000226 0.000080 0.002405 0.000509 0.000281 0.000068 0.001287
Vacuole 0.000951 0.001705 0.000684 0.004630 0.002363 0.001786 0.001004 0.019490 0.001437 0.001768 0.000836 0.012223
Vacuole Periphery 0.000220 0.000285 0.000075 0.001105 0.000497 0.000512 0.000070 0.006488 0.000315 0.000459 0.000072 0.003855

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.49 3.05 -2.11 3.09 -6.01 8.76 6.14 4.40 -8.77 -3.08 7.39 6.31 1.79 -7.53 -6.18
Bud Neck -9.40 -15.76 -7.03 5.67 6.53 -12.78 -13.82 -3.24 10.25 11.02 -16.31 -20.99 -6.96 10.28 12.15
Bud Site -5.66 -3.95 -6.94 -1.22 -5.16 1.82 2.02 -2.58 -5.04 -5.48 -1.75 -0.76 -6.90 -5.62 -7.44
Cell Periphery -1.28 0.85 -5.58 -4.70 -8.83 4.66 4.35 2.72 -9.94 -9.89 4.55 4.32 -0.07 -11.64 -13.08
Cytoplasm -1.34 0.02 -8.51 -6.71 -9.14 5.12 6.13 -10.26 -18.39 -19.59 2.95 5.41 -15.17 -18.80 -20.92
Cytoplasmic Foci -1.35 3.04 -2.32 -0.48 -3.20 2.45 4.07 -1.78 -4.08 -5.40 0.60 4.81 -3.47 -3.78 -6.25
Eisosomes -0.53 3.13 -1.13 -0.40 -4.24 5.56 3.04 0.86 -9.44 -4.30 7.51 4.50 -0.14 -9.55 -5.99
Endoplasmic Reticulum 0.85 12.26 9.09 5.91 -4.19 9.00 10.43 7.62 -2.63 -6.23 10.35 15.95 11.15 1.03 -7.46
Endosome -1.50 4.87 -1.25 0.70 -2.11 0.70 4.26 -2.06 -2.39 -3.71 -1.35 5.86 -2.76 -1.69 -4.24
Golgi -2.02 0.97 -1.48 -1.03 -1.54 1.19 2.05 -1.28 -2.04 -2.46 0.08 2.13 -2.12 -2.17 -2.88
Lipid Particles -2.82 2.76 -5.18 -0.03 -8.08 2.26 2.32 0.23 -7.28 -7.66 1.95 2.66 -1.41 -7.52 -9.88
Mitochondria 0.48 -0.10 -0.40 -3.69 -1.43 0.08 -1.97 -2.32 -2.37 -1.61 0.74 -0.32 -1.17 -3.46 -1.93
Mitotic Spindle -1.71 -0.80 -3.85 -1.09 -3.58 -5.20 -3.76 -9.04 -6.13 -7.61 -3.76 -1.88 -8.97 -5.64 -8.29
None 1.25 -0.16 -3.53 -5.08 -4.33 4.60 4.54 0.66 -7.55 -7.78 3.59 3.51 -2.68 -8.24 -8.76
Nuclear Periphery -4.38 -13.28 -7.42 -4.42 -3.90 -0.13 -0.74 -5.30 -11.87 -11.69 -2.50 -5.58 -10.64 -10.12 -8.64
Nuclear Periphery Foci 0.35 3.49 0.63 0.32 -2.07 3.74 4.13 2.85 -3.66 -6.39 3.85 5.27 2.49 -2.14 -5.01
Nucleolus 1.24 11.49 14.32 8.53 7.75 2.30 7.27 9.24 12.54 7.68 4.05 13.64 17.01 15.29 10.85
Nucleus 6.18 2.10 8.28 0.97 7.67 -2.51 -5.34 12.44 17.79 21.25 2.95 -2.44 16.81 15.08 21.19
Peroxisomes -2.11 8.01 7.25 5.86 -0.47 3.55 4.32 0.54 -1.00 -1.29 3.27 6.67 0.74 -0.41 -1.31
Vacuole -2.98 -0.64 -7.60 -5.62 -7.56 1.10 2.76 -12.52 -12.78 -13.17 -1.52 1.42 -14.72 -14.01 -15.04
Vacuole Periphery -1.09 2.87 -0.90 -0.42 -1.89 0.18 2.52 -1.38 -1.44 -1.98 -0.82 3.54 -1.66 -1.35 -2.27
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Peptidylprolyl-cis/trans-isomerase (PPIase); specific for phosphorylated S/T residues N-terminal to proline; regulates phosphorylation of RNAPII large subunit (Rpo21p) C-terminal domain (CTD) at Ser7; associates with phospho-Ser5 form of RNAPII in vivo; present along entire coding length of genes; represses initiation of CUTs; required for efficient termination of mRNA transcription, trimethylation of histone H3; human ortholog PIN1 can complement yeast null and ts mutants
Localization
Cell Percentages nucleus (92%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-5

Ess1

Ess1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Ess1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available