Standard name
Human Ortholog
Description General transcriptional co-repressor; acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+]
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0.06 0 0 0 0 0.08 0.09 0.07 0.05 0.09 0.05 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.05 0.05 0.06 0.12 0.15 0.09 0.1 0 0 0 0.05 0 0.08 0 0 0 0 0 0
Nucleus 0.69 0.68 0.72 0.89 0.73 0.65 0.66 0.58 0.54 0.56 0.54 0.47 0.72 0.76 0.68 0.75 0.7 0.78 0.6 0.68 0.64 0.59 0.65 0.51
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.61 0.46 0.54 0.37 0.49 0.48 0.56 0.55 0.6 0.66 0.7 0.71 0.62 0.53 0.53 0.37 0.35 0.32 0.33 0.24 0.31 0.33 0.25 0.41
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 1 0 0 2 0 1 0 1 0 1 1 1 0 0 2 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 2 1 0 1 0 4 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 2 0 5 5 8 11 6 2 7 1 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 2 2 6 0 2 7 5 17 8 6 3 5 3 10 6 8 9 6 1 0 0 0 0 2
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 3 0 1 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0
Mitochondria 0 1 6 2 4 8 13 17 22 30 16 19 1 0 2 8 4 10 0 1 1 0 0 0
Nucleus 76 34 130 108 99 115 166 166 99 115 93 89 28 84 60 123 73 102 74 54 122 29 79 73
Nuclear Periphery 0 0 0 1 2 1 2 1 1 1 4 3 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 67 23 97 45 67 85 142 155 109 135 120 134 24 58 47 61 37 42 41 19 60 16 30 58
Peroxisomes 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 1 0 0 0 0 2 1 0 0 1 0 1 0 3 0 2 0 0 0 0 0 0
Vac/Vac Membrane 0 1 1 0 0 0 1 1 0 0 0 0 0 0 0 1 1 4 1 1 6 1 7 6
Unique Cell Count 110 50 180 121 136 176 252 284 182 204 171 188 39 110 88 165 105 130 123 81 193 50 122 143
Labelled Cell Count 145 61 241 158 175 221 336 371 251 295 238 263 57 155 116 208 125 167 123 81 193 50 122 143


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 16.1 10.7 9.3 9.8 9.8 10.0 9.0 9.3 9.0 8.7 9.1 8.4 12.1 13.4 11.5 17.2 18.1 19.4 12.3 14.3 15.5
Std Deviation (1e-4) 5.5 3.9 3.1 2.6 2.6 3.8 2.3 3.0 3.1 2.9 3.6 3.2 4.1 6.0 3.9 5.9 6.8 6.3 2.5 3.4 5.9
Intensity Change (Log2) – – – 0.08 0.07 0.11 -0.05 -0.0 -0.05 -0.1 -0.03 -0.14 0.38 0.53 0.31 0.89 0.96 1.06 0.4 0.62 0.74

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70001020WT3HU80HU120HU16001020WT3rpd3Δ_1rpd3Δ_2rpd3Δ_301020WT1AF100AF140AF18001020
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 3.3 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0.3 0 1.3 0.5 -0.2 0 -0.4 0 2.1 0 0.7 1.9 0.6
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0.6 0.9 1.3 3.1 3.8 2.3 2.6 0 0 0 0.7 0 1.7
Nucleus 3.6 0.1 -1.4 -1.4 -3.0 -3.5 -3.2 -3.5 -4.9 -0.1 0.8 -0.7 0.5 -0.5 1.2
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus -2.8 -0.8 -1.1 0.5 0.1 1.2 2.5 3.1 3.4 0.9 -0.2 -0.1 -3.2 -3.0 -3.8
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 14.43 15.1094 13.8222 15.9156 12.4484 13.7113 12.5764 15.5585 12.7024 12.0396 10.6287 13.1211 18.0576 15.443 15.8215 14.5913 16.3715 15.0264
Actin 0.0038 0 0.0216 0.0077 0.006 0 0.0211 0 0.0018 0.002 0.0142 0 0 0 0 0 0 0
Bud 0.0021 0 0.0002 0.0001 0.0002 0 0.0004 0 0.0003 0.0001 0.0001 0 0 0 0 0 0.0001 0
Bud Neck 0.003 0 0.0008 0.0001 0.0002 0.0002 0.0025 0 0.0002 0.0007 0.0002 0.0002 0 0 0 0 0.0002 0.0003
Bud Periphery 0.0021 0 0.0003 0.0003 0.0004 0.0001 0.0007 0 0.0004 0.0001 0.0002 0 0 0 0 0 0.0002 0
Bud Site 0.0047 0 0.0023 0.0005 0.0007 0.0001 0.0026 0.0001 0.0016 0.0023 0.0015 0 0 0 0 0 0.0001 0
Cell Periphery 0.0011 0 0.0002 0.0001 0.0003 0.0001 0.0007 0 0.0002 0.0001 0.0002 0 0 0 0 0 0.0002 0
Cytoplasm 0.01 0 0.0004 0 0.0002 0 0.0046 0 0.0015 0.0003 0.0064 0.0003 0 0 0 0 0 0
Cytoplasmic Foci 0.0047 0 0.0014 0.0002 0.0186 0.0037 0.0161 0 0.0027 0.0105 0.0205 0.0061 0 0 0 0 0 0
Eisosomes 0.0002 0 0.0003 0.0003 0.0003 0 0.0004 0 0 0.0001 0.0004 0 0 0 0 0 0 0
Endoplasmic Reticulum 0.0029 0 0.0006 0 0.0003 0 0.0019 0 0.0009 0.0001 0.0036 0.0001 0 0 0 0 0 0
Endosome 0.0188 0 0.0021 0.0002 0.0083 0 0.0141 0 0.0027 0.0105 0.0156 0.0004 0 0 0 0 0 0
Golgi 0.0064 0 0.0035 0.0004 0.0087 0 0.0053 0 0.0007 0.0057 0.0059 0.0001 0 0 0 0 0 0
Lipid Particles 0.0264 0 0.0016 0.0014 0.0189 0.0011 0.0128 0 0.0038 0.0165 0.0111 0.0018 0 0 0 0 0 0
Mitochondria 0.0137 0.0001 0.0062 0.0242 0.028 0.0007 0.0035 0.0001 0.0061 0.0012 0.0014 0.0001 0.0003 0.0001 0.0001 0.0001 0.0009 0.0001
None 0.0242 0 0.0016 0.0001 0.001 0.0001 0.0044 0 0.0008 0.0004 0.0081 0.0003 0 0 0 0 0 0
Nuclear Periphery 0.0086 0.0001 0.0005 0.0001 0.0011 0 0.0044 0.0001 0.0052 0.0004 0.0024 0.0011 0.0001 0.0002 0.0002 0.0004 0.0002 0
Nucleolus 0.2315 0.1071 0.1052 0.1497 0.517 0.3699 0.1925 0.1239 0.087 0.1413 0.3339 0.2827 0.1655 0.0912 0.0801 0.1005 0.542 0.3234
Nucleus 0.6189 0.8924 0.8475 0.8111 0.381 0.623 0.6893 0.8753 0.8672 0.7984 0.507 0.7014 0.8337 0.8996 0.9193 0.8986 0.4553 0.6758
Peroxisomes 0.0057 0 0.0023 0.0029 0.0048 0 0.0118 0 0.0045 0.0044 0.057 0.0002 0 0 0 0 0 0
Punctate Nuclear 0.0031 0.0001 0.0008 0.0001 0.002 0.0005 0.0074 0.0003 0.0094 0.0039 0.0092 0.0047 0.0001 0.0088 0.0002 0.0002 0.0004 0.0002
Vacuole 0.005 0 0.0003 0.0001 0.0008 0.0002 0.0021 0 0.0012 0.0006 0.0005 0.0001 0.0001 0 0 0 0.0003 0
Vacuole Periphery 0.003 0 0.0003 0.0002 0.0014 0.0002 0.0014 0 0.0016 0.0004 0.0003 0.0002 0.0001 0 0 0 0.0002 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 55.1512 44.8816 29.5196 47.054 57.2048 39.915 43.7468 53.1355 36.5174 68.1059
Translational Efficiency 1.2963 1.2674 1.368 0.7138 1.2147 1.4872 1.0769 0.7772 1.167 0.9221

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
380 80 165 273 1495 2160 164 21 1875 2240 329 294

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 989.15 3049.28 2008.77 1427.43 1119.95 1254.13 1925.87 1772.03 1093.44 1318.24 1967.45 1452.04
Standard Deviation 174.72 4477.43 379.21 344.23 236.45 254.59 319.59 372.85 231.36 943.11 353.20 357.54
Intensity Change Log 2 — 1.624207 1.022051 0.529159 — 0.163253 0.782076 0.661969 — 1.028853 0.899604 0.601201

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000441 0.000788 0.001189 0.001557 0.000498 0.000457 0.001402 0.000987 0.000486 0.000469 0.001295 0.001517
Bud Neck 0.001893 0.005332 0.007712 0.013636 0.002988 0.003908 0.010736 0.010483 0.002766 0.003959 0.009220 0.013411
Bud Site 0.000269 0.001294 0.001418 0.004909 0.000327 0.000576 0.001410 0.000798 0.000315 0.000601 0.001414 0.004615
Cell Periphery 0.000027 0.003478 0.000026 0.000194 0.000022 0.000063 0.000032 0.000041 0.000023 0.000185 0.000029 0.000184
Cytoplasm 0.000872 0.067487 0.000023 0.001324 0.000140 0.000135 0.000056 0.000547 0.000288 0.002541 0.000039 0.001268
Cytoplasmic Foci 0.000770 0.004004 0.000985 0.007727 0.000073 0.000322 0.000559 0.000175 0.000214 0.000453 0.000773 0.007187
Eisosomes 0.000053 0.000102 0.000272 0.000085 0.000116 0.000145 0.000210 0.000093 0.000103 0.000144 0.000242 0.000086
Endoplasmic Reticulum 0.000527 0.000498 0.000382 0.001475 0.000537 0.000456 0.000498 0.000301 0.000535 0.000458 0.000440 0.001391
Endosome 0.000104 0.000857 0.000012 0.006593 0.000021 0.000481 0.000018 0.000025 0.000038 0.000494 0.000015 0.006124
Golgi 0.000235 0.010437 0.000169 0.001823 0.000059 0.000313 0.000174 0.000197 0.000095 0.000675 0.000171 0.001707
Lipid Particles 0.000151 0.004103 0.000018 0.004926 0.000104 0.000170 0.000022 0.000018 0.000113 0.000311 0.000020 0.004575
Mitochondria 0.001354 0.004508 0.002721 0.005243 0.000774 0.000708 0.003224 0.003302 0.000891 0.000844 0.002971 0.005105
Mitotic Spindle 0.003639 0.013273 0.000404 0.025785 0.000804 0.000670 0.000876 0.000459 0.001379 0.001120 0.000639 0.023976
None 0.000801 0.001298 0.000634 0.004208 0.000705 0.000575 0.000929 0.000798 0.000725 0.000601 0.000781 0.003965
Nuclear Periphery 0.000027 0.000267 0.000043 0.000791 0.000027 0.000045 0.000087 0.000228 0.000027 0.000053 0.000065 0.000751
Nuclear Periphery Foci 0.000074 0.003048 0.000007 0.000989 0.000583 0.000268 0.000015 0.000060 0.000480 0.000368 0.000011 0.000923
Nucleolus 0.197751 0.148379 0.196047 0.115522 0.172702 0.157158 0.146012 0.145774 0.177779 0.156845 0.171105 0.117682
Nucleus 0.786881 0.684412 0.727400 0.790603 0.813697 0.828869 0.804175 0.829824 0.808262 0.823710 0.765671 0.793405
Peroxisomes 0.003787 0.016239 0.059771 0.008600 0.005306 0.003917 0.028792 0.004727 0.004998 0.004357 0.044329 0.008323
Vacuole 0.000169 0.022443 0.000425 0.002509 0.000155 0.000387 0.000474 0.000641 0.000158 0.001175 0.000450 0.002376
Vacuole Periphery 0.000174 0.007753 0.000340 0.001499 0.000362 0.000374 0.000299 0.000523 0.000324 0.000638 0.000319 0.001430

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.60 -11.81 -12.57 -5.83 -3.98 0.95 -12.40 -3.60 -3.76 2.59 0.34 -16.90 -12.82 -12.36 -2.69
Bud Neck -2.23 -10.91 -6.54 -3.80 -3.33 -2.33 -10.52 -3.71 -3.26 0.43 -3.16 -13.69 -6.41 -5.68 -2.36
Bud Site -1.82 -8.47 -3.64 -2.45 -2.37 -2.22 -9.46 -1.55 -1.03 1.04 -2.58 -12.83 -3.66 -3.35 -2.31
Cell Periphery -2.83 -0.31 -3.03 2.72 -3.05 -2.35 -3.56 -1.27 0.06 -0.75 -3.37 -2.84 -3.30 0.55 -3.00
Cytoplasm -2.80 1.03 -0.37 2.79 -4.47 -0.36 0.70 -0.99 -0.97 -1.04 -2.54 1.30 -2.90 1.43 -4.38
Cytoplasmic Foci -1.69 -0.50 -1.33 -0.22 -1.24 -1.98 -6.60 -0.98 -0.38 0.19 -1.27 -4.03 -1.56 -1.46 -1.32
Eisosomes -3.45 -14.08 -5.06 0.94 11.44 -4.98 -8.65 1.57 3.08 6.07 -7.50 -14.19 2.23 7.59 14.16
Endoplasmic Reticulum 0.32 1.37 -5.29 -5.29 -5.78 1.26 -0.82 2.30 1.53 3.03 1.36 0.33 -5.16 -5.59 -5.30
Endosome -0.99 1.13 -2.15 -1.63 -2.20 -1.98 -0.90 -0.85 1.77 -0.73 -2.01 1.03 -2.18 -1.89 -2.19
Golgi -2.83 0.32 -2.19 2.50 -2.32 -1.63 -7.69 -1.11 -0.48 -0.72 -2.86 -4.32 -2.59 -1.21 -2.34
Lipid Particles -2.14 1.03 -1.23 0.39 -1.29 -0.54 1.03 0.67 1.17 -0.43 -1.53 1.41 -1.24 -1.15 -1.29
Mitochondria -0.96 -2.61 -3.47 -0.08 -2.26 0.62 -11.78 -3.08 -3.16 0.29 0.26 -12.45 -5.08 -5.14 -1.82
Mitotic Spindle -0.75 1.21 -3.37 -0.96 -4.14 0.26 -0.72 0.43 0.19 1.00 0.33 0.32 -3.95 -4.01 -4.01
None -1.47 0.68 -3.43 -2.85 -3.60 0.88 -2.70 -1.19 -1.56 -0.11 0.88 -1.42 -3.57 -3.68 -3.44
Nuclear Periphery -2.93 -2.60 -4.30 -2.51 -4.14 -1.57 -4.27 -2.24 -2.07 -1.25 -2.26 -4.89 -4.41 -4.22 -3.94
Nuclear Periphery Foci -2.30 2.88 -2.87 1.73 -3.15 0.65 1.19 0.74 0.27 -0.93 0.30 1.24 -0.50 -1.37 -3.17
Nucleolus 2.39 -0.11 4.33 0.53 3.67 2.81 1.38 1.05 0.65 0.58 4.04 0.06 3.65 1.82 2.96
Nucleus 2.79 3.54 0.61 -2.35 -2.41 -2.58 1.54 -0.61 -0.23 -1.13 -2.71 4.45 1.75 2.73 -1.35
Peroxisomes -2.14 -9.35 -3.87 1.25 8.40 4.08 -7.06 0.66 -0.47 6.89 1.77 -11.12 -2.92 -3.44 9.73
Vacuole -1.89 -2.85 -2.94 1.69 -2.58 -2.27 -3.64 -1.10 -0.94 -0.73 -2.30 -4.88 -3.08 -1.47 -2.53
Vacuole Periphery -1.64 -3.13 -2.13 1.42 -1.75 0.01 0.22 -0.90 -1.07 -1.24 -1.23 -0.04 -1.73 -1.08 -1.84
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description General transcriptional co-repressor; acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+]
Localization
Cell Percentages nucleus (89%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-2

Cyc8

Cyc8


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cyc8-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available