Standard name | |
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Human Ortholog | |
Description | Cyclin-dependent kinase (CDK) catalytic subunit; master regulator of mitotic and meiotic cell cycles; alternately associates with G1, S, G2/M phase cyclins, which provide substrate specificity; regulates metabolism, basal transcription, chromosome dynamics, growth and morphogenesis; transcript induction in osmostress involves antisense RNA; human homologs CDK1, CDK2, CDK3 can complement yeast conditional cdc28 mutants; human CDK1, CDK2 can complement yeast cdc28 null mutant |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 2 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 2 | 0 | 0 | 2 | 3 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 |
Bud | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 1 | 1 | 4 | 0 | 0 | 0 | 0 | 1 | 0 | 33 | 43 | 9 | 9 | 3 | 2 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 2 | 2 | 2 | 6 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 157 | 202 | 104 | 62 | 91 | 148 | 197 | 172 | 158 | 154 | 144 | 150 | 40 | 81 | 97 | 70 | 72 | 64 | 118 | 155 | 76 | 111 | 172 | 161 |
Endoplasmic Reticulum | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 2 | 4 | 1 | 0 | 0 | 0 | 1 | 8 | 3 | 0 | 1 | 1 | 0 | 0 | 2 |
Endosome | 1 | 1 | 0 | 1 | 2 | 3 | 3 | 3 | 1 | 2 | 2 | 2 | 1 | 6 | 3 | 1 | 0 | 2 | 5 | 7 | 4 | 1 | 2 | 2 |
Golgi | 4 | 0 | 6 | 2 | 12 | 5 | 11 | 6 | 0 | 0 | 0 | 3 | 0 | 1 | 1 | 1 | 7 | 7 | 0 | 0 | 1 | 0 | 0 | 0 |
Mitochondria | 1 | 2 | 0 | 0 | 0 | 4 | 3 | 5 | 42 | 22 | 23 | 45 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 1 | 3 | 0 | 2 | 2 |
Nucleus | 34 | 74 | 35 | 27 | 59 | 51 | 73 | 66 | 49 | 60 | 42 | 57 | 22 | 43 | 75 | 24 | 20 | 20 | 112 | 192 | 66 | 33 | 27 | 23 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3 | 2 | 0 | 1 | 0 |
Nucleolus | 12 | 7 | 3 | 1 | 8 | 5 | 9 | 22 | 13 | 17 | 13 | 14 | 7 | 5 | 11 | 3 | 2 | 2 | 14 | 9 | 4 | 1 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 3 | 4 | 0 | 0 | 0 | 14 | 15 | 7 | 1 | 0 | 0 |
Vac/Vac Membrane | 107 | 148 | 64 | 46 | 88 | 77 | 121 | 167 | 54 | 81 | 62 | 81 | 35 | 62 | 61 | 44 | 62 | 67 | 14 | 28 | 15 | 15 | 15 | 9 |
Unique Cell Count | 283 | 410 | 185 | 129 | 245 | 278 | 392 | 416 | 295 | 327 | 272 | 328 | 95 | 177 | 220 | 130 | 144 | 144 | 322 | 467 | 198 | 180 | 229 | 209 |
Labelled Cell Count | 319 | 437 | 213 | 139 | 263 | 293 | 420 | 445 | 322 | 343 | 300 | 359 | 105 | 204 | 256 | 149 | 173 | 165 | 322 | 467 | 198 | 180 | 229 | 209 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 16.9 | 11.3 | 14.9 | 14.4 | 15.3 | 13.2 | 13.5 | 12.8 | 11.3 | 11.9 | 11.7 | 11.6 | 13.7 | 14.8 | 15.6 | 13.9 | 18.0 | 18.3 | 14.3 | 14.7 | 13.8 |
Std Deviation (1e-4) | 2.9 | 2.2 | 2.9 | 3.4 | 3.7 | 2.9 | 3.7 | 2.9 | 3.0 | 3.0 | 2.7 | 2.7 | 4.0 | 4.4 | 5.4 | 3.7 | 4.7 | 4.9 | 2.9 | 2.9 | 3.1 |
Intensity Change (Log2) | – | – | – | -0.05 | 0.04 | -0.17 | -0.15 | -0.22 | -0.4 | -0.33 | -0.35 | -0.36 | -0.12 | -0.01 | 0.07 | -0.1 | 0.27 | 0.3 | -0.06 | -0.02 | -0.11 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -1.4 | -3.9 | -0.6 | -1.3 | -3.4 | -0.6 | -2.0 | -0.7 | -2.3 | -2.2 | -2.0 | -2.4 | -0.4 | -1.1 | -2.1 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0.8 | 0 | -0.3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.7 | 0.7 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 5.4 | 3.6 | 4.1 | 5.3 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0.4 | 1.3 | -0.2 | -0.1 | -0.9 | -0.6 | -0.2 | -1.0 | -0.4 | 0.8 | 1.2 | 3.4 | -0.1 | -1.2 | -1.2 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 2.1 | 1.7 | 2.0 | 1.8 | 1.6 | 0 | 0 | 1.9 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0.2 | 0.3 | -1.6 | -0.9 | 1.3 | -4.0 | -2.4 | -2.8 | -2.4 | 0.4 | 0.1 | -1.5 | -0.1 | 1.6 | 2.2 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 11.9538 | 17.071 | 15.2696 | 15.2944 | 14.397 | 14.2924 | 11.3257 | 14.7297 | 14.296 | 14.5666 | 12.0788 | 13.548 | 8.556 | 12.8147 | 11.741 | 10.7722 | 10.5099 | 10.67 |
Actin | 0.0414 | 0.0019 | 0.0091 | 0.0004 | 0.0032 | 0.0083 | 0.0241 | 0.0005 | 0.0059 | 0.0002 | 0.0023 | 0.002 | 0.0284 | 0.0007 | 0.0034 | 0.0018 | 0.0055 | 0.0016 |
Bud | 0.0016 | 0.0007 | 0.0007 | 0.0001 | 0.0005 | 0.0006 | 0.005 | 0.0006 | 0.0002 | 0 | 0.0001 | 0.0003 | 0.003 | 0.0007 | 0.0005 | 0.0001 | 0.0004 | 0.0003 |
Bud Neck | 0.0054 | 0.0009 | 0.0014 | 0.0015 | 0.0046 | 0.007 | 0.0033 | 0.0006 | 0.0008 | 0.0018 | 0.0026 | 0.0038 | 0.0029 | 0.0004 | 0.0008 | 0.0018 | 0.0029 | 0.0051 |
Bud Periphery | 0.0012 | 0.0002 | 0.0009 | 0.0001 | 0.001 | 0.0003 | 0.0026 | 0.0002 | 0.0002 | 0 | 0.0002 | 0.0001 | 0.0016 | 0.0002 | 0.0003 | 0.0003 | 0.0004 | 0.0002 |
Bud Site | 0.0042 | 0.0018 | 0.004 | 0.0001 | 0.0025 | 0.0005 | 0.0038 | 0.0011 | 0.0004 | 0.0001 | 0.0004 | 0.0002 | 0.0035 | 0.001 | 0.0011 | 0.0002 | 0.0006 | 0.0004 |
Cell Periphery | 0.0009 | 0.0001 | 0.0002 | 0 | 0.0005 | 0.0001 | 0.0003 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0003 | 0.0001 | 0.0001 | 0 | 0.0001 | 0.0001 |
Cytoplasm | 0.3888 | 0.2056 | 0.0092 | 0.0134 | 0.0133 | 0.2591 | 0.3623 | 0.216 | 0.032 | 0.0047 | 0.0107 | 0.2715 | 0.4548 | 0.1615 | 0.0195 | 0.0064 | 0.0152 | 0.2934 |
Cytoplasmic Foci | 0.0136 | 0.0004 | 0.0067 | 0.0001 | 0.0027 | 0.0073 | 0.0189 | 0.0014 | 0.0059 | 0 | 0.0363 | 0.0041 | 0.0092 | 0.01 | 0.004 | 0.0018 | 0.0018 | 0.0015 |
Eisosomes | 0.0009 | 0 | 0.0002 | 0 | 0.0003 | 0.0001 | 0.0001 | 0 | 0.0002 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0079 | 0.0011 | 0.0008 | 0.0006 | 0.0043 | 0.0024 | 0.0152 | 0.0008 | 0.001 | 0.0001 | 0.0014 | 0.0018 | 0.0101 | 0.0007 | 0.0013 | 0.002 | 0.0024 | 0.0019 |
Endosome | 0.0087 | 0.0003 | 0.0052 | 0.0004 | 0.0062 | 0.0053 | 0.0106 | 0.0004 | 0.0037 | 0.0001 | 0.0284 | 0.0022 | 0.0137 | 0.0005 | 0.0042 | 0.0025 | 0.0058 | 0.0015 |
Golgi | 0.0048 | 0 | 0.0016 | 0 | 0.0009 | 0.0036 | 0.0016 | 0 | 0.0012 | 0 | 0.0077 | 0.0003 | 0.0072 | 0.0001 | 0.0011 | 0.0009 | 0.0006 | 0.0011 |
Lipid Particles | 0.0059 | 0 | 0.0129 | 0 | 0.0106 | 0.0049 | 0.0048 | 0 | 0.0036 | 0 | 0.0219 | 0.0002 | 0.0009 | 0.0001 | 0.0009 | 0.0014 | 0.0008 | 0.0013 |
Mitochondria | 0.0029 | 0.0003 | 0.0016 | 0.0004 | 0.0249 | 0.0024 | 0.0019 | 0.0004 | 0.0105 | 0.0002 | 0.006 | 0.0009 | 0.0035 | 0.0004 | 0.0012 | 0.0306 | 0.0006 | 0.002 |
None | 0.0105 | 0.0005 | 0.0012 | 0.0002 | 0.0017 | 0.0079 | 0.0032 | 0.0005 | 0.0004 | 0 | 0.0003 | 0.0068 | 0.0032 | 0.0003 | 0.0006 | 0.0012 | 0.0023 | 0.0005 |
Nuclear Periphery | 0.0418 | 0.0173 | 0.0124 | 0.0302 | 0.0568 | 0.0201 | 0.0621 | 0.0118 | 0.0198 | 0.0237 | 0.0313 | 0.0163 | 0.0455 | 0.0093 | 0.0153 | 0.0201 | 0.022 | 0.0155 |
Nucleolus | 0.0038 | 0.0022 | 0.0049 | 0.0035 | 0.0154 | 0.0028 | 0.0032 | 0.0021 | 0.0038 | 0.0037 | 0.0128 | 0.0019 | 0.0015 | 0.0021 | 0.004 | 0.003 | 0.0075 | 0.0017 |
Nucleus | 0.424 | 0.7579 | 0.894 | 0.9447 | 0.8299 | 0.6502 | 0.4211 | 0.7591 | 0.8755 | 0.9636 | 0.7984 | 0.6659 | 0.3919 | 0.808 | 0.9341 | 0.9141 | 0.9083 | 0.6611 |
Peroxisomes | 0.0083 | 0.0001 | 0.0093 | 0 | 0.0018 | 0.0088 | 0.0067 | 0.0001 | 0.0034 | 0 | 0.0044 | 0.0013 | 0.0011 | 0.0004 | 0.0008 | 0.002 | 0.0003 | 0.0009 |
Punctate Nuclear | 0.0145 | 0.008 | 0.0215 | 0.0036 | 0.0133 | 0.0063 | 0.0384 | 0.0036 | 0.0305 | 0.0014 | 0.0328 | 0.0193 | 0.0102 | 0.0024 | 0.0058 | 0.009 | 0.0212 | 0.0084 |
Vacuole | 0.0077 | 0.0006 | 0.0019 | 0.0005 | 0.0042 | 0.0018 | 0.009 | 0.0007 | 0.0005 | 0.0002 | 0.0011 | 0.0009 | 0.0059 | 0.0011 | 0.0009 | 0.0003 | 0.0008 | 0.0012 |
Vacuole Periphery | 0.001 | 0.0001 | 0.0004 | 0.0003 | 0.0016 | 0.0004 | 0.0017 | 0.0002 | 0.0004 | 0.0001 | 0.0007 | 0.0002 | 0.0014 | 0.0002 | 0.0003 | 0.0004 | 0.0004 | 0.0002 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 63.9655 | 27.491 | 27.7433 | 41.8848 | 41.467 | 39.3416 | 32.7994 | 30.392 | 32.708 | 44.7326 |
Translational Efficiency | 1.7462 | 2.1214 | 1.6036 | 1.5202 | 1.8088 | 3.0111 | 1.8919 | 1.4326 | 1.7611 | 1.5961 |
Dataset | Hit |
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Protein Concentration | ✔ |
Protein Localization | ✔ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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