Standard name
Human Ortholog
Description Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0.06 0.07 0.06 0.07 0.07 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.99 0.96 0.92 0.95 0.91 0.85 0.66 0.66 0.68 0.61 0.58 0.6 0.98 0.99 0.98 0.96 0.96 0.9 0.95 0.95 0.9 0.96 0.96 0.93
Endoplasmic Reticulum 0 0 0.07 0 0 0 0.07 0.07 0.05 0 0 0 0 0 0 0 0 0 0 0 0.05 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.05 0.09 0.17 0.35 0.27 0.3 0.43 0.43 0.43 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0.07 0.05 0 0 0.07 0 0 0 0 0 0.08 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 1 0 2 1 6 14 6 7 5 1 3 0 0 0 0 0 0 0 0 3 0 0 0
Bud 2 0 0 2 0 3 10 3 6 14 11 17 1 1 0 0 0 0 1 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 12 3 18 8 36 36 23 37 27 26 14 21 17 3 10 5 0 0 1 0 0 0
Cytoplasm 134 177 270 277 406 375 419 360 273 337 233 273 475 612 562 156 244 181 127 170 263 301 300 425
Endoplasmic Reticulum 0 4 19 4 10 13 45 39 22 24 13 11 11 13 8 3 5 3 1 2 13 1 2 10
Endosome 0 0 0 0 1 2 1 0 0 5 1 2 1 0 0 0 0 0 0 0 0 1 0 2
Golgi 1 0 1 1 1 1 0 0 0 0 0 0 0 0 0 0 0 1 1 0 2 0 0 0
Mitochondria 2 0 3 14 40 77 219 150 121 238 174 198 0 0 0 0 4 3 0 0 3 0 1 0
Nucleus 0 1 0 0 2 1 1 2 0 0 0 1 0 1 0 2 2 1 0 2 0 1 0 4
Nuclear Periphery 0 0 0 0 0 0 1 2 0 0 1 2 0 0 0 0 0 0 0 0 0 0 0 2
Nucleolus 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 1 0 0 0 0 0 1
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 1 2 2 9 10 23 36 22 24 18 30 1 0 3 4 7 17 0 2 0 5 4 4
Unique Cell Count 135 184 292 291 445 440 633 547 402 548 402 456 483 621 571 162 255 202 134 179 294 314 315 460
Labelled Cell Count 139 184 307 305 488 496 770 635 474 685 479 563 503 648 590 168 272 212 134 179 294 314 315 460


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 12.3 16.1 13.3 12.1 10.9 9.4 8.6 8.5 8.0 7.6 7.2 7.1 15.3 14.9 14.3 22.0 24.5 23.3 15.8 15.7 16.3
Std Deviation (1e-4) 2.1 2.9 2.1 1.7 1.5 1.6 1.6 1.7 1.6 1.7 1.4 1.5 2.8 2.7 2.6 7.8 8.1 7.8 2.6 2.9 3.2
Intensity Change (Log2) – – – -0.14 -0.29 -0.51 -0.63 -0.64 -0.73 -0.81 -0.9 -0.91 0.2 0.16 0.1 0.73 0.88 0.81 0.24 0.24 0.29

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000102030WT3HU80HU120HU1600102030WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30102030WT1AF100AF140AF1800102030
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 3.3 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery -2.3 0 -1.9 1.0 1.5 1.0 1.6 1.5 1.0 -0.9 -0.5 -0.9 -1.3 -0.1 -1.0
Cytoplasm 1.4 -0.6 -3.0 -8.5 -8.5 -7.7 -9.5 -10.0 -9.8 4.1 4.7 4.5 1.6 1.6 -1.1
Endoplasmic Reticulum -3.2 -2.9 -2.3 0.3 0.3 -0.6 -1.3 -2.0 -2.8 -3.0 -3.4 -4.1 -2.2 -2.6 -2.7
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 2.7 4.5 7.0 11.1 9.4 9.9 12.9 12.6 12.8 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 2.6 3.9 3.4 2.9 2.9 3.9 0 0 0 0 0 4.4

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 10.7598 14.1615 12.6967 12.322 10.8947 12.7188 9.1941 13.3073 12.2707 10.6878 11.3606 12.2369 6.8945 11.7274 9.8708 8.8211 9.9018 10.8437
Actin 0.021 0.0002 0.0029 0.0007 0.0378 0.0024 0.0188 0.0004 0.0042 0.0189 0.0011 0.0007 0.0296 0.0011 0.0071 0.0225 0.0004 0.0002
Bud 0.0052 0.0002 0.006 0.0004 0.0005 0.0005 0.0008 0.0002 0.0002 0.0014 0.0002 0.0002 0.0019 0.0002 0.0004 0.0012 0.0004 0.0002
Bud Neck 0.0012 0.0002 0.0007 0.0007 0.0007 0.0013 0.0037 0.0002 0.0004 0.0013 0.0004 0.001 0.0028 0.0001 0.0005 0.0006 0.0005 0.0009
Bud Periphery 0.0022 0.0001 0.0025 0.0001 0.0003 0.0003 0.0008 0.0001 0.0001 0.0013 0.0001 0.0001 0.0015 0.0001 0.0001 0.0014 0.0001 0
Bud Site 0.0054 0.0004 0.0023 0.0004 0.0005 0.0001 0.0019 0.0005 0.0003 0.0026 0.0003 0 0.0075 0.0003 0.0007 0.0034 0.0002 0
Cell Periphery 0.0006 0.0002 0.0004 0.0002 0.0002 0.0002 0.0004 0.0002 0.0002 0.0003 0.0001 0.0002 0.0006 0.0001 0.0001 0.0004 0 0.0001
Cytoplasm 0.8236 0.9542 0.8907 0.8128 0.8098 0.892 0.7937 0.9568 0.9091 0.7762 0.8757 0.9132 0.7419 0.9571 0.8792 0.7851 0.8635 0.9484
Cytoplasmic Foci 0.0234 0.0079 0.0131 0.0215 0.0157 0.0123 0.017 0.0058 0.0105 0.0236 0.0216 0.0103 0.0328 0.0054 0.0135 0.0315 0.0133 0.0088
Eisosomes 0.0005 0 0 0 0.0001 0 0.0001 0 0 0.0001 0 0 0.0002 0 0 0.0002 0 0
Endoplasmic Reticulum 0.0293 0.0106 0.0214 0.0074 0.0159 0.0274 0.0412 0.0138 0.0087 0.0144 0.0071 0.0357 0.0192 0.0104 0.0115 0.0122 0.0101 0.0116
Endosome 0.0432 0.0192 0.0365 0.116 0.0752 0.0337 0.0519 0.0125 0.0322 0.0797 0.0634 0.0256 0.0648 0.0126 0.0431 0.0531 0.0786 0.0219
Golgi 0.0086 0.0015 0.004 0.0061 0.0073 0.0057 0.017 0.0021 0.0021 0.0121 0.0066 0.0041 0.0254 0.0022 0.013 0.0294 0.0173 0.0019
Lipid Particles 0.0052 0 0.0009 0.0001 0.0007 0.0006 0.0056 0.0001 0.0029 0.0016 0.0058 0.0001 0.0149 0.0004 0.0017 0.0025 0.0025 0
Mitochondria 0.0056 0.0004 0.0019 0.0011 0.0048 0.0075 0.0135 0.0005 0.0078 0.0184 0.0045 0.0015 0.0136 0.0025 0.0132 0.0276 0.0015 0.0012
None 0.0046 0.0005 0.0013 0.0026 0.0006 0.0031 0.0036 0.0005 0.001 0.0017 0.0008 0.0005 0.0029 0.0022 0.001 0.0006 0.0003 0.0003
Nuclear Periphery 0.0027 0.0004 0.0036 0.0043 0.0017 0.0067 0.0072 0.0008 0.0021 0.0075 0.0017 0.0017 0.0115 0.001 0.0033 0.0015 0.0025 0.0005
Nucleolus 0.0002 0 0.0001 0.0001 0 0 0.0002 0 0 0.0001 0.0001 0 0.0003 0 0 0.0001 0 0
Nucleus 0.0015 0.0005 0.0015 0.0067 0.0013 0.001 0.0041 0.0009 0.001 0.0034 0.0012 0.001 0.0072 0.001 0.0012 0.001 0.0009 0.0007
Peroxisomes 0.0045 0 0.0002 0.0001 0.0028 0.0002 0.0026 0 0.0043 0.0028 0.0036 0 0.0073 0.0001 0.0009 0.0061 0.0003 0
Punctate Nuclear 0.0028 0 0.0006 0.0009 0.0001 0.0003 0.004 0.0001 0.0006 0.0005 0.0008 0.0001 0.0022 0.0004 0.0011 0.0003 0.0003 0
Vacuole 0.0069 0.0028 0.0077 0.0138 0.0207 0.0029 0.0093 0.0039 0.01 0.0242 0.0033 0.0028 0.0088 0.0024 0.0067 0.0148 0.0045 0.0022
Vacuole Periphery 0.0017 0.0007 0.0018 0.004 0.0032 0.0017 0.0025 0.0006 0.0025 0.0077 0.0017 0.001 0.003 0.0005 0.0018 0.0046 0.0026 0.0009

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 92.4268 63.8845 77.1122 64.8462 69.1833 68.5675 55.3351 65.9757 58.7128 58.8145
Translational Efficiency 1.1734 1.5563 1.1825 1.4838 1.2994 1.2842 1.3892 1.102 1.2282 1.2417

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1931 640 1035 1137 1267 1434 376 1259 3198 2074 1411 2396

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1278.24 1307.60 1553.82 1886.95 1145.42 1314.65 1673.71 1990.34 1225.62 1312.47 1585.77 1941.28
Standard Deviation 170.58 221.16 234.20 325.37 188.41 187.22 225.76 370.98 189.35 198.34 237.96 353.86
Intensity Change Log 2 — 0.032763 0.281661 0.561897 — 0.198802 0.547173 0.797138 — 0.113618 0.413243 0.677861

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000215 0.000382 0.000487 0.000768 0.000239 0.000374 0.000723 0.000568 0.000224 0.000376 0.000550 0.000663
Bud Neck 0.000280 0.000447 0.002476 0.001826 0.000300 0.000453 0.004265 0.001093 0.000288 0.000452 0.002952 0.001440
Bud Site 0.016592 0.029357 0.024131 0.041007 0.015081 0.022760 0.027855 0.018995 0.015993 0.024796 0.025124 0.029441
Cell Periphery 0.000232 0.000297 0.000364 0.010288 0.000250 0.000222 0.000310 0.006574 0.000239 0.000245 0.000350 0.008337
Cytoplasm 0.789313 0.836120 0.741262 0.769364 0.812172 0.803694 0.501897 0.870866 0.798369 0.813700 0.677477 0.822699
Cytoplasmic Foci 0.133268 0.084193 0.070844 0.022118 0.098597 0.120408 0.095857 0.011313 0.119532 0.109233 0.077509 0.016440
Eisosomes 0.000005 0.000003 0.000005 0.000006 0.000003 0.000005 0.000012 0.000006 0.000005 0.000004 0.000007 0.000006
Endoplasmic Reticulum 0.003090 0.000948 0.002358 0.001824 0.009270 0.001990 0.004782 0.000585 0.005538 0.001669 0.003004 0.001173
Endosome 0.005372 0.004912 0.015188 0.003746 0.006350 0.006900 0.029197 0.002332 0.005760 0.006286 0.018921 0.003003
Golgi 0.018637 0.013293 0.008674 0.036354 0.010758 0.015364 0.008556 0.015142 0.015516 0.014725 0.008642 0.025208
Lipid Particles 0.000935 0.001000 0.005523 0.017753 0.000641 0.000901 0.006124 0.012756 0.000818 0.000932 0.005684 0.015127
Mitochondria 0.000686 0.001204 0.000043 0.000179 0.000648 0.000417 0.000024 0.000935 0.000671 0.000660 0.000038 0.000577
Mitotic Spindle 0.000978 0.002963 0.009413 0.002109 0.000649 0.001976 0.005979 0.000983 0.000848 0.002280 0.008498 0.001517
None 0.000320 0.000272 0.000175 0.000223 0.000535 0.000197 0.000067 0.000438 0.000405 0.000220 0.000146 0.000336
Nuclear Periphery 0.000015 0.000015 0.000169 0.000063 0.000064 0.000013 0.000182 0.000061 0.000035 0.000014 0.000172 0.000062
Nuclear Periphery Foci 0.000332 0.000755 0.004082 0.003700 0.001122 0.000393 0.004673 0.003092 0.000645 0.000505 0.004239 0.003381
Nucleolus 0.000054 0.000028 0.000064 0.000069 0.000047 0.000024 0.000091 0.000085 0.000051 0.000025 0.000071 0.000077
Nucleus 0.001561 0.002061 0.004745 0.002816 0.002756 0.001606 0.005390 0.004375 0.002034 0.001747 0.004916 0.003635
Peroxisomes 0.000217 0.000393 0.000473 0.000278 0.000168 0.000478 0.000974 0.000267 0.000197 0.000452 0.000606 0.000272
Vacuole 0.013219 0.014824 0.102107 0.064302 0.023439 0.015881 0.293677 0.043003 0.017268 0.015555 0.153156 0.053110
Vacuole Periphery 0.014680 0.006532 0.007418 0.021207 0.016912 0.005941 0.009365 0.006531 0.015564 0.006124 0.007937 0.013495

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -2.34 -5.08 -7.46 -4.22 -3.20 -2.51 -4.80 -1.74 -1.03 0.87 -3.94 -6.77 -4.30 -2.80 -0.93
Bud Neck -2.91 -12.74 -10.59 -9.18 3.43 -3.97 -9.07 -9.54 -7.46 7.13 -4.86 -15.47 -14.00 -11.79 8.26
Bud Site -4.29 -4.68 -9.08 -3.15 -5.55 -4.90 -5.28 -2.41 1.94 3.37 -6.34 -6.80 -8.67 -2.58 -2.11
Cell Periphery -2.30 -4.81 -11.22 -11.15 -11.07 1.10 -2.09 -7.95 -7.98 -7.86 -0.35 -5.15 -13.56 -13.54 -13.36
Cytoplasm -4.59 5.67 2.38 6.01 -3.06 0.92 17.32 -6.32 -7.60 -20.84 -2.34 13.93 -3.30 -0.82 -15.78
Cytoplasmic Foci 7.75 12.87 27.50 12.00 15.38 -3.78 0.58 21.53 25.59 15.73 2.40 11.07 35.30 27.47 22.64
Eisosomes 1.33 0.22 -0.39 -3.52 -1.67 -2.72 -8.06 -1.23 -0.54 2.29 0.06 -2.60 -1.04 -1.23 0.63
Endoplasmic Reticulum 3.84 1.27 2.01 -2.01 0.84 4.68 2.77 5.68 4.42 4.70 5.40 3.47 6.18 1.80 4.10
Endosome 0.76 -9.72 4.31 1.99 11.35 -0.73 -10.56 6.47 6.53 12.60 -1.05 -13.72 7.87 6.66 16.66
Golgi 4.29 12.21 -6.94 -8.66 -11.33 -3.97 2.46 -2.49 0.28 -3.70 0.90 11.22 -6.24 -6.23 -11.18
Lipid Particles -0.37 -10.51 -11.82 -11.71 -7.85 -2.38 -7.25 -11.26 -10.98 -4.83 -1.18 -12.86 -16.22 -16.05 -9.35
Mitochondria -0.62 1.95 1.53 1.34 -3.60 0.53 1.58 -0.41 -0.96 -1.87 0.04 2.49 0.33 0.29 -2.11
Mitotic Spindle -1.74 -5.80 -1.97 0.70 4.98 -3.27 -3.29 -1.55 2.22 3.06 -2.91 -6.70 -2.04 1.51 6.12
None 0.49 1.41 1.04 0.83 -1.42 4.10 6.71 0.98 -2.92 -5.31 2.52 3.77 0.96 -2.25 -4.48
Nuclear Periphery -0.00 -3.04 -6.60 -6.91 2.10 2.07 -3.55 0.08 -3.62 4.43 2.04 -3.58 -2.29 -6.32 2.91
Nuclear Periphery Foci -4.43 -9.77 -16.05 -12.91 1.40 4.89 -6.06 -5.30 -7.65 2.38 1.94 -11.11 -12.47 -13.39 2.60
Nucleolus 0.96 -0.37 -0.41 -7.69 -0.14 1.72 -3.23 -2.03 -4.13 0.58 1.44 -1.16 -1.21 -6.36 -0.26
Nucleus -1.38 -8.09 -5.43 -3.02 4.72 4.00 -5.41 -4.81 -8.52 1.68 1.38 -9.29 -7.49 -9.39 3.61
Peroxisomes -2.50 -6.31 -2.57 1.58 4.57 -6.05 -7.34 -2.62 3.57 6.23 -6.12 -9.73 -3.27 4.00 7.43
Vacuole -0.85 -16.97 -16.09 -13.71 6.52 3.22 -17.73 -7.11 -10.94 16.15 1.13 -22.71 -17.29 -17.80 15.80
Vacuole Periphery 4.53 5.11 -2.64 -6.06 -6.46 6.15 4.04 5.59 -0.37 1.55 8.16 6.64 1.72 -5.81 -4.47
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Npa3

Npa3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Npa3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available