Standard name
Human Ortholog
Description Coproporphyrinogen III oxidase; oxygen-requiring enzyme that catalyzes sixth step in heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p); human homolog CPOX can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0 0 0
Cytoplasm 0.97 0.98 0.98 0.97 0.95 0.83 0.79 0.77 0.73 0.68 0.78 0.71 0.99 1.0 1.0 0.93 0.89 0.95 0.96 0.89 0.95 0.96 0.97 0.94
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0.07 0.08 0.18 0.09 0.19 0.11 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0.05 0.18 0.18 0.14 0.11 0.24 0.09 0.16 0 0 0 0.07 0.07 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 1 0 0 1 0 0 0 0 1
Bud 0 0 0 0 1 1 2 3 3 2 2 6 0 1 1 0 0 0 0 1 0 0 0 5
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 0 0 0 2 6 9 2 3 9 5 7 0 2 0 7 10 7 0 0 0 0 0 0
Cytoplasm 287 86 50 227 335 230 289 297 184 193 211 216 218 370 414 189 136 179 284 83 95 176 306 365
Endoplasmic Reticulum 1 1 1 0 1 0 1 7 9 8 1 9 0 0 0 7 4 7 0 1 0 0 0 0
Endosome 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 2 1 0 1 0 0 0 0 1
Golgi 1 1 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 1 2 0 0 0 0 0
Mitochondria 7 1 1 2 7 11 24 32 46 27 51 32 0 0 0 1 2 2 0 2 0 0 0 0
Nucleus 0 0 0 1 0 0 6 10 6 7 5 8 1 1 1 4 4 1 0 0 0 0 0 0
Nuclear Periphery 1 0 0 0 0 0 0 0 1 3 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Nucleolus 0 0 0 0 0 0 0 0 1 0 0 2 0 0 0 0 1 0 0 0 0 1 0 1
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 1 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 0 1 1
Vac/Vac Membrane 3 0 0 9 19 49 67 56 27 69 24 49 2 1 1 14 11 6 0 0 0 1 1 0
Unique Cell Count 296 88 51 233 353 278 365 388 253 285 270 303 220 371 416 204 152 189 296 94 101 185 317 389
Labelled Cell Count 301 89 52 239 366 299 398 409 280 318 300 331 221 375 417 225 169 203 296 94 101 185 317 389


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.5 6.8 6.0 7.2 8.0 8.5 8.0 8.5 7.4 8.2 7.4 8.4 8.3 7.8 7.9 11.1 12.6 12.7 7.4 7.5 7.5
Std Deviation (1e-4) 3.1 1.3 0.9 1.4 1.3 2.1 1.7 1.8 1.7 1.8 1.7 1.8 1.3 1.1 1.3 2.0 2.4 2.3 2.4 1.2 1.7
Intensity Change (Log2) – – – 0.27 0.42 0.51 0.43 0.51 0.31 0.47 0.31 0.49 0.48 0.39 0.41 0.9 1.09 1.09 0.32 0.33 0.33

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700051015WT3HU80HU120HU160051015WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3051015WT1AF100AF140AF180051015
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -0.3 -1.0 -2.8 -3.2 -3.5 -3.9 -4.5 -3.3 -4.1 0.6 1.6 1.2 -1.4 -1.9 -1.0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 2.9 0 3.0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 3.2 3.3 2.9 0 3.9 0 3.1 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 2.6176 3.7845 3.2683 2.745 2.1594 3.144 3.0119 4.2847 4.274 3.6857 2.3314 3.9778 1.9285 3.625 2.9482 2.9158 2.5612 3.0709
Actin 0.0226 0.0039 0.0079 0.0071 0.003 0.0067 0.0196 0.0006 0.0071 0.0003 0.0152 0.0008 0.0259 0.0058 0.0089 0.0003 0.003 0.0007
Bud 0.0084 0.0117 0.0126 0.0056 0.0329 0.0055 0.0006 0.0011 0.0011 0.0001 0.0038 0.0001 0.002 0.005 0.003 0.0002 0.001 0.0001
Bud Neck 0.0021 0.0013 0.0011 0.0013 0.0006 0.0072 0.002 0.0001 0.0003 0.0003 0.0022 0.0009 0.0035 0.0004 0.0005 0.0003 0.0008 0.0009
Bud Periphery 0.0043 0.0029 0.0067 0.0022 0.0356 0.0029 0.0006 0.001 0.0025 0 0.007 0 0.0013 0.0013 0.0012 0.0001 0.0023 0.0001
Bud Site 0.0061 0.017 0.0104 0.0021 0.0009 0.001 0.0071 0.0009 0.0034 0.0001 0.0045 0.0001 0.005 0.0095 0.0038 0.0001 0.0031 0.0001
Cell Periphery 0.0004 0.0002 0.0003 0.0002 0.0002 0.0001 0.0003 0 0.0003 0 0.0003 0 0.0003 0.0004 0.0001 0 0.0001 0
Cytoplasm 0.7587 0.854 0.7299 0.8304 0.7452 0.8289 0.7451 0.9386 0.8976 0.9828 0.8603 0.9456 0.8536 0.9293 0.895 0.936 0.9005 0.9497
Cytoplasmic Foci 0.0178 0.0089 0.0163 0.018 0.0248 0.0193 0.0364 0.0096 0.01 0.0018 0.015 0.0116 0.0222 0.0044 0.0103 0.0139 0.0039 0.0043
Eisosomes 0.0005 0 0.0001 0 0 0.0001 0.0003 0 0.0001 0 0.0001 0 0.0004 0.0009 0.0001 0 0.0001 0
Endoplasmic Reticulum 0.0054 0.0015 0.004 0.0055 0.0011 0.0023 0.0033 0.0011 0.0017 0.0008 0.0024 0.0015 0.0031 0.0016 0.0021 0.0025 0.0029 0.0019
Endosome 0.0084 0.0023 0.0126 0.0063 0.003 0.0063 0.0227 0.0018 0.0102 0.0004 0.0281 0.0078 0.014 0.0016 0.005 0.0233 0.0129 0.0037
Golgi 0.002 0.0003 0.0016 0.0006 0.0011 0.0006 0.0065 0.0003 0.0046 0 0.0196 0.0032 0.0048 0.0002 0.0029 0.0007 0.0014 0.0004
Lipid Particles 0.0018 0.0001 0.0007 0.0005 0.0003 0.0015 0.0111 0.0001 0.0039 0 0.0029 0.0028 0.0059 0.0002 0.0053 0.0002 0.003 0.0006
Mitochondria 0.0029 0.0005 0.0028 0.0006 0.0005 0.001 0.0131 0.0002 0.0072 0.0001 0.0129 0.0003 0.0035 0.0021 0.0099 0.0002 0.0042 0.0007
None 0.1169 0.0694 0.1439 0.058 0.1154 0.0692 0.0919 0.0398 0.0296 0.0081 0.0081 0.0079 0.034 0.0304 0.0306 0.0119 0.0307 0.0212
Nuclear Periphery 0.0074 0.0017 0.0074 0.0063 0.001 0.0026 0.0035 0.0005 0.0008 0.0006 0.0016 0.0013 0.0023 0.001 0.0039 0.0019 0.0086 0.0039
Nucleolus 0.0055 0.0002 0.0009 0.0005 0.0001 0.0006 0.002 0 0.0001 0 0.0003 0 0.0003 0.0002 0.0003 0 0.0008 0.0004
Nucleus 0.0162 0.017 0.0272 0.0219 0.0071 0.0226 0.0054 0.0026 0.0031 0.004 0.0042 0.0102 0.0046 0.004 0.005 0.0061 0.0109 0.0085
Peroxisomes 0.0026 0.0012 0.0009 0.0007 0.0246 0.0021 0.0154 0.0003 0.0129 0 0.0041 0.0037 0.0096 0.0002 0.0094 0.0002 0.0015 0.0001
Punctate Nuclear 0.0065 0.0046 0.0102 0.0296 0.0018 0.0181 0.0098 0.0007 0.0004 0.0003 0.0009 0.0015 0.0013 0.0008 0.0016 0.0007 0.0017 0.0012
Vacuole 0.0026 0.0012 0.002 0.0022 0.0007 0.0011 0.0026 0.0006 0.0023 0.0002 0.0051 0.0006 0.0018 0.0007 0.0008 0.001 0.0043 0.0009
Vacuole Periphery 0.0007 0.0002 0.0007 0.0005 0.0001 0.0003 0.0006 0.0001 0.001 0 0.0014 0.0001 0.0005 0.0001 0.0003 0.0003 0.0021 0.0005

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 55.8969 84.9463 53.3933 47.5568 46.3826 65.9218 64.6694 44.6705 49.1272 47.5481
Translational Efficiency 1.804 1.7303 1.4688 1.6238 1.6402 1.382 1.6026 1.6976 1.5114 1.2213

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1318 820 2678 1423 1839 2132 165 1144 3157 2952 2843 2567

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 929.08 810.67 1129.86 1148.43 922.31 949.13 1251.53 1212.60 925.14 910.67 1136.92 1177.03
Standard Deviation 122.98 165.01 170.55 235.72 135.29 168.61 210.22 231.75 130.34 178.72 175.43 236.12
Intensity Change Log 2 — -0.196688 0.282269 0.305788 — 0.041354 0.440369 0.394780 — -0.073197 0.363195 0.350808

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000185 0.000317 0.000311 0.005409 0.000180 0.000223 0.000842 0.001147 0.000182 0.000249 0.000342 0.003510
Bud Neck 0.001691 0.001864 0.002324 0.005724 0.001726 0.003831 0.002145 0.010533 0.001711 0.003284 0.002314 0.007867
Bud Site 0.004163 0.014487 0.003661 0.046504 0.004367 0.007714 0.008253 0.051603 0.004282 0.009596 0.003928 0.048776
Cell Periphery 0.000095 0.000124 0.000038 0.000230 0.000066 0.000048 0.000319 0.000147 0.000078 0.000069 0.000054 0.000193
Cytoplasm 0.734717 0.759849 0.700719 0.551093 0.785253 0.769842 0.467664 0.600724 0.764155 0.767066 0.687193 0.573211
Cytoplasmic Foci 0.101651 0.063424 0.003963 0.021631 0.070985 0.058258 0.021883 0.023183 0.083787 0.059693 0.005003 0.022323
Eisosomes 0.000031 0.000025 0.000004 0.000031 0.000017 0.000016 0.000072 0.000020 0.000023 0.000019 0.000008 0.000026
Endoplasmic Reticulum 0.001164 0.001185 0.000350 0.002099 0.001027 0.000716 0.005533 0.001164 0.001084 0.000846 0.000651 0.001683
Endosome 0.004859 0.007818 0.000267 0.011936 0.003036 0.004792 0.006691 0.011849 0.003797 0.005632 0.000640 0.011897
Golgi 0.001356 0.002552 0.000507 0.013701 0.000577 0.002021 0.000269 0.007961 0.000902 0.002168 0.000493 0.011143
Lipid Particles 0.001574 0.001332 0.000213 0.004295 0.000905 0.000841 0.003000 0.001453 0.001184 0.000978 0.000375 0.003028
Mitochondria 0.001128 0.000552 0.000265 0.008484 0.000471 0.002025 0.000214 0.007882 0.000746 0.001616 0.000262 0.008215
Mitotic Spindle 0.002024 0.003458 0.002136 0.074661 0.003432 0.009266 0.001663 0.036073 0.002844 0.007653 0.002109 0.057464
None 0.002095 0.010823 0.008188 0.006173 0.004058 0.004957 0.002458 0.009394 0.003238 0.006587 0.007855 0.007608
Nuclear Periphery 0.000152 0.000234 0.000282 0.000783 0.000178 0.000451 0.001370 0.001111 0.000167 0.000391 0.000345 0.000929
Nuclear Periphery Foci 0.002092 0.003729 0.000792 0.004426 0.001744 0.000942 0.015780 0.004737 0.001890 0.001716 0.001661 0.004565
Nucleolus 0.000253 0.001144 0.000133 0.000549 0.000300 0.000978 0.000297 0.000259 0.000280 0.001024 0.000142 0.000419
Nucleus 0.077056 0.057308 0.260412 0.146694 0.079211 0.070479 0.225165 0.118457 0.078311 0.066820 0.258366 0.134110
Peroxisomes 0.000724 0.001316 0.000140 0.002055 0.000841 0.002025 0.000322 0.002578 0.000792 0.001828 0.000150 0.002288
Vacuole 0.061563 0.066998 0.015207 0.085723 0.041259 0.059768 0.235801 0.100194 0.049736 0.061776 0.028010 0.092172
Vacuole Periphery 0.001425 0.001463 0.000090 0.007800 0.000368 0.000806 0.000259 0.009532 0.000810 0.000988 0.000100 0.008572

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.96 -1.22 -2.94 -2.62 -2.20 -0.36 -7.71 -4.75 -3.83 2.92 -0.97 -1.49 -3.66 -3.38 -2.08
Bud Neck -0.80 -1.57 -6.87 -6.19 -3.33 -4.53 -4.63 -4.34 -1.14 -2.21 -4.67 -1.73 -7.40 -2.53 -3.70
Bud Site -5.06 0.28 -6.25 -0.69 -6.30 -3.48 -4.61 -5.78 -4.34 -3.55 -6.01 0.06 -8.51 -4.65 -8.17
Cell Periphery -2.16 6.55 -3.94 -1.75 -8.35 3.86 -9.34 -8.11 -11.34 6.98 2.09 2.88 -7.59 -8.94 -9.68
Cytoplasm -1.49 10.70 25.79 21.96 19.71 3.58 20.82 32.62 28.84 -5.39 1.09 22.12 42.34 38.09 22.17
Cytoplasmic Foci 7.36 27.52 24.10 12.93 -9.48 3.87 15.72 20.94 17.50 1.85 8.49 37.22 31.69 22.04 -12.28
Eisosomes 1.88 12.64 2.77 0.41 -11.38 0.41 -8.95 -4.69 -4.08 7.98 2.57 10.21 -0.81 -3.37 -11.76
Endoplasmic Reticulum 0.02 4.16 -0.46 -0.50 -4.47 1.19 -7.42 0.80 -0.82 8.07 1.31 1.98 -0.01 -1.48 -2.58
Endosome -3.37 13.90 2.93 5.01 -5.13 -3.18 -4.99 0.96 3.38 5.03 -3.92 14.12 2.37 5.18 -5.86
Golgi -1.15 2.01 -1.40 -0.18 -2.87 -3.00 3.80 -1.29 1.19 -1.97 -2.67 1.84 -2.11 0.18 -3.11
Lipid Particles 0.87 4.97 -2.39 -3.17 -5.74 0.50 -7.17 -6.54 -6.61 4.10 1.41 4.97 -4.58 -5.61 -7.86
Mitochondria 1.21 1.69 -0.89 -2.03 -2.41 -3.14 1.52 -1.85 0.86 -2.36 -2.03 2.00 -1.92 -0.18 -3.23
Mitotic Spindle -0.78 -0.94 -8.92 -8.52 -8.82 -3.32 0.94 -8.30 -6.31 -8.89 -3.66 -0.11 -11.99 -9.67 -12.18
None -4.29 -13.38 -7.33 2.26 4.50 -1.04 4.11 -7.09 -4.67 -10.34 -4.16 -12.68 -9.49 -1.15 0.77
Nuclear Periphery -2.10 -19.47 -20.40 -14.79 -14.20 -1.35 -10.50 -14.81 -4.71 2.80 -1.56 -16.82 -23.75 -6.33 -15.56
Nuclear Periphery Foci -4.12 4.90 -3.58 -0.52 -5.63 4.47 -7.44 -3.51 -5.64 6.51 0.75 0.16 -5.00 -5.32 -4.95
Nucleolus -4.87 2.71 -1.55 3.02 -2.41 -2.58 0.54 -0.56 2.50 -1.63 -3.68 3.08 -1.52 2.98 -3.39
Nucleus 4.10 -45.60 -19.72 -20.61 18.98 1.81 -8.71 -15.06 -16.20 3.68 3.51 -50.36 -24.89 -26.59 23.68
Peroxisomes -1.62 3.17 0.50 2.03 -2.57 -2.14 1.52 -0.01 2.47 -2.27 -2.69 2.96 0.32 3.30 -3.84
Vacuole -2.81 9.02 -23.34 -18.36 -28.44 -7.94 -14.13 -27.30 -23.53 3.39 -7.14 -0.64 -36.35 -30.97 -34.14
Vacuole Periphery 0.13 2.50 -0.07 -0.23 -2.96 -3.39 2.70 -1.62 -0.92 -1.84 -0.47 3.18 -1.37 -1.23 -3.58
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Coproporphyrinogen III oxidase; oxygen-requiring enzyme that catalyzes sixth step in heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p); human homolog CPOX can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Hem13

Hem13


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Hem13-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available