Standard name
Human Ortholog
Description Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0.05 0.05 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0.12 0.18 0.1 0.1 0.06 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.19 0.24 0.6 0.68 0.28 0.64 0.65 0.57 0.7 0.73 0.64 0.78 0.1 0 0.14 0 0 0.1 0 0 0 0 0 0
Nucleus 0.9 0.86 0.82 0.79 0.84 0.81 0.8 0.8 0.76 0.75 0.75 0.72 0.88 0.84 0.75 0.8 0.81 0.86 0.83 0.92 0.82 0.82 0.77 0.67
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0.06 0.11 0.09 0.15 0 0 0 0 0 0 0 0 0 0 0.08
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0.07 0.07 0 0 0.11 0.07 0.1 0.15
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0
Bud 0 0 0 0 0 4 2 4 2 4 5 0 0 0 1 0 0 0 0 0 0 1 2 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud Site 0 0 0 1 1 7 8 11 4 12 12 14 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 2 1 1 6 11 7 9 15 8 8 10 11 4 22 44 33 21 14 0 0 0 0 3 1
Endoplasmic Reticulum 0 0 1 0 0 1 0 0 0 0 0 0 0 0 0 4 2 5 0 0 0 0 0 1
Endosome 0 0 0 0 1 0 0 0 1 0 0 0 0 0 2 1 3 5 0 0 1 0 1 1
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 1 0 0 0 0 0
Mitochondria 20 12 74 104 89 142 212 206 167 281 165 237 7 3 33 14 9 26 1 0 0 0 0 3
Nucleus 96 44 101 122 263 180 262 289 179 287 193 219 60 158 182 268 164 216 90 66 103 64 147 109
Nuclear Periphery 0 0 0 1 3 0 3 4 2 6 5 1 0 1 1 0 0 1 0 0 0 0 0 0
Nucleolus 3 2 2 2 0 4 10 11 9 24 27 27 10 4 5 3 2 0 3 1 2 2 5 12
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 1 0 0 1 0 1 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 2 0 1 1 0 0 2 1 0 0 1 3 2 3 4 0 0 0 2 2
Vac/Vac Membrane 1 3 3 0 7 2 2 2 1 4 1 4 0 6 8 31 14 17 4 2 14 5 18 24
Unique Cell Count 107 51 123 154 313 222 327 361 237 385 257 305 68 188 244 335 203 252 109 73 125 79 192 165
Labelled Cell Count 122 62 182 236 377 347 509 543 373 626 420 515 81 194 278 358 218 288 109 73 125 79 192 165


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.2 4.5 3.6 3.6 4.3 3.7 3.5 3.7 3.4 3.4 3.5 3.2 5.6 5.9 5.0 6.6 6.8 7.2 5.5 5.5 6.4
Std Deviation (1e-4) 0.7 0.6 0.7 0.9 1.4 1.0 1.0 1.2 1.4 1.1 1.2 1.0 1.0 1.1 1.3 1.6 1.6 1.5 1.2 1.4 1.9
Intensity Change (Log2) – – – 0.01 0.25 0.04 -0.05 0.04 -0.07 -0.1 -0.05 -0.17 0.62 0.71 0.47 0.86 0.92 0.99 0.59 0.6 0.83

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 2.5 1.8 1.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 3.0496 3.4088 3.2434 3.4814 2.29 2.9876 4.4201 5.1222 4.4303 4.3754 3.9823 4.3512 1.7302 1.8273 1.4681 1.6298 1.0383 1.4994
Actin 0.0204 0.0112 0.011 0.0021 0.0285 0.0057 0.0192 0 0.0044 0.0001 0.0017 0.0024 0.0235 0 0.0008 0.0036 0 0.0002
Bud 0.0005 0 0.0003 0.0008 0.0011 0.0001 0.0005 0 0.0003 0.0002 0.0004 0.0001 0.0002 0.0006 0 0.0011 0 0
Bud Neck 0.0024 0.0002 0.0007 0.0007 0.0146 0.007 0.0016 0 0.0004 0.0002 0.0017 0.0006 0.0005 0.0002 0.0002 0.0025 0.0004 0.0005
Bud Periphery 0.0014 0 0.0005 0.0022 0.0021 0.0003 0.0006 0 0.0004 0.0005 0.001 0.0001 0.0005 0.0002 0 0.0038 0 0
Bud Site 0.0102 0.0002 0.002 0.0035 0.0111 0.0002 0.0088 0 0.0044 0.0003 0.001 0 0.0009 0.0006 0.0001 0.0023 0.0001 0.0001
Cell Periphery 0.0005 0 0.0002 0.0006 0.0006 0.0001 0.0002 0 0.0001 0.0001 0.0002 0 0.0001 0.0001 0 0.0007 0 0
Cytoplasm 0.0016 0.0001 0.0015 0.0007 0.0006 0.0001 0.0048 0 0.0058 0.0007 0.004 0.0003 0.0035 0.0491 0.0006 0.0011 0.0001 0.0002
Cytoplasmic Foci 0.009 0.0001 0.0022 0.0005 0.0079 0.0004 0.0102 0 0.0025 0.0003 0.0049 0.0005 0.0041 0.0015 0.0034 0.0006 0 0.0012
Eisosomes 0.0002 0 0.0001 0.0001 0.0006 0 0.0002 0 0.0001 0 0.0001 0 0.0004 0 0 0.0001 0 0
Endoplasmic Reticulum 0.0031 0 0.0008 0.0013 0.0012 0.0007 0.0025 0 0.0003 0.0007 0.0017 0.001 0.0011 0.0004 0.0001 0.0008 0 0
Endosome 0.0155 0 0.0068 0.008 0.0338 0.0018 0.0159 0 0.0032 0.0151 0.0229 0.0043 0.006 0.0014 0.001 0.0043 0 0.0007
Golgi 0.0053 0.0001 0.0023 0.0034 0.0124 0.0018 0.0055 0 0.001 0.0006 0.0064 0.0022 0.0022 0.0001 0.0011 0.0014 0 0.0008
Lipid Particles 0.0141 0 0.0038 0.0034 0.0421 0.0017 0.0139 0 0.0037 0.0003 0.0262 0.0003 0.003 0 0.0032 0.0017 0 0.0072
Mitochondria 0.0083 0.0001 0.0135 0.0295 0.0214 0.0031 0.0068 0.0002 0.0067 0.0028 0.0248 0.0009 0.025 0.0002 0.0021 0.0233 0.0002 0.0006
None 0.0014 0 0.0016 0.0004 0.0008 0.0001 0.0026 0 0.0005 0.0001 0.0015 0.0001 0.0026 0.0015 0.0007 0.0004 0 0.0002
Nuclear Periphery 0.0085 0.0008 0.0058 0.0077 0.0234 0.0039 0.0139 0.0002 0.0029 0.0027 0.0111 0.0012 0.0063 0.0009 0.0015 0.0232 0.0019 0.0006
Nucleolus 0.0151 0.0098 0.0118 0.0121 0.0341 0.0219 0.0062 0.006 0.0048 0.0059 0.0174 0.0159 0.0065 0.0105 0.0057 0.0084 0.0174 0.0132
Nucleus 0.8646 0.9769 0.9196 0.9027 0.7124 0.9496 0.858 0.9903 0.9544 0.9483 0.8335 0.9629 0.8904 0.9251 0.961 0.9117 0.9783 0.9708
Peroxisomes 0.008 0.0001 0.0095 0.0005 0.0076 0.0003 0.0126 0 0.0022 0.0001 0.0022 0.0001 0.0021 0 0.0089 0.0009 0 0.0013
Punctate Nuclear 0.0055 0.0001 0.0032 0.0011 0.0309 0.0005 0.0114 0.0031 0.001 0.0002 0.0283 0.0069 0.0193 0.002 0.0093 0.0024 0.0014 0.0024
Vacuole 0.0031 0.0001 0.0017 0.0091 0.0067 0.0005 0.002 0 0.0008 0.0145 0.0054 0.0001 0.0008 0.0048 0.0001 0.004 0.0001 0.0001
Vacuole Periphery 0.0013 0 0.0011 0.0096 0.006 0.0004 0.0025 0 0.0002 0.0064 0.0037 0.0002 0.0011 0.0008 0 0.0018 0 0

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 15.4906 8.5216 11.066 16.2542 17.2518 15.482 16.6939 18.0518 15.3675 18.4139
Translational Efficiency 0.7046 1.041 0.9407 0.5889 0.4921 0.7052 0.6191 0.5466 0.7087 0.7322

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
903 690 84 620 1558 1601 390 261 2461 2291 474 881

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 605.23 718.16 1190.62 1040.87 646.55 747.74 1027.41 1098.28 631.39 738.83 1056.33 1057.88
Standard Deviation 85.08 121.54 181.37 145.67 103.53 102.63 127.05 148.00 99.19 109.51 151.64 148.70
Intensity Change Log 2 — 0.246822 0.976158 0.782234 — 0.209775 0.668178 0.764412 — 0.227806 0.825298 0.773057

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000320 0.000537 0.001850 0.004612 0.000172 0.000169 0.000875 0.001312 0.000226 0.000280 0.001048 0.003635
Bud Neck 0.006412 0.005090 0.006514 0.033685 0.002786 0.007820 0.013240 0.019293 0.004116 0.006998 0.012048 0.029421
Bud Site 0.002786 0.001409 0.001775 0.007419 0.000798 0.001758 0.001159 0.002445 0.001527 0.001653 0.001268 0.005945
Cell Periphery 0.000535 0.000160 0.000107 0.000213 0.000208 0.000228 0.000060 0.000095 0.000328 0.000208 0.000068 0.000178
Cytoplasm 0.393600 0.039805 0.012248 0.011525 0.041015 0.042666 0.000983 0.004123 0.170387 0.041804 0.002979 0.009332
Cytoplasmic Foci 0.131617 0.004350 0.000330 0.005475 0.006742 0.008625 0.000023 0.001493 0.052562 0.007337 0.000078 0.004295
Eisosomes 0.000164 0.000026 0.000050 0.000041 0.000023 0.000029 0.000036 0.000035 0.000074 0.000028 0.000038 0.000039
Endoplasmic Reticulum 0.000832 0.003734 0.008241 0.005373 0.001766 0.002072 0.005896 0.005055 0.001424 0.002573 0.006311 0.005278
Endosome 0.005953 0.001778 0.000539 0.006844 0.000473 0.002298 0.000189 0.002704 0.002484 0.002142 0.000251 0.005617
Golgi 0.002226 0.000385 0.000130 0.001912 0.000321 0.000932 0.000073 0.001763 0.001020 0.000767 0.000083 0.001868
Lipid Particles 0.010491 0.002982 0.000303 0.001448 0.001358 0.001981 0.000092 0.000211 0.004709 0.002283 0.000130 0.001082
Mitochondria 0.007208 0.001554 0.001218 0.004294 0.001840 0.007545 0.001031 0.007919 0.003810 0.005741 0.001064 0.005368
Mitotic Spindle 0.001960 0.001593 0.000542 0.019726 0.001497 0.006071 0.001055 0.006532 0.001666 0.004722 0.000964 0.015817
None 0.057082 0.025493 0.000973 0.010722 0.029521 0.012643 0.001516 0.004359 0.039634 0.016513 0.001420 0.008837
Nuclear Periphery 0.000543 0.000493 0.000410 0.002278 0.000884 0.001995 0.000453 0.000815 0.000759 0.001542 0.000445 0.001844
Nuclear Periphery Foci 0.001317 0.000927 0.000368 0.002152 0.000473 0.000886 0.000078 0.000338 0.000783 0.000898 0.000129 0.001615
Nucleolus 0.007137 0.013693 0.004226 0.006505 0.011378 0.007913 0.006235 0.003482 0.009822 0.009654 0.005879 0.005609
Nucleus 0.350963 0.892437 0.954388 0.866053 0.896615 0.886546 0.965488 0.930081 0.696402 0.888320 0.963521 0.885022
Peroxisomes 0.004398 0.001092 0.000500 0.001236 0.001306 0.002025 0.000244 0.000283 0.002441 0.001744 0.000289 0.000954
Vacuole 0.013258 0.001766 0.005119 0.006089 0.000654 0.004537 0.001157 0.005527 0.005278 0.003702 0.001859 0.005923
Vacuole Periphery 0.001199 0.000697 0.000170 0.002399 0.000171 0.001261 0.000117 0.002136 0.000548 0.001091 0.000126 0.002321

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.29 -5.86 -2.56 -2.34 -0.89 -0.18 -12.78 -10.54 -10.42 -4.25 -1.00 -10.67 -3.26 -3.17 -1.88
Bud Neck 0.63 -1.42 -9.21 -9.81 -7.98 -4.80 -10.12 -8.18 -5.75 -1.90 -3.37 -9.22 -12.25 -10.61 -6.25
Bud Site 1.82 0.31 -3.95 -5.38 -4.22 -3.11 -4.27 -4.63 -3.14 -3.41 -0.65 -1.20 -6.16 -5.93 -5.87
Cell Periphery 2.57 2.78 2.49 -0.45 -1.35 -0.33 5.35 3.59 2.89 -3.63 1.95 4.59 3.08 1.69 -5.00
Cytoplasm 37.57 39.00 45.96 6.91 0.53 -0.33 14.60 13.49 13.60 -3.13 23.52 33.71 32.81 13.60 -2.65
Cytoplasmic Foci 24.78 26.35 25.60 2.14 -1.67 -0.64 7.35 6.14 6.96 -1.11 18.83 23.24 21.64 5.67 -2.24
Eisosomes 5.11 3.87 4.17 -6.46 0.68 -1.90 -6.29 -6.67 -5.19 -2.31 4.64 3.06 2.25 -8.29 -2.55
Endoplasmic Reticulum -9.26 -9.17 -14.33 -6.64 1.79 -1.73 -12.60 -8.09 -7.53 -1.31 -7.23 -15.91 -15.64 -11.95 -0.75
Endosome 3.65 5.85 2.10 -0.82 -1.84 -4.32 3.70 -1.22 1.17 -1.58 0.84 6.68 0.06 -0.38 -2.48
Golgi 3.52 4.21 2.27 -1.19 -2.10 -2.13 2.28 -0.70 0.22 -1.13 0.99 4.79 0.54 -0.20 -2.46
Lipid Particles 4.28 9.49 8.94 1.58 -1.20 -1.06 6.02 4.59 4.16 -3.13 3.88 10.98 8.90 3.03 -2.68
Mitochondria 3.19 3.35 1.61 -5.11 -6.29 -4.25 1.55 -1.67 1.38 -2.04 -1.77 3.69 -0.69 1.29 -5.26
Mitotic Spindle 0.08 1.38 -4.34 -4.36 -4.73 -3.04 -0.80 -2.24 -1.28 -1.85 -2.90 -0.63 -4.93 -3.69 -4.18
None 6.04 12.81 10.77 5.47 -3.51 6.27 11.14 10.52 6.52 -2.01 9.10 16.61 13.47 6.18 -3.18
Nuclear Periphery 0.41 0.03 -4.67 -4.75 -4.51 -2.48 1.46 -2.02 1.53 -3.52 -2.53 1.04 -4.46 -1.21 -4.91
Nuclear Periphery Foci 0.58 3.20 -0.06 -0.43 -1.67 -1.23 4.06 -0.17 0.81 -1.68 -0.48 6.48 -0.89 -0.53 -2.65
Nucleolus -3.10 2.89 -0.12 3.01 -3.02 3.41 2.36 7.14 4.00 3.13 0.56 2.40 3.23 2.58 0.36
Nucleus -44.34 -42.89 -42.78 1.02 5.21 1.00 -9.40 -1.81 -2.47 3.87 -22.68 -32.62 -20.25 -0.16 8.77
Peroxisomes 2.95 3.78 3.61 1.44 -0.55 -0.77 3.55 3.40 3.16 -0.96 1.38 5.21 4.34 2.87 -1.91
Vacuole 8.29 0.69 1.10 -4.07 -0.18 -6.10 -4.20 -3.32 -2.34 -2.98 2.15 1.76 -3.23 -4.00 -3.88
Vacuole Periphery 1.07 2.65 0.13 -0.59 -1.47 -4.57 1.40 -1.09 0.45 -1.14 -2.44 2.91 -1.02 0.12 -1.90
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; binds a DNA sequence in the PDC5 promoter; mutant fails to grow on 2% glucose and thus is scored as inviable under standard conditions
Localization
Cell Percentages nucleus (69%)
Cell Cycle Regulation No
Subcompartmental Group nucleus-3

Pdc2

Pdc2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pdc2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available