Standard name | |
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Human Ortholog | |
Description | Subunit of cohesin loading factor (Scc2p-Scc4p); a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; promotes gene expression program that supports translational fidelity; evolutionarily-conserved adherin; relocalizes to cytosol in response to hypoxia; human disorder Cornelia de Lange syndrome is caused by mutations in NIPBL, the human ortholog of SCC2 |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
Bud | 0 | 1 | 0 | 2 | 7 | 4 | 7 | 14 | 4 | 3 | 5 | 5 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 1 | 2 | 4 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Bud Site | 0 | 0 | 1 | 4 | 8 | 8 | 18 | 27 | 4 | 8 | 10 | 15 | 0 | 0 | 3 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 3 | 9 | 3 | 9 | 13 | 19 | 38 | 38 | 16 | 26 | 10 | 19 | 21 | 46 | 54 | 6 | 6 | 4 | 0 | 2 | 2 | 0 | 3 | 4 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 2 |
Endosome | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 2 | 2 | 1 | 0 | 5 | 5 |
Golgi | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
Mitochondria | 20 | 61 | 79 | 138 | 111 | 150 | 245 | 301 | 176 | 246 | 142 | 194 | 17 | 18 | 49 | 6 | 2 | 2 | 0 | 4 | 4 | 0 | 4 | 9 |
Nucleus | 216 | 301 | 116 | 157 | 183 | 158 | 237 | 255 | 108 | 174 | 99 | 136 | 177 | 276 | 252 | 78 | 49 | 49 | 218 | 296 | 112 | 145 | 157 | 170 |
Nuclear Periphery | 1 | 2 | 2 | 1 | 4 | 0 | 3 | 1 | 0 | 8 | 0 | 1 | 2 | 2 | 5 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 4 |
Nucleolus | 8 | 0 | 1 | 2 | 8 | 11 | 14 | 21 | 9 | 9 | 11 | 9 | 3 | 10 | 8 | 4 | 0 | 1 | 6 | 3 | 3 | 2 | 4 | 14 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 1 | 0 | 4 | 2 | 2 | 11 | 2 | 0 | 1 | 2 | 0 | 4 | 2 | 0 | 0 | 0 | 2 | 2 | 0 | 0 | 3 | 4 |
Vac/Vac Membrane | 4 | 13 | 1 | 1 | 8 | 4 | 3 | 5 | 1 | 13 | 3 | 8 | 1 | 12 | 11 | 4 | 5 | 6 | 7 | 25 | 16 | 17 | 62 | 91 |
Unique Cell Count | 225 | 339 | 142 | 200 | 252 | 235 | 347 | 411 | 206 | 303 | 173 | 230 | 204 | 341 | 331 | 95 | 58 | 58 | 242 | 347 | 149 | 170 | 250 | 323 |
Labelled Cell Count | 253 | 387 | 204 | 314 | 348 | 357 | 567 | 676 | 320 | 487 | 281 | 389 | 221 | 371 | 387 | 103 | 64 | 63 | 242 | 347 | 149 | 170 | 250 | 323 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 5.2 | 4.7 | 3.6 | 3.6 | 3.9 | 3.7 | 3.4 | 3.4 | 2.9 | 3.0 | 3.1 | 2.8 | 5.3 | 5.4 | 4.7 | 8.2 | 8.8 | 9.6 | 5.2 | 5.2 | 5.4 |
Std Deviation (1e-4) | 1.0 | 1.1 | 1.0 | 1.0 | 1.3 | 1.6 | 1.4 | 1.6 | 1.2 | 1.2 | 1.6 | 0.7 | 1.4 | 1.3 | 1.5 | 2.2 | 2.3 | 2.2 | 1.2 | 1.4 | 1.3 |
Intensity Change (Log2) | – | – | – | -0.01 | 0.12 | 0.04 | -0.11 | -0.07 | -0.31 | -0.25 | -0.2 | -0.37 | 0.56 | 0.58 | 0.37 | 1.18 | 1.29 | 1.42 | 0.52 | 0.52 | 0.59 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 0.9458 | 1.0871 | 1.1372 | 0.6258 | 0.955 | 1.1331 | 2.1151 | 2.5196 | 2.2294 | 2.0172 | 1.5144 | 1.8361 | 0.7839 | 0.8316 | 1.148 | 0.908 | 0.7756 | 0.9672 |
Actin | 0.0406 | 0.0002 | 0.0002 | 0.018 | 0.0323 | 0.0046 | 0.0367 | 0.0002 | 0.0077 | 0.0021 | 0.0024 | 0 | 0.0031 | 0.0001 | 0.0002 | 0.0005 | 0.001 | 0 |
Bud | 0.0004 | 0 | 0 | 0.0003 | 0.0005 | 0.0001 | 0.0007 | 0.0001 | 0.0004 | 0.001 | 0 | 0 | 0.0003 | 0 | 0 | 0.0002 | 0 | 0 |
Bud Neck | 0.0096 | 0.0002 | 0.0007 | 0.0015 | 0.0019 | 0.0021 | 0.0062 | 0.0005 | 0.001 | 0.0009 | 0.0003 | 0.0014 | 0.0043 | 0.0001 | 0.0002 | 0.0006 | 0.0004 | 0.0023 |
Bud Periphery | 0.0008 | 0 | 0.0001 | 0.0004 | 0.0008 | 0.0001 | 0.0015 | 0.0001 | 0.0008 | 0.0033 | 0.0001 | 0.0001 | 0.0023 | 0 | 0 | 0.0004 | 0 | 0.0001 |
Bud Site | 0.003 | 0.0002 | 0.0005 | 0.0025 | 0.0035 | 0.0002 | 0.0131 | 0.0036 | 0.0018 | 0.0017 | 0.0002 | 0.0001 | 0.0009 | 0.0002 | 0.0002 | 0.0009 | 0.0001 | 0.0001 |
Cell Periphery | 0.0003 | 0 | 0 | 0.0001 | 0.0003 | 0 | 0.0006 | 0.0001 | 0.0002 | 0.0004 | 0 | 0 | 0.0033 | 0 | 0 | 0.0002 | 0 | 0 |
Cytoplasm | 0.0134 | 0.0064 | 0.0033 | 0.0072 | 0.0408 | 0.0013 | 0.0043 | 0.0049 | 0.0018 | 0.0014 | 0.0004 | 0.0003 | 0.0089 | 0.0067 | 0.0056 | 0.0017 | 0.002 | 0.0029 |
Cytoplasmic Foci | 0.0077 | 0.0002 | 0.0014 | 0.0029 | 0.0133 | 0.0025 | 0.0171 | 0.0006 | 0.0014 | 0.0021 | 0.0177 | 0 | 0.0003 | 0.0005 | 0.0001 | 0.0001 | 0.011 | 0.0005 |
Eisosomes | 0.0005 | 0.0001 | 0 | 0.0003 | 0.0005 | 0 | 0.0004 | 0 | 0.0001 | 0.0001 | 0 | 0 | 0.0001 | 0.0001 | 0.0002 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.003 | 0.0004 | 0.0002 | 0.0009 | 0.0043 | 0.0001 | 0.0086 | 0.0005 | 0.0002 | 0.0005 | 0.0003 | 0 | 0.0301 | 0.0004 | 0.0005 | 0.0018 | 0.0002 | 0.0006 |
Endosome | 0.0175 | 0.0008 | 0.0028 | 0.0041 | 0.0475 | 0.0031 | 0.0301 | 0.0009 | 0.0025 | 0.0149 | 0.0339 | 0 | 0.0026 | 0.0004 | 0.0005 | 0.0012 | 0.0073 | 0.0015 |
Golgi | 0.0105 | 0 | 0.0004 | 0.004 | 0.0169 | 0.0043 | 0.0094 | 0.0002 | 0.0069 | 0.0059 | 0.01 | 0 | 0.0005 | 0 | 0 | 0.0001 | 0.0032 | 0.0001 |
Lipid Particles | 0.0113 | 0.0001 | 0.0028 | 0.0063 | 0.0248 | 0.0029 | 0.0185 | 0.0002 | 0.0031 | 0.0049 | 0.0274 | 0 | 0.0006 | 0.0003 | 0.0001 | 0.0002 | 0.0144 | 0.0009 |
Mitochondria | 0.0103 | 0.0003 | 0.0073 | 0.0048 | 0.0396 | 0.0009 | 0.0185 | 0.0005 | 0.0081 | 0.0309 | 0.0014 | 0.0001 | 0.0013 | 0.0002 | 0.0003 | 0.0012 | 0.0009 | 0.0001 |
None | 0.0432 | 0.0407 | 0.0128 | 0.0238 | 0.0249 | 0.0005 | 0.003 | 0.0099 | 0.0008 | 0.0004 | 0.0003 | 0 | 0.0169 | 0.1248 | 0.0399 | 0.0009 | 0.0017 | 0.0013 |
Nuclear Periphery | 0.0286 | 0.0099 | 0.0121 | 0.0968 | 0.0205 | 0.0092 | 0.0261 | 0.0202 | 0.0147 | 0.0049 | 0.001 | 0.0009 | 0.0126 | 0.0229 | 0.0191 | 0.0154 | 0.0043 | 0.0056 |
Nucleolus | 0.0137 | 0.0085 | 0.009 | 0.0122 | 0.0085 | 0.0154 | 0.0132 | 0.0101 | 0.0096 | 0.0038 | 0.0083 | 0.0147 | 0.0101 | 0.0061 | 0.0081 | 0.0212 | 0.01 | 0.0221 |
Nucleus | 0.7457 | 0.9177 | 0.938 | 0.7791 | 0.6835 | 0.933 | 0.7442 | 0.939 | 0.9265 | 0.9079 | 0.8653 | 0.9721 | 0.8763 | 0.8291 | 0.914 | 0.9471 | 0.9252 | 0.9477 |
Peroxisomes | 0.0061 | 0 | 0.0004 | 0.0097 | 0.0208 | 0.0056 | 0.0225 | 0.0001 | 0.0048 | 0.0017 | 0.0236 | 0 | 0 | 0 | 0 | 0 | 0.0133 | 0.0001 |
Punctate Nuclear | 0.0295 | 0.0135 | 0.0066 | 0.0235 | 0.0105 | 0.0137 | 0.0151 | 0.0065 | 0.0063 | 0.0013 | 0.0043 | 0.0099 | 0.0165 | 0.0075 | 0.0103 | 0.0045 | 0.0042 | 0.013 |
Vacuole | 0.0029 | 0.0006 | 0.001 | 0.0006 | 0.0027 | 0.0003 | 0.0072 | 0.0015 | 0.0006 | 0.0075 | 0.0015 | 0.0002 | 0.0078 | 0.0003 | 0.0004 | 0.0015 | 0.0004 | 0.0008 |
Vacuole Periphery | 0.0012 | 0.0002 | 0.0003 | 0.0012 | 0.0016 | 0.0001 | 0.003 | 0.0004 | 0.0006 | 0.0026 | 0.0018 | 0 | 0.0011 | 0.0001 | 0.0002 | 0.0005 | 0.0002 | 0.0001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 21.5413 | 7.4826 | 10.6148 | 17.1301 | 15.1616 | 15.009 | 11.3484 | 10.7382 | 11.7593 | 20.8499 |
Translational Efficiency | 0.656 | 0.8249 | 0.5839 | 0.4698 | 0.5652 | 1.0346 | 0.5503 | 0.481 | 0.5705 | 0.497 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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