Standard name | |
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Human Ortholog | |
Description | Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by human homolog DCAKD and by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies; also localized to lipid droplets |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 1 | – | 5 | 17 | 6 | 0 | 3 | 4 | 1 | 3 | 1 | 5 | 12 | 6 | 10 | 0 | 5 | 7 | 1 | 0 | 2 | 1 | 5 | 8 |
Bud | 0 | – | 1 | 5 | 0 | 1 | 10 | 6 | 13 | 7 | 16 | 11 | 1 | 2 | 1 | 0 | 2 | 3 | 2 | 0 | 0 | 1 | 4 | 4 |
Bud Neck | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3 | 1 | 8 | 6 |
Bud Site | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | – | 3 | 0 | 8 | 6 | 2 | 5 | 0 | 2 | 3 | 1 | 3 | 3 | 3 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 2 |
Cytoplasm | 24 | – | 116 | 179 | 265 | 267 | 269 | 273 | 176 | 163 | 112 | 149 | 274 | 450 | 467 | 30 | 79 | 109 | 13 | 15 | 39 | 66 | 229 | 196 |
Endoplasmic Reticulum | 19 | – | 47 | 49 | 31 | 26 | 17 | 4 | 10 | 22 | 3 | 9 | 109 | 132 | 68 | 3 | 6 | 9 | 68 | 21 | 121 | 32 | 123 | 201 |
Endosome | 0 | – | 6 | 11 | 10 | 31 | 47 | 61 | 49 | 60 | 45 | 79 | 35 | 35 | 72 | 15 | 34 | 43 | 1 | 1 | 9 | 4 | 11 | 23 |
Golgi | 1 | – | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 2 | 0 | 0 | 3 | 2 | 0 | 1 | 0 | 1 | 5 |
Mitochondria | 0 | – | 1 | 9 | 3 | 26 | 48 | 30 | 184 | 142 | 162 | 194 | 1 | 3 | 2 | 3 | 5 | 8 | 10 | 4 | 42 | 13 | 37 | 34 |
Nucleus | 2 | – | 1 | 3 | 4 | 5 | 5 | 8 | 10 | 7 | 12 | 12 | 0 | 1 | 3 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 2 | 2 |
Nuclear Periphery | 0 | – | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | 2 | 3 |
Nucleolus | 0 | – | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 3 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | – | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | – | 0 | 2 | 4 | 0 | 5 | 8 | 5 | 7 | 3 | 4 | 4 | 0 | 3 | 2 | 2 | 5 | 0 | 0 | 0 | 0 | 1 | 3 |
Vac/Vac Membrane | 7 | – | 29 | 21 | 35 | 96 | 161 | 186 | 139 | 161 | 113 | 168 | 19 | 25 | 44 | 13 | 21 | 28 | 10 | 3 | 11 | 12 | 40 | 50 |
Unique Cell Count | 51 | 191 | 269 | 338 | 422 | 513 | 522 | 490 | 493 | 385 | 538 | 425 | 612 | 628 | 58 | 143 | 195 | 115 | 48 | 240 | 140 | 474 | 550 | |
Labelled Cell Count | 54 | 210 | 296 | 367 | 458 | 570 | 587 | 590 | 580 | 474 | 640 | 460 | 657 | 675 | 67 | 157 | 217 | 115 | 48 | 240 | 140 | 474 | 550 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 6.6 | – | 7.2 | 6.9 | 7.4 | 6.3 | 6.2 | 6.7 | 5.6 | 5.9 | 5.9 | 6.0 | 7.1 | 7.3 | 7.1 | 6.8 | 8.3 | 8.7 | 8.0 | 7.9 | 8.3 |
Std Deviation (1e-4) | 0.9 | – | 1.4 | 1.4 | 1.5 | 1.3 | 1.5 | 2.2 | 1.1 | 1.1 | 3.4 | 1.0 | 1.0 | 0.9 | 0.9 | 1.3 | 1.6 | 1.9 | 1.5 | 1.3 | 1.5 |
Intensity Change (Log2) | – | – | – | -0.07 | 0.02 | -0.21 | -0.22 | -0.12 | -0.38 | -0.3 | -0.29 | -0.28 | -0.02 | 0.01 | -0.02 | -0.09 | 0.19 | 0.26 | 0.14 | 0.12 | 0.19 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 1.8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.1 | 0 | 0 | 0 | 0 | 0.6 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 1.3 | 4.3 | 0.6 | -2.0 | -2.0 | -5.9 | -6.6 | -7.3 | -8.2 | 0.9 | 3.4 | 3.6 | -1.2 | -1.0 | -1.0 |
Endoplasmic Reticulum | -1.7 | -4.8 | -6.5 | -8.7 | -10.9 | -9.6 | -7.8 | -9.6 | -10.2 | 0.3 | -0.9 | -4.8 | -3.2 | -5.1 | -5.6 |
Endosome | 0.5 | -0.1 | 2.0 | 2.7 | 3.5 | 3.0 | 3.6 | 3.4 | 4.3 | 2.3 | 1.4 | 3.4 | 0 | 5.7 | 5.6 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 3.2 | 4.1 | 3.0 | 9.8 | 8.2 | 10.4 | 9.5 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | -2.5 | -1.6 | 2.2 | 4.3 | 5.3 | 3.6 | 4.6 | 3.7 | 4.3 | -4.6 | -5.3 | -3.5 | 1.3 | -0.1 | -0.2 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 1.7714 | 1.9453 | 1.7186 | 1.8705 | 1.4669 | 1.7965 | 3.4316 | 4.1744 | 3.4893 | 3.6711 | 3.008 | 3.5869 | 1.9865 | 2.6595 | 2.1133 | 2.0493 | 2.3437 | 2.1536 |
Actin | 0.0043 | 0.0052 | 0.0039 | 0.0037 | 0.002 | 0.0013 | 0.0198 | 0.0004 | 0.0172 | 0.0054 | 0.0042 | 0.004 | 0.0235 | 0.0016 | 0.0043 | 0.0358 | 0.0008 | 0.001 |
Bud | 0.0011 | 0.0005 | 0.0047 | 0.0071 | 0.0233 | 0.0012 | 0.0002 | 0 | 0.0005 | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0.0009 | 0.0003 | 0.0005 | 0.0004 | 0.0001 |
Bud Neck | 0.0003 | 0.0007 | 0.0005 | 0.0009 | 0.0005 | 0.0011 | 0.0013 | 0.0006 | 0.0019 | 0.0086 | 0.0004 | 0.0016 | 0.0006 | 0.0004 | 0.0005 | 0.0006 | 0.0156 | 0.0009 |
Bud Periphery | 0.0006 | 0.0003 | 0.001 | 0.0041 | 0.0061 | 0.0008 | 0.0003 | 0.0001 | 0.0008 | 0.0001 | 0.0001 | 0.0002 | 0.0003 | 0.0003 | 0.0002 | 0.0005 | 0.0002 | 0.0001 |
Bud Site | 0.0023 | 0.016 | 0.0021 | 0.0093 | 0.0043 | 0.0002 | 0.0038 | 0.0019 | 0.0032 | 0.0011 | 0.0001 | 0.0007 | 0.0008 | 0.0095 | 0.0017 | 0.0022 | 0.0012 | 0.0001 |
Cell Periphery | 0.0003 | 0.0007 | 0.0007 | 0.0011 | 0.0004 | 0.0003 | 0.0016 | 0.001 | 0.0013 | 0.0006 | 0.0004 | 0.0007 | 0.0009 | 0.0008 | 0.0009 | 0.0005 | 0.0003 | 0.0002 |
Cytoplasm | 0.1177 | 0.1904 | 0.184 | 0.2168 | 0.1602 | 0.1816 | 0.1597 | 0.1986 | 0.2929 | 0.2753 | 0.2639 | 0.2728 | 0.1528 | 0.3309 | 0.2736 | 0.1879 | 0.2793 | 0.2822 |
Cytoplasmic Foci | 0.0549 | 0.0577 | 0.0683 | 0.0657 | 0.0481 | 0.0638 | 0.0597 | 0.0846 | 0.0674 | 0.0446 | 0.0703 | 0.0415 | 0.0578 | 0.0505 | 0.0608 | 0.0436 | 0.0559 | 0.0474 |
Eisosomes | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0.0005 | 0 | 0.0003 | 0.0018 | 0.0001 | 0.0004 | 0.0002 | 0 | 0 | 0.0001 | 0 | 0 |
Endoplasmic Reticulum | 0.2858 | 0.2485 | 0.282 | 0.2939 | 0.2364 | 0.3181 | 0.2958 | 0.3135 | 0.2576 | 0.2531 | 0.3472 | 0.3814 | 0.334 | 0.3337 | 0.2938 | 0.3759 | 0.2874 | 0.3754 |
Endosome | 0.2873 | 0.2627 | 0.2817 | 0.2181 | 0.3084 | 0.2602 | 0.1634 | 0.2189 | 0.1452 | 0.1373 | 0.1564 | 0.1165 | 0.1715 | 0.1398 | 0.1921 | 0.1814 | 0.1943 | 0.1438 |
Golgi | 0.0149 | 0.0222 | 0.028 | 0.0129 | 0.0172 | 0.0129 | 0.0239 | 0.0092 | 0.0145 | 0.0178 | 0.0156 | 0.0081 | 0.0155 | 0.0105 | 0.0122 | 0.0307 | 0.0143 | 0.0137 |
Lipid Particles | 0.112 | 0.0799 | 0.0455 | 0.0138 | 0.0413 | 0.0464 | 0.0896 | 0.0974 | 0.0729 | 0.04 | 0.0581 | 0.0629 | 0.1155 | 0.0528 | 0.0732 | 0.0589 | 0.019 | 0.0698 |
Mitochondria | 0.0062 | 0.0055 | 0.0058 | 0.01 | 0.006 | 0.0065 | 0.0128 | 0.0007 | 0.013 | 0.0055 | 0.0074 | 0.0074 | 0.0021 | 0.0009 | 0.0015 | 0.0048 | 0.002 | 0.0053 |
None | 0.0174 | 0.0207 | 0.0241 | 0.04 | 0.0491 | 0.0221 | 0.0932 | 0.0417 | 0.056 | 0.1202 | 0.0485 | 0.0627 | 0.0325 | 0.0119 | 0.0349 | 0.0228 | 0.0664 | 0.0223 |
Nuclear Periphery | 0.0571 | 0.0507 | 0.0363 | 0.0243 | 0.0426 | 0.0453 | 0.0284 | 0.0121 | 0.0137 | 0.023 | 0.0146 | 0.0124 | 0.042 | 0.0252 | 0.021 | 0.0165 | 0.0285 | 0.0186 |
Nucleolus | 0.0005 | 0.0003 | 0.0003 | 0.0043 | 0.0019 | 0.0007 | 0.0008 | 0.0001 | 0.0016 | 0.0036 | 0.0001 | 0.0009 | 0.0008 | 0.0005 | 0.0003 | 0.0004 | 0.0003 | 0.0001 |
Nucleus | 0.005 | 0.0071 | 0.0042 | 0.0123 | 0.0133 | 0.0061 | 0.0039 | 0.0011 | 0.0037 | 0.0337 | 0.0015 | 0.0036 | 0.005 | 0.0032 | 0.0025 | 0.0028 | 0.0028 | 0.0031 |
Peroxisomes | 0.003 | 0.0018 | 0.0008 | 0.0008 | 0.0008 | 0.001 | 0.0132 | 0.0009 | 0.0106 | 0.0036 | 0.0018 | 0.0013 | 0.0034 | 0.0005 | 0.0014 | 0.0019 | 0.0019 | 0.0007 |
Punctate Nuclear | 0.0051 | 0.0034 | 0.0052 | 0.0403 | 0.0063 | 0.0098 | 0.0057 | 0.0018 | 0.0092 | 0.0121 | 0.003 | 0.0039 | 0.0098 | 0.0037 | 0.0053 | 0.0153 | 0.0038 | 0.0038 |
Vacuole | 0.0188 | 0.0202 | 0.0168 | 0.0158 | 0.0244 | 0.0148 | 0.0196 | 0.0137 | 0.0143 | 0.0103 | 0.0048 | 0.0147 | 0.0278 | 0.0204 | 0.0172 | 0.0134 | 0.0222 | 0.0091 |
Vacuole Periphery | 0.0052 | 0.0058 | 0.0042 | 0.0046 | 0.0077 | 0.0057 | 0.003 | 0.0017 | 0.0022 | 0.0023 | 0.0016 | 0.0021 | 0.0031 | 0.0019 | 0.0022 | 0.0033 | 0.0035 | 0.0025 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 21.2778 | 31.2488 | 28.2288 | 26.7627 | 25.617 | 37.975 | 22.6665 | 28.2787 | 31.4584 | 27.9576 |
Translational Efficiency | 1.3048 | 0.8238 | 0.7206 | 0.9308 | 1.0337 | 0.669 | 1.3622 | 0.9657 | 0.9336 | 1.0762 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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