Standard name
Human Ortholog
Description Mitochondrial ribosomal protein of the large subunit; also involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.08 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.05 0 0 0 0 – 0 0 0 0 0 0 0 0.11 0.09 0.08 0 0 0 0 0 0
Cytoplasm 0 0 0 0.05 0 0 0 – 0 0 0 0 0 0 0 0.3 0.25 0.17 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.06 0.09 0.08 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0.05 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0.07 0.24 0.2 0.34 0 0.07 – 0 0 0 0 0.1 0.1 0.19 0.27 0.47 0.12 0 0.15 0.05 0.07 0.08 0.09
Mitochondria 0.92 0.94 0.86 0.89 0.73 0.88 0.71 – 0.85 0.83 0.9 0.87 0.9 0.9 0.87 0.14 0.16 0.17 0.85 0.74 0.86 0.75 0.76 0.71
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0.06 0 0 0.07 0.08 – 0.1 0.09 0.08 0.09 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.1 0.06 0.07 0 0.05 0.12 0.12 – 0.1 0.08 0.07 0.08 0.05 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.08 0 0.12 0 0 0 0.08 0.08 0.1
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.08 0 0 0 0 0 0
Vac/Vac Membrane 0 0.06 0.07 0.05 0.13 0.08 0.12 – 0.08 0.07 0.05 0.05 0 0.06 0 0.16 0.19 0.25 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 2 6 1 1 3 – 2 2 3 0 0 2 0 4 1 0 0 1 0 2 7 9
Bud 0 0 0 6 6 5 6 – 12 6 11 11 2 2 1 3 0 2 0 0 0 0 1 2
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0
Bud Site 0 0 0 0 0 0 1 – 0 2 4 4 0 0 1 1 0 0 – – – – – –
Cell Periphery 0 2 7 9 4 1 7 – 6 9 5 3 0 6 3 14 3 2 0 0 0 0 0 0
Cytoplasm 1 0 2 12 10 9 16 – 12 11 11 6 2 4 4 38 8 4 0 0 0 0 0 0
Endoplasmic Reticulum 0 1 0 2 2 0 4 – 0 5 2 7 1 0 0 8 3 2 0 0 0 0 0 0
Endosome 1 0 3 3 8 3 25 – 10 12 8 12 2 3 5 4 0 0 3 1 2 1 0 2
Golgi 0 6 33 48 91 1 41 – 12 17 24 25 17 23 49 34 15 3 4 14 7 7 15 20
Mitochondria 99 85 118 214 197 311 391 – 471 501 484 606 154 216 229 18 5 4 130 69 134 81 139 155
Nucleus 0 0 0 1 0 3 5 – 4 0 1 2 1 1 0 1 1 1 0 0 0 0 0 0
Nuclear Periphery 2 3 8 6 6 23 46 – 53 53 45 62 6 9 7 0 0 0 1 0 0 2 0 1
Nucleolus 11 5 10 3 13 42 65 – 58 50 35 59 8 5 10 3 0 1 2 0 0 1 1 2
Peroxisomes 1 0 3 5 8 4 7 – 2 12 5 10 6 10 11 10 0 3 3 1 6 9 14 21
SpindlePole 0 0 0 0 2 1 7 – 1 5 4 7 0 0 0 3 1 2 0 0 2 0 1 1
Vac/Vac Membrane 4 5 9 12 34 27 67 – 42 44 25 38 7 14 11 20 6 6 1 3 0 1 1 1
Unique Cell Count 108 90 138 241 271 352 548 555 600 537 698 171 240 262 125 32 24 154 93 156 109 185 220
Labelled Cell Count 119 107 195 327 382 431 691 685 729 667 852 206 295 331 161 43 30 154 93 156 109 185 220


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 11.2 12.1 11.5 11.8 12.7 8.5 12.1 – 11.4 11.5 11.5 11.4 14.2 14.4 13.8 13.0 14.7 13.3 12.4 13.0 13.0
Std Deviation (1e-4) 2.5 2.5 2.3 2.2 2.5 2.3 2.9 – 2.7 3.0 3.1 3.0 3.1 2.5 2.5 3.8 3.4 3.2 3.4 3.2 3.0
Intensity Change (Log2) – – – 0.04 0.15 -0.44 0.07 – -0.01 0.0 0.0 -0.01 0.31 0.32 0.27 0.17 0.35 0.21 0.11 0.18 0.18


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery -0.6 0 0 0 – 0 0 0 0 0 0 0 1.8 0 0
Cytoplasm 1.8 0 0 0 – 0 0 0 0 0 0 0 6.5 0 0
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 1.3 – 0 0 0 0 0 0 0 0 0 0
Golgi -0.9 2.0 -9.3 -5.6 – -9.3 -8.9 -7.3 -8.6 -3.3 -3.8 -1.2 0.6 2.6 -1.2
Mitochondria 0.9 -2.9 0.9 -3.4 – -0.2 -0.6 1.6 0.4 1.2 1.3 0.5 -11.5 -8.0 -7.2
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery -1.6 0 0.3 1.0 – 1.4 1.2 1.0 1.2 -1.0 -0.9 -1.6 0 0 0
Nucleolus 0 -1.0 1.5 1.6 – 1.1 0.4 -0.3 0.5 -1.0 -2.5 -1.5 -1.8 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 2.2 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole -0.6 1.9 0.4 1.9 – 0.4 0.3 -0.9 -0.5 -1.0 -0.3 -1.0 2.5 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 11.1895 11.4979 10.6833 9.0789 8.2654 10.5031 11.6557 13.2346 12.3176 11.1346 9.9036 13.188 16.6321 15.1836 15.9121 15.8757 15.1517 15.1266
Actin 0.0059 0.006 0.0148 0.0022 0.0453 0.0026 0.0522 0.0138 0.0056 0.0028 0.0186 0.0019 0.0029 0.0051 0.0025 0.0045 0.0002 0.0017
Bud 0.0001 0.0001 0.0005 0.0001 0.0002 0 0.0012 0.0037 0.0005 0 0.0032 0.0001 0.0001 0.0002 0.0002 0.0001 0 0
Bud Neck 0.0001 0.0001 0.0002 0 0.0004 0.0001 0.0021 0.0001 0.0002 0.0001 0.0007 0.0001 0.0001 0.0001 0.0003 0 0 0
Bud Periphery 0.0002 0.0001 0.0009 0.0004 0.0005 0.0001 0.0024 0.002 0.0008 0.0001 0.0059 0.0002 0.0002 0.0003 0.0006 0.0001 0 0.0001
Bud Site 0.0003 0.0004 0.0012 0 0.0006 0 0.0037 0.0055 0.0029 0.0001 0.0222 0.0001 0.0006 0.0013 0.0007 0.0001 0 0
Cell Periphery 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0003 0.0001 0.0002 0.0001 0.0002 0.0001 0.0001 0.0002 0.0002 0 0 0
Cytoplasm 0.0015 0 0.0002 0 0.0012 0.0002 0.0022 0 0 0 0.0001 0.0006 0.0013 0 0.0001 0 0 0
Cytoplasmic Foci 0.0071 0.0004 0.0036 0 0.0035 0.0015 0.01 0.0016 0.0009 0.0061 0.0072 0.001 0.0047 0.0011 0.0015 0.001 0.0001 0.0002
Eisosomes 0.0002 0.0001 0.0003 0.0007 0.0005 0.0002 0.0009 0.0002 0.0002 0.0001 0.0003 0.0002 0.0003 0.0003 0.0001 0.0001 0 0.0002
Endoplasmic Reticulum 0.0007 0 0.0001 0 0.002 0.0003 0.0012 0 0 0 0.0001 0.0001 0.0008 0 0.0002 0 0 0.0001
Endosome 0.0083 0.0016 0.0025 0 0.0122 0.0026 0.0131 0.0035 0.0024 0.0037 0.0028 0.0069 0.0033 0.001 0.0066 0.0004 0.0002 0.0019
Golgi 0.0062 0.0106 0.0064 0.0002 0.0085 0.0065 0.0165 0.026 0.012 0.0167 0.0137 0.0115 0.008 0.0051 0.0072 0.0041 0.0007 0.0058
Lipid Particles 0.014 0.0016 0.0076 0.0002 0.0211 0.0028 0.0315 0.0019 0.0119 0.0423 0.03 0.0009 0.0176 0.0055 0.0106 0.0006 0.0062 0.0007
Mitochondria 0.9363 0.9718 0.943 0.9951 0.8687 0.9735 0.808 0.9298 0.9461 0.9199 0.8552 0.942 0.9398 0.969 0.9529 0.9849 0.9896 0.9857
None 0.0017 0 0.0004 0 0.0014 0.0002 0.0028 0 0 0 0.0003 0.0001 0.0016 0 0.0001 0 0 0
Nuclear Periphery 0.0005 0 0.0005 0 0.0112 0.0023 0.01 0 0.0001 0 0.0003 0.0065 0.0013 0.0001 0.0003 0 0 0.0001
Nucleolus 0.0006 0.0001 0.0017 0 0.0018 0.0002 0.0008 0.0001 0.0012 0.0001 0.0014 0.0003 0.0008 0.0001 0.0006 0 0.0001 0
Nucleus 0.0003 0 0.0006 0 0.0022 0.0003 0.0108 0 0.0006 0 0.0005 0.003 0.0007 0.0001 0.0002 0 0 0
Peroxisomes 0.0072 0.0043 0.0034 0.0004 0.0081 0.0007 0.018 0.0101 0.0033 0.0055 0.0326 0.0009 0.004 0.0073 0.0022 0.0038 0.0017 0.0016
Punctate Nuclear 0.0005 0 0.0015 0 0.0068 0.0046 0.0043 0 0 0.0004 0.0026 0.0205 0.0028 0 0.0002 0 0 0
Vacuole 0.0021 0.0006 0.0017 0.0001 0.0009 0.0002 0.0027 0.0004 0.0018 0.0003 0.0007 0.0007 0.0014 0.0005 0.0037 0.0001 0.0002 0.0002
Vacuole Periphery 0.006 0.002 0.009 0.0004 0.0026 0.0011 0.0056 0.0012 0.0091 0.0017 0.0011 0.0025 0.0075 0.0028 0.0088 0.0003 0.0009 0.0014

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 29.975 37.659 25.795 35.0089 37.8135 45.3425 48.6946 41.5144 52.1116 47.2056
Translational Efficiency 1.3471 1.2122 1.7937 1.3593 1.087 1.2395 1.1615 1.2836 1.2502 1.1719

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1360 1189 657 1541 1336 2386 770 863 2696 3575 1427 2404

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1016.71 1275.79 1797.19 1689.93 1132.95 1274.99 1641.36 1703.85 1074.31 1275.26 1713.11 1694.93
Standard Deviation 197.24 273.86 308.27 319.26 189.97 245.06 295.52 332.18 202.21 255.00 311.30 324.03
Intensity Change Log 2 — 0.327483 0.821835 0.733055 — 0.170402 0.534808 0.588714 — 0.246830 0.677692 0.658785

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.003293 0.008087 0.006819 0.005837 0.002423 0.004543 0.008550 0.013962 0.002862 0.005722 0.007753 0.008754
Bud Neck 0.001164 0.001291 0.004169 0.001317 0.000716 0.000664 0.003437 0.002205 0.000942 0.000873 0.003774 0.001636
Bud Site 0.002527 0.001717 0.002006 0.002305 0.001020 0.000681 0.003545 0.004649 0.001780 0.001025 0.002836 0.003146
Cell Periphery 0.000488 0.000190 0.000107 0.000233 0.000061 0.000101 0.000162 0.000616 0.000276 0.000131 0.000137 0.000370
Cytoplasm 0.000298 0.000350 0.000378 0.000351 0.000263 0.000198 0.000499 0.000687 0.000281 0.000249 0.000443 0.000472
Cytoplasmic Foci 0.003817 0.015556 0.034949 0.007809 0.013954 0.006041 0.025980 0.007161 0.008840 0.009205 0.030110 0.007576
Eisosomes 0.000301 0.000773 0.000444 0.000443 0.000160 0.000315 0.000454 0.001347 0.000231 0.000467 0.000449 0.000768
Endoplasmic Reticulum 0.000184 0.000224 0.000389 0.000221 0.000162 0.000101 0.000176 0.000630 0.000173 0.000142 0.000274 0.000368
Endosome 0.003862 0.004785 0.005076 0.002820 0.004469 0.003648 0.005502 0.003839 0.004163 0.004026 0.005306 0.003186
Golgi 0.008365 0.038260 0.065877 0.035783 0.018903 0.017491 0.028573 0.038589 0.013587 0.024399 0.045748 0.036791
Lipid Particles 0.002909 0.006524 0.008473 0.002205 0.005055 0.004096 0.004483 0.003860 0.003973 0.004904 0.006320 0.002799
Mitochondria 0.956491* 0.891223* 0.805993* 0.907393* 0.929820* 0.948109* 0.874441* 0.885571* 0.943274* 0.929189* 0.842927* 0.899559*
Mitotic Spindle 0.000241 0.001320 0.009144 0.002117 0.001658 0.000203 0.005714 0.002209 0.000943 0.000574 0.007293 0.002150
None 0.000798 0.001067 0.003323 0.001778 0.000747 0.000661 0.001410 0.001842 0.000773 0.000796 0.002291 0.001801
Nuclear Periphery 0.000181 0.000126 0.002573 0.000473 0.000119 0.000052 0.000547 0.000534 0.000150 0.000076 0.001480 0.000495
Nuclear Periphery Foci 0.000346 0.000137 0.001145 0.000266 0.000198 0.000105 0.000356 0.000234 0.000273 0.000116 0.000719 0.000255
Nucleolus 0.000361 0.000709 0.001189 0.000225 0.000335 0.000272 0.001026 0.000279 0.000348 0.000417 0.001101 0.000244
Nucleus 0.000132 0.000339 0.000144 0.000048 0.000497 0.000107 0.000122 0.000180 0.000313 0.000184 0.000132 0.000095
Peroxisomes 0.011685 0.019665 0.012383 0.006126 0.013609 0.008935 0.020695 0.006359 0.012638 0.012504 0.016868 0.006209
Vacuole 0.001233 0.003664 0.009811 0.006954 0.002886 0.002256 0.006390 0.010447 0.002052 0.002724 0.007965 0.008208
Vacuole Periphery 0.001325 0.003993 0.025607 0.015297 0.002947 0.001421 0.007939 0.014801 0.002128 0.002277 0.016073 0.015119

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.54 -2.51 -2.18 1.72 0.72 -1.95 -3.94 -4.74 -3.98 -2.06 -3.43 -4.62 -5.18 -2.74 -0.77
Bud Neck -0.35 -4.79 -0.49 -0.14 4.78 0.27 -6.03 -3.27 -3.33 1.91 0.34 -7.42 -2.79 -3.30 5.23
Bud Site 0.80 0.55 0.07 -0.86 -0.58 0.83 -2.68 -2.95 -3.35 -0.77 1.49 -1.59 -2.01 -3.58 -0.52
Cell Periphery 2.20 3.11 2.00 -0.67 -3.70 -1.83 -2.58 -2.89 -2.67 -2.32 2.20 2.13 -1.01 -3.17 -3.12
Cytoplasm -0.42 -0.66 -0.52 -0.24 0.13 1.02 -2.56 -2.03 -2.36 -0.99 0.46 -2.09 -1.94 -2.64 -0.54
Cytoplasmic Foci -8.09 -9.72 -4.62 5.14 8.41 5.41 -4.02 4.13 -1.12 6.62 -0.38 -9.78 1.34 1.96 10.60
Eisosomes -5.75 -2.67 -2.56 3.97 0.01 -5.83 -7.01 -1.94 -1.69 -1.46 -6.71 -6.38 -2.42 -1.35 -1.43
Endoplasmic Reticulum -0.65 -1.47 -0.54 0.06 1.23 1.76 -0.37 -2.41 -2.75 -2.35 0.89 -1.49 -2.43 -2.96 -0.95
Endosome -0.95 -1.31 1.31 2.69 3.33 1.02 -0.95 0.71 -0.33 1.61 0.22 -1.58 1.71 1.73 3.45
Golgi -8.71 -10.14 -8.82 0.57 4.81 0.60 -2.60 -4.75 -5.33 -2.05 -5.96 -9.70 -9.18 -4.62 2.31
Lipid Particles -2.80 -4.75 0.84 4.01 6.72 0.99 0.53 0.81 0.15 0.41 -1.22 -2.97 1.61 2.88 4.63
Mitochondria 8.50 12.88 7.57 -1.91 -8.38 -3.05 5.43 4.84 7.56 -0.90 3.14 12.99 8.18 5.73 -6.86
Mitotic Spindle -1.69 -4.49 -2.77 -0.90 3.35 2.97 -2.42 -0.74 -3.39 2.04 1.16 -4.97 -2.25 -3.03 3.81
None -2.75 -12.61 -7.91 -5.91 7.29 1.57 -6.38 -4.49 -4.88 -1.68 -0.44 -13.63 -8.89 -8.98 3.29
Nuclear Periphery 0.38 -4.65 -1.79 -4.31 4.19 4.44 -6.38 -1.85 -2.15 0.05 1.01 -5.48 -2.89 -4.39 3.93
Nuclear Periphery Foci 0.76 -2.20 0.27 -1.96 3.54 1.97 -2.61 -0.67 -2.13 1.56 1.11 -2.49 0.09 -2.80 3.76
Nucleolus -0.82 -2.03 0.66 1.26 2.67 0.34 -1.53 0.30 -0.09 1.72 -0.37 -2.44 0.77 1.17 3.00
Nucleus -0.92 -0.19 1.31 1.33 2.35 0.90 0.86 0.68 -0.62 -0.53 0.55 0.82 0.96 0.92 0.63
Peroxisomes -2.73 -0.26 2.77 5.30 2.61 2.33 -2.16 3.33 1.56 4.65 0.08 -1.95 4.39 4.84 5.39
Vacuole -2.96 -7.39 -6.20 -2.86 1.96 0.83 -3.31 -4.17 -4.59 -2.16 -1.30 -7.63 -6.87 -5.93 -0.31
Vacuole Periphery -2.68 -9.18 -9.35 -6.48 3.42 2.99 -3.89 -6.97 -8.17 -3.43 -0.34 -9.84 -11.38 -11.13 0.51
Standard name
Human Ortholog
Description Mitochondrial ribosomal protein of the large subunit; also involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
Localization
Cell Percentages mitochondrion (99%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Mhr1

Mhr1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mhr1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available