Standard name | |
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Human Ortholog | |
Description | Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding by the complex; required for tRNA genes clustering at the nucleolus; required for replication slow zone breakage following Mec1p inactivation; transcription is cell cycle regulated, peaking in mitosis and declining in G1; protein is constitutively degraded by the proteasome; rate limiting for condensin recruitment to chromatin |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 |
Bud | 0 | 0 | 0 | 2 | 2 | 1 | 0 | 4 | 5 | – | 2 | 3 | 0 | 0 | 1 | 0 | 0 | 3 | 3 | 2 | 0 | 2 | 6 | 3 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 0 | 0 | – | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 2 |
Bud Site | 0 | 0 | 0 | 1 | 1 | 3 | 4 | 8 | 6 | – | 8 | 15 | 0 | 0 | 0 | 1 | 0 | 1 | – | – | – | – | – | – |
Cell Periphery | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 2 | 4 | 0 | 6 | 7 | 11 | 7 | 12 | 8 | – | 6 | 9 | 32 | 53 | 78 | 15 | 9 | 18 | 0 | 0 | 0 | 2 | 2 | 2 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 1 | 3 | 3 | 2 | 0 | 0 | 0 | 1 | 1 | 0 |
Endosome | 12 | 3 | 0 | 0 | 9 | 2 | 4 | 0 | 0 | – | 0 | 1 | 2 | 20 | 13 | 16 | 18 | 22 | 22 | 9 | 5 | 33 | 59 | 89 |
Golgi | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 1 | 2 | 2 |
Mitochondria | 15 | 24 | 14 | 52 | 62 | 83 | 136 | 173 | 148 | – | 98 | 182 | 13 | 17 | 115 | 12 | 6 | 22 | 3 | 2 | 2 | 2 | 4 | 13 |
Nucleus | 145 | 159 | 8 | 34 | 57 | 57 | 97 | 133 | 100 | – | 60 | 82 | 207 | 222 | 221 | 128 | 79 | 79 | 83 | 145 | 24 | 69 | 77 | 83 |
Nuclear Periphery | 7 | 10 | 0 | 2 | 2 | 1 | 3 | 6 | 5 | – | 1 | 7 | 6 | 9 | 7 | 9 | 10 | 6 | 14 | 2 | 3 | 2 | 2 | 7 |
Nucleolus | 73 | 38 | 3 | 18 | 50 | 45 | 47 | 61 | 51 | – | 19 | 43 | 38 | 85 | 121 | 54 | 54 | 82 | 74 | 48 | 12 | 66 | 55 | 76 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | – | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 2 |
SpindlePole | 19 | 3 | 0 | 0 | 30 | 16 | 17 | 29 | 19 | – | 7 | 8 | 0 | 7 | 14 | 6 | 10 | 16 | 34 | 13 | 4 | 39 | 58 | 88 |
Vac/Vac Membrane | 6 | 11 | 0 | 0 | 0 | 2 | 5 | 2 | 0 | – | 2 | 5 | 4 | 9 | 13 | 17 | 9 | 14 | 9 | 14 | 7 | 16 | 43 | 58 |
Unique Cell Count | 229 | 217 | 19 | 71 | 155 | 147 | 219 | 297 | 211 | 132 | 220 | 277 | 376 | 475 | 214 | 161 | 204 | 259 | 243 | 64 | 248 | 328 | 450 | |
Labelled Cell Count | 280 | 253 | 25 | 115 | 220 | 223 | 323 | 429 | 342 | 204 | 355 | 302 | 423 | 584 | 261 | 199 | 266 | 259 | 243 | 64 | 248 | 328 | 450 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 6.2 | 5.2 | 3.7 | 4.0 | 4.2 | 3.8 | 3.6 | 3.7 | 3.2 | – | 3.3 | 2.8 | 5.6 | 5.7 | 4.8 | 8.1 | 9.0 | 9.4 | 5.7 | 5.1 | 5.9 |
Std Deviation (1e-4) | 0.9 | 0.8 | 0.3 | 1.2 | 1.4 | 1.3 | 1.1 | 1.2 | 1.2 | – | 1.2 | 0.7 | 1.3 | 1.4 | 1.3 | 2.3 | 2.4 | 2.9 | 1.3 | 1.3 | 1.3 |
Intensity Change (Log2) | – | – | – | 0.09 | 0.15 | 0.01 | -0.07 | -0.02 | -0.23 | – | -0.18 | -0.4 | 0.59 | 0.62 | 0.36 | 1.11 | 1.27 | 1.33 | 0.6 | 0.45 | 0.66 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0.4 | -0.5 | -0.3 | 0.2 | 0.2 | 0.4 | – | 0.3 | -0.4 | 3.1 | 1.5 | 0.4 | 1.5 | 0.6 | -0.3 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 1.6 | 2.1 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 2.019 | 1.6757 | 1.8376 | 1.6545 | 1.5313 | 1.4015 | 3.2021 | 2.5995 | 2.6106 | 2.1116 | 2.0271 | 2.3309 | 0.7623 | 1.0011 | 0.8362 | 0.655 | 0.474 | 0.7083 |
Actin | 0.0464 | 0.0005 | 0.0119 | 0.0021 | 0.0465 | 0.0005 | 0.0403 | 0.0002 | 0.0227 | 0.0026 | 0.0007 | 0.0046 | 0.0222 | 0.0004 | 0.0063 | 0.0008 | 0.0004 | 0.0003 |
Bud | 0.0008 | 0.0003 | 0.0003 | 0.0003 | 0.0003 | 0.0001 | 0.001 | 0.0001 | 0.001 | 0.0001 | 0.0001 | 0.0002 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0.0001 |
Bud Neck | 0.0037 | 0.0026 | 0.0054 | 0.0132 | 0.0604 | 0.0052 | 0.0031 | 0.0014 | 0.0027 | 0.0014 | 0.0068 | 0.0035 | 0.0014 | 0.0008 | 0.007 | 0.0019 | 0.047 | 0.0047 |
Bud Periphery | 0.0019 | 0.0011 | 0.0011 | 0.0012 | 0.0007 | 0.0003 | 0.0027 | 0.0003 | 0.0014 | 0.0002 | 0.0004 | 0.0005 | 0.0004 | 0.0003 | 0.0003 | 0.0006 | 0.0005 | 0.0002 |
Bud Site | 0.0157 | 0.0055 | 0.0115 | 0.0019 | 0.0011 | 0.0004 | 0.0046 | 0.002 | 0.0048 | 0.0006 | 0.0005 | 0.0005 | 0.0011 | 0.0009 | 0.0022 | 0.0004 | 0.0015 | 0.0004 |
Cell Periphery | 0.0007 | 0.0007 | 0.002 | 0.0007 | 0.0002 | 0.0001 | 0.0005 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0004 | 0.0003 | 0.0003 | 0.0001 | 0.0002 | 0.0001 |
Cytoplasm | 0.0023 | 0.0101 | 0.0029 | 0.0002 | 0.0004 | 0.0011 | 0.0086 | 0.0046 | 0.002 | 0.001 | 0.0002 | 0.0009 | 0.0044 | 0.0048 | 0.0016 | 0.0005 | 0.0003 | 0.0011 |
Cytoplasmic Foci | 0.0109 | 0.0026 | 0.0062 | 0.0028 | 0.0104 | 0.0003 | 0.0119 | 0.0017 | 0.0088 | 0.0042 | 0.0033 | 0.002 | 0.0021 | 0.0006 | 0.0028 | 0.0012 | 0.0071 | 0.0006 |
Eisosomes | 0.0015 | 0.0001 | 0.0002 | 0.0002 | 0.0002 | 0 | 0.0006 | 0 | 0.0002 | 0.0001 | 0.0001 | 0 | 0.0004 | 0 | 0.0001 | 0.0001 | 0.0001 | 0 |
Endoplasmic Reticulum | 0.0039 | 0.0017 | 0.0014 | 0.0005 | 0.0011 | 0.0008 | 0.005 | 0.0004 | 0.0018 | 0.0014 | 0.0001 | 0.0004 | 0.0078 | 0.0023 | 0.0005 | 0.0002 | 0.0001 | 0.0003 |
Endosome | 0.0189 | 0.0054 | 0.007 | 0.0054 | 0.0059 | 0.0009 | 0.0355 | 0.0018 | 0.0149 | 0.0099 | 0.0072 | 0.0046 | 0.0101 | 0.0029 | 0.0017 | 0.0007 | 0.0016 | 0.0007 |
Golgi | 0.008 | 0.0007 | 0.0035 | 0.0025 | 0.0066 | 0.0002 | 0.0123 | 0.0003 | 0.0043 | 0.0064 | 0.0066 | 0.0025 | 0.002 | 0.0003 | 0.0008 | 0.0003 | 0.0013 | 0.0002 |
Lipid Particles | 0.0267 | 0.0054 | 0.0213 | 0.0169 | 0.021 | 0.0011 | 0.0247 | 0.0018 | 0.0189 | 0.0139 | 0.0148 | 0.0021 | 0.006 | 0.0033 | 0.0042 | 0.0036 | 0.0196 | 0.0018 |
Mitochondria | 0.0055 | 0.0021 | 0.0021 | 0.0031 | 0.0013 | 0.0011 | 0.0398 | 0.0005 | 0.0053 | 0.0127 | 0.0249 | 0.0022 | 0.0024 | 0.0009 | 0.0006 | 0.0005 | 0.0006 | 0.0005 |
None | 0.0056 | 0.0128 | 0.0018 | 0.0004 | 0.0006 | 0.0003 | 0.0099 | 0.0006 | 0.0006 | 0.0015 | 0.0004 | 0.0007 | 0.0192 | 0.0639 | 0.0026 | 0.0006 | 0.0004 | 0.0009 |
Nuclear Periphery | 0.047 | 0.06 | 0.0514 | 0.0049 | 0.0057 | 0.045 | 0.067 | 0.0301 | 0.0548 | 0.0115 | 0.0115 | 0.0151 | 0.0171 | 0.0883 | 0.0678 | 0.0631 | 0.0031 | 0.0337 |
Nucleolus | 0.1337 | 0.1843 | 0.3322 | 0.4826 | 0.2818 | 0.2096 | 0.1185 | 0.2074 | 0.2963 | 0.3929 | 0.2904 | 0.223 | 0.1727 | 0.1033 | 0.3512 | 0.4835 | 0.3705 | 0.1769 |
Nucleus | 0.6159 | 0.5831 | 0.3799 | 0.1714 | 0.161 | 0.6124 | 0.4972 | 0.6671 | 0.4377 | 0.285 | 0.2239 | 0.6136 | 0.5917 | 0.5369 | 0.4023 | 0.2703 | 0.1464 | 0.6144 |
Peroxisomes | 0.0069 | 0.0006 | 0.0029 | 0.002 | 0.0265 | 0.0001 | 0.0085 | 0.0006 | 0.004 | 0.0054 | 0.0015 | 0.0011 | 0.0033 | 0.0002 | 0.0058 | 0.0006 | 0.0038 | 0.0002 |
Punctate Nuclear | 0.0353 | 0.1063 | 0.1447 | 0.2836 | 0.3674 | 0.1187 | 0.0965 | 0.0765 | 0.1145 | 0.2473 | 0.4051 | 0.1213 | 0.1302 | 0.1844 | 0.139 | 0.1699 | 0.3943 | 0.1617 |
Vacuole | 0.0057 | 0.0112 | 0.0068 | 0.0031 | 0.0006 | 0.0009 | 0.0065 | 0.0017 | 0.0015 | 0.0009 | 0.0005 | 0.0007 | 0.0039 | 0.0027 | 0.0022 | 0.0003 | 0.0008 | 0.0007 |
Vacuole Periphery | 0.003 | 0.003 | 0.0035 | 0.0008 | 0.0003 | 0.0009 | 0.0052 | 0.0007 | 0.0015 | 0.0009 | 0.0008 | 0.0004 | 0.001 | 0.0026 | 0.0007 | 0.0007 | 0.0001 | 0.0005 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 18.9936 | 17.1378 | 8.478 | 11.0199 | 14.7296 | 19.8702 | 24.9491 | 17.1097 | 13.2836 | 17.4591 |
Translational Efficiency | 0.5842 | 0.8344 | 0.692 | 0.5137 | 0.551 | 0.4106 | 0.4853 | 0.3937 | 0.5015 | 0.4689 |
Dataset | Hit |
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Protein Abundance | ✘ |
Protein Localization | ✔ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |