Standard name | |
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Human Ortholog | |
Description | Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase); binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking; relocalizes from nucleus to vacuole upon DNA replication stress; mutation is functionally complemented by human FKBP2 |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 1 | 0 | 0 | 0 | 2 | 5 | 2 | 3 | 8 | 5 | 1 | 1 | 2 | 2 | 1 | 0 | 0 | 2 | 3 | 1 | 1 | 0 | 2 |
Bud | 2 | 1 | 1 | 3 | 3 | 18 | 25 | 21 | 12 | 15 | 16 | 13 | 1 | 3 | 0 | 2 | 1 | 0 | 3 | 3 | 4 | 1 | 3 | 6 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 4 | 7 | 1 | 1 | 2 | 1 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 1 | 0 | 0 | 0 | 0 | 11 | 7 | 1 | 12 | 6 | 11 | 10 | 23 | 50 | 62 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 371 | 436 | 294 | 274 | 286 | 395 | 549 | 591 | 399 | 480 | 305 | 377 | 310 | 437 | 531 | 153 | 109 | 100 | 67 | 127 | 43 | 52 | 26 | 27 |
Endoplasmic Reticulum | 26 | 8 | 7 | 3 | 3 | 10 | 4 | 5 | 2 | 3 | 0 | 4 | 66 | 41 | 85 | 9 | 10 | 11 | 87 | 39 | 47 | 79 | 38 | 62 |
Endosome | 4 | 2 | 12 | 5 | 2 | 4 | 3 | 6 | 3 | 7 | 0 | 2 | 1 | 1 | 1 | 14 | 7 | 3 | 11 | 11 | 12 | 5 | 8 | 16 |
Golgi | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 2 |
Mitochondria | 1 | 5 | 1 | 1 | 3 | 10 | 18 | 23 | 32 | 39 | 21 | 28 | 0 | 0 | 0 | 13 | 1 | 5 | 2 | 8 | 5 | 9 | 6 | 11 |
Nucleus | 10 | 1 | 1 | 0 | 3 | 5 | 14 | 13 | 8 | 8 | 2 | 8 | 3 | 2 | 4 | 129 | 94 | 72 | 0 | 0 | 0 | 0 | 1 | 1 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 1 | 0 | 6 | 0 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 0 | 1 | 1 |
Nucleolus | 0 | 0 | 0 | 1 | 0 | 2 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4 | 0 | 0 | 2 | 0 |
Vac/Vac Membrane | 103 | 36 | 89 | 45 | 26 | 27 | 56 | 52 | 53 | 86 | 43 | 58 | 1 | 7 | 5 | 258 | 202 | 154 | 338 | 304 | 288 | 175 | 197 | 277 |
Unique Cell Count | 474 | 475 | 373 | 301 | 306 | 433 | 623 | 659 | 461 | 559 | 347 | 428 | 371 | 495 | 611 | 446 | 340 | 276 | 531 | 519 | 411 | 334 | 294 | 416 |
Labelled Cell Count | 519 | 490 | 406 | 332 | 327 | 484 | 689 | 720 | 525 | 659 | 403 | 501 | 406 | 547 | 690 | 580 | 425 | 345 | 531 | 519 | 411 | 334 | 294 | 416 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 6.4 | 5.4 | 5.2 | 5.9 | 5.9 | 6.0 | 5.2 | 5.5 | 5.3 | 5.2 | 5.3 | 5.5 | 7.5 | 7.3 | 7.3 | 7.6 | 7.6 | 7.6 | 8.2 | 8.4 | 8.4 |
Std Deviation (1e-4) | 1.1 | 0.9 | 1.1 | 1.8 | 1.4 | 1.5 | 1.3 | 1.3 | 1.3 | 1.3 | 1.2 | 1.5 | 1.2 | 1.1 | 1.2 | 1.5 | 1.8 | 1.8 | 1.5 | 1.5 | 1.9 |
Intensity Change (Log2) | – | – | – | 0.18 | 0.17 | 0.2 | -0.0 | 0.07 | 0.01 | -0.02 | 0.02 | 0.08 | 0.52 | 0.48 | 0.48 | 0.53 | 0.54 | 0.54 | 0.65 | 0.68 | 0.68 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 3.6 | 3.6 | 3.1 | 2.7 | 2.8 | 3.8 | 3.0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 3.1 | 0 | 0 | 3.1 | 0 | 3.5 | 0 | 4.9 | 6.3 | 6.4 | 0 | 0 | 0 |
Cytoplasm | 4.3 | 5.4 | 5.0 | 3.9 | 4.8 | 3.0 | 2.8 | 3.3 | 3.5 | 1.7 | 3.8 | 3.3 | -12.7 | -12.6 | -11.0 |
Endoplasmic Reticulum | 0 | 0 | 0.4 | 0 | 0 | 0 | 0 | 0 | -1.1 | 7.3 | 4.1 | 6.3 | 0.1 | 0.9 | 1.6 |
Endosome | -1.3 | -2.3 | -2.3 | -3.4 | -2.7 | -2.8 | -2.1 | -3.4 | -3.0 | -3.1 | -3.6 | 0 | -0.1 | -1.0 | -1.8 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 2.5 | 2.9 | 3.3 | 4.9 | 5.0 | 4.5 | 4.7 | 0 | 0 | 0 | 2.9 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 2.5 | 2.3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 11.2 | 10.7 | 10.3 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | -2.9 | -5.3 | -7.1 | -6.4 | -7.2 | -4.7 | -3.2 | -4.0 | -3.8 | -9.9 | -10.4 | -11.9 | 9.8 | 9.6 | 8.3 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 3.2498 | 3.7813 | 3.9753 | 3.6078 | 3.2966 | 3.8586 | 6.4365 | 7.709 | 7.2339 | 6.7556 | 6.5723 | 7.3573 | 5.5123 | 6.0852 | 5.6866 | 4.764 | 5.2203 | 5.2878 |
Actin | 0.0001 | 0.0002 | 0.0003 | 0.0001 | 0 | 0.0001 | 0.0011 | 0.0002 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0041 | 0.0002 | 0.0237 | 0.0106 | 0.1586 | 0.0028 |
Bud | 0.0016 | 0.0022 | 0.0009 | 0.0009 | 0.001 | 0.0014 | 0.0002 | 0.002 | 0.0005 | 0.0003 | 0.0008 | 0.0004 | 0.0008 | 0.0002 | 0.001 | 0.0003 | 0.0028 | 0.0003 |
Bud Neck | 0.0013 | 0.0042 | 0.0045 | 0.0018 | 0.0031 | 0.0039 | 0.0004 | 0.0019 | 0.0015 | 0.0017 | 0.0019 | 0.0037 | 0.0017 | 0.0015 | 0.0041 | 0.001 | 0.0022 | 0.006 |
Bud Periphery | 0.0024 | 0.0019 | 0.0018 | 0.0011 | 0.0026 | 0.0035 | 0.0007 | 0.0017 | 0.0014 | 0.0006 | 0.0014 | 0.0014 | 0.0014 | 0.0006 | 0.0016 | 0.0005 | 0.0034 | 0.0009 |
Bud Site | 0.01 | 0.0103 | 0.0043 | 0.0025 | 0.0023 | 0.0015 | 0.0006 | 0.0057 | 0.0018 | 0.0013 | 0.0033 | 0.001 | 0.002 | 0.0026 | 0.0085 | 0.001 | 0.0028 | 0.0008 |
Cell Periphery | 0.0034 | 0.0034 | 0.0034 | 0.0013 | 0.0026 | 0.0043 | 0.0063 | 0.0072 | 0.0061 | 0.0068 | 0.0048 | 0.0052 | 0.0055 | 0.0095 | 0.0073 | 0.0044 | 0.0013 | 0.0036 |
Cytoplasm | 0.1909 | 0.1995 | 0.2179 | 0.1743 | 0.1289 | 0.1947 | 0.2207 | 0.2382 | 0.2215 | 0.1737 | 0.1816 | 0.2563 | 0.2045 | 0.2629 | 0.1891 | 0.1252 | 0.1093 | 0.1623 |
Cytoplasmic Foci | 0.0241 | 0.0182 | 0.0233 | 0.024 | 0.0139 | 0.0212 | 0.0118 | 0.0167 | 0.0157 | 0.0065 | 0.0136 | 0.0078 | 0.021 | 0.0126 | 0.0277 | 0.0164 | 0.022 | 0.0153 |
Eisosomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0004 | 0 |
Endoplasmic Reticulum | 0.1372 | 0.073 | 0.1388 | 0.0566 | 0.0623 | 0.1206 | 0.3785 | 0.2727 | 0.2733 | 0.4155 | 0.2584 | 0.2997 | 0.1889 | 0.2339 | 0.2609 | 0.214 | 0.06 | 0.2728 |
Endosome | 0.1765 | 0.1413 | 0.1839 | 0.2254 | 0.1671 | 0.1444 | 0.0912 | 0.079 | 0.1193 | 0.0713 | 0.1277 | 0.0533 | 0.1074 | 0.0579 | 0.0883 | 0.1615 | 0.1288 | 0.0822 |
Golgi | 0.0024 | 0.0023 | 0.0039 | 0.0027 | 0.0021 | 0.0023 | 0.0022 | 0.0021 | 0.0038 | 0.001 | 0.0026 | 0.0013 | 0.0106 | 0.0012 | 0.008 | 0.0039 | 0.016 | 0.007 |
Lipid Particles | 0.0088 | 0.0041 | 0.0051 | 0.0016 | 0.0027 | 0.0053 | 0.0157 | 0.0147 | 0.0214 | 0.0111 | 0.0057 | 0.0054 | 0.0197 | 0.0127 | 0.0282 | 0.0152 | 0.0108 | 0.0111 |
Mitochondria | 0.0029 | 0.0018 | 0.0061 | 0.001 | 0.001 | 0.0032 | 0.0007 | 0.0005 | 0.0012 | 0.0002 | 0.0008 | 0.0008 | 0.0036 | 0.0003 | 0.0057 | 0.0011 | 0.0071 | 0.0021 |
None | 0.0217 | 0.0259 | 0.0193 | 0.0016 | 0.0025 | 0.0218 | 0.0183 | 0.0081 | 0.0045 | 0.0009 | 0.016 | 0.0103 | 0.0298 | 0.0105 | 0.0178 | 0.0083 | 0.0026 | 0.0036 |
Nuclear Periphery | 0.019 | 0.0157 | 0.0189 | 0.011 | 0.0136 | 0.013 | 0.0136 | 0.0118 | 0.0113 | 0.0103 | 0.0192 | 0.0133 | 0.0373 | 0.017 | 0.0154 | 0.0286 | 0.0343 | 0.0242 |
Nucleolus | 0.0026 | 0.003 | 0.0026 | 0.0007 | 0.0014 | 0.0022 | 0.0003 | 0.0023 | 0.0009 | 0.0003 | 0.0007 | 0.0007 | 0.0012 | 0.0008 | 0.0015 | 0.0007 | 0.001 | 0.0005 |
Nucleus | 0.0141 | 0.0194 | 0.0128 | 0.0063 | 0.0093 | 0.0194 | 0.0034 | 0.0092 | 0.004 | 0.0036 | 0.0084 | 0.0067 | 0.052 | 0.0056 | 0.0065 | 0.0078 | 0.0209 | 0.0109 |
Peroxisomes | 0.0003 | 0.0002 | 0.0004 | 0.0003 | 0.0002 | 0.0005 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0002 | 0.0001 | 0.0012 | 0.0001 | 0.0048 | 0.001 | 0.0459 | 0.0054 |
Punctate Nuclear | 0.0012 | 0.0013 | 0.0016 | 0.0003 | 0.0005 | 0.0015 | 0.0004 | 0.0017 | 0.0003 | 0.0003 | 0.0007 | 0.0005 | 0.0045 | 0.0005 | 0.002 | 0.0079 | 0.0065 | 0.001 |
Vacuole | 0.3587 | 0.4547 | 0.3292 | 0.4558 | 0.5562 | 0.4145 | 0.2261 | 0.3177 | 0.2993 | 0.2882 | 0.3414 | 0.3223 | 0.2876 | 0.361 | 0.2852 | 0.3756 | 0.3389 | 0.3738 |
Vacuole Periphery | 0.0208 | 0.0173 | 0.0211 | 0.0307 | 0.0267 | 0.0206 | 0.0077 | 0.0064 | 0.012 | 0.0064 | 0.0107 | 0.0095 | 0.0149 | 0.0084 | 0.0127 | 0.0151 | 0.0247 | 0.0134 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 94.6548 | 60.4397 | 77.1401 | 81.1515 | 87.6601 | 97.3053 | 91.6658 | 80.8412 | 94.7312 | 91.8758 |
Translational Efficiency | 1.661 | 2.1227 | 1.578 | 1.7857 | 1.5763 | 1.5471 | 1.3445 | 1.5398 | 1.4631 | 1.3318 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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