Standard name | |
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Human Ortholog | |
Description | Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 |
Bud | 0 | 0 | 0 | 0 | 0 | 1 | – | 1 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 2 | 1 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 3 | – | 3 | 5 | 3 | 9 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 22 | 12 | 3 | 7 | 7 | 10 | – | 5 | 11 | 9 | 6 | 8 | 23 | 23 | 33 | 39 | 38 | 12 | 1 | 2 | 0 | 2 | 3 | 2 |
Endoplasmic Reticulum | 0 | 0 | 1 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 5 | 4 | 1 | 0 | 0 | 0 | 0 | 3 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3 | 2 | 0 | 1 | 4 | 2 | 1 | 1 | 0 | 3 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3 | 2 | 0 | 0 | 0 | 0 |
Mitochondria | 3 | 5 | 1 | 4 | 0 | 8 | – | 9 | 30 | 18 | 14 | 15 | 1 | 0 | 2 | 5 | 10 | 2 | 1 | 1 | 0 | 1 | 2 | 2 |
Nucleus | 468 | 216 | 79 | 43 | 99 | 166 | – | 180 | 176 | 191 | 121 | 137 | 183 | 147 | 125 | 285 | 292 | 212 | 482 | 220 | 76 | 113 | 125 | 98 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | – | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 2 |
Nucleolus | 6 | 4 | 1 | 5 | 9 | 39 | – | 72 | 88 | 100 | 76 | 85 | 7 | 13 | 22 | 12 | 5 | 8 | 0 | 0 | 0 | 6 | 8 | 15 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 4 | 3 | 0 | 0 | 2 | 4 | – | 1 | 2 | 0 | 2 | 1 | 1 | 2 | 1 | 19 | 16 | 13 | 8 | 4 | 1 | 11 | 31 | 47 |
Unique Cell Count | 497 | 236 | 82 | 53 | 113 | 194 | 226 | 243 | 256 | 172 | 190 | 213 | 178 | 179 | 354 | 358 | 242 | 508 | 240 | 83 | 140 | 179 | 183 | |
Labelled Cell Count | 503 | 240 | 85 | 59 | 117 | 231 | 273 | 313 | 324 | 229 | 252 | 216 | 193 | 196 | 365 | 368 | 253 | 508 | 240 | 83 | 140 | 179 | 183 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 13.7 | 15.8 | 9.8 | 11.7 | 15.6 | 12.1 | – | 11.9 | 11.3 | 11.5 | 10.9 | 10.8 | 16.0 | 15.0 | 14.9 | 25.6 | 25.2 | 24.7 | 14.4 | 15.4 | 15.7 |
Std Deviation (1e-4) | 4.6 | 4.7 | 3.7 | 3.1 | 3.5 | 4.2 | – | 4.9 | 5.9 | 5.0 | 6.1 | 4.6 | 7.8 | 5.9 | 7.9 | 10.7 | 11.6 | 8.7 | 5.9 | 4.4 | 4.9 |
Intensity Change (Log2) | – | – | – | 0.26 | 0.67 | 0.31 | – | 0.28 | 0.21 | 0.24 | 0.16 | 0.15 | 0.7 | 0.62 | 0.61 | 1.39 | 1.36 | 1.33 | 0.56 | 0.65 | 0.68 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 1.9 | 2.3 | 3.2 | 2.0 | 2.0 | 0 |
Endoplasmic Reticulum | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | – | 0 | 3.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | -2.9 | -2.1 | -2.6 | – | -3.5 | -4.6 | -4.3 | -4.7 | -4.5 | -2.5 | -3.1 | -4.8 | -3.5 | -3.3 | -2.3 |
Nuclear Periphery | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 4.1 | – | 5.6 | 6.1 | 6.5 | 7.0 | 7.1 | 0 | 0 | 2.9 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 8.5672 | 9.4892 | 8.6641 | 7.431 | 9.7653 | 9.0141 | 9.2694 | 9.3584 | 9.1066 | 7.877 | 8.1544 | 8.6442 | 10.607 | 11.1768 | 10.2893 | 9.5362 | 9.3488 | 9.8973 |
Actin | 0.0083 | 0 | 0.0155 | 0.0019 | 0 | 0 | 0.0087 | 0 | 0 | 0.036 | 0.0003 | 0 | 0.0417 | 0 | 0.0048 | 0.0078 | 0.0216 | 0.0092 |
Bud | 0.0002 | 0 | 0.0002 | 0.0001 | 0 | 0.0001 | 0.0006 | 0.0019 | 0.0002 | 0.0001 | 0.0001 | 0 | 0.0004 | 0 | 0.0002 | 0.0001 | 0.0003 | 0.0001 |
Bud Neck | 0.0007 | 0.0001 | 0.0002 | 0.0001 | 0.0004 | 0.0005 | 0.0014 | 0.0001 | 0 | 0.0002 | 0.0007 | 0.0005 | 0.0004 | 0 | 0.0004 | 0.0271 | 0.0003 | 0.0007 |
Bud Periphery | 0.0002 | 0 | 0.0002 | 0.0001 | 0.0001 | 0.0003 | 0.0012 | 0.0008 | 0.0002 | 0.0002 | 0.0005 | 0.0001 | 0.0007 | 0 | 0.0002 | 0.0004 | 0.0005 | 0.0004 |
Bud Site | 0.0017 | 0 | 0.0008 | 0.0005 | 0 | 0.0001 | 0.0014 | 0.002 | 0.0002 | 0.0007 | 0.0001 | 0 | 0.0012 | 0 | 0.0025 | 0.0033 | 0.0005 | 0.0001 |
Cell Periphery | 0.0001 | 0 | 0.0003 | 0.0001 | 0.0001 | 0.0001 | 0.0006 | 0.0003 | 0.0002 | 0 | 0.0005 | 0 | 0.0002 | 0 | 0 | 0.0006 | 0.0001 | 0.0002 |
Cytoplasm | 0.0081 | 0.0001 | 0.0039 | 0.0041 | 0 | 0 | 0.0037 | 0.0025 | 0.0003 | 0.0033 | 0.0001 | 0.0001 | 0.0028 | 0.0153 | 0.0002 | 0.0002 | 0.0013 | 0.0003 |
Cytoplasmic Foci | 0.019 | 0.0001 | 0.0063 | 0.0096 | 0 | 0 | 0.0106 | 0.0001 | 0.0017 | 0.0223 | 0.0005 | 0.002 | 0.0143 | 0 | 0.0033 | 0.0079 | 0.0393 | 0.0029 |
Eisosomes | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0.0003 | 0 | 0 | 0.0001 | 0 | 0 | 0.0001 | 0.0001 | 0.0001 |
Endoplasmic Reticulum | 0.0021 | 0 | 0.0005 | 0.0028 | 0 | 0 | 0.002 | 0.0001 | 0.0001 | 0.0003 | 0.0001 | 0 | 0.0016 | 0 | 0.0003 | 0 | 0.0018 | 0.0002 |
Endosome | 0.0238 | 0.0001 | 0.0042 | 0.0246 | 0 | 0 | 0.0123 | 0 | 0.0002 | 0.0041 | 0.004 | 0.0001 | 0.0152 | 0 | 0.0076 | 0.0009 | 0.0189 | 0.0012 |
Golgi | 0.0049 | 0 | 0.0038 | 0.0058 | 0 | 0 | 0.0029 | 0 | 0 | 0.0065 | 0.0018 | 0.0001 | 0.0057 | 0 | 0.0032 | 0.0017 | 0.0196 | 0.0023 |
Lipid Particles | 0.0151 | 0 | 0.0074 | 0.0364 | 0 | 0 | 0.0183 | 0 | 0.0006 | 0.0105 | 0.0004 | 0.0022 | 0.0083 | 0 | 0.0023 | 0.0023 | 0.0061 | 0.0098 |
Mitochondria | 0.0025 | 0.0001 | 0.0106 | 0.0049 | 0.0007 | 0.0002 | 0.0123 | 0.0002 | 0.001 | 0.0028 | 0.0405 | 0.0002 | 0.0025 | 0.0001 | 0.005 | 0.0003 | 0.0078 | 0.0046 |
None | 0.0031 | 0 | 0.0004 | 0.0042 | 0 | 0 | 0.0032 | 0.0003 | 0.0001 | 0.0188 | 0.0001 | 0 | 0.003 | 0.0001 | 0.0001 | 0.0001 | 0.003 | 0.0003 |
Nuclear Periphery | 0.0062 | 0.0011 | 0.0032 | 0.0108 | 0.0005 | 0.0003 | 0.0132 | 0.002 | 0.0019 | 0.0009 | 0.0014 | 0.0003 | 0.0265 | 0.0006 | 0.0026 | 0.001 | 0.0027 | 0.0014 |
Nucleolus | 0.0103 | 0.0228 | 0.0119 | 0.0104 | 0.1228 | 0.0562 | 0.0254 | 0.0127 | 0.0126 | 0.0044 | 0.0957 | 0.0594 | 0.0126 | 0.0073 | 0.0051 | 0.0231 | 0.1156 | 0.0675 |
Nucleus | 0.8656 | 0.974 | 0.9253 | 0.8667 | 0.8747 | 0.9406 | 0.8518 | 0.9745 | 0.9774 | 0.8595 | 0.8469 | 0.9339 | 0.8367 | 0.9764 | 0.9599 | 0.9036 | 0.7156 | 0.8936 |
Peroxisomes | 0.0058 | 0 | 0.0007 | 0.0015 | 0 | 0 | 0.0054 | 0 | 0 | 0.0162 | 0.0006 | 0.0001 | 0.0025 | 0 | 0.0017 | 0.0181 | 0.0293 | 0.0008 |
Punctate Nuclear | 0.0184 | 0.0012 | 0.0028 | 0.0105 | 0.0001 | 0.0001 | 0.0143 | 0.0004 | 0.0006 | 0.0125 | 0.0003 | 0.0005 | 0.0196 | 0.0002 | 0.0004 | 0.0009 | 0.0141 | 0.0013 |
Vacuole | 0.0025 | 0.0002 | 0.0009 | 0.0029 | 0.0002 | 0.0011 | 0.0066 | 0.0017 | 0.0012 | 0.0001 | 0.0018 | 0.0002 | 0.0018 | 0 | 0.0003 | 0.0005 | 0.0006 | 0.0014 |
Vacuole Periphery | 0.0013 | 0.0001 | 0.0007 | 0.002 | 0.0003 | 0.0003 | 0.0039 | 0.0003 | 0.0013 | 0.0001 | 0.0039 | 0.0001 | 0.0024 | 0 | 0.0002 | 0.0001 | 0.001 | 0.0018 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 42.9898 | 61.9154 | 57.0338 | 66.8384 | 78.9624 | 47.74 | 64.7613 | 87.419 | 108.7563 | 68.5665 |
Translational Efficiency | 4.8816 | 3.6874 | 3.4565 | 3.9311 | 2.7841 | 4.0589 | 2.7288 | 2.2455 | 1.855 | 2.385 |
Dataset | Hit |
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Protein Concentration | ✔ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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