Standard name | |
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Human Ortholog | |
Description | Protein phosphatase required for mitotic exit; required for rDNA segregation, cytokinesis, meiosis I spindle disassembly, environmental stress response; held in nucleolus by Cdc55p in early meiosis, liberated by FEAR and Mitotic Exit Network in anaphase, enabling it to effect a decrease in CDK/B-cyclin activity and mitotic exit; sequestered in metaphase II, released upon entry into anaphase II; human homolog CDC14A can complement thermosensitivity of yeast cdc14-1 mutant |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 3 |
Bud | 2 | 0 | 1 | 2 | 1 | 3 | 4 | 8 | 5 | 8 | 1 | 4 | 0 | 0 | 1 | 0 | 1 | 0 | 4 | 2 | 7 | 1 | 4 | 11 |
Bud Neck | 9 | 4 | 14 | 14 | 13 | 17 | 18 | 38 | 21 | 28 | 14 | 11 | 24 | 30 | 11 | 5 | 0 | 1 | 2 | 1 | 7 | 3 | 15 | 21 |
Bud Site | 1 | 1 | 4 | 3 | 3 | 5 | 10 | 18 | 19 | 34 | 9 | 6 | 1 | 0 | 0 | 2 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 4 | 7 | 8 | 9 | 20 | 11 | 10 | 10 | 10 | 10 | 5 | 6 | 55 | 90 | 108 | 45 | 34 | 21 | 0 | 1 | 0 | 1 | 1 | 1 |
Endoplasmic Reticulum | 0 | 0 | 1 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4 | 5 | 3 | 0 | 0 | 0 | 3 | 1 | 2 |
Endosome | 5 | 11 | 16 | 11 | 19 | 12 | 15 | 12 | 7 | 9 | 4 | 3 | 6 | 12 | 16 | 13 | 17 | 10 | 15 | 17 | 28 | 11 | 27 | 16 |
Golgi | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 3 | 2 | 2 | 3 | 4 |
Mitochondria | 35 | 10 | 16 | 14 | 18 | 29 | 34 | 52 | 40 | 50 | 31 | 23 | 6 | 6 | 4 | 20 | 2 | 4 | 2 | 5 | 6 | 1 | 3 | 2 |
Nucleus | 49 | 57 | 43 | 22 | 18 | 14 | 15 | 32 | 15 | 20 | 10 | 10 | 21 | 20 | 28 | 22 | 17 | 10 | 33 | 40 | 18 | 2 | 11 | 10 |
Nuclear Periphery | 2 | 1 | 2 | 7 | 7 | 2 | 8 | 8 | 6 | 8 | 6 | 3 | 3 | 1 | 1 | 2 | 5 | 0 | 1 | 2 | 2 | 1 | 5 | 2 |
Nucleolus | 192 | 205 | 240 | 155 | 138 | 241 | 262 | 330 | 249 | 305 | 139 | 132 | 222 | 276 | 267 | 205 | 160 | 102 | 113 | 162 | 113 | 54 | 147 | 137 |
Peroxisomes | 0 | 1 | 15 | 18 | 25 | 35 | 38 | 30 | 14 | 21 | 16 | 17 | 5 | 24 | 28 | 17 | 1 | 2 | 0 | 0 | 6 | 2 | 1 | 2 |
SpindlePole | 57 | 76 | 156 | 109 | 132 | 172 | 231 | 330 | 192 | 247 | 104 | 98 | 140 | 195 | 206 | 142 | 120 | 51 | 79 | 54 | 170 | 148 | 332 | 163 |
Vac/Vac Membrane | 10 | 16 | 6 | 5 | 5 | 2 | 4 | 3 | 2 | 1 | 3 | 2 | 1 | 2 | 4 | 10 | 6 | 7 | 8 | 8 | 8 | 0 | 4 | 5 |
Unique Cell Count | 264 | 282 | 354 | 244 | 278 | 367 | 417 | 564 | 363 | 449 | 213 | 195 | 339 | 462 | 471 | 320 | 246 | 146 | 272 | 305 | 387 | 241 | 579 | 406 |
Labelled Cell Count | 366 | 389 | 523 | 370 | 400 | 545 | 649 | 871 | 580 | 741 | 342 | 315 | 484 | 657 | 674 | 488 | 370 | 211 | 272 | 305 | 387 | 241 | 579 | 406 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 6.1 | 7.8 | 7.7 | 7.9 | 7.7 | 7.1 | 6.5 | 6.2 | 6.5 | 5.7 | 6.2 | 6.3 | 8.6 | 8.0 | 7.8 | 9.6 | 11.4 | 11.1 | 7.0 | 7.2 | 8.4 |
Std Deviation (1e-4) | 1.2 | 1.5 | 2.5 | 3.2 | 3.7 | 2.8 | 3.0 | 2.5 | 2.6 | 2.3 | 2.6 | 2.6 | 4.1 | 3.5 | 3.2 | 2.7 | 3.4 | 3.3 | 1.7 | 2.2 | 2.8 |
Intensity Change (Log2) | – | – | – | 0.03 | -0.01 | -0.12 | -0.25 | -0.31 | -0.25 | -0.44 | -0.32 | -0.3 | 0.15 | 0.06 | 0.02 | 0.32 | 0.55 | 0.52 | -0.13 | -0.1 | 0.12 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 1.0 | 0.4 | 0.4 | 0.3 | 1.8 | 1.1 | 1.4 | 1.4 | 0.9 | 1.8 | 1.6 | -1.3 | -1.9 | -3.2 | 0 |
Bud Site | 0 | 0 | 0 | 1.3 | 2.0 | 3.1 | 4.3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 1.0 | 3.0 | 0.6 | 0.1 | -0.5 | 0.4 | 0 | 0 | 0 | 6.4 | 7.5 | 8.5 | 5.7 | 5.5 | 5.3 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 1.3 | -0.9 | -0.6 | -2.1 | -2.0 | -2.0 | -1.7 | -1.8 | -2.1 | -1.5 | -0.8 | -0.3 | 1.3 | 1.1 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0.7 | 1.1 | 1.9 | 2.0 | 2.6 | 3.2 | 3.4 | 4.2 | 3.2 | -2.1 | -2.8 | -3.4 | 1.0 | -2.6 | -0.9 |
Nucleus | -1.2 | -2.4 | -4.1 | -4.5 | -3.5 | -3.9 | -4.0 | -3.0 | -2.7 | -2.7 | -4.1 | -3.1 | -2.3 | -2.1 | -1.7 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | -1.1 | -4.6 | -0.6 | -1.4 | -2.8 | 0.2 | 0 | -0.6 | 0 | -0.6 | -2.4 | -3.2 | -1.0 | -0.7 | 0.5 |
Peroxisomes | 1.7 | 2.4 | 2.8 | 2.7 | 0.7 | -0.3 | 0.3 | 1.7 | 2.1 | -2.2 | 0.6 | 1.1 | 0.7 | -2.9 | 0 |
SpindlePole | 0.1 | 0.9 | 0.8 | 3.1 | 4.3 | 2.4 | 3.1 | 1.1 | 1.4 | -0.7 | -0.5 | -0.1 | 0.1 | 1.1 | -1.9 |
Vacuole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.2 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 3.8391 | 4.5814 | 4.4849 | 4.1149 | 3.3214 | 3.9603 | 6.6246 | 7.5413 | 6.356 | 6.7487 | 6.9168 | 6.5345 | 7.7163 | 8.2616 | 7.6485 | 8.187 | 7.9357 | 7.9023 |
Actin | 0 | 0 | 0 | 0 | 0.0002 | 0.0002 | 0.032 | 0 | 0.0108 | 0.0002 | 0.0232 | 0.0029 | 0.0151 | 0 | 0.0042 | 0.0138 | 0.001 | 0.0008 |
Bud | 0 | 0 | 0.0005 | 0 | 0 | 0 | 0.0007 | 0.0001 | 0 | 0.0001 | 0.0006 | 0.0001 | 0.0005 | 0 | 0.0001 | 0.0001 | 0.0002 | 0.0001 |
Bud Neck | 0.0001 | 0.0007 | 0.0017 | 0.0011 | 0.0005 | 0.0044 | 0.0029 | 0.0007 | 0.0008 | 0.0011 | 0.0014 | 0.0027 | 0.0036 | 0.0008 | 0.0013 | 0.0044 | 0.0013 | 0.0361 |
Bud Periphery | 0 | 0.0001 | 0.0003 | 0.0001 | 0.0002 | 0.0001 | 0.0011 | 0.0001 | 0.0001 | 0.0002 | 0.0007 | 0.0002 | 0.0005 | 0 | 0.0002 | 0.0002 | 0.0002 | 0.0002 |
Bud Site | 0.0001 | 0.0005 | 0.0016 | 0.0002 | 0.0003 | 0.0003 | 0.0114 | 0.0009 | 0.0003 | 0.0005 | 0.0036 | 0.0004 | 0.006 | 0.0007 | 0.0011 | 0.0004 | 0.0025 | 0.0005 |
Cell Periphery | 0.0001 | 0.0002 | 0.0018 | 0.0005 | 0.0001 | 0.0002 | 0.0008 | 0.0001 | 0.0002 | 0.0017 | 0.0001 | 0.0001 | 0.001 | 0.0001 | 0.0002 | 0.0008 | 0.0001 | 0.0002 |
Cytoplasm | 0 | 0 | 0 | 0 | 0.0001 | 0.0006 | 0.0039 | 0 | 0.0016 | 0.0001 | 0.0004 | 0.0037 | 0.0763 | 0 | 0.0005 | 0.0014 | 0.0095 | 0.0137 |
Cytoplasmic Foci | 0.0059 | 0.0099 | 0.0128 | 0.004 | 0.0027 | 0.0285 | 0.0715 | 0.0154 | 0.0158 | 0.0129 | 0.0113 | 0.0181 | 0.0453 | 0.011 | 0.0434 | 0.0356 | 0.0418 | 0.0362 |
Eisosomes | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0.0005 | 0 | 0 | 0 | 0.0001 | 0 | 0.0002 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0.006 | 0 | 0.0094 | 0 | 0.0004 | 0.0011 | 0.0096 | 0 | 0.0005 | 0.0007 | 0.0007 | 0.0018 |
Endosome | 0.0001 | 0.0004 | 0.0004 | 0.0003 | 0.0002 | 0.0015 | 0.0298 | 0.0005 | 0.0038 | 0.0008 | 0.0038 | 0.0071 | 0.0258 | 0.0002 | 0.0126 | 0.0094 | 0.0252 | 0.0155 |
Golgi | 0.0001 | 0.0007 | 0.0005 | 0.0002 | 0.0007 | 0.0014 | 0.0085 | 0.0003 | 0.0035 | 0.001 | 0.0045 | 0.0024 | 0.0125 | 0.0003 | 0.0066 | 0.1213 | 0.0025 | 0.0133 |
Lipid Particles | 0.0172 | 0.0314 | 0.0532 | 0.0167 | 0.0672 | 0.0728 | 0.092 | 0.0161 | 0.0217 | 0.1007 | 0.0241 | 0.0412 | 0.0829 | 0.0117 | 0.0622 | 0.0143 | 0.0185 | 0.0593 |
Mitochondria | 0.0003 | 0.0005 | 0.0031 | 0.0001 | 0.0084 | 0.0002 | 0.0167 | 0.0001 | 0.0005 | 0.0005 | 0.0011 | 0.0046 | 0.0036 | 0.0001 | 0.0032 | 0.0004 | 0.0003 | 0.0063 |
None | 0 | 0.0001 | 0.0001 | 0 | 0.0001 | 0.0001 | 0.0147 | 0 | 0.0002 | 0.0002 | 0.0004 | 0.0042 | 0.0036 | 0 | 0.0006 | 0.0001 | 0.0004 | 0.0019 |
Nuclear Periphery | 0 | 0.0003 | 0.0003 | 0 | 0.0483 | 0.0009 | 0.0383 | 0.0004 | 0.0005 | 0.003 | 0.0018 | 0.0073 | 0.0078 | 0.0001 | 0.0044 | 0.0001 | 0.0017 | 0.0051 |
Nucleolus | 0.947 | 0.702 | 0.8613 | 0.9467 | 0.4662 | 0.7008 | 0.448 | 0.8236 | 0.8005 | 0.6563 | 0.4317 | 0.5822 | 0.5128 | 0.7647 | 0.7055 | 0.645 | 0.4696 | 0.5785 |
Nucleus | 0.0247 | 0.0345 | 0.0213 | 0.0229 | 0.0478 | 0.061 | 0.0305 | 0.0482 | 0.0389 | 0.0894 | 0.0889 | 0.0693 | 0.0267 | 0.0525 | 0.0469 | 0.0193 | 0.1155 | 0.0504 |
Peroxisomes | 0.0005 | 0.0015 | 0.0011 | 0.0003 | 0.0019 | 0.0012 | 0.0113 | 0.0005 | 0.0015 | 0.001 | 0.0042 | 0.0018 | 0.0112 | 0.0003 | 0.0054 | 0.0005 | 0.0011 | 0.0035 |
Punctate Nuclear | 0.0038 | 0.2165 | 0.0368 | 0.0055 | 0.3529 | 0.1251 | 0.17 | 0.092 | 0.0893 | 0.1206 | 0.3968 | 0.2488 | 0.1531 | 0.1573 | 0.0992 | 0.1294 | 0.3061 | 0.1752 |
Vacuole | 0.0001 | 0.0006 | 0.0024 | 0.0011 | 0.0003 | 0.0005 | 0.0052 | 0.0007 | 0.0005 | 0.0088 | 0.0004 | 0.001 | 0.0013 | 0.0002 | 0.0009 | 0.0027 | 0.0016 | 0.0009 |
Vacuole Periphery | 0.0001 | 0.0002 | 0.0007 | 0.0002 | 0.0019 | 0.0002 | 0.0042 | 0.0001 | 0.0001 | 0.0009 | 0.0003 | 0.0006 | 0.0007 | 0 | 0.0006 | 0.0002 | 0.0003 | 0.0004 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 33.9817 | 38.7165 | 34.4751 | 36.9048 | 36.2836 | 16.6485 | 41.8563 | 45.7287 | 33.3119 | 40.7378 |
Translational Efficiency | 0.7563 | 0.9126 | 0.701 | 0.6253 | 0.739 | 1.1952 | 0.7596 | 0.5309 | 0.6644 | 0.7278 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✔ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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