Standard name
Human Ortholog
Description RNA-binding protein that activates mRNA decapping directly; binds to mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; EDC1 has a paralog, EDC2, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.06 0.08 0.1 0 0 0 0 0 0
Cytoplasm 0.98 0.99 0.98 0.97 0.98 0.93 0.89 – 0.8 0.79 0.71 0.69 0.99 0.99 0.99 0.92 0.93 0.94 0.95 0.95 0.94 0.97 0.98 0.94
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0.05 0 0.1 0 – 0.2 0.24 0.33 0.3 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0.09 – 0.08 0.06 0.07 0.07 0 0 0 0.06 0.07 0.05 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 1 0 0 0 – 0 1 0 2 0 2 2 1 0 1 0 0 1 0 0 1
Bud 0 1 0 2 1 6 0 – 3 4 6 14 0 1 0 0 0 0 0 0 0 0 0 1
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 1 2 3 6 0 3 – 2 4 3 6 5 13 18 16 28 23 0 0 0 0 0 0
Cytoplasm 295 233 153 184 261 208 311 – 251 246 234 230 261 429 509 252 321 226 285 226 146 105 320 345
Endoplasmic Reticulum 1 1 0 1 0 0 0 – 1 2 1 7 0 3 2 9 10 13 2 0 1 0 3 3
Endosome 1 0 0 1 0 0 1 – 1 2 6 2 1 2 1 2 2 2 2 1 1 0 0 1
Golgi 1 0 1 0 1 0 0 – 0 0 0 0 0 0 0 2 1 0 2 1 0 0 0 1
Mitochondria 2 2 0 9 2 23 14 – 63 75 108 99 0 0 0 4 3 2 3 2 1 0 0 2
Nucleus 0 0 2 1 1 4 6 – 3 4 4 9 0 1 1 2 2 0 0 2 0 0 0 1
Nuclear Periphery 0 0 0 0 0 0 0 – 0 2 1 2 0 0 0 0 0 0 0 0 0 0 0 1
Nucleolus 0 0 0 0 0 2 1 – 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 – 0 0 1 0 0 1 0 0 0 0 1 0 0 0 0 1
Vac/Vac Membrane 5 0 0 3 3 3 33 – 24 18 24 22 1 0 5 16 24 13 0 0 0 0 1 2
Unique Cell Count 301 235 156 190 265 224 348 314 310 328 335 263 432 515 273 345 240 302 239 156 109 328 366
Labelled Cell Count 306 238 158 205 275 246 369 348 358 389 393 268 452 538 304 391 280 302 239 156 109 328 366


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.8 6.7 7.1 7.2 8.2 5.3 6.5 – 5.6 5.6 5.6 5.5 8.7 9.0 9.5 11.8 12.1 12.0 6.6 7.2 7.4
Std Deviation (1e-4) 0.9 0.8 1.2 1.2 1.3 1.3 1.3 – 1.1 1.1 1.1 0.9 1.0 1.2 1.3 2.2 2.4 2.7 0.7 1.2 1.3
Intensity Change (Log2) – – – 0.02 0.2 -0.42 -0.13 – -0.36 -0.34 -0.35 -0.38 0.28 0.34 0.41 0.73 0.76 0.75 -0.12 0.02 0.05

WT3RAP60RAP140RAP220RAP300RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 – 0 0 0 0 0 0 0 2.3 3.0 3.3
Cytoplasm -0.7 0.3 -2.3 -3.3 – -5.3 -5.4 -6.9 -7.3 1.1 1.3 0.7 -2.5 -2.3 -1.9
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 3.0
Endosome 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 4.1 0 – 6.0 6.7 8.1 7.6 0 0 0 0 0 0
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 4.0 – 3.5 3.1 3.5 3.3 0 0 0 3.1 3.4 3.0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.9877 2.115 2.268 1.895 1.7362 2.1537 3.496 3.3424 3.3032 3.111 3.0946 3.26 5.237 5.3936 5.2579 5.2271 4.549 4.9113
Actin 0.0359 0.0082 0.0267 0.0027 0.0279 0.0031 0.0483 0.0024 0.0163 0.038 0.003 0.0141 0.0408 0.0202 0.0112 0.033 0.0299 0.0176
Bud 0.0007 0.0013 0.0046 0.0006 0.0004 0.0004 0.0013 0.0042 0.0012 0.0044 0.0003 0.0005 0.0014 0.0003 0.0048 0.0008 0.0012 0.0002
Bud Neck 0.0035 0.0004 0.0026 0.0005 0.0017 0.003 0.0018 0.0002 0.0004 0.0116 0.0006 0.0029 0.0115 0.0001 0.0003 0.0052 0.0017 0.001
Bud Periphery 0.0008 0.0008 0.0035 0.0003 0.0005 0.0003 0.0014 0.0047 0.0014 0.004 0.0004 0.0008 0.0021 0.0002 0.0014 0.0007 0.0017 0.0001
Bud Site 0.0017 0.0064 0.0047 0.0006 0.001 0.0002 0.0057 0.0086 0.001 0.0234 0.0008 0.0003 0.0087 0.0005 0.0043 0.0231 0.0015 0.0002
Cell Periphery 0.0002 0.0004 0.0002 0.0001 0.0001 0.0001 0.0002 0.0002 0.0001 0.0019 0.0001 0.0001 0.0006 0.0001 0.0001 0.0004 0.0004 0
Cytoplasm 0.7203 0.7693 0.7803 0.8036 0.7175 0.8441 0.742 0.8721 0.8805 0.7383 0.7831 0.8696 0.691 0.8869 0.8131 0.8105 0.7713 0.9039
Cytoplasmic Foci 0.0224 0.0109 0.014 0.0192 0.0168 0.0081 0.0337 0.0114 0.0088 0.0389 0.0287 0.0122 0.0352 0.0059 0.0196 0.0256 0.0401 0.0182
Eisosomes 0.0004 0.0002 0.0003 0 0.0002 0 0.0003 0 0.0001 0.0007 0.0001 0.0001 0.0011 0 0.0001 0.0001 0.0001 0
Endoplasmic Reticulum 0.0108 0.0047 0.0053 0.0033 0.008 0.0019 0.0089 0.0029 0.0022 0.003 0.0016 0.0029 0.0064 0.0028 0.0046 0.0019 0.0027 0.0018
Endosome 0.0174 0.0044 0.0144 0.0273 0.0314 0.0094 0.0337 0.0043 0.0053 0.0331 0.0338 0.0113 0.0289 0.0066 0.0115 0.0127 0.0168 0.0044
Golgi 0.0033 0.0005 0.0043 0.0013 0.0059 0.001 0.0107 0.0007 0.0034 0.0124 0.0151 0.0052 0.0105 0.0007 0.0076 0.0038 0.016 0.0026
Lipid Particles 0.0025 0.0005 0.006 0.0021 0.0169 0.0015 0.0058 0.0002 0.0018 0.0052 0.0337 0.0019 0.0135 0.0002 0.0012 0.0031 0.0144 0.0009
Mitochondria 0.002 0.0005 0.0025 0.0011 0.0134 0.0005 0.0063 0.0007 0.0018 0.0073 0.0175 0.011 0.0115 0.0002 0.0031 0.0013 0.0064 0.0015
None 0.1478 0.1815 0.1157 0.1086 0.0944 0.1187 0.0599 0.0733 0.0689 0.047 0.0441 0.0445 0.0919 0.0728 0.0995 0.0537 0.0473 0.0417
Nuclear Periphery 0.0096 0.0029 0.0029 0.013 0.0271 0.0033 0.011 0.0009 0.0013 0.0025 0.0024 0.0051 0.0106 0.0006 0.0045 0.0006 0.0009 0.0003
Nucleolus 0.0005 0.0002 0.0014 0.0004 0.0018 0.0003 0.0008 0.0001 0 0.0006 0.0003 0.0001 0.0008 0 0.0001 0.0004 0.0002 0
Nucleus 0.0041 0.0027 0.0029 0.0041 0.0112 0.0014 0.0085 0.0094 0.0016 0.0021 0.0015 0.0113 0.0031 0.0007 0.0064 0.0013 0.0012 0.001
Peroxisomes 0.0045 0.0003 0.0014 0.002 0.0089 0.0002 0.008 0.0015 0.0017 0.0106 0.0232 0.0032 0.0166 0.0001 0.0043 0.0168 0.0367 0.0034
Punctate Nuclear 0.0091 0.0023 0.0027 0.0047 0.01 0.0014 0.0053 0.0006 0.0011 0.011 0.0052 0.0012 0.0074 0.0002 0.0009 0.001 0.0081 0.0006
Vacuole 0.0019 0.0016 0.0028 0.0036 0.0027 0.0009 0.005 0.0013 0.001 0.0031 0.0027 0.0011 0.0038 0.0009 0.0011 0.0035 0.0009 0.0004
Vacuole Periphery 0.0009 0.0002 0.0006 0.0011 0.0019 0.0003 0.0016 0.0002 0.0003 0.0008 0.0019 0.0006 0.0026 0.0001 0.0003 0.0005 0.0004 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 24.0325 13.077 6.9312 16.428 28.4497 8.3545 14.6388 17.848 11.6457 16.4433
Translational Efficiency 1.5863 3.2141 4.3109 1.4908 1.3614 5.1542 2.6799 2.5123 3.2293 2.2762

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1804 451 1724 121 1755 2371 1710 1561 3559 2822 3434 1682

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 773.58 845.08 1014.10 1212.65 765.35 886.16 1109.33 1190.06 769.52 879.59 1061.52 1191.69
Standard Deviation 89.27 117.80 124.04 170.39 96.20 112.79 136.79 158.85 92.85 114.60 138.96 159.81
Intensity Change Log 2 — 0.127537 0.390578 0.648541 — 0.211448 0.535497 0.636843 — 0.169878 0.464469 0.642735

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000271 0.000632 0.000152 0.001215 0.000577 0.000334 0.000368 0.001775 0.000422 0.000382 0.000259 0.001735
Bud Neck 0.013615 0.010909 0.000718 0.001949 0.004427 0.010907 0.000761 0.001407 0.009084 0.010908 0.000740 0.001446
Bud Site 0.015619 0.025538 0.003643 0.018228 0.007618 0.017610 0.006948 0.013735 0.011673 0.018877 0.005289 0.014058
Cell Periphery 0.000223 0.000112 0.000053 0.000176 0.000093 0.000084 0.000045 0.000090 0.000159 0.000089 0.000049 0.000096
Cytoplasm 0.531612 0.535357 0.807843 0.646819 0.626373 0.617544 0.782860 0.782176 0.578340 0.604409 0.795402 0.772439
Cytoplasmic Foci 0.246562 0.224557 0.014698 0.042705 0.208253 0.130642 0.012593 0.033001 0.227671 0.145651 0.013650 0.033699
Eisosomes 0.000138 0.000085 0.000007 0.000025 0.000062 0.000049 0.000008 0.000010 0.000101 0.000055 0.000007 0.000011
Endoplasmic Reticulum 0.001919 0.001288 0.000579 0.001264 0.001536 0.000908 0.000542 0.000468 0.001730 0.000969 0.000561 0.000525
Endosome 0.014476 0.025565 0.000800 0.002344 0.014153 0.016180 0.000858 0.004527 0.014317 0.017679 0.000829 0.004370
Golgi 0.009090 0.003160 0.000130 0.000206 0.004178 0.002765 0.000090 0.002164 0.006668 0.002828 0.000110 0.002023
Lipid Particles 0.005174 0.002055 0.000387 0.001685 0.003828 0.002176 0.000361 0.000534 0.004510 0.002157 0.000374 0.000617
Mitochondria 0.006377 0.002044 0.000114 0.000059 0.001633 0.003310 0.000114 0.000548 0.004038 0.003107 0.000114 0.000513
Mitotic Spindle 0.001998 0.000936 0.002769 0.015735 0.001985 0.009637 0.004096 0.015377 0.001991 0.008246 0.003430 0.015403
None 0.002410 0.000756 0.004019 0.003917 0.003303 0.002410 0.005737 0.003210 0.002850 0.002145 0.004874 0.003261
Nuclear Periphery 0.000132 0.000141 0.000264 0.000337 0.000303 0.000386 0.000292 0.000194 0.000217 0.000346 0.000278 0.000205
Nuclear Periphery Foci 0.000268 0.001140 0.002419 0.006927 0.000533 0.000286 0.003119 0.002619 0.000399 0.000422 0.002768 0.002929
Nucleolus 0.000524 0.000447 0.000097 0.000093 0.000384 0.000697 0.000086 0.000163 0.000455 0.000657 0.000092 0.000158
Nucleus 0.063579 0.027262 0.120761 0.059308 0.043329 0.050305 0.132519 0.036254 0.053593 0.046622 0.126616 0.037913
Peroxisomes 0.003225 0.006190 0.000094 0.000794 0.001621 0.003062 0.000312 0.000603 0.002434 0.003562 0.000203 0.000616
Vacuole 0.080390 0.129853 0.040354 0.196107 0.074170 0.128203 0.048225 0.095572 0.077323 0.128467 0.044273 0.102805
Vacuole Periphery 0.002399 0.001973 0.000098 0.000109 0.001641 0.002505 0.000068 0.005573 0.002025 0.002420 0.000083 0.005180

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.78 0.77 -1.84 -0.86 -2.03 0.54 0.58 -0.48 -1.51 -1.56 0.18 0.70 -1.16 -1.52 -1.96
Bud Neck 2.26 18.35 14.69 6.44 -4.66 -9.36 14.50 11.31 14.27 -3.16 -2.48 21.58 19.33 15.76 -3.72
Bud Site -3.00 7.22 -0.35 1.23 -2.53 -6.74 1.92 -1.85 5.14 -3.39 -4.90 6.89 1.20 5.85 -5.36
Cell Periphery 1.09 1.55 0.55 -2.60 -5.26 1.92 9.80 4.38 2.70 -2.45 1.36 1.93 1.62 2.35 -2.98
Cytoplasm -0.31 -26.97 2.96 2.88 10.91 1.23 -11.31 -8.54 -10.07 1.83 -3.71 -26.95 -13.63 -9.74 6.58
Cytoplasmic Foci 2.52 45.21 30.74 18.65 -3.68 14.23 42.35 37.61 29.08 -10.86 18.21 61.66 54.05 34.24 -11.16
Eisosomes 3.85 18.56 12.71 3.64 -6.05 3.33 15.41 15.08 15.20 -1.05 9.65 23.05 22.07 14.14 -3.85
Endoplasmic Reticulum 1.54 4.44 3.58 1.03 -0.69 2.57 3.96 5.73 4.40 7.01 3.74 5.94 8.08 4.77 7.10
Endosome -4.13 17.28 14.90 9.53 -3.48 -1.61 15.29 12.71 15.77 -3.33 -3.26 22.98 17.86 18.06 -3.73
Golgi 8.21 14.22 14.17 7.38 -1.23 3.45 11.33 8.11 6.50 -3.17 9.40 17.82 14.19 7.47 -3.12
Lipid Particles 6.83 12.55 3.35 -1.39 -4.05 3.91 8.59 8.03 7.23 -4.60 7.60 14.92 13.36 6.99 -5.91
Mitochondria 2.76 8.16 8.20 1.30 1.20 -2.75 6.60 5.93 5.53 -1.59 1.50 9.63 9.33 5.51 -1.40
Mitotic Spindle 0.85 -1.85 -1.92 -2.06 -1.61 -4.80 -1.13 -3.62 0.66 -2.87 -4.93 -2.06 -4.18 -0.15 -3.24
None 4.24 -3.07 -0.92 -3.25 0.65 1.18 -2.57 1.66 0.62 7.72 1.42 -3.82 1.37 -0.13 6.84
Nuclear Periphery -0.96 -13.97 -3.03 -2.95 -1.68 -0.36 -1.40 0.22 0.57 9.34 -0.75 -3.78 -1.46 0.21 5.78
Nuclear Periphery Foci -5.31 -11.80 -5.51 -4.58 -3.22 3.81 -14.03 -12.71 -14.74 4.72 -0.89 -18.30 -14.78 -14.33 2.02
Nucleolus 1.03 9.87 10.29 5.28 0.69 -3.24 3.95 3.24 7.74 -3.38 -2.95 8.46 7.22 8.41 -2.88
Nucleus 12.89 -20.54 0.38 -5.08 11.46 -3.33 -31.16 -2.63 0.88 29.52 3.48 -36.12 2.12 -1.28 36.24
Peroxisomes -3.52 16.48 12.30 7.11 -2.88 -2.99 4.76 4.33 6.83 -1.24 -2.81 13.08 11.40 8.90 -2.58
Vacuole -6.94 0.57 -11.85 -9.55 -11.90 -13.23 -4.36 -19.04 -9.17 -14.62 -15.08 -2.77 -21.65 -11.52 -19.45
Vacuole Periphery 1.50 13.54 13.61 6.15 0.45 -3.59 15.67 -0.34 0.94 -2.86 -1.72 19.50 0.50 1.07 -2.84
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description RNA-binding protein that activates mRNA decapping directly; binds to mRNA substrate and enhances activity of decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress; EDC1 has a paralog, EDC2, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (95%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Edc1

Edc1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Edc1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available