Standard name
Human Ortholog
Description Beta subunit of geranylgeranyltransferase type I; subunit of the Ram2p-Cdc43p heterodimer that catalyzes the geranylgeranylation of the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.96 0.99 0.98 0.97 0.93 0.89 0.81 0.83 0.73 0.79 0.67 0.75 0.95 0.97 0.98 0.93 0.93 0.93 0.95 0.94 0.95 0.93 0.93 0.88
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0.05 0.18 0.27 0.23 0.41 0.25 0.53 0.33 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0.06 0 0.05 0 0.05 0 0 0.06 0.09 0.07 0.05 0.09 0.08 0.07 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 2 0 1 1 2 5
Bud 1 1 0 0 1 0 3 6 10 7 10 9 0 0 0 0 0 0 2 0 1 6 8 20
Bud Neck 0 0 1 0 1 0 1 0 0 5 0 0 0 1 0 0 0 0 0 0 0 0 2 5
Bud Site 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 1 2 2 3 4 4 3 2 3 0 3 1 1 0 6 7 5 0 0 0 0 0 1
Cytoplasm 449 264 320 331 430 395 392 446 323 400 292 276 341 425 485 206 166 177 486 255 323 354 503 532
Endoplasmic Reticulum 1 1 4 0 1 0 0 2 1 1 1 0 0 0 0 5 6 3 0 0 1 1 3 8
Endosome 3 0 0 0 2 0 0 1 0 0 0 0 0 1 1 2 1 2 3 2 0 2 2 1
Golgi 1 0 0 0 2 0 0 0 0 0 0 0 0 1 0 2 1 2 1 0 0 1 0 2
Mitochondria 3 1 1 6 24 80 130 122 182 127 232 122 0 1 0 4 4 2 2 4 5 2 5 5
Nucleus 3 1 0 1 0 3 5 13 7 10 8 5 0 0 2 3 3 3 3 2 0 0 1 0
Nuclear Periphery 2 0 0 1 1 1 0 1 0 1 1 0 0 0 0 0 0 0 1 0 0 0 0 0
Nucleolus 1 0 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0
Peroxisomes 1 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 1 1 2 3 1 1 0 0 0 0 0 3 0 1 1 3 9
Vac/Vac Membrane 15 5 3 12 29 20 26 15 20 20 10 22 33 30 23 19 14 13 2 1 2 2 1 3
Unique Cell Count 467 268 326 340 463 446 486 537 440 508 435 368 360 440 496 222 179 191 515 272 342 382 544 603
Labelled Cell Count 481 274 331 353 494 503 562 611 546 577 558 439 376 460 512 247 202 207 515 272 342 382 544 603


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 5.7 7.0 6.0 5.7 5.6 4.5 4.2 4.8 3.9 4.2 3.8 4.2 6.3 6.9 6.8 7.0 7.8 7.2 6.6 6.7 7.3
Std Deviation (1e-4) 0.9 1.2 0.8 1.5 1.4 1.1 1.2 1.2 1.2 1.2 1.0 1.2 1.1 1.9 1.5 1.5 1.5 1.7 1.8 1.7 2.2
Intensity Change (Log2) – – – -0.07 -0.12 -0.44 -0.53 -0.34 -0.63 -0.51 -0.68 -0.52 0.05 0.19 0.16 0.22 0.37 0.26 0.13 0.15 0.26

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP70002468WT3HU80HU120HU16002468WT3rpd3Δ_1rpd3Δ_2rpd3Δ_302468WT1AF100AF140AF18002468
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm -0.7 -3.4 -5.0 -7.4 -6.8 -9.2 -8.0 -10.7 -8.7 -2.4 -1.3 -0.4 -3.1 -3.1 -3.1
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 3.9 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 2.3 3.7 2.9 3.3 1.9 2.9 2.6 1.5 3.6 4.8 4.0 3.0 4.5 4.1 3.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.9516 2.6256 2.3886 2.0349 2.2912 2.33 0.8695 1.1909 1.074 0.5733 0.2847 1.454 0.8895 1.4125 1.2816 1.2603 1.1261 1.3569
Actin 0.0148 0.0045 0.0127 0.0012 0.0264 0.004 0.0066 0.0003 0.0014 0.0165 0.0015 0.0082 0.0098 0.0002 0.0007 0.0001 0.0032 0.0007
Bud 0.0008 0.0025 0.006 0.0031 0.0031 0.0004 0.0031 0.0087 0.0053 0.0004 0.0009 0.0035 0.0004 0.0002 0.0003 0.0002 0.0003 0.0004
Bud Neck 0.0041 0.0009 0.003 0.0004 0.0135 0.001 0.0019 0.0002 0.0009 0.0004 0.0201 0.0016 0.0033 0.0002 0.0003 0.0006 0.0016 0.0023
Bud Periphery 0.0011 0.0016 0.0048 0.0157 0.0056 0.0004 0.0018 0.0019 0.0012 0.0008 0.0009 0.0019 0.0002 0.0001 0.0002 0.0001 0.0002 0.0005
Bud Site 0.0107 0.0102 0.0071 0.0008 0.0173 0.0003 0.0065 0.0067 0.0082 0.0002 0.0137 0.0006 0.0066 0.0019 0.0007 0.0002 0.0008 0.0002
Cell Periphery 0.0003 0.0002 0.0005 0.0001 0.0003 0.0001 0.0003 0.0002 0.0001 0 0.0001 0.0001 0.0002 0.0001 0 0 0.0001 0
Cytoplasm 0.4268 0.6582 0.4928 0.5378 0.507 0.5806 0.3752 0.5945 0.453 0.5328 0.4933 0.5607 0.6628 0.7043 0.6708 0.7699 0.8057 0.7518
Cytoplasmic Foci 0.0211 0.0142 0.0117 0.0101 0.0411 0.0166 0.0508 0.0092 0.0211 0.0079 0.0138 0.0179 0.0105 0.0087 0.0082 0.0051 0.0163 0.0104
Eisosomes 0.0002 0.0001 0.0004 0.0001 0.0002 0.0001 0.0001 0 0 0.0001 0 0 0 0 0 0 0 0
Endoplasmic Reticulum 0.0039 0.0028 0.0024 0.0024 0.0041 0.0022 0.0037 0.0016 0.0018 0.0007 0.0009 0.0019 0.0033 0.0024 0.0021 0.0014 0.0032 0.0021
Endosome 0.0201 0.0067 0.0072 0.0111 0.0198 0.0066 0.0233 0.0014 0.0144 0.0017 0.0017 0.0136 0.006 0.0027 0.003 0.0023 0.0094 0.0025
Golgi 0.0068 0.0014 0.0026 0.0004 0.0081 0.0012 0.0042 0.0001 0.0023 0.0003 0.0015 0.0024 0.0006 0.0001 0.0002 0.0001 0.0013 0.0001
Lipid Particles 0.0089 0.0005 0.0078 0.0003 0.0093 0.0014 0.0063 0.0002 0.004 0.0001 0.0005 0.0059 0.0005 0.0002 0.0001 0 0.0014 0.0001
Mitochondria 0.0054 0.0024 0.0098 0.0022 0.0141 0.0017 0.0045 0.0009 0.0016 0.0007 0.0008 0.0012 0.0003 0.0002 0.0004 0.0004 0.0005 0.0003
None 0.4448 0.2525 0.3909 0.3706 0.2724 0.3502 0.4496 0.3611 0.4527 0.3987 0.4374 0.3411 0.2791 0.264 0.2816 0.1679 0.1157 0.1881
Nuclear Periphery 0.007 0.003 0.0035 0.0091 0.0053 0.0051 0.0113 0.0009 0.0023 0.0009 0.0008 0.0028 0.0019 0.0013 0.0016 0.0018 0.0026 0.0019
Nucleolus 0.0013 0.0009 0.001 0.0005 0.0009 0.0003 0.0017 0.0007 0.001 0.0001 0.0002 0.0002 0.0002 0.0001 0.0002 0.0002 0.0003 0.0002
Nucleus 0.0068 0.0167 0.0161 0.0246 0.013 0.0188 0.0221 0.0081 0.0126 0.0105 0.0038 0.0165 0.0095 0.0081 0.0245 0.0463 0.0243 0.031
Peroxisomes 0.0065 0.0019 0.0047 0.0009 0.0194 0.0014 0.013 0.0001 0.0063 0.0247 0.006 0.0133 0.0004 0.0002 0.0004 0.0001 0.001 0.0005
Punctate Nuclear 0.0056 0.0168 0.0127 0.0051 0.0163 0.0064 0.0089 0.0018 0.0063 0.0017 0.0012 0.0049 0.003 0.0038 0.0032 0.0017 0.0106 0.0058
Vacuole 0.0023 0.0017 0.0017 0.0022 0.0021 0.0008 0.0041 0.0012 0.003 0.0007 0.0006 0.0012 0.0012 0.0011 0.0012 0.0015 0.0012 0.0009
Vacuole Periphery 0.0008 0.0003 0.0006 0.0012 0.0008 0.0004 0.001 0.0002 0.0005 0.0001 0.0001 0.0004 0.0002 0.0001 0.0002 0.0002 0.0002 0.0001

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 24.39 27.9081 23.9448 25.988 34.1525 18.5262 29.5405 21.1282 24.2322 30.9132
Translational Efficiency 0.707 0.5943 0.611 0.5733 0.3957 0.7977 0.5221 0.6857 0.64 0.48

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
34 442 199 1575 1352 2192 166 1004 1386 2634 365 2579

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 687.46 866.01 775.91 801.07 710.86 790.15 946.53 857.88 710.29 802.88 853.51 823.19
Standard Deviation 124.23 129.64 90.50 144.38 84.08 111.02 105.64 122.79 85.37 117.82 129.46 139.16
Intensity Change Log 2 — 0.333108 0.174614 0.220653 — 0.152561 0.413083 0.271210 — 0.244148 0.300759 0.246576

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.001038 0.000505 0.000397 0.000542 0.000198 0.000255 0.000400 0.004974 0.000219 0.000297 0.000399 0.002268
Bud Neck 0.072995 0.015385 0.001011 0.011469 0.006308 0.010063 0.001484 0.010413 0.007944 0.010956 0.001226 0.011058
Bud Site 0.054019 0.015978 0.002305 0.046572 0.002803 0.011467 0.001824 0.067714 0.004060 0.012224 0.002086 0.054802
Cell Periphery 0.001153 0.000144 0.000215 0.000228 0.000114 0.000130 0.000152 0.000243 0.000140 0.000133 0.000186 0.000234
Cytoplasm 0.196310 0.507898 0.336180 0.496656 0.591973 0.652009 0.295345 0.475081 0.582267 0.627826 0.317608 0.488257
Cytoplasmic Foci 0.107393 0.191715 0.021590 0.022811 0.146241 0.087753 0.011766 0.016160 0.145288 0.105198 0.017122 0.020222
Eisosomes 0.000270 0.000094 0.000096 0.000049 0.000071 0.000038 0.000082 0.000042 0.000076 0.000048 0.000090 0.000046
Endoplasmic Reticulum 0.005076 0.001679 0.004449 0.001923 0.000999 0.000649 0.005635 0.002381 0.001099 0.000822 0.004988 0.002102
Endosome 0.011489 0.014507 0.003522 0.008414 0.005881 0.006018 0.003199 0.008648 0.006019 0.007442 0.003375 0.008505
Golgi 0.005741 0.005054 0.000096 0.005863 0.000892 0.002019 0.000079 0.018416 0.001011 0.002528 0.000088 0.010750
Lipid Particles 0.025220 0.003126 0.003652 0.001429 0.004064 0.001923 0.002275 0.000866 0.004582 0.002125 0.003026 0.001210
Mitochondria 0.035521 0.003355 0.000292 0.006764 0.001814 0.004695 0.000289 0.006410 0.002641 0.004470 0.000290 0.006626
Mitotic Spindle 0.009955 0.013070 0.000234 0.042284 0.003461 0.011628 0.001441 0.031008 0.003621 0.011870 0.000783 0.037895
None 0.011954 0.003825 0.005726 0.006296 0.003496 0.004593 0.008790 0.006997 0.003703 0.004464 0.007119 0.006569
Nuclear Periphery 0.001104 0.000752 0.001523 0.001289 0.000491 0.000349 0.001945 0.001284 0.000506 0.000417 0.001715 0.001287
Nuclear Periphery Foci 0.006294 0.001163 0.002552 0.001595 0.000878 0.000456 0.002258 0.000993 0.001010 0.000575 0.002418 0.001361
Nucleolus 0.035571 0.000971 0.000916 0.000701 0.001159 0.000710 0.000482 0.000424 0.002003 0.000753 0.000719 0.000593
Nucleus 0.355592 0.113647 0.529523 0.202716 0.188656 0.150736 0.533586 0.229499 0.192751 0.144512 0.531371 0.213143
Peroxisomes 0.015229 0.009817 0.000556 0.001928 0.002219 0.004198 0.000227 0.001572 0.002538 0.005141 0.000406 0.001790
Vacuole 0.042516 0.096053 0.084986 0.135980 0.037763 0.049609 0.128599 0.113880 0.037880 0.057403 0.104821 0.127377
Vacuole Periphery 0.005559 0.001260 0.000180 0.004489 0.000518 0.000702 0.000143 0.002992 0.000642 0.000796 0.000163 0.003906

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.61 1.47 1.77 0.50 0.65 -0.53 -3.69 -1.80 -1.74 -1.21 -0.75 -3.21 -2.15 -1.99 -1.01
Bud Neck 1.64 2.05 1.85 3.33 -7.44 -3.37 3.70 -1.59 1.28 -4.63 -2.21 4.98 -0.22 2.67 -8.45
Bud Site 1.36 1.83 1.02 -2.89 -8.55 -7.15 -2.04 -8.17 -5.56 -7.72 -6.37 0.61 -10.73 -6.80 -11.47
Cell Periphery 1.89 1.71 1.87 -0.76 3.06 -0.29 -4.74 -2.14 -0.59 1.87 0.32 -3.60 -0.72 -0.68 3.63
Cytoplasm -6.58 -2.28 -4.35 7.26 -4.53 -6.27 21.79 22.13 28.82 -7.58 -4.71 22.44 23.21 31.80 -8.30
Cytoplasmic Foci -2.11 2.63 2.76 18.35 1.45 10.99 28.35 29.18 25.24 -1.48 7.80 27.17 28.82 29.75 0.41
Eisosomes 2.73 2.27 3.25 3.94 5.05 9.98 -4.80 2.76 -8.86 5.87 7.49 -5.00 4.93 -4.75 7.50
Endoplasmic Reticulum 1.99 -0.86 1.28 -3.42 5.04 2.36 -8.77 -10.18 -11.81 5.81 1.60 -11.45 -12.84 -15.74 7.74
Endosome -0.66 1.87 1.81 6.27 -0.35 -0.07 2.37 2.89 3.28 0.79 -1.82 2.90 2.92 5.56 0.16
Golgi 0.61 2.51 1.62 1.69 -3.34 -2.45 4.44 -2.41 -1.74 -2.88 -3.16 5.06 -2.88 -1.01 -4.16
Lipid Particles 2.83 2.71 3.02 4.44 4.19 4.71 2.06 6.45 1.82 4.88 5.15 1.84 6.74 2.49 5.79
Mitochondria 1.89 2.06 1.90 0.10 -3.51 -2.84 2.80 -0.58 1.81 -2.31 -1.76 3.46 -0.18 1.69 -4.20
Mitotic Spindle -0.48 1.60 -3.11 -3.79 -10.00 -3.72 -1.04 -5.31 -2.46 -2.46 -4.06 0.02 -9.13 -5.62 -8.28
None 1.94 1.85 1.78 -0.82 -0.55 -1.27 -2.11 -3.25 -1.16 0.09 -0.80 -1.67 -2.66 -1.11 -0.27
Nuclear Periphery 0.52 -1.80 -3.23 -7.81 -1.83 1.79 -11.33 -15.29 -18.03 0.03 0.87 -9.74 -20.02 -23.94 -1.52
Nuclear Periphery Foci 1.23 0.69 1.05 -2.25 2.85 2.99 -6.43 -5.18 -8.50 3.87 2.46 -7.20 -4.02 -7.71 4.54
Nucleolus 2.73 2.74 2.76 2.83 1.40 1.03 1.58 1.84 2.52 1.00 2.35 2.51 2.85 2.33 1.54
Nucleus 3.89 -2.44 1.49 -15.51 11.99 5.96 -13.51 -11.39 -16.35 8.51 7.75 -20.00 -11.74 -21.84 14.72
Peroxisomes 1.11 2.41 2.36 5.47 -0.85 -2.71 4.57 3.44 6.03 -2.15 -3.45 4.69 3.59 7.42 -1.57
Vacuole -4.76 -5.56 -14.30 -14.10 -7.42 -5.95 -10.27 -24.69 -22.49 -0.61 -9.08 -12.57 -37.50 -31.93 -4.82
Vacuole Periphery 1.51 1.86 1.30 -1.27 -3.93 -1.60 4.88 -1.67 -1.01 -3.09 -1.05 4.56 -2.87 -2.47 -4.80
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Beta subunit of geranylgeranyltransferase type I; subunit of the Ram2p-Cdc43p heterodimer that catalyzes the geranylgeranylation of the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
Localization
Cell Percentages cytoplasm (60%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Cdc43

Cdc43


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Cdc43-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available