Standard name
Description Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; relocalizes to the cytosol in response to hypoxia; PDR1 has a paralog, PDR3, that arose from the whole genome duplication

Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0.05 0 0.06 0 0 0 0.06 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0 0 0 0 0 0 0 0 0.1 0.12 0.15 0.07 0.06 0.07 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0.47 0.57 0.63 0.31 0.55 0.51 0.56 0.74 0.73 0.72 0.75 0.05 0 0.17 0 0 0.09 0 0 0 0 0 0
Nucleus 0.94 0.87 0.88 0.88 0.86 0.78 0.75 0.74 0.62 0.65 0.66 0.65 0.85 0.81 0.78 0.85 0.88 0.86 0.81 0.89 0.77 0.76 0.72 0.52
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.05 0.06 0 0.05 0.08 0.12 0.12 0.19 0.16 0.18 0.19 0.19 0 0.05 0 0 0 0 0.09 0 0.07 0.06 0.09 0.15
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.05 0.1 0.05 0.11 0.16
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 0 1 0 0 0 0 0 0
Bud 0 0 2 1 2 4 1 6 4 8 3 4 0 1 0 1 0 2 0 1 1 0 2 3
Bud Neck 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1
Bud Site 0 0 4 0 6 22 19 43 13 15 8 26 0 1 1 0 0 1
Cell Periphery 0 0 0 0 0 0 0 0 1 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0
Cytoplasm 3 1 5 4 6 8 9 8 9 8 7 6 17 32 45 52 25 40 0 0 1 0 1 1
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 2 0 11 4 13 0 0 0 0 0 1
Endosome 1 0 0 0 1 0 0 0 0 0 0 0 0 0 1 11 4 6 1 0 1 2 3 10
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 1 1 1 0 0 0 1 3 1
Mitochondria 4 63 139 152 116 233 298 405 292 327 262 347 9 8 49 30 11 55 4 0 2 1 3 7
Nucleus 159 116 213 212 328 331 442 531 246 292 240 301 142 214 230 608 369 511 157 117 186 72 189 146
Nuclear Periphery 1 0 0 0 2 12 24 13 6 14 14 11 0 3 0 2 0 4 1 0 0 0 0 2
Nucleolus 9 8 8 11 32 49 73 136 62 82 68 90 7 12 12 18 18 19 17 5 16 5 24 41
Peroxisomes 0 0 0 0 0 0 0 1 0 0 0 0 0 3 2 0 0 1 0 0 0 0 0 0
SpindlePole 0 0 3 2 4 4 7 16 0 4 3 3 0 2 2 9 5 6 1 0 4 1 3 11
Vac/Vac Membrane 1 4 2 2 2 1 1 0 3 0 0 5 1 3 3 26 9 19 6 6 23 4 28 45
Unique Cell Count 170 133 243 240 380 426 586 717 397 450 365 465 168 263 295 717 418 591 193 132 242 96 264 281
Labelled Cell Count 178 192 376 384 499 664 874 1161 636 751 606 794 176 283 345 769 446 679 193 132 242 96 264 281


Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 6.7 4.3 3.8 3.8 4.3 3.8 3.8 3.8 3.3 3.4 3.3 3.2 5.8 6.0 5.2 7.3 7.7 8.2 5.2 5.6 6.0
Std Deviation (1e-4) 1.4 1.4 0.5 0.8 0.8 0.8 0.7 0.9 0.8 0.8 1.0 1.1 1.4 1.6 1.4 1.4 1.6 1.6 0.9 1.2 1.1
Intensity Change (Log2) -0.0 0.17 0.01 -0.01 0.02 -0.19 -0.15 -0.17 -0.25 0.63 0.68 0.45 0.95 1.04 1.11 0.46 0.56 0.67


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin
Bud 0 0
Bud Neck 0 0
Bud Site 0 0
Cell Periphery 0 0
Cyto
Endoplasmic Reticulum 0 0
Endosome 0 0
Golgi 0 0
Mitochondria 0 0
Nuclear Periphery 0 0
Nuc
Nucleolus 0 0
Peroxisomes 0 0
SpindlePole 0 0
Vac
Cortical Patches 0 0
Cytoplasm 0 0
Nucleus 0 0
Vacuole 2.2 2.0


Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pdr1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available