Standard name | |
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Description | Nitric oxide oxidoreductase; flavohemoglobin that plays role in oxidative and nitrosative stress responses; protects against nitration of cellular targets and against cell growth inhibition under aerobic or anaerobic conditions; yeast flavohemoglobin Yhb1p and human homolog neuroglobin NGB protect cells against alpha-synuclein cytotoxicity and aggregate formation; protein increases in abundance, relocalizes from nucleus to cytoplasmic foci upon DNA replication stress |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 7 | 15 | 13 | 13 | 26 | 26 | 18 | 0 | 2 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 |
Bud | 0 | 1 | 0 | 0 | 3 | 1 | 2 | 5 | 2 | 8 | 6 | 5 | 0 | 4 | 3 | 0 | 0 | 0 | 11 | 14 | 10 | 14 | 61 | 62 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 1 | 3 | 2 | 7 | 6 | 11 | 16 | 17 | 20 | 13 | 10 | 1 | 6 | 7 | 2 | 5 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 152 | 201 | 277 | 260 | 466 | 363 | 418 | 319 | 283 | 294 | 225 | 252 | 347 | 492 | 596 | 86 | 110 | 40 | 143 | 187 | 243 | 134 | 364 | 382 |
Endoplasmic Reticulum | 0 | 0 | 1 | 2 | 10 | 20 | 94 | 99 | 64 | 104 | 53 | 84 | 2 | 2 | 13 | 2 | 6 | 2 | 1 | 0 | 3 | 2 | 1 | 1 |
Endosome | 0 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 |
Golgi | 0 | 0 | 0 | 2 | 1 | 9 | 19 | 37 | 18 | 27 | 31 | 17 | 2 | 0 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 5 | 0 | 2 | 2 | 4 | 12 | 20 | 9 | 8 | 24 | 18 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 2 |
Nucleus | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 3 | 2 | 3 | 2 | 1 | 2 | 2 | 0 | 2 | 0 | 0 | 1 | 3 | 0 | 3 | 8 | 5 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Nucleolus | 2 | 0 | 0 | 1 | 1 | 3 | 4 | 11 | 5 | 13 | 8 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 5 | 0 | 0 | 0 | 1 | 0 | 2 | 1 | 2 | 2 |
Vac/Vac Membrane | 2 | 0 | 5 | 9 | 30 | 32 | 65 | 90 | 50 | 49 | 37 | 34 | 6 | 19 | 40 | 8 | 6 | 2 | 0 | 3 | 2 | 2 | 9 | 4 |
Unique Cell Count | 159 | 201 | 281 | 275 | 514 | 435 | 612 | 571 | 433 | 519 | 386 | 422 | 357 | 512 | 660 | 92 | 115 | 41 | 163 | 214 | 270 | 162 | 456 | 476 |
Labelled Cell Count | 161 | 203 | 288 | 279 | 523 | 457 | 650 | 603 | 463 | 568 | 419 | 444 | 360 | 531 | 682 | 100 | 127 | 46 | 163 | 214 | 270 | 162 | 456 | 476 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 11.4 | 23.7 | 14.6 | 20.5 | 25.8 | 26.0 | 30.4 | 34.6 | 37.0 | 39.0 | 39.8 | 44.0 | 25.8 | 29.8 | 30.1 | 20.5 | 27.3 | 36.0 | 21.8 | 23.5 | 23.7 |
Std Deviation (1e-4) | 6.0 | 13.2 | 7.2 | 9.3 | 12.6 | 11.8 | 12.0 | 12.5 | 13.0 | 13.3 | 15.3 | 14.1 | 15.7 | 17.8 | 18.6 | 11.4 | 17.4 | 20.9 | 13.7 | 13.3 | 12.9 |
Intensity Change (Log2) | – | – | – | 0.5 | 0.83 | 0.84 | 1.06 | 1.25 | 1.35 | 1.42 | 1.45 | 1.6 | 0.83 | 1.03 | 1.05 | 0.49 | 0.91 | 1.31 | 0.58 | 0.69 | 0.7 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 2.9 | 3.8 | 4.4 | 3.5 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 1.6 | 2.3 | 2.3 | 1.9 | 1.3 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -2.6 | -4.3 | -6.4 | -10.1 | -12.8 | -10.5 | -12.5 | -11.9 | -11.7 | -1.2 | -2.0 | -4.5 | -2.6 | -1.8 | -0.5 |
Endoplasmic Reticulum | 0 | 0 | 3.3 | 6.8 | 7.2 | 6.5 | 7.9 | 6.3 | 7.8 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 3.0 | 4.4 | 3.5 | 3.9 | 4.9 | 3.4 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 1.9 | 2.3 | 0 | 0 | 3.0 | 3.0 | 1.8 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 1.1 | 2.7 | 3.3 | 4.6 | 6.1 | 4.8 | 4.1 | 4.1 | 3.6 | 0 | 1.5 | 2.8 | 0 | 0 | 0 |