Standard name
Human Ortholog
Description Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic26p is a non-essential component of the complex
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0.05 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0.07 0 0 0 0 0.06 0.06
Bud 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.08 0 0.09 0 0 0 0 0 0
Cytoplasm 0 0 0 0 0.05 0 0 – 0 0 0 0 0 0 0 0.55 0.35 0.4 0 0 0 0 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Endosome 0 0 0.06 0 0 0 0.06 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0.1 0.16 0.22 0.24 0 0.1 – 0 0 0 0 0.13 0.15 0.16 0.23 0.35 0.28 0.06 0.13 0 0.11 0.09 0.12
Mitochondria 0.91 0.88 0.83 0.88 0.72 0.89 0.62 – 0.91 0.84 0.85 0.84 0.87 0.86 0.81 0.11 0.13 0 0.85 0.72 0.82 0.69 0.64 0.62
Nucleus 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0
Nuclear Periphery 0.07 0 0.06 0 0.06 0 0.1 – 0.13 0.08 0.07 0.1 0.07 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.09 0 0 0 0 0.13 0.11 – 0.06 0.08 0.1 0.08 0.05 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0.07 0.07 0.09 0.08
SpindlePole 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.12 0.12 0.1 0.09 0.16 0 0.14 – 0.05 0.06 0 0.07 0.12 0.11 0.14 0.13 0.18 0.19 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 1 2 10 2 1 0 0 – 0 0 1 1 1 2 0 3 0 6 0 3 2 11 21 24
Bud 0 1 2 3 2 4 2 – 4 2 6 5 3 0 1 0 0 2 0 0 0 2 1 4
Bud Neck 0 0 0 0 0 1 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1
Bud Site 1 0 0 0 0 1 0 – 1 1 3 0 0 1 0 0 0 0 – – – – – –
Cell Periphery 0 6 6 5 4 1 2 – 1 2 0 3 7 5 3 11 4 8 1 0 0 2 0 0
Cytoplasm 0 5 2 6 9 6 13 – 5 9 10 11 6 7 13 77 37 36 0 0 0 0 0 0
Endoplasmic Reticulum 0 4 1 2 1 1 1 – 6 4 3 3 5 3 2 7 4 3 0 2 0 1 0 0
Endosome 5 1 11 4 8 0 17 – 0 5 4 4 4 4 8 1 1 0 6 8 4 8 13 13
Golgi 6 17 31 36 45 0 30 – 1 6 5 5 40 50 58 33 37 25 14 24 9 30 31 44
Mitochondria 211 156 159 144 135 208 189 – 210 200 221 243 271 294 292 16 14 4 209 135 181 195 213 238
Nucleus 1 0 0 0 1 3 3 – 0 6 3 2 0 1 0 7 2 3 0 0 0 0 0 0
Nuclear Periphery 16 1 12 5 11 10 32 – 31 18 18 30 23 15 4 0 1 2 1 0 2 1 4 8
Nucleolus 20 2 8 3 8 30 34 – 14 18 25 24 15 10 3 0 2 4 1 0 1 1 1 1
Peroxisomes 3 3 5 2 3 0 6 – 1 1 3 2 9 8 15 1 3 1 3 2 15 19 29 32
SpindlePole 1 1 3 0 2 1 4 – 0 2 4 0 1 1 0 0 2 0 1 0 1 0 1 1
Vac/Vac Membrane 28 22 19 14 30 10 42 – 11 14 11 20 36 38 49 18 19 17 2 6 1 4 6 8
Unique Cell Count 232 178 191 164 188 235 306 232 238 261 289 310 343 361 141 105 90 246 187 222 284 333 386
Labelled Cell Count 293 221 269 226 260 276 375 285 288 317 353 421 439 448 174 126 111 246 187 222 284 333 386


Mitochondria

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 11.0 9.8 9.3 9.8 10.7 6.8 9.7 – 8.0 8.2 8.5 8.2 11.5 11.8 11.8 12.6 13.0 12.8 9.8 10.5 10.4
Std Deviation (1e-4) 2.1 1.9 1.4 1.6 1.9 1.7 2.3 – 2.1 2.2 2.3 2.2 2.1 2.3 2.3 3.6 3.7 3.5 1.9 2.1 2.2
Intensity Change (Log2) – – – 0.08 0.2 -0.45 0.07 – -0.22 -0.18 -0.12 -0.17 0.31 0.35 0.35 0.44 0.49 0.47 0.08 0.18 0.17


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -2.1 -2.7 0 0 – 0 0 0 0 0 0 0 -1.4 0 0.5
Bud 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Cell Periphery -0.1 0 0 0 – 0 0 0 0 0 0 0 1.9 0 0
Cytoplasm 0 2.2 0 2.0 – 0 0 1.8 1.8 0 0 1.8 11.3 8.3 8.9
Endoplasmic Reticulum 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Endosome -1.6 -0.7 0 -0.1 – 0 -2.0 -2.5 -2.7 -2.9 -3.1 -2.2 -2.4 0 0
Golgi 1.4 1.9 -6.4 -2.1 – -6.1 -5.0 -5.6 -5.9 -1.0 -0.5 0 1.6 3.7 2.3
Mitochondria 1.2 -2.7 1.6 -5.1 – 2.2 0.2 0.4 0.2 1.3 0.8 -0.7 -13.0 -11.7 -12.5
Nucleus 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery -1.4 -0.2 -0.9 1.6 – 2.4 0.5 0.3 1.6 0.5 -1.0 -3.4 -3.0 0 0
Nucleolus -1.3 0 3.1 2.7 – 0.9 1.5 2.2 1.8 0.3 -0.8 0 0 0 0
Peroxisomes 0 0 0 0 – 0 0 0 0 0.2 0 0.9 0 0 0
SpindlePole 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0
Vacuole -0.5 1.7 -2.3 1.2 – -2.1 -1.6 -2.4 -1.2 0.6 0.4 1.2 0.8 2.0 2.1

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 7.6618 7.5602 7.5036 7.3994 6.3367 7.3967 9.2247 10.0556 9.3122 8.5342 7.691 9.3229 11.8385 12.0834 11.9855 11.0881 10.891 11.9871
Actin 0.0072 0.0098 0.0068 0.0004 0.0034 0.0006 0.0314 0.0183 0.0146 0.0008 0.0005 0.0033 0.0335 0.0156 0.0096 0.0026 0.0003 0.0071
Bud 0.0003 0.0005 0.0004 0 0.0002 0 0.0014 0.0021 0.0007 0.0003 0.0001 0.0009 0.0007 0.0008 0.0017 0.0001 0.0001 0
Bud Neck 0.0003 0.0002 0.0002 0 0.0001 0 0.0005 0.0004 0.0003 0.0002 0.0001 0.0001 0.0005 0.0002 0.0003 0.001 0 0.0001
Bud Periphery 0.0008 0.0015 0.0007 0.0002 0.0004 0.0001 0.0018 0.003 0.0013 0.0008 0.0002 0.0024 0.0015 0.0013 0.0026 0.0002 0.0002 0.0001
Bud Site 0.0007 0.0014 0.0017 0 0.0003 0 0.0031 0.0106 0.0062 0.0006 0.0001 0.004 0.0022 0.0076 0.001 0.0006 0.0001 0.0001
Cell Periphery 0.0003 0.0009 0.0003 0.0001 0.0001 0.0001 0.0004 0.0012 0.0046 0.0002 0.0001 0.0003 0.0003 0.0007 0.0004 0.0001 0.0001 0.0001
Cytoplasm 0.0006 0.0001 0.0003 0 0.0001 0 0.0005 0.0003 0.0016 0.0001 0.0001 0 0.0023 0.0001 0.0004 0.0004 0 0
Cytoplasmic Foci 0.0054 0.0013 0.0017 0.0007 0.0077 0.0006 0.0136 0.0038 0.0013 0.0015 0.0026 0.0007 0.0094 0.0042 0.0068 0.0144 0.0006 0.0005
Eisosomes 0.0003 0.0004 0.0005 0.0004 0.0002 0.0001 0.0006 0.0005 0.0005 0.0001 0.0001 0.0002 0.0006 0.0007 0.0004 0.0002 0.0001 0.0002
Endoplasmic Reticulum 0.0009 0.0019 0.0002 0.0001 0.0002 0.0001 0.001 0.0002 0.0009 0.0001 0.0002 0.0005 0.0018 0.0001 0.0015 0.0002 0 0.0002
Endosome 0.0088 0.0138 0.0081 0.0158 0.0069 0.0054 0.0294 0.0211 0.0055 0.0053 0.0792 0.0063 0.0166 0.0085 0.0077 0.0045 0.0141 0.0039
Golgi 0.0081 0.0163 0.0111 0.0112 0.0118 0.0171 0.0687 0.0356 0.0186 0.0051 0.0257 0.0233 0.0141 0.0181 0.0088 0.0032 0.003 0.0162
Lipid Particles 0.0094 0.0066 0.0031 0.0114 0.0087 0.0011 0.0787 0.0065 0.0013 0.0041 0.0746 0.0048 0.0289 0.013 0.0089 0.0114 0.0019 0.0051
Mitochondria 0.9282 0.9037 0.9438 0.9404 0.9162 0.9654 0.679 0.8731 0.9214 0.9717 0.7733 0.9224 0.8478 0.9073 0.9278 0.9247 0.9535 0.9589
None 0.0008 0.0001 0.0017 0 0.0001 0 0.0009 0.0001 0.0001 0 0.0001 0.0002 0.006 0.0001 0.0004 0.0009 0 0.0001
Nuclear Periphery 0.0037 0.0013 0.0005 0.0003 0.0001 0.0001 0.0204 0.0001 0.0002 0 0.0002 0.0211 0.0077 0.0002 0.0042 0.0005 0.0001 0.0011
Nucleolus 0.0004 0.0005 0.0004 0.0001 0.0001 0 0.0008 0.0005 0.0001 0.0001 0.0002 0.0008 0.0013 0.0003 0.0002 0.0005 0.0001 0
Nucleus 0.0007 0.0003 0.0002 0.0001 0.0001 0 0.0027 0.0003 0.0001 0.0001 0.0001 0.0005 0.0014 0.0001 0.0007 0.0003 0.0001 0.0001
Peroxisomes 0.0057 0.0033 0.0042 0.0006 0.0312 0.0029 0.0363 0.0075 0.0044 0.005 0.0143 0.0013 0.0095 0.0125 0.0063 0.0203 0.0007 0.0019
Punctate Nuclear 0.0022 0 0.0009 0 0.0003 0 0.0014 0 0 0 0.0001 0.0002 0.0056 0.0001 0.0008 0.0121 0 0.0002
Vacuole 0.0065 0.0178 0.0034 0.003 0.0017 0.0008 0.0103 0.0066 0.0075 0.0018 0.0117 0.0011 0.003 0.0026 0.0038 0.0005 0.0113 0.0005
Vacuole Periphery 0.0085 0.0183 0.0099 0.015 0.0102 0.0053 0.0171 0.0081 0.009 0.0022 0.0164 0.0055 0.005 0.0061 0.0057 0.0012 0.0137 0.0036

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 47.9399 39.3426 32.3219 35.4443 41.7771 37.7023 47.2379 49.3818 50.5527 50.6403
Translational Efficiency 2.1655 2.1796 2.3645 2.3391 1.9826 3.0218 2.0025 1.9146 2.1457 1.9407

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
2068 695 192 858 1721 2216 1878 1130 3789 2911 2070 1988

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 923.75 1119.61 1432.44 1336.67 932.02 1149.38 1320.79 1353.67 927.51 1142.27 1331.15 1346.33
Standard Deviation 155.24 194.88 255.68 229.98 143.93 187.26 213.11 234.49 150.27 189.53 219.81 232.71
Intensity Change Log 2 — 0.277422 0.632900 0.533069 — 0.302423 0.502968 0.538443 — 0.290032 0.569107 0.535771

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.002788 0.007384 0.007249 0.010895 0.002541 0.002016 0.003091 0.009096 0.002676 0.003298 0.003476 0.009872
Bud Neck 0.001476 0.001896 0.008152 0.001850 0.000694 0.000920 0.000893 0.001293 0.001121 0.001153 0.001566 0.001533
Bud Site 0.004321 0.004626 0.005628 0.008332 0.001411 0.002551 0.003073 0.006988 0.002999 0.003046 0.003310 0.007568
Cell Periphery 0.001051 0.000580 0.000982 0.001946 0.000357 0.000237 0.000252 0.003262 0.000736 0.000319 0.000320 0.002694
Cytoplasm 0.000363 0.000389 0.000512 0.000842 0.000195 0.000387 0.000427 0.000858 0.000287 0.000387 0.000434 0.000851
Cytoplasmic Foci 0.005754 0.016772 0.044789 0.010716 0.009480 0.013281 0.010022 0.009462 0.007447 0.014114 0.013247 0.010004
Eisosomes 0.000071 0.000269 0.000329 0.000201 0.000061 0.000077 0.000109 0.000170 0.000067 0.000123 0.000129 0.000183
Endoplasmic Reticulum 0.000302 0.000504 0.001330 0.002033 0.000448 0.000297 0.000320 0.001071 0.000368 0.000347 0.000413 0.001486
Endosome 0.015177 0.019561 0.034949 0.016829 0.017356 0.015328 0.009644 0.011813 0.016167 0.016338 0.011991 0.013978
Golgi 0.017035 0.054216 0.070332 0.092674 0.022035 0.033133 0.037968 0.092750 0.019306 0.038166 0.040970 0.092717
Lipid Particles 0.003177 0.004025 0.007973 0.000886 0.003143 0.003215 0.001265 0.000231 0.003162 0.003408 0.001887 0.000513
Mitochondria 0.930977* 0.858787* 0.671524* 0.795581* 0.924653* 0.904901* 0.899643* 0.824523* 0.928104* 0.893891* 0.878484* 0.812032*
Mitotic Spindle 0.000413 0.001080 0.018175 0.006809 0.001127 0.001111 0.001957 0.004127 0.000738 0.001104 0.003461 0.005284
None 0.000315 0.000638 0.001612 0.000810 0.000300 0.000594 0.000800 0.000737 0.000308 0.000604 0.000875 0.000768
Nuclear Periphery 0.000101 0.000159 0.003881 0.000251 0.000132 0.000140 0.000260 0.000131 0.000115 0.000144 0.000596 0.000183
Nuclear Periphery Foci 0.000163 0.000240 0.003783 0.000458 0.000189 0.000193 0.000213 0.000133 0.000175 0.000204 0.000544 0.000273
Nucleolus 0.000066 0.000418 0.002351 0.000099 0.000066 0.000219 0.000111 0.000042 0.000066 0.000266 0.000319 0.000066
Nucleus 0.000043 0.001116 0.000674 0.000074 0.000052 0.000330 0.000040 0.000045 0.000047 0.000517 0.000099 0.000057
Peroxisomes 0.007223 0.014504 0.008532 0.004703 0.004508 0.004653 0.005811 0.004521 0.005989 0.007005 0.006064 0.004600
Vacuole 0.003304 0.006770 0.048536 0.016626 0.003957 0.008119 0.008059 0.009436 0.003601 0.007797 0.011814 0.012539
Vacuole Periphery 0.005880 0.006066 0.058707 0.027386 0.007296 0.008299 0.016042 0.019312 0.006523 0.007766 0.020000 0.022797

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.00 -2.91 -4.16 -1.51 -1.57 0.76 -0.75 -3.90 -4.34 -3.63 -1.03 -1.32 -5.65 -5.11 -4.97
Bud Neck -0.78 -5.18 -0.77 0.07 4.81 -0.90 -1.03 -1.63 -1.02 -1.19 -0.13 -1.88 -1.36 -1.28 0.06
Bud Site -0.17 -0.82 -2.77 -1.89 -1.49 -1.78 -2.29 -5.52 -4.04 -3.40 -0.07 -0.43 -5.19 -4.79 -4.39
Cell Periphery 2.25 0.14 -1.99 -3.22 -1.57 1.50 1.37 -3.62 -3.78 -3.76 3.82 3.66 -3.92 -4.85 -4.84
Cytoplasm -0.27 -1.27 -2.83 -2.91 -2.11 -2.63 -2.39 -6.00 -3.71 -3.03 -1.41 -1.52 -5.48 -4.48 -3.47
Cytoplasmic Foci -6.01 -6.56 -4.09 2.95 5.66 -2.82 -0.44 0.01 2.87 0.45 -6.57 -5.17 -3.06 3.71 2.69
Eisosomes -3.38 -3.52 -6.15 1.11 1.70 -2.57 -2.97 -6.59 -5.70 -2.78 -3.80 -3.92 -8.90 -3.15 -2.70
Endoplasmic Reticulum -2.11 -5.11 -4.72 -4.07 -1.70 1.30 1.12 -3.50 -5.20 -5.06 0.31 -0.66 -6.05 -6.28 -5.88
Endosome -1.88 -4.03 -0.87 1.09 3.63 1.12 4.53 3.29 2.60 -1.81 -0.13 3.18 1.77 1.91 -1.64
Golgi -7.10 -6.49 -11.66 -4.76 -2.18 -4.08 -5.15 -12.04 -9.97 -8.89 -8.24 -8.06 -16.90 -11.75 -10.66
Lipid Particles -0.79 -2.38 2.80 3.93 3.75 -0.10 2.92 4.75 6.46 5.25 -0.39 2.26 5.11 7.02 4.91
Mitochondria 7.13 11.52 12.55 4.63 -5.08 3.16 3.86 10.89 8.69 7.97 6.82 8.54 16.65 10.87 8.22
Mitotic Spindle -2.52 -3.32 -5.15 -4.53 2.05 0.03 -2.02 -4.05 -4.11 -2.95 -1.44 -4.65 -6.73 -6.02 -2.13
None -6.09 -9.45 -10.64 -2.62 5.63 -1.86 -11.83 -9.80 -0.81 1.23 -2.45 -15.25 -14.46 -1.25 2.41
Nuclear Periphery -1.51 -6.09 -3.26 -1.98 5.84 -0.23 -3.24 0.03 0.25 3.13 -1.19 -6.89 -2.28 -1.37 5.79
Nuclear Periphery Foci -0.93 -2.64 -1.36 -1.04 2.39 -0.11 -0.47 1.07 1.35 1.97 -0.60 -2.67 -1.00 -0.73 1.67
Nucleolus -1.41 -2.69 -1.34 1.27 2.65 -1.37 -1.45 0.94 1.62 3.34 -1.95 -3.05 -0.05 1.95 3.06
Nucleus -1.04 -2.71 -2.24 1.01 2.57 -1.13 0.55 0.22 1.15 -0.45 -1.51 -2.06 -0.83 1.47 1.63
Peroxisomes -2.77 -0.62 1.77 3.71 1.76 -0.18 -1.17 -0.02 0.12 0.98 -1.06 -0.08 1.52 2.38 1.33
Vacuole -2.54 -7.31 -5.53 -3.67 4.80 -4.04 -4.47 -3.78 -0.85 -0.91 -5.18 -8.37 -6.76 -3.25 -0.49
Vacuole Periphery -0.23 -7.90 -7.69 -7.63 4.35 -0.88 -5.67 -5.96 -5.74 -1.50 -1.67 -9.52 -9.87 -9.11 -1.37
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Component of the MICOS complex; MICOS (formerly MINOS or MitOS) is a mitochondrial inner membrane complex that extends into the intermembrane space and has a role in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane; Mic26p is a non-essential component of the complex
Localization
Cell Percentages mitochondrion (98%)
Cell Cycle Regulation No
Subcompartmental Group mito-2

Mic26

Mic26


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mic26-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
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