Standard name
Description 6-phosphogluconolactonase; protein abundance increases in response to DNA replication stress; SOL4 has a paralog, SOL3, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0.06 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0.05 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.05 0 0 0 0 0 0 0 – 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.98 0.99 1.0 1.0 0.92 0.84 0.83 0.65 0.7 0.64 – 0.76 0.98 0.99 0.99 0.98 0.95 0.95 0.9 0.93 0.77 0.91 0.9 0.88
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0.05 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0.05 0.07 0.11 0.06 0.3 0.44 – 0.17 0 0 0 0 0 0 0 0 0.08 0 0 0
Nucleus 0 0 0 0 0 0 0 0.12 0.05 0.08 – 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0.06 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0.09 0.06 0.12 0.08 0.08 – 0.1 0 0 0 0 0.11 0.12 0 0 0.07 0 0.05 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 1 1 0 1 0 0
Bud 0 2 0 0 0 0 1 1 1 1 – 0 0 0 0 0 0 0 2 9 0 1 0 2
Bud Neck 1 0 0 0 0 2 0 0 0 0 – 0 0 0 0 0 0 0 2 0 0 1 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 1 1 0 0 0 0 0 0 0 – 2 0 0 1 3 4 2 0 0 0 0 0 0
Cytoplasm 394 588 20 18 34 36 39 11 51 16 – 32 83 279 269 297 243 231 369 546 30 171 93 139
Endoplasmic Reticulum 0 1 0 0 1 0 0 0 1 0 – 0 0 0 0 8 13 9 0 0 0 1 0 0
Endosome 1 1 0 0 0 0 0 0 0 0 – 0 0 0 0 0 1 0 2 5 0 0 0 0
Golgi 1 0 0 0 0 0 0 0 0 0 – 0 0 0 0 1 1 0 4 4 0 0 0 0
Mitochondria 3 2 0 0 2 3 5 1 22 11 – 7 0 0 2 5 0 4 11 5 3 0 1 2
Nucleus 0 0 0 0 0 0 2 2 4 2 – 2 0 5 2 0 3 2 0 1 0 1 0 0
Nuclear Periphery 0 1 0 0 0 0 0 1 0 1 – 0 0 0 0 0 0 0 1 0 0 0 0 0
Nucleolus 0 0 0 0 1 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 – 0 1 0 0 0 0 0 2 3 0 0 0 0
Vac/Vac Membrane 3 0 0 0 1 4 3 2 6 2 – 4 1 1 1 10 28 30 4 2 2 3 5 6
Unique Cell Count 402 592 20 18 37 43 47 17 73 25 42 85 283 271 304 255 243 409 586 40 188 104 159
Labelled Cell Count 403 596 21 18 39 45 50 18 85 33 47 85 285 275 324 293 278 409 586 40 188 104 159


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 4.4 5.1 4.5 4.4 5.3 5.9 6.2 6.3 5.7 5.7 – 6.9 6.1 7.3 8.1 9.8 12.1 11.6 9.7 5.9 10.4
Std Deviation (1e-4) 1.6 1.6 0.5 0.4 1.8 1.7 2.4 2.5 2.7 3.2 – 4.2 1.7 2.8 3.5 3.2 4.1 4.4 17.3 1.7 19.1
Intensity Change (Log2) – – – -0.05 0.23 0.38 0.47 0.48 0.35 0.34 – 0.61 0.44 0.7 0.85 1.13 1.43 1.36 1.11 0.39 1.21


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – 0 0 0 0 0 0 – 0 0 0 0 0 0 0
Bud Neck – 0 0 0 0 0 0 – 0 0 0 0 0 0 0
Bud Site – 0 0 0 0 0 0 – 0 0 0 0 0 0 0
Cell Periphery – 0 0 0 0 0 0 – 0 0 0 0 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – 0 0 0 0 0 0 – 0 0 0 0 0 0 0
Endosome – 0 0 0 0 0 0 – 0 0 0 0 0 0 0
Golgi – 0 0 0 0 0 0 – 0 0 0 0 0 0 0
Mitochondria – 0 0 0 0 0 0 – 0 0 0 0 0 0 0
Nuclear Periphery – 0 0 0 0 0 0 – 0 0 0 0 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – 0 0 0 0 0 0 – 0 0 0 0 0 0 0
Peroxisomes – 0 0 0 0 0 0 – 0 0 0 0 0 0 0
SpindlePole – 0 0 0 0 0 0 – 0 0 0 0 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – 0 0 0 0 0 0 – 0 0 0 0 0 0 0
Cytoplasm – -1.3 -1.9 -2.0 -2.9 -2.8 -3.0 – -2.4 -0.7 -0.5 -0.4 -0.7 -1.0 -1.0
Nucleus – 0 0 0 0 0 0 – 0 0 0 0 0 0 0
Vacuole – 0 0 0 0 0 0 – 0 0 0 0 0 0 0