Standard name
Human Ortholog
Description Ribosome-associated chaperone; zuotin functions in ribosome biogenesis and as a chaperone for nascent polypeptide chains in partnership with Ssz1p and SSb1/2; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p; human gene DNAJC2 can partially complement yeast zuo1 null mutant
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0.05 0.07 0.09 0.09 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0.05 0.08 0.09 0.11 0.09 0.11 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.0 0.99 0.97 0.97 0.9 0.86 0.7 0.59 0.66 0.63 0.63 0.57 0.99 0.98 0.97 0.97 0.98 0.98 0.94 0.95 0.93 0.94 0.93 0.91
Endoplasmic Reticulum 0 0 0 0 0.08 0.09 0.23 0.28 0.21 0.22 0.22 0.25 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0.07 0 0 0.05 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0.05 0 0 0.06 0.06 0.05 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 1 1 14 26 29 36 48 55 61 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 1 0 1 0 1 3 2 3 7 3 7 0 0 0 3 1 0 1 0 5 2 6 11
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 1 11 9 8 17 32 62 59 77 57 78 4 3 6 4 2 1 0 0 4 0 0 0
Cytoplasm 177 251 614 479 446 518 481 450 433 442 403 403 322 389 421 341 457 390 168 247 620 357 414 396
Endoplasmic Reticulum 0 3 14 7 39 55 156 215 138 154 144 175 1 8 6 13 14 17 3 4 19 1 6 8
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0
Golgi 0 0 0 2 7 9 7 56 21 19 31 38 0 1 3 0 1 3 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 10 31 16 25 43 39 34 0 0 0 0 4 1 0 0 2 0 0 1
Nucleus 0 0 0 0 0 0 1 1 1 0 1 1 0 0 0 0 0 0 0 0 0 3 1 1
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0
Nucleolus 0 0 0 0 0 1 2 3 0 0 1 1 0 0 0 0 0 0 0 0 0 0 1 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 1 0 0 1 1 2 6 3 1 1 7 2 1 1 5 5 8 1 1 2 8 8 9
Unique Cell Count 177 254 630 493 495 604 688 762 656 698 641 709 325 396 432 350 467 397 180 261 668 381 445 435
Labelled Cell Count 177 257 639 499 502 626 741 840 719 791 735 805 329 402 437 366 484 420 180 261 668 381 445 435


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 88.7 104.0 78.0 68.2 58.1 53.7 48.3 48.6 46.1 44.2 43.8 42.0 87.2 86.7 85.1 113.4 106.1 114.9 88.8 96.7 103.1
Std Deviation (1e-4) 18.9 24.9 18.4 15.4 12.1 10.4 10.6 11.5 11.2 10.0 10.4 10.0 25.2 22.4 22.8 43.6 38.6 43.4 26.5 30.6 34.0
Intensity Change (Log2) – – – -0.19 -0.43 -0.54 -0.69 -0.68 -0.76 -0.82 -0.83 -0.89 0.16 0.15 0.13 0.54 0.44 0.56 0.19 0.31 0.4

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP700050100150WT3HU80HU120HU160050100150WT3rpd3Δ_1rpd3Δ_2rpd3Δ_3050100150WT1AF100AF140AF180050100150
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 3.8 4.9 4.9 6.0 6.7 7.5 7.5 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0.1 -0.2 1.3 3.0 5.3 5.7 6.8 5.7 6.8 -0.6 -1.3 -0.5 -0.7 -2.0 0
Cytoplasm -0.3 -5.3 -7.5 -13.3 -16.8 -14.5 -15.4 -15.4 -17.4 1.7 0.8 0 0 0.4 0.8
Endoplasmic Reticulum -1.0 4.4 5.3 11.1 13.0 10.4 10.9 10.9 11.8 -2.3 -0.2 -1.0 1.4 0.8 1.9
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 6.9 4.5 4.2 5.6 5.9 0 0 0 0 0 0
Mitochondria 0 0 0 5.4 3.7 4.9 6.3 6.3 5.6 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 83.5658 113.0872 96.0038 95.5762 88.3054 99.7935 79.7312 119.6097 111.0206 96.5534 97.6014 91.61 93.7335 115.9042 107.2458 104.5823 101.2402 108.3078
Actin 0.0054 0.0001 0.0003 0.0005 0.001 0.0013 0.0075 0.0001 0.0005 0.0001 0.0003 0.0036 0.0066 0.0003 0.0054 0.0011 0.0001 0.0011
Bud 0.0015 0.0005 0.0014 0.0016 0.0008 0.002 0.0024 0.0003 0.0007 0.0014 0.0014 0.0025 0.0019 0.0003 0.0013 0.0009 0.0007 0.001
Bud Neck 0.0007 0.0007 0.0008 0.0006 0.0011 0.0022 0.0009 0.0003 0.0005 0.0005 0.0007 0.0012 0.0006 0.0006 0.0009 0.0008 0.0005 0.0013
Bud Periphery 0.0017 0.0003 0.0012 0.0025 0.0004 0.0018 0.0038 0.0001 0.0003 0.0011 0.0029 0.002 0.0025 0.0003 0.0016 0.0003 0.0006 0.0008
Bud Site 0.0008 0.0003 0.0005 0.0004 0.0004 0.0003 0.0022 0.0002 0.0003 0.0002 0.0003 0.001 0.0016 0.0002 0.0009 0.0002 0.0001 0.0002
Cell Periphery 0.0255 0.0045 0.0114 0.0155 0.0061 0.0079 0.0239 0.0096 0.0078 0.0181 0.0059 0.0146 0.0143 0.0109 0.0083 0.0085 0.0009 0.0022
Cytoplasm 0.6636 0.9255 0.8059 0.7288 0.7726 0.7898 0.6448 0.9389 0.8974 0.6342 0.7549 0.7151 0.7289 0.9202 0.8614 0.699 0.8024 0.7427
Cytoplasmic Foci 0.0055 0.0009 0.0087 0.0013 0.0067 0.0092 0.008 0.0008 0.0052 0.0059 0.0347 0.03 0.0043 0.0013 0.0056 0.0055 0.0056 0.0108
Eisosomes 0.0001 0 0 0.0001 0.0001 0 0.0002 0 0.0002 0 0.0009 0.0005 0.001 0 0.0001 0.0001 0 0.0001
Endoplasmic Reticulum 0.0387 0.0124 0.0087 0.0031 0.0252 0.0431 0.0381 0.0049 0.0093 0.0034 0.0032 0.0175 0.0615 0.0158 0.0166 0.0077 0.0062 0.0771
Endosome 0.0114 0.0032 0.0069 0.008 0.0256 0.0244 0.0199 0.0013 0.0035 0.0319 0.0158 0.0334 0.012 0.0031 0.0087 0.014 0.054 0.033
Golgi 0.0015 0.0004 0.0004 0.0007 0.003 0.0029 0.0055 0.0001 0.0006 0.0048 0.0016 0.0079 0.0065 0.001 0.0021 0.0083 0.0019 0.0104
Lipid Particles 0.0022 0.0005 0.0014 0.0006 0.0042 0.0009 0.0106 0.0014 0.0039 0.0024 0.0201 0.0106 0.0027 0.0008 0.0023 0.0014 0.0001 0.002
Mitochondria 0.0074 0.0006 0.0017 0.0089 0.0241 0.0133 0.013 0.0002 0.0036 0.0032 0.0043 0.0145 0.0192 0.0015 0.0052 0.0009 0.001 0.0116
None 0.0024 0.0001 0.0017 0.0004 0.0027 0.0034 0.0049 0.0007 0.0018 0.0042 0.0195 0.0086 0.0046 0.0002 0.0007 0.0005 0.0002 0.0033
Nuclear Periphery 0.0225 0.002 0.0054 0.0052 0.017 0.0077 0.0196 0.0022 0.0037 0.0061 0.003 0.009 0.0117 0.0032 0.0033 0.0057 0.0044 0.0071
Nucleolus 0.004 0.0001 0.0015 0.0006 0.0025 0.0015 0.0074 0.0002 0.0036 0.0016 0.0022 0.0104 0.0095 0.0001 0.0005 0.0019 0 0.0374
Nucleus 0.0099 0.0013 0.0047 0.0042 0.0113 0.0038 0.0105 0.0015 0.0024 0.0067 0.0041 0.0084 0.0047 0.0013 0.0017 0.0045 0.0021 0.0119
Peroxisomes 0.0007 0 0.0002 0 0.0013 0.0003 0.0018 0 0.0003 0.0002 0.0022 0.0013 0.0008 0 0.0012 0.0001 0 0.0002
Punctate Nuclear 0.0005 0 0.0012 0.0001 0.0024 0.0004 0.0019 0 0.001 0.0001 0.0025 0.008 0.0002 0 0.0037 0.0001 0 0.0006
Vacuole 0.1568 0.0416 0.1118 0.1611 0.0705 0.0551 0.1421 0.0354 0.0473 0.2238 0.0919 0.0773 0.0842 0.0356 0.0556 0.2062 0.0865 0.0241
Vacuole Periphery 0.037 0.005 0.024 0.056 0.021 0.0286 0.031 0.002 0.0063 0.05 0.0277 0.0226 0.0208 0.0033 0.0131 0.0326 0.0328 0.0212

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 547.0411 706.0696 717.3175 540.9957 634.5457 637.7908 560.133 494.2464 578.5943 437.1301
Translational Efficiency 2.2173 2.0879 1.921 2.9479 2.2163 1.8102 1.8728 2.4696 1.8555 2.2954

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1907 1210 2162 1371 1386 1991 1703 323 3293 3201 3865 1694

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 5389.15 6144.32 8400.43 11644.20 5274.71 5971.07 9551.79 12161.89 5340.98 6036.56 8907.74 11742.91
Standard Deviation 1146.95 1520.59 1796.36 2748.20 1204.54 1348.79 1951.80 3111.27 1172.89 1418.67 1952.02 2828.36
Intensity Change Log 2 — 0.189196 0.640405 1.111482 — 0.178898 0.856679 1.205204 — 0.184111 0.751433 1.158601

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000039 0.000086 0.000084 0.000269 0.000053 0.000047 0.000150 0.000325 0.000045 0.000062 0.000113 0.000280
Bud Neck 0.000195 0.000700 0.001031 0.000981 0.000214 0.000388 0.001271 0.001932 0.000203 0.000506 0.001137 0.001163
Bud Site 0.002161 0.004095 0.004254 0.008696 0.001865 0.002837 0.005969 0.010886 0.002037 0.003312 0.005010 0.009113
Cell Periphery 0.013983 0.015533 0.009888 0.050235 0.018397 0.003030 0.018767 0.065085 0.015841 0.007756 0.013801 0.053066
Cytoplasm 0.615488 0.534192 0.615901 0.536398 0.557871 0.739945 0.671510 0.369558 0.591238 0.662169 0.640404 0.504586
Cytoplasmic Foci 0.017082 0.016527 0.008740 0.004283 0.011781 0.010629 0.006289 0.008565 0.014851 0.012859 0.007660 0.005100
Eisosomes 0.000001 0.000002 0.000002 0.000006 0.000001 0.000001 0.000003 0.000010 0.000001 0.000001 0.000002 0.000007
Endoplasmic Reticulum 0.001474 0.000851 0.000675 0.000498 0.001635 0.000355 0.000452 0.000249 0.001542 0.000542 0.000577 0.000450
Endosome 0.000861 0.000998 0.000739 0.000519 0.000762 0.000674 0.000559 0.002942 0.000819 0.000796 0.000660 0.000981
Golgi 0.106413 0.122459 0.038953 0.016500 0.103148 0.053745 0.031222 0.025716 0.105039 0.079719 0.035546 0.018257
Lipid Particles 0.012769 0.009663 0.007643 0.018382 0.011545 0.002809 0.014603 0.037740 0.012254 0.005400 0.010710 0.022073
Mitochondria 0.000256 0.000268 0.000274 0.000589 0.000253 0.000299 0.000358 0.000591 0.000255 0.000287 0.000311 0.000589
Mitotic Spindle 0.001012 0.002598 0.001289 0.000591 0.000916 0.001748 0.000962 0.000639 0.000972 0.002069 0.001145 0.000600
None 0.001322 0.002056 0.001246 0.002171 0.001578 0.001615 0.001610 0.000604 0.001430 0.001782 0.001406 0.001873
Nuclear Periphery 0.000449 0.001068 0.000717 0.000412 0.000686 0.000377 0.000736 0.000649 0.000549 0.000639 0.000726 0.000457
Nuclear Periphery Foci 0.009805 0.013317 0.007680 0.004050 0.011577 0.006921 0.008024 0.006615 0.010551 0.009339 0.007832 0.004539
Nucleolus 0.000116 0.000185 0.000136 0.000258 0.000198 0.000084 0.000118 0.000187 0.000150 0.000122 0.000128 0.000245
Nucleus 0.002259 0.005693 0.011973 0.010776 0.003653 0.007561 0.013138 0.007294 0.002846 0.006855 0.012487 0.010112
Peroxisomes 0.000022 0.000018 0.000028 0.000110 0.000023 0.000014 0.000033 0.000131 0.000023 0.000016 0.000030 0.000114
Vacuole 0.066348 0.097332 0.183604 0.284083 0.094911 0.067805 0.167176 0.407763 0.078370 0.078966 0.176366 0.307665
Vacuole Periphery 0.147943 0.172359 0.105143 0.060193 0.178930 0.099116 0.057047 0.052520 0.160985 0.126802 0.083951 0.058730

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.67 -6.72 -3.40 -2.88 -2.67 0.40 -3.94 -2.14 -2.16 -1.55 -3.10 -6.28 -3.96 -3.74 -2.88
Bud Neck -4.92 -7.75 -7.00 -3.15 1.72 -3.85 -9.56 -7.02 -6.10 -2.34 -5.85 -11.54 -9.52 -6.55 0.84
Bud Site -3.08 -4.75 -7.53 -4.89 -4.39 -3.44 -5.69 -4.77 -4.22 -2.63 -4.22 -7.37 -9.08 -7.29 -4.75
Cell Periphery -1.26 4.50 -13.01 -12.09 -15.04 14.43 -0.25 -7.29 -10.21 -7.26 10.68 2.68 -14.52 -18.35 -15.66
Cytoplasm 6.25 1.52 6.80 0.18 5.59 -15.20 -7.78 8.76 17.96 13.67 -7.95 -3.96 8.56 15.04 11.99
Cytoplasmic Foci 0.16 7.04 10.52 9.93 5.11 0.61 5.04 1.37 1.05 -1.50 1.85 8.72 10.04 8.96 3.55
Eisosomes -5.08 -5.08 -4.26 -3.61 -3.60 4.36 -5.29 -1.77 -1.84 -1.56 -0.01 -7.20 -3.80 -3.80 -3.13
Endoplasmic Reticulum 3.10 4.66 5.54 3.17 2.62 7.13 6.79 8.08 1.79 3.89 7.47 7.78 8.60 1.58 2.47
Endosome -1.99 1.53 3.58 4.56 2.70 0.74 3.61 -1.19 -1.23 -1.31 0.14 3.43 -0.33 -0.36 -0.76
Golgi -3.06 19.94 27.13 26.50 13.82 12.36 19.77 18.97 9.39 2.64 8.25 27.93 34.93 27.88 13.74
Lipid Particles 2.77 5.19 -3.59 -6.16 -8.23 10.29 -2.82 -7.56 -10.41 -6.38 9.95 1.64 -7.19 -13.55 -8.48
Mitochondria -0.51 -1.40 -2.95 -2.81 -2.65 -0.98 -1.53 -1.35 -1.29 -1.13 -1.20 -1.92 -2.91 -2.72 -2.32
Mitotic Spindle -3.01 -2.73 0.48 2.87 1.42 -2.64 -0.92 2.00 3.34 2.47 -3.95 -2.70 0.60 3.36 1.42
None -3.57 0.72 -1.61 -0.27 -1.72 -0.25 -0.35 6.88 4.08 3.75 -2.35 -0.07 -1.11 -0.28 -1.06
Nuclear Periphery -5.88 -6.88 0.56 6.01 7.01 4.21 -1.75 0.39 -3.81 2.20 -2.20 -5.90 2.06 3.74 8.16
Nuclear Periphery Foci -3.56 3.57 11.74 9.72 8.93 6.34 4.39 6.47 0.91 2.85 1.82 5.56 14.90 10.15 10.37
Nucleolus -0.89 -0.64 -2.04 -0.71 -3.28 0.86 0.54 -0.05 -4.72 -3.01 0.25 0.08 -1.45 -3.09 -4.05
Nucleus -6.29 -12.57 -11.02 -6.06 2.72 -4.66 -9.12 -3.50 -1.19 2.56 -8.41 -15.57 -10.45 -5.19 3.57
Peroxisomes 1.14 -1.37 -7.51 -7.85 -6.75 2.11 -1.79 -2.69 -2.92 -2.44 2.51 -2.23 -7.57 -8.17 -6.84
Vacuole -6.68 -22.34 -28.88 -22.98 -10.07 5.08 -12.52 -18.14 -19.71 -13.06 -0.77 -25.18 -32.67 -31.99 -15.74
Vacuole Periphery -3.38 9.21 18.08 18.62 10.64 12.71 21.56 19.50 8.97 1.69 7.80 20.86 26.06 17.86 8.21
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Ribosome-associated chaperone; zuotin functions in ribosome biogenesis and as a chaperone for nascent polypeptide chains in partnership with Ssz1p and SSb1/2; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p; human gene DNAJC2 can partially complement yeast zuo1 null mutant
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-2

Zuo1

Zuo1


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Zuo1-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available