Standard name
Human Ortholog
Description Subunit c'' of the vacuolar ATPase; v-ATPase functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Neck – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Site – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – – – – – – –
Cell Periphery – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Cytoplasm – 0.5 0.45 0.56 0.59 0.65 0.65 0.76 – 0.72 0.82 0.78 0.35 0.37 0.48 – – – 0 0 0 0 0 0
Endoplasmic Reticulum – 0.46 0.45 0.44 0.42 0.34 0.29 0.14 – 0.15 0.14 0.13 0.62 0.58 0.39 – – – 0.66 0.62 0.65 0.67 0.65 0.58
Endosome – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Golgi – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Mitochondria – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nucleus – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nuclear Periphery – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Nucleolus – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Peroxisomes – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
SpindlePole – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Vac/Vac Membrane – 0.13 0.2 0.06 0 0 0.09 0.1 – 0.18 0.09 0.14 0.08 0.13 0.15 – – – 0.19 0.35 0.28 0.29 0.3 0.34
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0 0 3 2 0 1 1 – 0 0 0 0 1 3 – – – 2 0 0 0 0 1
Bud – 0 0 0 0 1 1 1 – 1 1 0 0 1 0 – – – 0 0 0 0 0 0
Bud Neck – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Bud Site – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – – – – – – –
Cell Periphery – 0 1 3 2 3 0 1 – 0 0 0 2 6 7 – – – 0 0 0 0 0 0
Cytoplasm – 74 30 79 108 115 145 185 – 92 113 111 46 60 109 – – – 0 1 2 2 1 3
Endoplasmic Reticulum – 69 30 61 77 60 64 35 – 19 19 19 83 94 88 – – – 53 114 76 76 129 119
Endosome – 0 0 0 0 0 1 0 – 0 0 0 0 0 1 – – – 0 0 0 0 1 2
Golgi – 0 1 0 0 0 0 1 – 1 0 1 1 3 3 – – – 1 0 1 0 0 4
Mitochondria – 0 0 0 0 0 2 0 – 0 1 0 0 0 0 – – – 1 1 0 1 0 1
Nucleus – 0 0 0 0 0 2 0 – 0 0 0 0 1 0 – – – 3 0 0 0 0 0
Nuclear Periphery – 0 0 1 0 0 1 0 – 1 1 0 1 0 0 – – – 1 0 0 0 0 0
Nucleolus – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Peroxisomes – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
SpindlePole – 0 0 0 0 0 0 0 – 0 0 0 0 0 0 – – – 0 0 0 0 0 0
Vac/Vac Membrane – 19 13 8 5 7 20 24 – 23 13 20 10 21 33 – – – 14 64 32 33 60 70
Unique Cell Count 149 66 140 183 178 222 242 128 138 142 133 162 225 80 183 118 115 200 208
Labelled Cell Count 162 75 155 194 186 237 248 137 148 151 143 187 244 80 183 118 115 200 208


Endoplasmic Reticulum, Vacuole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) – 25.1 19.0 19.9 19.1 17.9 17.6 17.6 – 15.6 17.5 16.5 23.2 23.8 21.7 – – – 24.3 25.6 25.7
Std Deviation (1e-4) – 4.4 4.0 4.1 3.9 3.9 4.5 4.3 – 4.4 4.4 4.5 5.3 5.6 4.5 – – – 5.9 5.4 5.8
Intensity Change (Log2) – – – 0.07 0.01 -0.08 -0.11 -0.11 – -0.28 -0.12 -0.2 0.29 0.33 0.2 – – – 0.36 0.43 0.44

WT3RAP60RAP140RAP220RAP300RAP380RAP540RAP620RAP7000102030WT3HU80HU120HU1600102030WT30102030AF100AF140AF1800102030
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 – 0 0 0 0 0 0 – – –
Bud 0 0 0 0 0 – 0 0 0 0 0 0 – – –
Bud Neck 0 0 0 0 0 – 0 0 0 0 0 0 – – –
Bud Site 0 0 0 0 0 – 0 0 0 0 0 0 – – –
Cell Periphery 0 0 0 0 0 – 0 0 0 0 0 0 – – –
Cytoplasm 1.5 1.9 2.7 2.9 4.9 – 3.6 5.3 4.7 -1.5 -1.2 0.4 – – –
Endoplasmic Reticulum -0.3 -0.5 -1.7 -2.5 -5.5 – -4.6 -5.0 -5.1 2.3 1.7 -0.9 – – –
Endosome 0 0 0 0 0 – 0 0 0 0 0 0 – – –
Golgi 0 0 0 0 0 – 0 0 0 0 0 0 – – –
Mitochondria 0 0 0 0 0 – 0 0 0 0 0 0 – – –
Nucleus 0 0 0 0 0 – 0 0 0 0 0 0 – – –
Nuclear Periphery 0 0 0 0 0 – 0 0 0 0 0 0 – – –
Nucleolus 0 0 0 0 0 – 0 0 0 0 0 0 – – –
Peroxisomes 0 0 0 0 0 – 0 0 0 0 0 0 – – –
SpindlePole 0 0 0 0 0 – 0 0 0 0 0 0 – – –
Vacuole -3.1 0 -4.0 -2.4 -2.2 – -0.3 -2.1 -1.0 -2.5 -1.3 -1.0 – – –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 14.5054 22.1586 21.1476 18.4524 19.1968 20.7296 16.8148 23.1437 23.4973 24.4608 19.9697 22.796 15.396 23.2569 21.5715 21.1734 20.3531 21.5135
Actin 0.0547 0.0001 0.0087 0.003 0.0145 0.0003 0.2161 0.003 0.0002 0.0002 0.0052 0.0194 0.0441 0.0001 0.0037 0.0227 0.043 0.0006
Bud 0.0007 0.0001 0.0006 0.0009 0.0003 0.0001 0.0007 0.0003 0.0001 0.0003 0.0003 0.0002 0.0003 0 0.0002 0.0001 0.0009 0.0001
Bud Neck 0.0129 0.0006 0.0013 0.0018 0.0045 0.0066 0.0006 0.0008 0.0005 0.0016 0.0013 0.0014 0.0026 0.0003 0.0009 0.0008 0.0017 0.0008
Bud Periphery 0.0014 0.0005 0.0013 0.0024 0.0016 0.0008 0.0008 0.0011 0.0007 0.002 0.0004 0.0011 0.0006 0.0003 0.0008 0.0009 0.0031 0.0005
Bud Site 0.0046 0.0003 0.0091 0.0034 0.0006 0.0001 0.0034 0.0011 0.0001 0.0003 0.0016 0.0003 0.0041 0.0001 0.0009 0.0004 0.0011 0.0001
Cell Periphery 0.0129 0.0667 0.075 0.0705 0.092 0.0444 0.0024 0.0734 0.0319 0.042 0.0039 0.0437 0.0139 0.0832 0.071 0.0726 0.1138 0.0518
Cytoplasm 0.0434 0.0526 0.0187 0.0273 0.0886 0.0252 0.03 0.0289 0.0126 0.0244 0.0172 0.0058 0.0166 0.0102 0.0147 0.0056 0.0062 0.0077
Cytoplasmic Foci 0.0293 0.0011 0.0053 0.0135 0.0057 0.001 0.0098 0.0018 0.0007 0.0008 0.0009 0.0198 0.0179 0.0002 0.0096 0.003 0.0017 0.0004
Eisosomes 0.0005 0 0 0.0001 0.0001 0 0.0021 0 0 0 0.0001 0.0001 0.0003 0 0 0.0001 0.0001 0
Endoplasmic Reticulum 0.4807 0.5645 0.5705 0.4757 0.3648 0.6337 0.5661 0.6073 0.7356 0.5904 0.7647 0.6583 0.6022 0.6634 0.5577 0.6412 0.5459 0.7042
Endosome 0.0635 0.0074 0.0144 0.0202 0.0191 0.0106 0.0534 0.013 0.0042 0.0182 0.0083 0.0069 0.0339 0.0028 0.014 0.0053 0.0064 0.008
Golgi 0.0131 0.0005 0.0109 0.0058 0.0069 0.0008 0.0286 0.0034 0.0005 0.0014 0.0008 0.0096 0.0083 0.0001 0.0036 0.0016 0.0089 0.0004
Lipid Particles 0.0169 0.0245 0.019 0.0122 0.0205 0.0136 0.0041 0.0357 0.0769 0.0103 0.0023 0.0092 0.0265 0.0099 0.0157 0.0127 0.0134 0.01
Mitochondria 0.0071 0.0002 0.0012 0.0078 0.0531 0.0005 0.004 0.0003 0.0001 0.0005 0.001 0.0021 0.0127 0 0.0007 0.0004 0.0029 0.0002
None 0.0127 0.0001 0.0001 0.0002 0.0008 0.0004 0.0013 0.0001 0.0001 0.0001 0.0011 0.0002 0.0045 0 0.0016 0.0001 0.0001 0.0001
Nuclear Periphery 0.0865 0.0324 0.0348 0.0283 0.0409 0.0762 0.0425 0.0177 0.0243 0.033 0.0372 0.0301 0.0995 0.0403 0.0573 0.0517 0.0287 0.0585
Nucleolus 0.0022 0.0004 0.0005 0.0003 0.0008 0.0008 0.0001 0.0004 0.0001 0.0002 0.003 0.0002 0.0003 0.0001 0.0003 0.0001 0.0003 0.0006
Nucleus 0.012 0.003 0.0023 0.0023 0.0079 0.0061 0.0041 0.002 0.0035 0.0022 0.0302 0.0013 0.0066 0.0014 0.0043 0.0015 0.0017 0.004
Peroxisomes 0.006 0 0.0019 0.0032 0.0034 0 0.0032 0.0001 0 0 0.0001 0.0008 0.0103 0 0.0037 0.0113 0.001 0
Punctate Nuclear 0.0197 0.0002 0.0011 0.0003 0.0059 0.0002 0.0011 0.0002 0.0002 0.0001 0.0159 0.0012 0.0033 0 0.0031 0.0001 0.0003 0.0005
Vacuole 0.1088 0.2401 0.2179 0.2974 0.2638 0.1671 0.021 0.205 0.1054 0.2592 0.1019 0.1801 0.0837 0.1846 0.2273 0.1592 0.2148 0.1464
Vacuole Periphery 0.0106 0.0047 0.0053 0.0233 0.0044 0.0116 0.0046 0.0046 0.0023 0.0129 0.0026 0.0083 0.0077 0.0029 0.0089 0.0085 0.004 0.0048

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 251.7893 221.2433 223.4564 206.6776 200.5531 223.3071 214.378 197.1149 219.1936 205.2273
Translational Efficiency 1.0338 1.1177 1.0844 1.0795 1.14 1.1906 1.1638 1.2517 1.0411 1.0068

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
43 180 2468 469 92 1555 551 31 135 1735 3019 500

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1398.19 1987.77 3227.47 3085.12 1411.46 1782.66 3422.34 3394.86 1407.23 1803.94 3263.04 3104.32
Standard Deviation 247.75 403.22 545.17 656.07 361.62 354.04 536.94 503.91 329.70 364.86 548.86 651.97
Intensity Change Log 2 — 0.507590 1.206843 1.141766 — 0.336843 1.277795 1.266164 — 0.424339 1.242923 1.205599

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000169 0.000139 0.000080 0.001334 0.000938 0.000194 0.000320 0.000070 0.000693 0.000188 0.000124 0.001255
Bud Neck 0.000876 0.000584 0.000620 0.009124 0.007965 0.000354 0.003259 0.001088 0.005707 0.000378 0.001102 0.008626
Bud Site 0.002463 0.002891 0.000454 0.005933 0.022251 0.001147 0.002861 0.000232 0.015948 0.001328 0.000893 0.005580
Cell Periphery 0.031591 0.054459 0.070492 0.125779 0.029627 0.027623 0.127323 0.157314 0.030252 0.030407 0.080864 0.127734
Cytoplasm 0.002309 0.000623 0.000698 0.000506 0.018394 0.001686 0.000482 0.000125 0.013270 0.001576 0.000658 0.000482
Cytoplasmic Foci 0.000505 0.000833 0.000035 0.002932 0.022149 0.001122 0.000181 0.000036 0.015255 0.001092 0.000062 0.002753
Eisosomes 0.000022 0.000044 0.000195 0.000432 0.000120 0.000024 0.001083 0.000658 0.000089 0.000026 0.000357 0.000446
Endoplasmic Reticulum 0.247551 0.717987 0.800407 0.420172 0.419059 0.829140 0.584546 0.593293 0.364431 0.817608 0.761010 0.430906
Endosome 0.004972 0.008405 0.002412 0.014035 0.040527 0.012129 0.007372 0.006645 0.029202 0.011743 0.003317 0.013577
Golgi 0.000373 0.001563 0.000992 0.007308 0.012199 0.001794 0.003655 0.010747 0.008433 0.001770 0.001478 0.007521
Lipid Particles 0.000526 0.001545 0.002945 0.038700 0.024241 0.002307 0.024328 0.023251 0.016687 0.002228 0.006847 0.037742
Mitochondria 0.000100 0.000249 0.000162 0.001275 0.000775 0.000311 0.000276 0.000086 0.000560 0.000304 0.000183 0.001202
Mitotic Spindle 0.000011 0.000304 0.000040 0.001267 0.000407 0.000044 0.000198 0.000032 0.000281 0.000071 0.000069 0.001190
None 0.000006 0.000009 0.000080 0.000095 0.000185 0.000248 0.000039 0.000047 0.000128 0.000223 0.000072 0.000092
Nuclear Periphery 0.000192 0.000761 0.002074 0.002969 0.004450 0.000537 0.004728 0.003772 0.003093 0.000560 0.002558 0.003019
Nuclear Periphery Foci 0.000471 0.002604 0.001009 0.007570 0.028756 0.002591 0.004362 0.002235 0.019747 0.002592 0.001621 0.007239
Nucleolus 0.000135 0.000047 0.000017 0.000098 0.000175 0.000074 0.000028 0.000017 0.000162 0.000071 0.000019 0.000093
Nucleus 0.000447 0.000079 0.000064 0.000160 0.001915 0.000128 0.000099 0.000037 0.001447 0.000123 0.000070 0.000153
Peroxisomes 0.000079 0.000033 0.000124 0.000249 0.000755 0.000108 0.000289 0.000061 0.000540 0.000100 0.000154 0.000237
Vacuole 0.680067 0.199387 0.115980 0.354058 0.349202 0.114396 0.231276 0.197726 0.454589 0.123214 0.137023 0.344365
Vacuole Periphery 0.027135 0.007453 0.001121 0.006002 0.015911 0.004042 0.003294 0.002529 0.019486 0.004396 0.001518 0.005787

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 0.23 0.49 -1.61 -1.65 -1.68 2.75 2.19 3.51 1.46 2.18 2.54 3.02 -0.82 -1.55 -1.62
Bud Neck 0.79 0.51 -5.89 -6.14 -6.09 2.15 1.05 1.95 -2.49 3.31 2.20 1.80 -1.30 -6.32 -5.62
Bud Site -0.17 1.68 -2.13 -1.39 -3.32 2.96 2.64 3.10 3.26 2.33 2.96 3.01 1.80 -2.88 -3.02
Cell Periphery -2.17 -5.61 -9.48 -6.27 -6.94 0.27 -10.09 -4.11 -4.28 -1.02 -0.03 -8.87 -10.93 -12.99 -6.06
Cytoplasm 2.11 1.92 1.95 -0.34 0.32 3.13 3.35 3.43 4.93 2.70 3.16 3.38 3.40 2.31 0.30
Cytoplasmic Foci -0.48 1.26 -1.81 -1.50 -2.22 3.22 3.36 3.39 4.68 1.91 3.12 3.35 2.64 -1.36 -2.19
Eisosomes -1.59 -7.13 -7.41 -7.10 -4.03 3.24 -1.84 -2.95 -3.51 0.75 3.00 -2.71 -6.37 -8.06 -0.80
Endoplasmic Reticulum -9.60 -12.81 -3.61 10.28 21.28 -10.06 -3.73 -2.49 4.04 -0.25 -14.19 -12.36 -1.71 22.19 19.05
Endosome -1.78 1.69 -4.42 -2.81 -7.51 3.93 4.57 4.62 3.03 0.55 3.37 5.04 2.92 -1.15 -7.00
Golgi -1.94 -2.56 -4.41 -3.46 -4.03 3.19 2.61 0.23 -1.71 -1.35 2.92 3.07 0.38 -3.75 -4.01
Lipid Particles -1.30 -5.37 -7.33 -7.07 -6.81 3.01 -0.13 0.08 -2.76 0.23 2.86 1.86 -3.05 -7.23 -6.18
Mitochondria -0.75 -1.99 -1.31 -1.12 -1.22 1.73 1.84 2.74 2.22 2.67 1.31 2.07 -0.75 -1.06 -1.19
Mitotic Spindle -0.98 -1.68 -1.63 -1.22 -1.57 1.49 0.74 1.55 0.58 1.36 1.24 1.15 -1.27 -1.56 -1.54
None -0.52 -2.16 -1.56 -1.51 -0.20 -0.37 1.53 1.40 1.40 -0.10 -0.67 0.78 0.45 0.97 -0.29
Nuclear Periphery -6.47 -17.88 -12.10 -9.18 -3.69 1.53 -0.12 0.24 -3.77 1.06 1.45 0.29 -0.00 -10.95 -2.04
Nuclear Periphery Foci -3.91 -4.35 -4.29 -3.04 -3.94 2.07 1.88 2.09 0.46 2.46 1.97 2.07 1.30 -3.07 -3.57
Nucleolus 1.78 2.75 0.33 -1.46 -2.46 1.83 3.12 3.42 1.95 2.15 2.09 4.13 1.03 -0.84 -2.40
Nucleus 1.25 1.27 0.88 -1.91 -2.79 2.40 2.40 2.52 2.84 2.66 2.55 2.63 2.44 -1.23 -2.49
Peroxisomes 1.24 -1.19 -1.70 -2.28 -1.33 2.95 1.58 3.10 0.99 1.08 2.88 2.47 1.70 -1.54 -0.89
Vacuole 10.29 13.37 7.26 -6.31 -16.05 6.43 3.01 2.87 -2.12 0.95 10.57 10.09 3.12 -15.30 -14.52
Vacuole Periphery 1.63 2.18 1.76 0.75 -5.80 2.90 3.07 3.24 1.76 0.92 3.20 3.81 2.87 -1.61 -5.37
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Subunit c'' of the vacuolar ATPase; v-ATPase functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain
Localization
Cell Percentages ER (46%), vacuole (10%), mixed (41%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Vma16

Vma16


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Vma16-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available