Standard name | |
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Human Ortholog | |
Description | Delta-1-pyrroline-5-carboxylate dehydrogenase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of human homolog ALDH4A1 causes type II hyperprolinemia (HPII), an autosomal recessive inborn error of metabolism; human homolog ALDH4A1 can complement yeast null mutant |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 2 | 9 | 6 | 4 | 4 | 0 | 4 | 4 | 0 | 3 | 0 | 0 | 4 | 5 | 6 | 19 | 19 | 18 | 1 | 12 | 3 | 2 | 6 | 12 |
Bud | 2 | 3 | 0 | 1 | 3 | 1 | 2 | 3 | 0 | 0 | 2 | 2 | 2 | 1 | 0 | 6 | 1 | 1 | 0 | 2 | 2 | 0 | 1 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 3 | 15 | 3 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 2 | 5 | 3 | 3 | 9 | 8 | 7 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 2 | 1 | 1 | 3 | 6 | 5 | 6 | 5 | 4 | 3 | 5 | 3 | 5 | 9 | 8 | 2 | 3 | 11 | 0 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0 | 2 | 0 | 0 | 0 | 2 | 1 | 1 | 2 | 1 | 1 | 3 | 0 | 2 | 5 | 5 | 8 | 7 | 0 | 1 | 0 | 0 | 0 | 0 |
Endosome | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 3 | 2 | 4 | 0 | 4 | 1 | 1 | 3 | 3 |
Golgi | 5 | 46 | 26 | 26 | 66 | 16 | 16 | 30 | 2 | 17 | 14 | 20 | 75 | 101 | 135 | 100 | 92 | 64 | 9 | 53 | 12 | 11 | 30 | 25 |
Mitochondria | 183 | 335 | 76 | 107 | 151 | 145 | 167 | 230 | 149 | 159 | 236 | 161 | 174 | 199 | 171 | 32 | 34 | 15 | 173 | 337 | 82 | 71 | 128 | 145 |
Nucleus | 0 | 2 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 7 | 5 | 2 | 2 | 8 | 4 | 11 | 5 | 13 | 3 | 16 | 7 | 3 | 2 | 4 | 3 | 5 | 4 | 0 | 1 | 0 | 0 | 1 | 0 |
Nucleolus | 8 | 18 | 1 | 9 | 16 | 29 | 30 | 30 | 15 | 24 | 30 | 18 | 6 | 4 | 6 | 19 | 16 | 23 | 0 | 5 | 0 | 2 | 3 | 2 |
Peroxisomes | 3 | 10 | 3 | 1 | 2 | 2 | 4 | 5 | 1 | 0 | 2 | 1 | 2 | 1 | 3 | 10 | 14 | 13 | 4 | 11 | 8 | 2 | 4 | 5 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 1 | 2 | 1 | 0 | 1 | 0 | 0 | 7 | 6 | 2 | 0 | 1 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 8 | 45 | 12 | 3 | 11 | 12 | 10 | 8 | 5 | 9 | 9 | 14 | 13 | 18 | 13 | 21 | 21 | 26 | 0 | 13 | 2 | 2 | 7 | 4 |
Unique Cell Count | 190 | 397 | 92 | 115 | 198 | 182 | 209 | 273 | 165 | 183 | 254 | 187 | 205 | 242 | 255 | 192 | 184 | 161 | 192 | 449 | 116 | 99 | 190 | 202 |
Labelled Cell Count | 224 | 491 | 131 | 158 | 268 | 217 | 255 | 324 | 192 | 222 | 320 | 235 | 288 | 345 | 360 | 241 | 229 | 196 | 192 | 449 | 116 | 99 | 190 | 202 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 17.0 | 24.8 | 20.8 | 21.5 | 25.4 | 25.4 | 23.0 | 24.2 | 21.3 | 21.6 | 21.2 | 21.5 | 22.3 | 22.3 | 22.0 | 29.3 | 30.4 | 28.7 | 18.8 | 21.5 | 23.0 |
Std Deviation (1e-4) | 4.3 | 6.6 | 5.6 | 5.8 | 6.8 | 7.9 | 7.1 | 7.7 | 6.7 | 7.2 | 7.4 | 7.7 | 5.3 | 5.3 | 6.2 | 12.6 | 12.3 | 12.8 | 5.6 | 5.9 | 6.1 |
Intensity Change (Log2) | – | – | – | 0.05 | 0.29 | 0.29 | 0.15 | 0.22 | 0.03 | 0.05 | 0.03 | 0.05 | 0.1 | 0.1 | 0.08 | 0.49 | 0.55 | 0.46 | -0.15 | 0.05 | 0.14 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.9 | 1.0 | 1.2 |
Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | -0.9 | 0.9 | -4.2 | -4.8 | -4.0 | -6.7 | -4.1 | -5.8 | -3.7 | 1.4 | 2.3 | 4.1 | 3.8 | 3.4 | 1.8 |
Mitochondria | 2.3 | -1.2 | -0.6 | -0.5 | 0.4 | 1.8 | 0.9 | 2.8 | 0.8 | 0.5 | -0.1 | -2.8 | -10.7 | -10.3 | -11.7 |
Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 1.9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 2.4 | 3.7 | 3.5 | 2.9 | 2.5 | 3.3 | 3.1 | 2.7 | 0 | 0 | 0 | 2.7 | 2.5 | 3.4 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.4 | 1.5 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | -2.9 | -2.2 | -1.8 | -2.5 | -3.7 | -3.1 | -2.4 | -3.3 | -1.5 | -1.9 | -1.6 | -2.5 | -0.5 | -0.4 | 0.7 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 15.9216 | 15.9046 | 15.5074 | 14.9771 | 13.9787 | 14.896 | 13.3457 | 14.0949 | 13.5215 | 12.763 | 10.4607 | 12.9438 | 13.338 | 13.4495 | 13.1127 | 12.1078 | 11.9805 | 12.1076 |
Actin | 0.0022 | 0.0026 | 0.0042 | 0.0006 | 0.0057 | 0.0011 | 0.0196 | 0.0014 | 0.0095 | 0.0171 | 0.0022 | 0.0051 | 0.0055 | 0.0114 | 0.0087 | 0.0011 | 0.0003 | 0.001 |
Bud | 0.0001 | 0.0003 | 0.0001 | 0 | 0.0001 | 0 | 0.0008 | 0.0003 | 0.0006 | 0.0003 | 0.0001 | 0.0001 | 0.0002 | 0.0041 | 0.0001 | 0 | 0 | 0 |
Bud Neck | 0.0001 | 0.0001 | 0 | 0 | 0.0001 | 0 | 0.0057 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0004 | 0.0002 | 0.0003 | 0 | 0 | 0 | 0 |
Bud Periphery | 0.0002 | 0.0008 | 0.0002 | 0 | 0.0001 | 0.0001 | 0.0019 | 0.0005 | 0.0048 | 0.0004 | 0.0003 | 0.0002 | 0.0003 | 0.0019 | 0.0004 | 0.0001 | 0 | 0 |
Bud Site | 0.0002 | 0.0007 | 0.0003 | 0 | 0.0002 | 0 | 0.0031 | 0.0018 | 0.0012 | 0.0004 | 0.0004 | 0.0001 | 0.0006 | 0.0037 | 0.0001 | 0.0001 | 0 | 0 |
Cell Periphery | 0.0003 | 0.0008 | 0.0001 | 0 | 0.0002 | 0.0001 | 0.0003 | 0.0003 | 0.0003 | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0.0009 | 0.0005 | 0.0002 | 0.0001 | 0 |
Cytoplasm | 0.0001 | 0 | 0.0001 | 0 | 0.0005 | 0 | 0.0026 | 0 | 0.0001 | 0.0004 | 0.0004 | 0.0001 | 0.0001 | 0.0002 | 0 | 0 | 0 | 0 |
Cytoplasmic Foci | 0.0013 | 0.0011 | 0.0007 | 0.0001 | 0.0099 | 0.0001 | 0.006 | 0.0012 | 0.0012 | 0.0101 | 0.005 | 0.0009 | 0.0093 | 0.0043 | 0.001 | 0.0015 | 0.0001 | 0.0005 |
Eisosomes | 0.0003 | 0.0007 | 0.0005 | 0.0002 | 0.0002 | 0.0002 | 0.0005 | 0.0003 | 0.0019 | 0.0001 | 0.0001 | 0.0004 | 0.0002 | 0.0003 | 0.0003 | 0.0003 | 0.0001 | 0.0002 |
Endoplasmic Reticulum | 0.0004 | 0.0001 | 0.0004 | 0 | 0.0024 | 0 | 0.0008 | 0.0002 | 0.0004 | 0.0005 | 0.0004 | 0.0003 | 0.0001 | 0.0002 | 0.0001 | 0 | 0 | 0 |
Endosome | 0.0054 | 0.0044 | 0.0045 | 0.0004 | 0.0046 | 0.0012 | 0.0046 | 0.0028 | 0.0031 | 0.0156 | 0.0169 | 0.0044 | 0.0052 | 0.0049 | 0.0013 | 0.001 | 0.0003 | 0.0026 |
Golgi | 0.0049 | 0.0247 | 0.0175 | 0.0008 | 0.0024 | 0.0081 | 0.004 | 0.01 | 0.0097 | 0.0136 | 0.0131 | 0.005 | 0.0188 | 0.0231 | 0.0084 | 0.0023 | 0.0013 | 0.0164 |
Lipid Particles | 0.0137 | 0.0152 | 0.0057 | 0.0015 | 0.0089 | 0.0083 | 0.0137 | 0.006 | 0.0029 | 0.0072 | 0.0341 | 0.0196 | 0.0183 | 0.0071 | 0.0059 | 0.0181 | 0.0003 | 0.0084 |
Mitochondria | 0.9405 | 0.9236 | 0.9573 | 0.995 | 0.9449 | 0.9672 | 0.9134 | 0.9603 | 0.947 | 0.9042 | 0.8933 | 0.9588 | 0.9148 | 0.8972 | 0.9634 | 0.9551 | 0.9959 | 0.9595 |
None | 0.0001 | 0 | 0.0002 | 0 | 0.0007 | 0 | 0.0029 | 0 | 0.0003 | 0.0004 | 0.0007 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0.0043 | 0.0006 | 0.0022 | 0 | 0.0022 | 0 | 0.0011 | 0.0003 | 0.0009 | 0.0003 | 0.0061 | 0.0004 | 0.0001 | 0.0004 | 0 | 0 | 0 | 0.0001 |
Nucleolus | 0.0004 | 0.0013 | 0.0002 | 0 | 0.0082 | 0.0082 | 0.0004 | 0.0003 | 0.0003 | 0.0001 | 0.0014 | 0.0001 | 0.0002 | 0.0033 | 0.0001 | 0.0001 | 0 | 0 |
Nucleus | 0.0004 | 0.0003 | 0.0006 | 0 | 0.0013 | 0.0011 | 0.0007 | 0.0001 | 0.0005 | 0.0001 | 0.002 | 0.0001 | 0.0001 | 0.0006 | 0 | 0 | 0 | 0 |
Peroxisomes | 0.0046 | 0.0028 | 0.0012 | 0.0006 | 0.0008 | 0.0006 | 0.0064 | 0.0064 | 0.0052 | 0.0171 | 0.0128 | 0.0015 | 0.0226 | 0.0072 | 0.0062 | 0.0171 | 0.0007 | 0.0087 |
Punctate Nuclear | 0.0012 | 0 | 0.0002 | 0 | 0.0008 | 0 | 0.0027 | 0 | 0.0003 | 0.0012 | 0.0076 | 0.0002 | 0.0002 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0.0033 | 0.0052 | 0.0008 | 0.0002 | 0.0016 | 0.0003 | 0.0035 | 0.0037 | 0.0027 | 0.0027 | 0.0012 | 0.0003 | 0.0007 | 0.0103 | 0.001 | 0.0008 | 0.0001 | 0.0003 |
Vacuole Periphery | 0.0159 | 0.0146 | 0.0031 | 0.0006 | 0.0041 | 0.0033 | 0.0052 | 0.004 | 0.0072 | 0.008 | 0.0017 | 0.0021 | 0.0024 | 0.0186 | 0.0022 | 0.0021 | 0.0007 | 0.002 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 50.7643 | 46.8072 | 41.5101 | 51.4874 | 33.53 | 47.8643 | 54.2526 | 57.8468 | 64.9662 | 58.5267 |
Translational Efficiency | 1.2134 | 1.048 | 1.2452 | 1.015 | 1.4025 | 1.6259 | 1.2561 | 1.1299 | 1.1723 | 1.0698 |
Dataset | Hit |
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Protein Concentration | ✔ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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