Standard name | |
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Human Ortholog | |
Description | Component of the CCR4-NOT core complex, involved in mRNA decapping; involved in transcription initiation and elongation and in mRNA degradation; conserved lysine in human homolog of Not3p and Not5p is mutated in cancers |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 1 | 1 | 2 | 4 | – | 2 | 2 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 |
Bud | 0 | 1 | 1 | 0 | 0 | 0 | 3 | – | 2 | 1 | 4 | 0 | 3 | 2 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 12 | 7 | 10 | 3 | 6 | 2 | 7 | – | 8 | 5 | 5 | 4 | 4 | 5 | 6 | 6 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 241 | 323 | 175 | 58 | 108 | 124 | 165 | – | 107 | 86 | 70 | 96 | 328 | 351 | 349 | 152 | 118 | 94 | 251 | 316 | 190 | 198 | 259 | 270 |
Endoplasmic Reticulum | 2 | 12 | 9 | 1 | 11 | 4 | 6 | – | 2 | 4 | 5 | 10 | 7 | 14 | 7 | 5 | 4 | 6 | 4 | 7 | 6 | 60 | 70 | 44 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 4 | – | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 |
Golgi | 0 | 1 | 0 | 1 | 0 | 0 | 1 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | 0 | 1 |
Mitochondria | 2 | 0 | 0 | 1 | 1 | 28 | 35 | – | 84 | 89 | 69 | 56 | 4 | 1 | 7 | 3 | 4 | 3 | 0 | 1 | 4 | 4 | 4 | 3 |
Nucleus | 4 | 0 | 0 | 0 | 1 | 3 | 1 | – | 2 | 3 | 4 | 5 | 1 | 0 | 1 | 2 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 2 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 2 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 2 | 0 | 1 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 0 | 2 | 1 | 2 | 4 | 3 | 10 | – | 10 | 12 | 6 | 16 | 0 | 5 | 0 | 23 | 9 | 13 | 3 | 7 | 3 | 8 | 7 | 8 |
Unique Cell Count | 252 | 335 | 186 | 66 | 121 | 146 | 212 | 178 | 174 | 132 | 163 | 339 | 367 | 359 | 171 | 131 | 110 | 264 | 339 | 212 | 286 | 352 | 339 | |
Labelled Cell Count | 261 | 346 | 196 | 67 | 132 | 166 | 236 | 222 | 205 | 164 | 194 | 349 | 378 | 372 | 191 | 142 | 124 | 264 | 339 | 212 | 286 | 352 | 339 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 13.9 | 13.2 | 11.0 | 9.8 | 9.5 | 7.6 | 8.2 | – | 6.9 | 6.0 | 6.2 | 6.6 | 10.6 | 11.1 | 10.8 | 15.3 | 15.7 | 13.2 | 10.7 | 10.9 | 11.5 |
Std Deviation (1e-4) | 2.3 | 2.5 | 1.4 | 1.6 | 1.4 | 1.3 | 1.4 | – | 1.4 | 1.1 | 1.2 | 1.3 | 1.6 | 1.6 | 1.6 | 3.8 | 3.9 | 4.1 | 1.5 | 1.8 | 1.7 |
Intensity Change (Log2) | – | – | – | -0.16 | -0.2 | -0.52 | -0.42 | – | -0.67 | -0.88 | -0.83 | -0.73 | -0.05 | 0.02 | -0.02 | 0.48 | 0.52 | 0.26 | -0.03 | -0.01 | 0.07 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | -0.2 | -1.9 | -1.0 | – | -0.4 | -1.2 | -0.7 | -1.4 | 0 | -2.7 | -2.4 | -0.9 | -1.0 | -0.7 |
Cytoplasm | -1.6 | -1.5 | -2.8 | -4.6 | – | -7.8 | -9.5 | -8.6 | -7.9 | 1.5 | 0.8 | 1.8 | -1.8 | -1.3 | -2.5 |
Endoplasmic Reticulum | 0 | 1.5 | -1.0 | -1.0 | – | -2.1 | -1.3 | -0.5 | 0.5 | -1.8 | -0.6 | -1.9 | -0.9 | -0.8 | 0.2 |
Endosome | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 6.2 | 5.8 | – | 10.7 | 11.2 | 11.1 | 8.7 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 2.5 | – | 2.8 | 3.2 | 0 | 4.0 | 0 | 0 | 0 | 4.9 | 0 | 4.4 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 8.2665 | 10.7277 | 9.6079 | 9.4311 | 9.0232 | 9.801 | 8.0062 | 10.6956 | 9.345 | 9.4641 | 8.5451 | 9.9153 | 8.1731 | 10.1436 | 9.3261 | 9.1713 | 8.6734 | 9.5077 |
Actin | 0.0137 | 0.0006 | 0.0122 | 0.001 | 0.0005 | 0.0011 | 0.0208 | 0.0019 | 0.005 | 0.0373 | 0.003 | 0.002 | 0.0085 | 0.0003 | 0.0009 | 0.0004 | 0.001 | 0.0015 |
Bud | 0.0009 | 0.0004 | 0.0007 | 0.0026 | 0.0007 | 0.0005 | 0.001 | 0.0006 | 0.0018 | 0.0009 | 0.0009 | 0.0005 | 0.0004 | 0.0003 | 0.0004 | 0.0005 | 0.0002 | 0.0002 |
Bud Neck | 0.0008 | 0.0003 | 0.0009 | 0.0011 | 0.0011 | 0.0012 | 0.0022 | 0.0006 | 0.0026 | 0.001 | 0.0007 | 0.0012 | 0.0029 | 0.0002 | 0.0005 | 0.0013 | 0.0007 | 0.0009 |
Bud Periphery | 0.0012 | 0.0002 | 0.0006 | 0.0023 | 0.0002 | 0.0008 | 0.0013 | 0.0005 | 0.0015 | 0.0007 | 0.0008 | 0.0004 | 0.0004 | 0.0002 | 0.0003 | 0.0003 | 0.0002 | 0.0001 |
Bud Site | 0.0016 | 0.0013 | 0.0014 | 0.0021 | 0.0005 | 0.0002 | 0.0021 | 0.0034 | 0.0028 | 0.0025 | 0.0003 | 0.0001 | 0.0012 | 0.0007 | 0.0007 | 0.0001 | 0.0001 | 0.0001 |
Cell Periphery | 0.0011 | 0.0003 | 0.0009 | 0.0008 | 0.0001 | 0.0006 | 0.0007 | 0.0015 | 0.0004 | 0.0003 | 0.0001 | 0.0001 | 0.0005 | 0.0017 | 0.0004 | 0.0002 | 0.0001 | 0.0001 |
Cytoplasm | 0.6153 | 0.9111 | 0.7805 | 0.7682 | 0.8418 | 0.8112 | 0.6447 | 0.9313 | 0.8148 | 0.7122 | 0.7862 | 0.8031 | 0.7576 | 0.9188 | 0.8472 | 0.8118 | 0.8608 | 0.8668 |
Cytoplasmic Foci | 0.0404 | 0.0098 | 0.021 | 0.0267 | 0.0253 | 0.0211 | 0.025 | 0.0092 | 0.0216 | 0.0244 | 0.0218 | 0.0163 | 0.0148 | 0.0111 | 0.0167 | 0.015 | 0.0134 | 0.0131 |
Eisosomes | 0.0005 | 0 | 0.0006 | 0 | 0 | 0 | 0.0001 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0.0951 | 0.0333 | 0.0351 | 0.0437 | 0.0129 | 0.0527 | 0.081 | 0.0143 | 0.0279 | 0.0138 | 0.0134 | 0.0667 | 0.098 | 0.0265 | 0.0414 | 0.0301 | 0.0305 | 0.0426 |
Endosome | 0.1084 | 0.0269 | 0.0652 | 0.1012 | 0.0793 | 0.0691 | 0.0998 | 0.0183 | 0.067 | 0.1123 | 0.068 | 0.0685 | 0.0609 | 0.0255 | 0.0557 | 0.0919 | 0.0545 | 0.0454 |
Golgi | 0.0164 | 0.0028 | 0.0104 | 0.0064 | 0.0057 | 0.0086 | 0.0165 | 0.0028 | 0.0094 | 0.0113 | 0.0259 | 0.0075 | 0.0063 | 0.0023 | 0.0058 | 0.0029 | 0.0024 | 0.0039 |
Lipid Particles | 0.0116 | 0.0001 | 0.0074 | 0.0003 | 0.0002 | 0.0021 | 0.006 | 0.0003 | 0.0011 | 0.0021 | 0.0166 | 0.0006 | 0.0023 | 0.0003 | 0.0007 | 0.0001 | 0.0009 | 0.0009 |
Mitochondria | 0.0217 | 0.0013 | 0.014 | 0.0084 | 0.0078 | 0.0119 | 0.0185 | 0.0032 | 0.0053 | 0.0021 | 0.0098 | 0.0071 | 0.0041 | 0.0013 | 0.0051 | 0.0022 | 0.0018 | 0.0104 |
None | 0.0126 | 0.0013 | 0.0111 | 0.004 | 0.0009 | 0.0015 | 0.0037 | 0.0006 | 0.0009 | 0.0009 | 0.001 | 0.0009 | 0.0025 | 0.0007 | 0.001 | 0.0007 | 0.0015 | 0.001 |
Nuclear Periphery | 0.013 | 0.0018 | 0.0099 | 0.0026 | 0.0021 | 0.0016 | 0.0216 | 0.0009 | 0.0043 | 0.0033 | 0.0233 | 0.005 | 0.0099 | 0.0013 | 0.0027 | 0.0021 | 0.0163 | 0.0033 |
Nucleolus | 0.0004 | 0 | 0.0007 | 0.0001 | 0 | 0 | 0.0009 | 0 | 0.0001 | 0.0001 | 0.0009 | 0 | 0.0002 | 0 | 0.0001 | 0 | 0.0001 | 0 |
Nucleus | 0.0044 | 0.001 | 0.0027 | 0.0021 | 0.0015 | 0.001 | 0.011 | 0.0011 | 0.0021 | 0.0022 | 0.0027 | 0.0101 | 0.0032 | 0.0009 | 0.0014 | 0.0013 | 0.0041 | 0.0014 |
Peroxisomes | 0.0076 | 0.0001 | 0.0022 | 0.0002 | 0.0003 | 0.0052 | 0.0028 | 0.0001 | 0.0007 | 0.0034 | 0.0025 | 0.0002 | 0.0062 | 0.0001 | 0.0005 | 0.0001 | 0.0001 | 0.0006 |
Punctate Nuclear | 0.0058 | 0.0001 | 0.0008 | 0.0002 | 0.0001 | 0.0006 | 0.0027 | 0.0001 | 0.0007 | 0.0026 | 0.0136 | 0.0002 | 0.0043 | 0.0001 | 0.0002 | 0.0001 | 0.001 | 0.0003 |
Vacuole | 0.0206 | 0.0057 | 0.0182 | 0.0213 | 0.0148 | 0.0062 | 0.0301 | 0.008 | 0.0257 | 0.0551 | 0.0053 | 0.0062 | 0.0133 | 0.0063 | 0.0155 | 0.0312 | 0.0074 | 0.0052 |
Vacuole Periphery | 0.007 | 0.0015 | 0.0036 | 0.0045 | 0.0042 | 0.0029 | 0.0074 | 0.0013 | 0.0044 | 0.0112 | 0.0031 | 0.0033 | 0.0028 | 0.0013 | 0.0027 | 0.0079 | 0.0028 | 0.0021 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 28.3431 | 20.8196 | 30.898 | 37.3864 | 31.9053 | 21.0809 | 28.0013 | 30.158 | 29.5954 | 33.8051 |
Translational Efficiency | 2.3213 | 2.4197 | 1.6716 | 1.2938 | 1.8418 | 2.7083 | 1.3477 | 1.3643 | 1.2895 | 1.3211 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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