Standard name | |
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Human Ortholog | |
Description | Cytoplasmic heavy chain dynein; microtubule motor protein; member of the AAA+ protein family, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p; motility along microtubules inhibited by She1p |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 5 | 5 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 2 | 1 | 0 | 8 | 12 | 7 | 8 | 13 | 13 | 10 | 15 | 15 |
Bud | 3 | 5 | 12 | 14 | 12 | 7 | 18 | 22 | 17 | – | 19 | 11 | 2 | 2 | 7 | 2 | 2 | 3 | 1 | 6 | 6 | 1 | 6 | 10 |
Bud Neck | 3 | 2 | 11 | 2 | 1 | 3 | 1 | 8 | 1 | – | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 4 | 10 | 10 | 2 | 5 | 2 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 2 | – | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 7 | 6 | 3 | 2 | 4 | 4 | 2 | 4 | 6 | – | 6 | 2 | 1 | 0 | 2 | 11 | 7 | 8 | 0 | 3 | 2 | 0 | 2 | 1 |
Cytoplasm | 267 | 445 | 515 | 310 | 443 | 563 | 655 | 641 | 386 | – | 298 | 314 | 306 | 419 | 452 | 310 | 319 | 354 | 241 | 384 | 383 | 243 | 311 | 342 |
Endoplasmic Reticulum | 1 | 3 | 4 | 0 | 0 | 5 | 1 | 3 | 1 | – | 2 | 1 | 4 | 1 | 0 | 22 | 16 | 14 | 3 | 0 | 6 | 0 | 5 | 2 |
Endosome | 18 | 13 | 9 | 2 | 15 | 6 | 4 | 2 | 0 | – | 1 | 0 | 15 | 15 | 9 | 26 | 22 | 22 | 28 | 25 | 21 | 5 | 4 | 7 |
Golgi | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 5 | 2 | 4 | 0 | 1 | 0 |
Mitochondria | 4 | 16 | 10 | 35 | 48 | 128 | 187 | 256 | 229 | – | 240 | 236 | 1 | 4 | 9 | 6 | 5 | 8 | 22 | 51 | 90 | 23 | 43 | 26 |
Nucleus | 0 | 2 | 0 | 0 | 0 | 1 | 2 | 7 | 2 | – | 1 | 4 | 1 | 0 | 0 | 3 | 4 | 4 | 0 | 1 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 2 | 0 | 0 | 1 | 1 | 2 | 0 | 0 | – | 1 | 0 | 1 | 0 | 3 | 0 | 0 | 2 | 1 | 1 | 1 | 0 | 0 | 0 |
Nucleolus | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 4 | 0 | – | 0 | 2 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Peroxisomes | 2 | 1 | 1 | 2 | 2 | 0 | 2 | 0 | 0 | – | 1 | 0 | 5 | 6 | 2 | 0 | 1 | 0 | 2 | 0 | 0 | 0 | 1 | 0 |
SpindlePole | 10 | 5 | 6 | 9 | 11 | 4 | 16 | 9 | 3 | – | 5 | 5 | 11 | 13 | 4 | 17 | 10 | 6 | 16 | 11 | 15 | 4 | 6 | 5 |
Vac/Vac Membrane | 8 | 3 | 2 | 1 | 6 | 0 | 5 | 6 | 2 | – | 6 | 3 | 0 | 4 | 4 | 18 | 24 | 16 | 4 | 13 | 10 | 4 | 7 | 6 |
Unique Cell Count | 308 | 490 | 553 | 343 | 498 | 635 | 757 | 791 | 498 | 449 | 445 | 340 | 453 | 473 | 373 | 382 | 403 | 345 | 536 | 582 | 303 | 419 | 426 | |
Labelled Cell Count | 330 | 510 | 576 | 377 | 544 | 723 | 895 | 963 | 649 | 585 | 579 | 350 | 466 | 494 | 425 | 425 | 444 | 345 | 536 | 582 | 303 | 419 | 426 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 6.2 | 4.5 | 4.0 | 3.9 | 4.0 | 3.7 | 3.4 | 3.3 | 3.1 | – | 3.0 | 2.8 | 4.6 | 4.8 | 4.4 | 8.0 | 8.7 | 7.9 | 4.9 | 5.3 | 5.7 |
Std Deviation (1e-4) | 0.8 | 0.9 | 1.0 | 1.4 | 1.2 | 1.2 | 1.1 | 1.0 | 1.3 | – | 1.1 | 0.9 | 0.8 | 1.0 | 1.0 | 1.5 | 1.7 | 1.8 | 1.0 | 1.2 | 1.3 |
Intensity Change (Log2) | – | – | – | -0.06 | 0.01 | -0.13 | -0.23 | -0.3 | -0.38 | – | -0.42 | -0.54 | 0.2 | 0.25 | 0.13 | 1.0 | 1.12 | 0.98 | 0.29 | 0.39 | 0.51 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | 4.6 | 5.4 | 4.1 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 3.8757 | 3.7191 | 3.4572 | 3.3317 | 3.9908 | 3.4614 | -1.0832 | -0.7265 | -0.8304 | -1.0447 | -1.3681 | -0.6023 | 3.7862 | 4.7724 | 4.3157 | 3.9462 | 3.9411 | 4.4509 |
Actin | 0.0266 | 0.0026 | 0.0285 | 0.0061 | 0.0421 | 0.0049 | 0.0479 | 0.0014 | 0.0017 | 0.0017 | 0.0013 | 0.0042 | 0.0068 | 0.0047 | 0.0051 | 0.0075 | 0.0081 | 0.0062 |
Bud | 0.0011 | 0.0031 | 0.0027 | 0.0006 | 0.0014 | 0.0003 | 0.0047 | 0.0139 | 0.0022 | 0.0041 | 0.0013 | 0.0078 | 0.0008 | 0.0038 | 0.0055 | 0.0066 | 0.0091 | 0.0013 |
Bud Neck | 0.0135 | 0.0003 | 0.0078 | 0.0735 | 0.0008 | 0.0014 | 0.0058 | 0.0008 | 0.0175 | 0.0186 | 0.0257 | 0.0045 | 0.0006 | 0.0011 | 0.0189 | 0.0364 | 0.001 | 0.0049 |
Bud Periphery | 0.0013 | 0.0053 | 0.0055 | 0.0009 | 0.0017 | 0.0004 | 0.0067 | 0.0061 | 0.0018 | 0.006 | 0.0025 | 0.003 | 0.0014 | 0.0024 | 0.0055 | 0.0076 | 0.0285 | 0.0017 |
Bud Site | 0.0115 | 0.0121 | 0.0158 | 0.0074 | 0.002 | 0.0002 | 0.0075 | 0.0392 | 0.0121 | 0.0248 | 0.0005 | 0.0027 | 0.0036 | 0.0259 | 0.0166 | 0.036 | 0.002 | 0.0009 |
Cell Periphery | 0.0007 | 0.0014 | 0.0011 | 0.0016 | 0.0003 | 0.0004 | 0.0006 | 0.0006 | 0.0002 | 0.0005 | 0.0001 | 0.0003 | 0.0004 | 0.0005 | 0.0006 | 0.0016 | 0.0006 | 0.0002 |
Cytoplasm | 0.2987 | 0.5749 | 0.4921 | 0.3118 | 0.3731 | 0.5979 | 0.2771 | 0.4025 | 0.3673 | 0.3446 | 0.3626 | 0.4517 | 0.2904 | 0.4195 | 0.3013 | 0.2826 | 0.3332 | 0.3981 |
Cytoplasmic Foci | 0.0415 | 0.0156 | 0.0465 | 0.1902 | 0.059 | 0.0405 | 0.083 | 0.0537 | 0.0604 | 0.1688 | 0.0906 | 0.0787 | 0.0541 | 0.0292 | 0.0759 | 0.163 | 0.099 | 0.0521 |
Eisosomes | 0.0004 | 0.0001 | 0.0003 | 0.0005 | 0.0004 | 0.0001 | 0.0004 | 0.0001 | 0.0001 | 0.0001 | 0 | 0 | 0.0003 | 0.0001 | 0.0002 | 0.0002 | 0.0002 | 0.0001 |
Endoplasmic Reticulum | 0.0091 | 0.0061 | 0.005 | 0.0028 | 0.0046 | 0.0071 | 0.0069 | 0.0036 | 0.003 | 0.0029 | 0.0021 | 0.0035 | 0.0031 | 0.0021 | 0.0027 | 0.0024 | 0.0045 | 0.0029 |
Endosome | 0.0196 | 0.0047 | 0.0097 | 0.0182 | 0.0462 | 0.0122 | 0.0377 | 0.0254 | 0.0305 | 0.0681 | 0.0731 | 0.0296 | 0.0138 | 0.013 | 0.0164 | 0.0151 | 0.0381 | 0.0146 |
Golgi | 0.0053 | 0.0007 | 0.0026 | 0.0032 | 0.015 | 0.0013 | 0.006 | 0.0016 | 0.0016 | 0.0021 | 0.0031 | 0.0015 | 0.0015 | 0.0017 | 0.0016 | 0.0011 | 0.0025 | 0.0012 |
Lipid Particles | 0.0064 | 0.0009 | 0.0063 | 0.0051 | 0.027 | 0.0043 | 0.0074 | 0.0014 | 0.0026 | 0.0015 | 0.0032 | 0.0035 | 0.0019 | 0.0006 | 0.0012 | 0.0005 | 0.0013 | 0.0007 |
Mitochondria | 0.0027 | 0.0004 | 0.0042 | 0.0018 | 0.0417 | 0.0009 | 0.0065 | 0.0019 | 0.0021 | 0.0023 | 0.0038 | 0.0012 | 0.0009 | 0.0018 | 0.0014 | 0.0011 | 0.002 | 0.0016 |
None | 0.4955 | 0.3642 | 0.3385 | 0.3568 | 0.3066 | 0.3178 | 0.4511 | 0.4249 | 0.4731 | 0.3267 | 0.4117 | 0.3807 | 0.611 | 0.4776 | 0.5279 | 0.4242 | 0.451 | 0.5 |
Nuclear Periphery | 0.0323 | 0.0007 | 0.005 | 0.0009 | 0.0144 | 0.0028 | 0.0071 | 0.0017 | 0.0016 | 0.0017 | 0.0008 | 0.008 | 0.0009 | 0.0012 | 0.0015 | 0.001 | 0.0028 | 0.0012 |
Nucleolus | 0.0019 | 0.0003 | 0.0029 | 0.0009 | 0.0011 | 0.0001 | 0.0029 | 0.001 | 0.0006 | 0.0008 | 0.0002 | 0.0006 | 0.0003 | 0.0008 | 0.0006 | 0.0008 | 0.0005 | 0.0004 |
Nucleus | 0.0032 | 0.0013 | 0.0042 | 0.0019 | 0.003 | 0.0011 | 0.0112 | 0.0053 | 0.0034 | 0.0043 | 0.0019 | 0.0062 | 0.0012 | 0.0037 | 0.0023 | 0.003 | 0.0027 | 0.0023 |
Peroxisomes | 0.0141 | 0.0012 | 0.0104 | 0.0083 | 0.044 | 0.0016 | 0.012 | 0.001 | 0.0019 | 0.0034 | 0.0041 | 0.0029 | 0.0024 | 0.0018 | 0.0068 | 0.0027 | 0.0035 | 0.0047 |
Punctate Nuclear | 0.0112 | 0.0011 | 0.0073 | 0.0042 | 0.0119 | 0.0029 | 0.0064 | 0.0088 | 0.0125 | 0.0065 | 0.0018 | 0.0052 | 0.0021 | 0.0056 | 0.0058 | 0.0049 | 0.0035 | 0.0034 |
Vacuole | 0.0021 | 0.0028 | 0.0031 | 0.003 | 0.0024 | 0.0013 | 0.0093 | 0.0044 | 0.0033 | 0.0079 | 0.0082 | 0.0035 | 0.002 | 0.0024 | 0.0019 | 0.0016 | 0.0048 | 0.0011 |
Vacuole Periphery | 0.0013 | 0.0002 | 0.0005 | 0.0003 | 0.0013 | 0.0003 | 0.0017 | 0.0006 | 0.0006 | 0.0024 | 0.0012 | 0.0007 | 0.0003 | 0.0004 | 0.0004 | 0.0003 | 0.0011 | 0.0003 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 15.4112 | 14.4595 | 17.2865 | 16.1989 | 13.3985 | 10.8672 | 25.1179 | 24.1205 | 19.9162 | 19.2341 |
Translational Efficiency | – | – | – | – | – | – | – | – | – | – |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | – |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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