Standard name | |
---|---|
Human Ortholog | |
Description | Histone acetyltransferase; critical for cell survival in presence of DNA damage during S phase, required for recovery after DSB repair; acetylates H3K56, H3K9; H3K56 acetylation activity required for expression homeostasis, buffering of mRNA synthesis rate against changes in gene dosage during S phase; involved in non-homologous end joining and regulation of Ty1 transposition; prevents hyper-amplification of rDNA; interacts physically with Vps75p |
ensLOC | DeepLoc | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 2 | 2 |
Bud | 1 | 0 | 2 | 1 | 0 | 13 | 12 | 5 | 7 | 18 | 9 | 11 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5 | 5 | 2 | 9 | 12 |
Bud Neck | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3 | 4 |
Bud Site | 1 | 0 | 1 | 1 | 6 | 13 | 11 | 22 | 18 | 25 | 19 | 25 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 14 | 23 | 39 | 25 | 46 | 33 | 42 | 28 | 27 | 18 | 21 | 10 | 99 | 118 | 160 | 68 | 54 | 70 | 5 | 15 | 16 | 31 | 35 | 46 |
Endoplasmic Reticulum | 0 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 5 | 14 | 12 | 20 | 1 | 0 | 0 | 2 | 3 | 3 |
Endosome | 0 | 0 | 18 | 8 | 11 | 0 | 0 | 4 | 1 | 3 | 0 | 0 | 2 | 3 | 7 | 3 | 9 | 8 | 2 | 4 | 4 | 3 | 6 | 11 |
Golgi | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 4 | 1 | 0 | 3 | 1 | 0 | 1 | 3 |
Mitochondria | 64 | 94 | 57 | 68 | 131 | 406 | 498 | 311 | 350 | 474 | 482 | 382 | 2 | 0 | 3 | 9 | 13 | 15 | 4 | 3 | 10 | 12 | 22 | 31 |
Nucleus | 122 | 326 | 459 | 302 | 364 | 593 | 587 | 555 | 605 | 622 | 512 | 518 | 430 | 353 | 439 | 291 | 300 | 316 | 135 | 331 | 474 | 264 | 293 | 281 |
Nuclear Periphery | 3 | 0 | 1 | 2 | 3 | 3 | 2 | 5 | 8 | 7 | 8 | 8 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 5 |
Nucleolus | 0 | 0 | 0 | 1 | 2 | 4 | 12 | 19 | 14 | 21 | 23 | 27 | 0 | 0 | 0 | 1 | 1 | 2 | 0 | 0 | 2 | 2 | 6 | 11 |
Peroxisomes | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
SpindlePole | 2 | 1 | 3 | 1 | 2 | 0 | 2 | 1 | 4 | 2 | 0 | 3 | 3 | 3 | 3 | 1 | 5 | 1 | 3 | 7 | 15 | 8 | 18 | 28 |
Vac/Vac Membrane | 10 | 28 | 28 | 14 | 25 | 27 | 27 | 15 | 24 | 15 | 17 | 36 | 20 | 18 | 19 | 10 | 31 | 30 | 34 | 43 | 94 | 105 | 135 | 226 |
Unique Cell Count | 160 | 397 | 561 | 371 | 491 | 794 | 849 | 730 | 809 | 818 | 726 | 706 | 549 | 485 | 625 | 370 | 392 | 414 | 194 | 422 | 640 | 442 | 554 | 687 |
Labelled Cell Count | 217 | 474 | 613 | 423 | 591 | 1092 | 1194 | 965 | 1059 | 1206 | 1091 | 1020 | 559 | 498 | 641 | 399 | 429 | 464 | 194 | 422 | 640 | 442 | 554 | 687 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 3.7 | 4.5 | 4.6 | 4.4 | 4.5 | 3.8 | 3.9 | 4.0 | 3.9 | 3.8 | 3.4 | 3.6 | 6.0 | 5.9 | 5.7 | 7.1 | 6.8 | 7.0 | 5.9 | 6.1 | 6.2 |
Std Deviation (1e-4) | 0.4 | 0.7 | 0.9 | 1.6 | 2.0 | 1.2 | 1.6 | 1.0 | 0.8 | 0.8 | 0.8 | 0.8 | 1.1 | 0.9 | 1.1 | 1.6 | 1.7 | 1.9 | 1.2 | 1.5 | 1.5 |
Intensity Change (Log2) | – | – | – | -0.07 | -0.01 | -0.28 | -0.22 | -0.21 | -0.24 | -0.29 | -0.41 | -0.34 | 0.39 | 0.36 | 0.32 | 0.63 | 0.57 | 0.61 | 0.37 | 0.41 | 0.43 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | -1.7 | 1.8 | 1.5 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 1.9264 | 2.3062 | 2.077 | 2.2202 | 1.7668 | 2.2015 | 1.9243 | 1.2526 | 1.6961 | 0.9247 | 1.2838 | 1.1425 | 0.6093 | 0.6294 | 0.2266 | 1.1189 | 0.3719 | 0.3667 |
Actin | 0.0209 | 0.0002 | 0.0016 | 0.0065 | 0.0034 | 0.0005 | 0.0349 | 0.0002 | 0.0226 | 0.0187 | 0.0097 | 0.0008 | 0.0087 | 0.0001 | 0.0001 | 0.0089 | 0.0032 | 0.0023 |
Bud | 0.0002 | 0.0001 | 0.0024 | 0.0001 | 0.0001 | 0.0001 | 0.0011 | 0.0001 | 0.0004 | 0.0003 | 0.0007 | 0.0001 | 0.0035 | 0.0003 | 0.0001 | 0.0003 | 0.0002 | 0.0012 |
Bud Neck | 0.0025 | 0.0005 | 0.0005 | 0.0315 | 0.001 | 0.0042 | 0.0072 | 0.0003 | 0.0088 | 0.0019 | 0.0033 | 0.0019 | 0.0099 | 0.0003 | 0.0015 | 0.047 | 0.001 | 0.0028 |
Bud Periphery | 0.0005 | 0.0001 | 0.0009 | 0.0002 | 0.0001 | 0.0001 | 0.003 | 0.0001 | 0.0007 | 0.0008 | 0.0015 | 0.0001 | 0.0018 | 0.0001 | 0.0001 | 0.0004 | 0.0004 | 0.0006 |
Bud Site | 0.0015 | 0.0012 | 0.0007 | 0.0012 | 0.0004 | 0.0003 | 0.004 | 0.0005 | 0.0071 | 0.0009 | 0.0019 | 0.0002 | 0.0032 | 0.0009 | 0.0006 | 0.0004 | 0.0004 | 0.0003 |
Cell Periphery | 0.0002 | 0.0001 | 0.0001 | 0.0006 | 0.0001 | 0.0001 | 0.0008 | 0 | 0.0004 | 0.0001 | 0.0001 | 0 | 0.0002 | 0 | 0 | 0.0001 | 0.0001 | 0 |
Cytoplasm | 0.0324 | 0.05 | 0.0259 | 0.0283 | 0.0261 | 0.0318 | 0.0483 | 0.0618 | 0.0384 | 0.017 | 0.0493 | 0.0431 | 0.0235 | 0.04 | 0.0179 | 0.0112 | 0.044 | 0.0226 |
Cytoplasmic Foci | 0.0122 | 0.0012 | 0.0036 | 0.0027 | 0.0035 | 0.0023 | 0.0111 | 0.0011 | 0.003 | 0.0015 | 0.0061 | 0.0016 | 0.0104 | 0.0021 | 0.0009 | 0.0008 | 0.0021 | 0.0088 |
Eisosomes | 0.0007 | 0.0001 | 0.0002 | 0.0015 | 0.0002 | 0 | 0.0004 | 0 | 0.0003 | 0.0007 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0.0001 | 0.0001 | 0 |
Endoplasmic Reticulum | 0.0026 | 0.0015 | 0.0029 | 0.0025 | 0.0008 | 0.0008 | 0.0089 | 0.0031 | 0.0021 | 0.0021 | 0.0048 | 0.001 | 0.0028 | 0.0007 | 0.0008 | 0.0035 | 0.0032 | 0.001 |
Endosome | 0.0111 | 0.0019 | 0.0084 | 0.0089 | 0.0031 | 0.0019 | 0.0287 | 0.0009 | 0.0051 | 0.0087 | 0.0273 | 0.0018 | 0.0108 | 0.0008 | 0.0008 | 0.0045 | 0.0047 | 0.0012 |
Golgi | 0.0017 | 0.0001 | 0.0008 | 0.0007 | 0.0005 | 0.0001 | 0.0051 | 0 | 0.0029 | 0.0013 | 0.0039 | 0.0005 | 0.0045 | 0 | 0 | 0.0006 | 0.0008 | 0.0004 |
Lipid Particles | 0.0042 | 0.0002 | 0.0061 | 0.0012 | 0.0021 | 0.0003 | 0.0101 | 0.0001 | 0.001 | 0.0035 | 0.0073 | 0.0045 | 0.0118 | 0.0001 | 0.0002 | 0.0004 | 0.001 | 0.001 |
Mitochondria | 0.003 | 0.0008 | 0.0053 | 0.001 | 0.0015 | 0.0004 | 0.0094 | 0.0005 | 0.0012 | 0.0043 | 0.0079 | 0.001 | 0.0039 | 0.0002 | 0.0002 | 0.001 | 0.0017 | 0.0004 |
None | 0.2072 | 0.142 | 0.1565 | 0.1428 | 0.1159 | 0.0843 | 0.0949 | 0.076 | 0.0738 | 0.0177 | 0.07 | 0.0388 | 0.0355 | 0.0482 | 0.0265 | 0.0034 | 0.1146 | 0.0314 |
Nuclear Periphery | 0.0277 | 0.0254 | 0.016 | 0.0298 | 0.012 | 0.0067 | 0.0579 | 0.0068 | 0.0154 | 0.0396 | 0.0352 | 0.0158 | 0.024 | 0.0128 | 0.0119 | 0.0269 | 0.0432 | 0.0063 |
Nucleolus | 0.0105 | 0.0134 | 0.0104 | 0.0052 | 0.012 | 0.0193 | 0.0187 | 0.004 | 0.0043 | 0.0073 | 0.0131 | 0.0093 | 0.0126 | 0.0094 | 0.0066 | 0.009 | 0.0067 | 0.0102 |
Nucleus | 0.6187 | 0.7105 | 0.717 | 0.661 | 0.7437 | 0.8129 | 0.5819 | 0.8223 | 0.7841 | 0.809 | 0.6859 | 0.8301 | 0.7858 | 0.8405 | 0.8824 | 0.8383 | 0.7561 | 0.8598 |
Peroxisomes | 0.0092 | 0.0001 | 0.001 | 0.0015 | 0.0038 | 0.0001 | 0.0082 | 0.0001 | 0.0007 | 0.0058 | 0.0029 | 0.0019 | 0.0078 | 0 | 0 | 0.0001 | 0.0002 | 0.0006 |
Punctate Nuclear | 0.0298 | 0.0483 | 0.0375 | 0.0715 | 0.0678 | 0.0325 | 0.0555 | 0.0201 | 0.0257 | 0.0562 | 0.0597 | 0.0459 | 0.0363 | 0.0427 | 0.0489 | 0.041 | 0.008 | 0.0483 |
Vacuole | 0.0026 | 0.0021 | 0.0014 | 0.0007 | 0.0015 | 0.001 | 0.0065 | 0.0014 | 0.0014 | 0.0013 | 0.0069 | 0.0012 | 0.002 | 0.0007 | 0.0004 | 0.0012 | 0.0031 | 0.0005 |
Vacuole Periphery | 0.0007 | 0.0004 | 0.0008 | 0.0005 | 0.0004 | 0.0002 | 0.0035 | 0.0004 | 0.0005 | 0.0013 | 0.0023 | 0.0005 | 0.0008 | 0.0002 | 0.0001 | 0.0009 | 0.0053 | 0.0001 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 19.358 | 6.7715 | 5.583 | 9.1872 | 13.6405 | 9.253 | 5.8957 | 6.1613 | 8.0404 | 14.1846 |
Translational Efficiency | 0.6433 | 0.8044 | 0.6363 | 0.5453 | 0.5922 | 1.4362 | 0.6964 | 0.5726 | 0.5407 | 0.5002 |
Dataset | Hit |
---|---|
Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✔ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
---|
Gene | Images |
---|
Gene | Images |
---|