Standard name | |
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Human Ortholog | |
Description | Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; with Trx2p, facilitates mitochondrial import of small Tims Tim9p, Tim10p, Tim13p by maintaining them in reduced form; abundance increases iunder DNA replication stress; TRX1 has a paralog, TRX2, that arose from the whole genome duplication |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 1 | – | 2 | 2 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | – | 1 | 0 | 1 | 0 | 0 | 0 | 3 | 0 | 1 | 4 | 2 | 0 | 0 | 4 | 5 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 0 | 0 | 1 | 0 | 4 | 3 | 4 | 1 | – | 10 | 8 | 6 | 0 | 1 | 2 | 5 | 2 | 7 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 633 | 210 | 163 | 63 | 236 | 243 | 229 | 247 | – | 170 | 166 | 228 | 282 | 258 | 341 | 340 | 275 | 331 | 608 | 188 | 147 | 184 | 254 | 233 |
Endoplasmic Reticulum | 3 | 2 | 0 | 1 | 2 | 6 | 8 | 12 | – | 6 | 5 | 9 | 1 | 3 | 3 | 7 | 18 | 8 | 3 | 1 | 0 | 1 | 7 | 4 |
Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 1 | 2 | 0 | 0 | 0 | 2 | 7 | 6 | – | 12 | 19 | 22 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 1 | 2 |
Nucleus | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 3 | – | 3 | 5 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 7 | 8 | 2 | 6 | 8 | 7 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vac/Vac Membrane | 9 | 2 | 1 | 5 | 4 | 3 | 21 | 15 | – | 21 | 16 | 13 | 1 | 4 | 4 | 12 | 1 | 2 | 4 | 2 | 0 | 7 | 9 | 10 |
Unique Cell Count | 645 | 215 | 164 | 66 | 240 | 257 | 257 | 277 | 212 | 209 | 276 | 284 | 262 | 345 | 354 | 279 | 334 | 637 | 211 | 153 | 204 | 290 | 270 | |
Labelled Cell Count | 646 | 216 | 165 | 69 | 248 | 262 | 270 | 286 | 227 | 221 | 293 | 284 | 266 | 350 | 368 | 298 | 350 | 637 | 211 | 153 | 204 | 290 | 270 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 37.1 | 35.4 | 27.4 | 27.1 | 25.2 | 22.7 | 20.9 | 20.9 | – | 19.9 | 19.5 | 20.9 | 35.5 | 36.6 | 38.3 | 55.3 | 54.5 | 58.8 | 37.8 | 37.8 | 39.7 |
Std Deviation (1e-4) | 7.0 | 9.2 | 4.6 | 5.8 | 5.4 | 5.4 | 5.5 | 5.0 | – | 5.2 | 5.3 | 6.2 | 6.5 | 8.2 | 8.3 | 14.2 | 14.3 | 13.9 | 7.9 | 9.0 | 10.6 |
Intensity Change (Log2) | – | – | – | -0.01 | -0.12 | -0.27 | -0.39 | -0.39 | – | -0.46 | -0.49 | -0.39 | 0.37 | 0.42 | 0.48 | 1.02 | 0.99 | 1.1 | 0.47 | 0.47 | 0.53 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -2.1 | -0.9 | -2.6 | -4.1 | -4.1 | – | -5.8 | -5.9 | -5.4 | -0.1 | -0.9 | -0.6 | -2.1 | -0.8 | -0.3 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.3 | 0 |
Endosome | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mitochondria | 0 | 0 | 0 | 0 | 0 | – | 3.1 | 4.0 | 3.7 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleus | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | 0 | 0 | 0 | 3.4 | 2.6 | – | 3.8 | 3.2 | 2.4 | 0 | 0 | 0 | 0 | 0 | 0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 31.5055 | 34.8439 | 32.3748 | 30.9515 | 29.301 | 31.8934 | 37.1274 | 38.6876 | 36.3438 | 34.0958 | 34.5141 | 35.8121 | 28.879 | 35.8515 | 33.9782 | 30.0665 | 27.2447 | 31.6923 |
Actin | 0.0005 | 0.0001 | 0.0039 | 0.0001 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0002 | 0.0188 | 0.002 | 0.0002 | 0.0065 | 0.0007 | 0.0632 |
Bud | 0.0006 | 0.0001 | 0.0005 | 0 | 0.0009 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0.0004 | 0.0003 | 0 | 0.0049 | 0.0001 | 0.0003 |
Bud Neck | 0.0003 | 0.0002 | 0.0003 | 0.0003 | 0.0006 | 0.0007 | 0.0001 | 0.0001 | 0.0002 | 0.0003 | 0.0003 | 0.0006 | 0.0005 | 0.0001 | 0.0002 | 0.001 | 0.0005 | 0.0011 |
Bud Periphery | 0.0005 | 0 | 0.0001 | 0 | 0.0007 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0002 | 0.0002 | 0 | 0.0058 | 0 | 0.0006 |
Bud Site | 0.0003 | 0 | 0.0001 | 0 | 0.0002 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0023 | 0.0002 | 0 | 0.0205 | 0.0001 | 0.0003 |
Cell Periphery | 0.0002 | 0 | 0 | 0 | 0.0003 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0.0008 | 0 | 0.0002 |
Cytoplasm | 0.8074 | 0.9241 | 0.8502 | 0.8922 | 0.8835 | 0.8362 | 0.8986 | 0.956 | 0.9274 | 0.9532 | 0.9292 | 0.9016 | 0.8272 | 0.9769 | 0.9729 | 0.8802 | 0.8954 | 0.8657 |
Cytoplasmic Foci | 0.0031 | 0.0002 | 0.0005 | 0.0003 | 0.0009 | 0.0002 | 0.0001 | 0.0001 | 0.0002 | 0.0002 | 0.0002 | 0.0003 | 0.0044 | 0.0002 | 0.0003 | 0.0029 | 0.0077 | 0.0012 |
Eisosomes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0.0007 |
Endoplasmic Reticulum | 0.0019 | 0.0005 | 0.0006 | 0.0006 | 0.001 | 0.0017 | 0.0006 | 0.0004 | 0.0004 | 0.0003 | 0.0008 | 0.0008 | 0.0165 | 0.0002 | 0.0002 | 0.0029 | 0.0005 | 0.0075 |
Endosome | 0.0024 | 0.0001 | 0.0005 | 0.0001 | 0.0005 | 0.0006 | 0.0001 | 0 | 0.0001 | 0 | 0.0001 | 0.0001 | 0.0169 | 0.0001 | 0 | 0.0122 | 0.0517 | 0.0024 |
Golgi | 0.0002 | 0 | 0.0003 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0017 | 0 | 0 | 0.0016 | 0.0261 | 0.0017 |
Lipid Particles | 0.001 | 0 | 0.0002 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0011 | 0 | 0 | 0.0004 | 0.0004 | 0.0006 |
Mitochondria | 0.0017 | 0.0001 | 0.0003 | 0.0001 | 0.0006 | 0.0001 | 0.0001 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0.0024 | 0.0033 | 0.0001 | 0.0031 | 0.0014 | 0.0118 |
None | 0.0018 | 0.0002 | 0.0004 | 0.0003 | 0.0004 | 0.0002 | 0.0002 | 0.0001 | 0.0001 | 0.0002 | 0.0002 | 0.0002 | 0.0076 | 0.0003 | 0.0002 | 0.0006 | 0.0003 | 0.0012 |
Nuclear Periphery | 0.0155 | 0.0049 | 0.011 | 0.0074 | 0.0114 | 0.015 | 0.0076 | 0.0029 | 0.0046 | 0.0041 | 0.0101 | 0.007 | 0.0303 | 0.0013 | 0.0014 | 0.0052 | 0.0012 | 0.0046 |
Nucleolus | 0.0052 | 0 | 0.0002 | 0 | 0.001 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0003 | 0.0001 | 0 | 0.0004 | 0 | 0.0001 |
Nucleus | 0.1474 | 0.069 | 0.1289 | 0.097 | 0.0905 | 0.1431 | 0.0916 | 0.0396 | 0.0664 | 0.041 | 0.0581 | 0.0882 | 0.0603 | 0.0144 | 0.0242 | 0.0344 | 0.0117 | 0.0352 |
Peroxisomes | 0.0009 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0006 | 0.0001 | 0 | 0.0002 | 0.0004 | 0.0002 |
Punctate Nuclear | 0.0051 | 0.0002 | 0.0009 | 0.001 | 0.0009 | 0.0006 | 0.0004 | 0.0002 | 0.0002 | 0.0004 | 0.0005 | 0.0005 | 0.005 | 0.0001 | 0.0002 | 0.0004 | 0.0003 | 0.0007 |
Vacuole | 0.0029 | 0.0003 | 0.0005 | 0.0004 | 0.0054 | 0.0012 | 0.0002 | 0.0001 | 0.0002 | 0.0001 | 0.0002 | 0.0002 | 0.002 | 0.0001 | 0.0001 | 0.0128 | 0.0005 | 0.0002 |
Vacuole Periphery | 0.0009 | 0 | 0.0003 | 0.0001 | 0.0008 | 0.0003 | 0.0001 | 0 | 0 | 0 | 0.0001 | 0.0001 | 0.0011 | 0.0001 | 0 | 0.0029 | 0.0008 | 0.0004 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 438.5325 | 354.0838 | 412.8857 | 390.8055 | 421.8472 | 413.5476 | 476.2861 | 460.617 | 466.7994 | 426.4311 |
Translational Efficiency | 1.9676 | 2.4318 | 1.9424 | 2.0456 | 1.9395 | 2.2058 | 2.0845 | 2.2102 | 2.2717 | 2.215 |
Dataset | Hit |
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Protein Concentration | ✔ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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