| Standard name | |
|---|---|
| Human Ortholog | |
| Description (SGD) | Cysteine desulfurase involved in iron-sulfur cluster biogenesis; required for thio-modification of mitochondrial and cytoplasmic tRNAs; involved in DNA damage response by providing iron-sulfur cluster cofactors for DNA repair enzymes; essential protein located predominantly in mitochondria |
Micrographs
Sub-cellular Localization
Yeast GFP Assignment
Protein Abundance
Localization Change
External localization resources
| ensLOC | DeepLoc | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
| Cortical Patches | 0 | 5 | 3 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 4 | 0 | 0 | 3 | 15 | 3 | 4 | 5 | 14 | 3 | 4 | 8 |
| Bud | 2 | 0 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 3 | 3 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Bud Site | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
| Cell Periphery | 2 | 3 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 2 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cytoplasm | 0 | 3 | 1 | 4 | 2 | 3 | 2 | 0 | 2 | 2 | 3 | 2 | 0 | 1 | 5 | 2 | 2 | 1 | 0 | 2 | 0 | 0 | 0 | 0 |
| Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Endosome | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 2 | 0 | 0 | 2 |
| Golgi | 0 | 19 | 12 | 4 | 4 | 1 | 1 | 3 | 1 | 0 | 1 | 1 | 8 | 3 | 6 | 32 | 67 | 13 | 9 | 25 | 20 | 4 | 10 | 9 |
| Mitochondria | 150 | 178 | 253 | 122 | 196 | 239 | 256 | 337 | 301 | 284 | 186 | 295 | 119 | 94 | 90 | 2 | 18 | 2 | 127 | 171 | 214 | 23 | 72 | 80 |
| Nucleus | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Nuclear Periphery | 3 | 2 | 8 | 0 | 6 | 6 | 15 | 17 | 18 | 14 | 8 | 13 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Nucleolus | 25 | 9 | 26 | 13 | 30 | 61 | 67 | 112 | 62 | 63 | 43 | 56 | 2 | 6 | 8 | 3 | 2 | 0 | 3 | 1 | 1 | 1 | 3 | 0 |
| Peroxisomes | 1 | 0 | 7 | 3 | 1 | 0 | 6 | 2 | 5 | 4 | 4 | 2 | 0 | 0 | 0 | 0 | 1 | 1 | 3 | 2 | 19 | 2 | 1 | 6 |
| SpindlePole | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 4 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
| Vac/Vac Membrane | 3 | 18 | 2 | 3 | 8 | 6 | 15 | 14 | 4 | 5 | 1 | 1 | 5 | 5 | 5 | 10 | 10 | 5 | 0 | 5 | 2 | 1 | 1 | 1 |
| Unique Cell Count | 152 | 198 | 268 | 132 | 215 | 256 | 287 | 390 | 315 | 308 | 207 | 312 | 122 | 98 | 105 | 48 | 86 | 21 | 151 | 220 | 280 | 39 | 96 | 112 |
| Labelled Cell Count | 187 | 237 | 320 | 152 | 249 | 318 | 368 | 490 | 398 | 380 | 251 | 376 | 138 | 112 | 120 | 56 | 118 | 27 | 151 | 220 | 280 | 39 | 96 | 112 |
Yeast GFP Assignment
Protein Abundance
| Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean Cell GFP Intensity (1e-4) | 24.3 | 29.7 | 27.2 | 26.9 | 29.7 | 29.4 | 27.1 | 26.7 | 25.2 | 23.0 | 24.3 | 23.8 | 24.7 | 24.7 | 24.2 | 27.9 | 33.0 | 34.3 | 19.9 | 24.0 | 25.7 |
| Std Deviation (1e-4) | 5.8 | 7.1 | 7.1 | 7.3 | 7.8 | 8.4 | 8.3 | 8.5 | 7.8 | 7.7 | 8.2 | 7.9 | 5.0 | 5.5 | 6.5 | 9.0 | 10.7 | 10.8 | 4.9 | 6.3 | 8.4 |
| Intensity Change (Log2) | – | – | – | -0.01 | 0.13 | 0.11 | -0.01 | -0.03 | -0.11 | -0.24 | -0.16 | -0.2 | -0.14 | -0.14 | -0.17 | 0.04 | 0.28 | 0.34 | -0.45 | -0.18 | -0.08 |
Localization Change
| Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Bud | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Bud Site | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cell Periphery | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cytoplasm | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Endoplasmic Reticulum | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Endosome | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Golgi | -0.7 | -1.6 | -3.0 | -3.2 | -3.1 | -3.4 | -3.8 | -2.6 | -3.4 | 0.9 | 0 | 0.5 | 11.5 | 14.2 | 0 |
| Mitochondria | -0.8 | -1.4 | -0.5 | -2.2 | -3.3 | 0.6 | -1.0 | -1.9 | 0.1 | 1.4 | 0.6 | -2.8 | -14.6 | -14.0 | -11.6 |
| Nucleus | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Nuclear Periphery | 0 | -0.1 | -0.5 | 1.3 | 0.9 | 1.6 | 1.0 | 0.5 | 0.8 | 0 | 0 | 0 | 0 | 0 | 0 |
| Nucleolus | 0 | 1.5 | 4.3 | 4.3 | 5.9 | 3.4 | 3.6 | 3.4 | 2.8 | -2.9 | -1.1 | -0.6 | 0 | -2.2 | 0 |
| Peroxisomes | 0 | 0 | 0 | -0.4 | 0 | -0.9 | -1.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| SpindlePole | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Vacuole | 0 | 0 | 0 | 3.1 | 2.3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
External localization resources
Images
Protein Concentration and Protein Localization Data
| R1 | R2 | R3 | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
| Concentration | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Cytoplasmic Foci | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Eisosomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Endosome | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Golgi | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Lipid Particles | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| None | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Punctate Nuclear | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
| Vacuole Periphery | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Sequencing Data
| R1 | R2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
| Gene Expression | 75.3328 | 72.6248 | 59.2798 | 62.6039 | 69.9027 | 65.6952 | 73.9315 | 69.3852 | 75.1416 | 82.2217 |
| Translational Efficiency | 1.2937 | 1.1715 | 1.2685 | 1.1657 | 0.9567 | 1.4923 | 1.2774 | 1.2169 | 1.135 | 1.1193 |
Hit Data
| Dataset | Hit |
|---|---|
| Protein Concentration | – |
| Protein Localization | – |
| Gene Expression | ✘ |
| Translational Efficiency | ✘ |
Micrographs
Cell Count
Number of cells analysed for each strain. R1, R2: biological replicates; R1 & R2: both replicates combined.
| R1 | R2 | R1 & R2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 |
| 12 | 1134 | 1500 | 728 | 1799 | 1459 | 1512 | 348 | 1811 | 2593 | 3012 | 1076 |
Protein Abundance
Mean and standard deviation of cell GFP intensity, and intensity change (log2) of each mutant relative to wild type.
| R1 | R2 | R1 & R2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | |
| Mean | 286.36 | 2106.90 | 1763.46 | 2356.33 | 1838.92 | 2158.14 | 1908.20 | 2499.05 | 1828.63 | 2135.73 | 1836.12 | 2402.49 |
| Standard Deviation | 4.34 | 592.27 | 583.45 | 601.22 | 461.54 | 552.10 | 459.72 | 692.51 | 476.94 | 570.59 | 529.96 | 635.70 |
| Intensity Change Log 2 | — | 2.879220 | 2.622507 | 3.040640 | — | 0.230930 | 0.053354 | 0.442521 | — | 1.004906 | 0.788780 | 1.191931 |
Localization Score (DeepLoc)
Localization score for each compartment. Values highlighted in green denote significant localization scores (marked * in the plot).
| R1 | R2 | R1 & R2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | WT | UBP2 | UBP14 | UBP2UBP14 | |
| Actin | 0.000023 | 0.007171 | 0.004546 | 0.011621 | 0.001677 | 0.007326 | 0.006977 | 0.008577 | 0.001666 | 0.007259 | 0.005767 | 0.010637 |
| Bud Neck | 0.000012 | 0.002507 | 0.015192 | 0.002943 | 0.000510 | 0.001899 | 0.005573 | 0.005559 | 0.000507 | 0.002165 | 0.010364 | 0.003789 |
| Bud Site | 0.000028 | 0.002685 | 0.068964 | 0.002962 | 0.000199 | 0.000988 | 0.010326 | 0.006398 | 0.000198 | 0.001730 | 0.039528 | 0.004073 |
| Cell Periphery | 0.000078 | 0.000138 | 0.008523 | 0.000307 | 0.000044 | 0.000087 | 0.000493 | 0.000417 | 0.000044 | 0.000109 | 0.004492 | 0.000343 |
| Cytoplasm | 0.000030 | 0.000429 | 0.008550 | 0.000459 | 0.000138 | 0.000181 | 0.000677 | 0.000627 | 0.000137 | 0.000290 | 0.004598 | 0.000513 |
| Cytoplasmic Foci | 0.000010 | 0.025236 | 0.029011 | 0.017381 | 0.013456 | 0.021177 | 0.023263 | 0.016114 | 0.013367 | 0.022952 | 0.026126 | 0.016971 |
| Eisosomes | 0.000039 | 0.003859 | 0.000890 | 0.002290 | 0.002093 | 0.001564 | 0.000852 | 0.001193 | 0.002080 | 0.002567 | 0.000871 | 0.001935 |
| Endoplasmic Reticulum | 0.000001 | 0.000121 | 0.003111 | 0.000298 | 0.000049 | 0.000132 | 0.000339 | 0.000263 | 0.000049 | 0.000127 | 0.001720 | 0.000287 |
| Endosome | 0.000001 | 0.001411 | 0.018781 | 0.002459 | 0.000461 | 0.001246 | 0.005198 | 0.003575 | 0.000458 | 0.001318 | 0.011963 | 0.002820 |
| Golgi | 0.000005 | 0.014439 | 0.019458 | 0.034752 | 0.007602 | 0.022993 | 0.022100 | 0.026966 | 0.007551 | 0.019252 | 0.020784 | 0.032234 |
| Lipid Particles | 0.000017 | 0.007367 | 0.013114 | 0.003005 | 0.004705 | 0.012692 | 0.013099 | 0.003618 | 0.004674 | 0.010363 | 0.013106 | 0.003203 |
| Mitochondria | 0.000010 | 0.899086* | 0.701543* | 0.880735* | 0.944592* | 0.888554* | 0.854163* | 0.857872* | 0.938333* | 0.893160* | 0.778157* | 0.873340* |
| Mitotic Spindle | 0.000203 | 0.000699 | 0.006616 | 0.002005 | 0.000123 | 0.002059 | 0.004938 | 0.003456 | 0.000124 | 0.001464 | 0.005774 | 0.002474 |
| None | 0.999428* | 0.003113 | 0.005183 | 0.003700 | 0.003884 | 0.004751 | 0.003313 | 0.003253 | 0.010481 | 0.004035 | 0.004244 | 0.003555 |
| Nuclear Periphery | 0.000000 | 0.000237 | 0.002285 | 0.000470 | 0.000189 | 0.001178 | 0.001816 | 0.000992 | 0.000188 | 0.000767 | 0.002049 | 0.000639 |
| Nuclear Periphery Foci | 0.000017 | 0.000193 | 0.001981 | 0.000236 | 0.000144 | 0.000476 | 0.000863 | 0.000615 | 0.000143 | 0.000353 | 0.001420 | 0.000359 |
| Nucleolus | 0.000028 | 0.001876 | 0.004895 | 0.001069 | 0.000598 | 0.001335 | 0.002149 | 0.001931 | 0.000594 | 0.001572 | 0.003517 | 0.001348 |
| Nucleus | 0.000010 | 0.000319 | 0.002615 | 0.000168 | 0.000033 | 0.000084 | 0.000312 | 0.000350 | 0.000033 | 0.000187 | 0.001459 | 0.000227 |
| Peroxisomes | 0.000059 | 0.021139 | 0.009627 | 0.009535 | 0.012860 | 0.006380 | 0.009335 | 0.008974 | 0.012775 | 0.012835 | 0.009480 | 0.009353 |
| Vacuole | 0.000001 | 0.004028 | 0.039218 | 0.009301 | 0.002545 | 0.009223 | 0.013625 | 0.023771 | 0.002528 | 0.006951 | 0.026371 | 0.013981 |
| Vacuole Periphery | 0.000000 | 0.003945 | 0.035895 | 0.014304 | 0.004097 | 0.015675 | 0.020591 | 0.025478 | 0.004070 | 0.010545 | 0.028212 | 0.017918 |
Localization Changes (T-score)
Change in localization of each mutant relative to its control (e.g. UBP2_WT: ubp2Δ vs wild type). Values highlighted in yellow (increase) or blue (decrease) denote significant changes (marked * in the plot).
| R1 | R2 | R1 & R2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UBP2_ |
UBP14_ |
UBP2UBP14_ |
UBP2UBP14_ |
UBP2UBP14_ |
UBP2_ |
UBP14_ |
UBP2UBP14_ |
UBP2UBP14_ |
UBP2UBP14_ |
UBP2_ |
UBP14_ |
UBP2UBP14_ |
UBP2UBP14_ |
UBP2UBP14_ |
|
| Actin | N/A | N/A | N/A | -1.91 | -3.28 | -4.74 | -5.14 | -4.39 | -0.66 | -0.88 | -6.33 | -5.95 | -5.90 | -2.02 | -3.06 |
| Bud Neck | N/A | N/A | N/A | -0.78 | 8.64 | -5.09 | -8.65 | -4.95 | -3.53 | -0.07 | -7.24 | -13.44 | -6.97 | -3.28 | 7.52 |
| Bud Site | N/A | N/A | N/A | -0.29 | 13.94 | -3.67 | -6.29 | -3.00 | -2.61 | 1.40 | -4.20 | -15.63 | -4.58 | -2.60 | 13.27 |
| Cell Periphery | N/A | N/A | N/A | -2.84 | 7.59 | -3.10 | -5.77 | -4.17 | -3.68 | 0.62 | -4.12 | -8.17 | -6.34 | -4.86 | 7.59 |
| Cytoplasm | N/A | N/A | N/A | -0.29 | 7.24 | -1.30 | -4.79 | -2.78 | -2.55 | 0.21 | -2.48 | -7.98 | -4.18 | -2.27 | 7.18 |
| Cytoplasmic Foci | N/A | N/A | N/A | 2.25 | 3.47 | -3.83 | -4.70 | -0.91 | 1.29 | 1.90 | -5.32 | -7.00 | -1.72 | 2.35 | 3.71 |
| Eisosomes | N/A | N/A | N/A | 2.39 | -2.46 | 2.65 | 6.82 | 4.07 | 2.06 | -2.12 | -2.11 | 7.00 | 0.35 | 1.52 | -2.74 |
| Endoplasmic Reticulum | N/A | N/A | N/A | -2.83 | 5.43 | -4.85 | -5.60 | -4.01 | -2.39 | 1.03 | -5.76 | -6.46 | -5.35 | -3.51 | 5.46 |
| Endosome | N/A | N/A | N/A | -1.65 | 10.66 | -4.74 | -9.27 | -3.72 | -2.77 | 1.65 | -4.96 | -15.02 | -4.99 | -3.07 | 10.21 |
| Golgi | N/A | N/A | N/A | -4.67 | -3.57 | -7.77 | -7.22 | -4.62 | -0.89 | -1.08 | -7.63 | -8.91 | -7.94 | -3.99 | -3.54 |
| Lipid Particles | N/A | N/A | N/A | 3.21 | 5.91 | -5.39 | -5.51 | 1.06 | 5.61 | 5.73 | -5.33 | -7.16 | 1.82 | 6.58 | 8.28 |
| Mitochondria | N/A | N/A | N/A | 1.83 | -14.04 | 8.87 | 12.61 | 6.49 | 2.26 | -0.19 | 8.20 | 22.86 | 8.26 | 2.55 | -10.26 |
| Mitotic Spindle | N/A | N/A | N/A | -2.18 | 3.52 | -3.07 | -5.31 | -2.15 | -0.88 | 0.76 | -3.70 | -7.60 | -3.67 | -1.41 | 3.33 |
| None | N/A | N/A | N/A | -1.68 | 2.67 | -2.84 | 2.36 | 2.01 | 4.24 | 0.21 | 3.37 | 3.24 | 3.61 | 1.79 | 2.09 |
| Nuclear Periphery | N/A | N/A | N/A | -2.73 | 4.80 | -4.50 | -5.76 | -2.75 | 0.48 | 2.00 | -4.61 | -7.99 | -4.08 | 0.75 | 5.48 |
| Nuclear Periphery Foci | N/A | N/A | N/A | -0.79 | 6.20 | -4.78 | -4.39 | -2.54 | -0.75 | 0.96 | -4.65 | -7.88 | -2.98 | -0.14 | 6.05 |
| Nucleolus | N/A | N/A | N/A | 1.61 | 5.11 | -2.09 | -2.65 | -2.28 | -1.00 | 0.18 | -3.25 | -6.12 | -2.51 | 0.49 | 4.10 |
| Nucleus | N/A | N/A | N/A | 0.66 | 5.51 | -3.49 | -3.69 | -2.35 | -1.99 | -0.36 | -2.03 | -6.51 | -2.92 | -0.61 | 5.22 |
| Peroxisomes | N/A | N/A | N/A | 4.12 | 0.06 | 3.58 | 1.89 | 1.55 | -1.20 | 0.15 | -0.03 | 1.96 | 1.71 | 2.01 | 0.09 |
| Vacuole | N/A | N/A | N/A | -2.74 | 10.22 | -6.15 | -10.21 | -4.48 | -3.02 | -2.11 | -6.22 | -18.54 | -5.68 | -3.40 | 5.17 |
| Vacuole Periphery | N/A | N/A | N/A | -5.11 | 7.62 | -8.48 | -10.38 | -6.15 | -2.67 | -1.30 | -6.93 | -17.31 | -7.87 | -3.94 | 4.81 |
| Standard name | |
|---|---|
| Human Ortholog | |
| Description (SGD) | Cysteine desulfurase involved in iron-sulfur cluster biogenesis; required for thio-modification of mitochondrial and cytoplasmic tRNAs; involved in DNA damage response by providing iron-sulfur cluster cofactors for DNA repair enzymes; essential protein located predominantly in mitochondria |
| Localization | |
| Cell Percentages | mitochondrion (100%) |
| Cell Cycle Regulation | No |
| Subcompartmental Group | mito-3 |
Nfs1
Nfs1
Nearest neighbours ( genes)
correlation threshold
0.80
