Standard name
Human Ortholog
Description Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0.15 0.23 0.11 0.05 0 0 0 0 0 0 0 0 0.14 0.13 0.07 – 0.29 – 0.1 0.12 0.14 0.14 0.14 0.1
Bud 0 0 0 0 0 0.05 0 0 0.06 0.06 0.09 0.06 0 0 0 – 0 – 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 – 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 – – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 – 0 0 0 0 0 0
Cytoplasm 0 0.06 0 0.06 0.05 0 0 0 0 0 0 0 0.06 0.06 0 – 0.29 – 0 0 0 0 0 0
Endoplasmic Reticulum 0.06 0.14 0.06 0.05 0 0 0 0 0 0 0 0 0.13 0.11 0 – 0 – 0 0 0 0 0 0
Endosome 0.08 0 0.09 0.1 0.17 0 0.07 0.05 0 0 0 0 0.05 0.09 0.08 – 0.12 – 0.15 0.14 0.12 0.11 0.08 0.08
Golgi 0.7 0.55 0.59 0.26 0.15 0 0 0 0 0 0 0 0.64 0.68 0.69 – 0.35 – 0.65 0.61 0.62 0.63 0.67 0.68
Mitochondria 0.41 0.53 0.54 0.75 0.71 0.9 0.86 0.84 0.94 0.91 0.94 0.92 0.27 0.17 0.16 – 0.18 – 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 – 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 – 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0.05 0.06 0.07 0.05 0.05 0.05 0.05 0 0 0 – 0 – 0 0 0 0 0 0
Peroxisomes 0 0 0 0.05 0.05 0 0.07 0.05 0 0 0 0 0 0 0 – 0 – 0 0 0.07 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 – 0 0 0 0 0 0
Vac/Vac Membrane 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0.09 0.09 – 0 – 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 68 62 46 13 4 6 7 19 10 4 10 10 16 21 12 – 5 – 52 40 67 43 50 41
Bud 2 9 5 6 13 23 22 30 26 31 50 32 1 2 2 – 0 – 4 4 1 1 1 1
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – 0 – 0 0 0 0 0 0
Bud Site 0 0 0 0 1 5 7 7 6 2 14 12 0 0 0 – 0 – – – – – – –
Cell Periphery 1 2 3 1 3 1 7 2 1 1 3 0 0 1 0 – 0 – 0 0 0 0 0 0
Cytoplasm 16 15 10 15 15 14 14 18 8 15 10 8 7 10 7 – 5 – 2 3 1 1 2 0
Endoplasmic Reticulum 28 38 23 12 5 7 3 11 5 6 14 6 15 18 4 – 0 – 7 8 2 3 6 11
Endosome 36 5 37 26 52 16 47 40 4 6 6 12 6 14 13 – 2 – 78 44 60 33 28 34
Golgi 319 147 242 69 45 17 12 26 10 7 4 24 72 111 118 – 6 – 343 196 306 199 251 289
Mitochondria 185 142 222 196 220 422 589 615 401 452 530 511 30 28 27 – 3 – 7 8 11 11 13 14
Nucleus 2 2 0 0 0 0 0 3 4 3 0 3 1 0 1 – 0 – 0 0 0 0 0 0
Nuclear Periphery 1 1 4 4 2 4 6 10 5 7 10 12 0 0 0 – 0 – 0 1 1 0 0 1
Nucleolus 8 0 7 7 8 25 39 52 23 27 27 29 1 0 1 – 0 – 0 0 0 0 0 0
Peroxisomes 0 0 15 12 14 11 51 36 8 13 22 14 0 0 2 – 0 – 10 2 36 14 10 17
SpindlePole 1 0 5 2 3 8 11 12 2 3 5 5 0 2 3 – 0 – 3 1 1 1 2 1
Vac/Vac Membrane 26 8 9 4 8 6 22 12 3 14 3 10 4 15 16 – 0 – 12 10 4 2 3 3
Unique Cell Count 454 266 411 263 309 467 684 731 426 498 565 556 113 163 170 17 527 325 498 315 375 423
Labelled Cell Count 693 431 628 367 393 565 837 893 516 591 708 688 153 222 206 21 527 325 498 315 375 423


Early Golgi, Late Golgi

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 12.6 13.0 10.5 9.8 9.2 8.2 8.0 8.0 7.6 7.1 7.0 7.4 10.7 11.5 11.8 – 9.8 – 11.7 12.2 12.7
Std Deviation (1e-4) 1.8 2.2 1.7 1.7 1.8 1.7 1.8 1.8 1.7 1.5 1.7 1.8 2.0 2.0 2.2 – 2.2 – 1.8 1.8 1.8
Intensity Change (Log2) – – – -0.1 -0.2 -0.37 -0.4 -0.4 -0.48 -0.57 -0.59 -0.51 0.02 0.12 0.17 – -0.1 – 0.15 0.21 0.27

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000510WT3HU80HU120HU1600510WT3rpd3Δ_20510WT1AF100AF140AF1800510
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -2.8 -5.2 -6.2 -7.6 -6.0 -5.1 -6.8 -6.2 -6.2 0.9 0.6 -1.5 – 0 –
Bud 0 2.5 3.1 2.1 2.7 3.7 3.9 5.1 3.6 0 0 0 – 0 –
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 – 0 –
Bud Site 0 0 0 0 0 0 0 3.2 3.0 0 0 0 – 0 –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 – 0 –
Cytoplasm 2.2 1.8 0.5 -0.4 0 -0.6 0.5 -0.7 -1.1 0 2.2 0 – 0 –
Endoplasmic Reticulum -0.6 -2.7 -3.3 -5.4 -3.9 -3.6 -3.7 -2.5 -4.1 2.8 2.3 -1.7 – 0 –
Endosome 0.4 3.2 -3.5 -1.3 -2.3 -5.4 -5.5 -6.0 -4.8 -1.3 -0.2 -0.5 – 0 –
Golgi -8.3 -12.0 -17.9 -21.7 -21.2 -17.8 -19.3 -20.7 -18.8 0.9 2.0 2.4 – -1.9 –
Mitochondria 5.4 4.7 12.2 11.7 11.0 13.3 12.6 14.6 13.6 -5.2 -8.0 -8.5 – -2.9 –
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 – 0 –
Nuclear Periphery 0 0 0 0 0.6 0 0 1.0 1.4 0 0 0 – 0 –
Nucleolus 0.9 0.8 2.9 3.2 4.0 2.9 2.9 2.6 2.9 0 0 0 – 0 –
Peroxisomes 0.6 0.6 -1.1 2.6 1.0 -1.6 -0.9 0.2 -1.0 0 0 0 – 0 –
SpindlePole 0 0 0.6 0.5 0.6 0 0 0 0 0 0 0 – 0 –
Vacuole -0.6 0.3 -1.0 1.0 -0.7 -1.8 0.6 -2.3 -0.4 0 3.8 3.9 – 0 –

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 7.5376 8.7902 8.4782 8.0707 7.3575 8.242 8.0191 10.1815 9.9369 9.3654 8.3437 9.6294 10.8668 11.356 10.3221 9.9648 10.9148 10.1762
Actin 0.0621 0.0197 0.0178 0.0045 0.0301 0.0298 0.0583 0.035 0.0187 0.0109 0.0091 0.0277 0.0239 0.1267 0.0713 0.0166 0.0008 0.0534
Bud 0.0007 0.0008 0.0003 0.0001 0.0003 0.0002 0.0006 0.0001 0.0002 0.0002 0.0002 0.0002 0.0003 0.0003 0.0006 0.0001 0 0.0002
Bud Neck 0.0021 0.0008 0.0005 0.0003 0.0007 0.0008 0.0006 0.0003 0.0006 0.0007 0.0008 0.0006 0.0009 0.0006 0.0014 0.0004 0.0001 0.0012
Bud Periphery 0.0009 0.0004 0.0002 0.0001 0.0003 0.0002 0.0007 0.0001 0.0002 0.0001 0.0002 0.0002 0.0002 0.0002 0.0005 0.0001 0 0.0001
Bud Site 0.0068 0.008 0.0004 0.0002 0.0004 0.0003 0.0013 0.0009 0.0005 0.0004 0.0004 0.0002 0.0006 0.0024 0.0062 0.0004 0 0.0003
Cell Periphery 0.0003 0.0002 0.0001 0 0.0002 0.0001 0.0001 0 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0002 0.0005 0 0.0001
Cytoplasm 0.0073 0.01 0.0023 0.0015 0.0027 0.0032 0.0021 0.0037 0.0014 0.0014 0.0016 0.002 0.0014 0.0304 0.0018 0.0117 0.0003 0.0012
Cytoplasmic Foci 0.1193 0.1633 0.0947 0.0883 0.0773 0.0733 0.0666 0.1583 0.1106 0.0838 0.1249 0.0633 0.1293 0.1755 0.1136 0.0903 0.069 0.065
Eisosomes 0.0003 0.0001 0.0001 0 0.0006 0.0001 0.0003 0 0.0003 0.0001 0 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0001
Endoplasmic Reticulum 0.0079 0.0026 0.0018 0.0005 0.002 0.0024 0.0019 0.0007 0.0004 0.0008 0.0014 0.002 0.0003 0.0072 0.0005 0.1055 0.0002 0.0006
Endosome 0.1968 0.2418 0.216 0.2763 0.2553 0.1985 0.1418 0.1917 0.1775 0.1326 0.2277 0.1562 0.1215 0.1225 0.1607 0.1863 0.1108 0.1322
Golgi 0.4134 0.4899 0.5639 0.5865 0.5818 0.6332 0.562 0.5505 0.6151 0.6974 0.5533 0.6918 0.5557 0.4588 0.5413 0.5519 0.809 0.709
Lipid Particles 0.0792 0.0262 0.0553 0.0173 0.0231 0.0241 0.0787 0.0441 0.0155 0.0543 0.0353 0.0159 0.0482 0.0202 0.0308 0.0257 0.0061 0.0131
Mitochondria 0.0289 0.0109 0.0164 0.0168 0.0107 0.0232 0.0247 0.0023 0.0251 0.0076 0.008 0.0201 0.0337 0.0054 0.0078 0.0031 0.0021 0.0062
None 0.0119 0.0001 0.0059 0 0.0019 0.0001 0.0027 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0002 0.0005 0.0002 0 0
Nuclear Periphery 0.0124 0.0006 0.0013 0.0002 0.003 0.0008 0.0082 0.0002 0.0001 0.0003 0.0003 0.0004 0.0001 0.0026 0.0003 0.0017 0 0.0001
Nucleolus 0.0008 0.0005 0.0001 0 0.0001 0.0001 0.0011 0.0001 0 0 0 0 0.0001 0.0001 0.0004 0 0 0
Nucleus 0.004 0.0005 0.0003 0 0.0003 0.0002 0.0017 0.0001 0 0 0.0001 0.0001 0 0.0007 0.0003 0.0002 0 0
Peroxisomes 0.0306 0.0137 0.0164 0.0035 0.0039 0.0053 0.017 0.0097 0.032 0.0075 0.0333 0.016 0.0819 0.0433 0.0566 0.0025 0.001 0.0156
Punctate Nuclear 0.0071 0.0014 0.0025 0.0001 0.0015 0.0005 0.0259 0.0004 0.0002 0.0003 0.0006 0.0002 0.0004 0.0011 0.0032 0.0002 0 0.0001
Vacuole 0.0038 0.0068 0.0021 0.0014 0.0017 0.0016 0.0016 0.001 0.0006 0.0007 0.0011 0.0012 0.0005 0.0011 0.0011 0.0015 0.0001 0.0006
Vacuole Periphery 0.0032 0.0019 0.0019 0.0021 0.0023 0.0021 0.0021 0.0007 0.0007 0.0008 0.0014 0.0017 0.0007 0.0005 0.001 0.0011 0.0005 0.0009

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 34.8543 21.0951 25.9092 32.4101 31.1232 24.3981 30.7067 30.6944 28.8487 39.0506
Translational Efficiency 0.4382 0.5653 0.5641 0.4582 0.4068 0.6291 0.4012 0.3507 0.3904 0.3473

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✔
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1184 1569 1200 1337 1998 1577 604 2004 3182 3146 1804 3341

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1048.18 1180.46 1334.29 1252.23 884.72 1104.27 1254.58 1300.88 945.54 1142.27 1307.60 1281.41
Standard Deviation 130.00 181.14 190.51 189.70 134.92 162.93 215.99 187.15 154.79 176.41 202.92 189.68
Intensity Change Log 2 — 0.171463 0.348186 0.256613 — 0.319800 0.503912 0.556195 — 0.241257 0.421556 0.401489

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.023219 0.014348 0.012692 0.137564 0.007909 0.004865 0.036881 0.035147 0.013606 0.009594 0.020791 0.076132
Bud Neck 0.000521 0.000166 0.001233 0.006666 0.000561 0.000254 0.001666 0.000512 0.000546 0.000210 0.001378 0.002974
Bud Site 0.012367 0.002191 0.005346 0.119770 0.003488 0.001574 0.007329 0.017992 0.006792 0.001882 0.006010 0.058722
Cell Periphery 0.000278 0.000087 0.000152 0.038704 0.000175 0.000081 0.000179 0.001186 0.000214 0.000084 0.000161 0.016200
Cytoplasm 0.003007 0.001120 0.000945 0.016464 0.001087 0.000870 0.001002 0.004584 0.001801 0.000994 0.000964 0.009338
Cytoplasmic Foci 0.182418 0.203226 0.198529 0.082650 0.149471 0.227653 0.188338 0.129822 0.161730 0.215471 0.195117 0.110945
Eisosomes 0.000128 0.000087 0.000066 0.001661 0.000118 0.000051 0.000139 0.000196 0.000122 0.000069 0.000091 0.000782
Endoplasmic Reticulum 0.001747 0.000897 0.006222 0.012889 0.000930 0.000591 0.003809 0.002971 0.001234 0.000744 0.005414 0.006940
Endosome 0.200233 0.136424 0.166225 0.110615 0.203523 0.216319 0.185186 0.137985 0.202299 0.176473 0.172573 0.127032
Golgi 0.536233 0.606471 0.523467 0.417913 0.510449 0.497625 0.505399 0.637712 0.520043 0.551910 0.517418 0.549753
Lipid Particles 0.006527 0.009158 0.036528 0.015827 0.011295 0.011264 0.031915 0.005664 0.009521 0.010213 0.034984 0.009731
Mitochondria 0.008895 0.013303 0.001752 0.012219 0.089851 0.017819 0.002608 0.003974 0.059728 0.015567 0.002038 0.007274
Mitotic Spindle 0.004944 0.001762 0.008581 0.003578 0.001605 0.003243 0.008579 0.003366 0.002848 0.002504 0.008581 0.003451
None 0.000023 0.000145 0.000018 0.000095 0.000122 0.000046 0.000026 0.000031 0.000085 0.000095 0.000021 0.000056
Nuclear Periphery 0.000070 0.000035 0.000477 0.000054 0.000054 0.000089 0.000262 0.000049 0.000060 0.000062 0.000405 0.000051
Nuclear Periphery Foci 0.000586 0.000199 0.005978 0.000678 0.000281 0.000625 0.003440 0.000502 0.000395 0.000413 0.005128 0.000572
Nucleolus 0.000014 0.000008 0.000006 0.000011 0.000259 0.000146 0.000005 0.000004 0.000168 0.000077 0.000005 0.000007
Nucleus 0.000045 0.000693 0.000023 0.000219 0.000662 0.000102 0.000029 0.000023 0.000433 0.000397 0.000025 0.000102
Peroxisomes 0.003666 0.002810 0.001196 0.006075 0.007620 0.004467 0.004000 0.001567 0.006149 0.003641 0.002135 0.003371
Vacuole 0.009458 0.003275 0.024177 0.011453 0.004463 0.006094 0.015228 0.010017 0.006322 0.004688 0.021181 0.010591
Vacuole Periphery 0.005621 0.003596 0.006387 0.004894 0.006076 0.006222 0.003979 0.006697 0.005906 0.004912 0.005580 0.005975

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 2.80 3.23 -16.17 -18.39 -18.54 2.38 -6.23 -9.30 -10.58 0.32 2.68 -3.18 -18.25 -20.03 -14.80
Bud Neck 4.77 -3.76 -8.96 -9.55 -7.71 2.40 -2.98 0.34 -3.51 3.23 4.04 -4.54 -8.33 -9.86 -4.87
Bud Site 6.06 3.95 -18.00 -20.48 -19.82 3.14 -3.63 -8.52 -10.15 -5.84 6.61 0.88 -19.03 -21.54 -19.62
Cell Periphery 3.34 2.20 -9.78 -9.83 -9.81 4.87 -0.18 -2.46 -2.69 -2.45 5.31 2.11 -9.85 -9.93 -9.89
Cytoplasm 3.39 4.06 -8.76 -10.36 -10.61 1.09 0.58 -5.12 -5.44 -5.34 3.19 3.72 -10.15 -11.41 -11.60
Cytoplasmic Foci -3.99 -2.70 21.78 27.27 22.06 -16.20 -5.87 5.35 20.75 8.95 -15.38 -7.79 17.53 31.90 20.52
Eisosomes 3.32 5.12 -6.68 -6.87 -6.96 9.67 -1.67 -4.86 -9.67 -3.07 8.21 4.19 -7.10 -7.68 -7.44
Endoplasmic Reticulum 2.81 -5.42 -8.35 -9.17 -4.39 2.00 -5.07 -6.16 -7.78 1.39 3.15 -7.40 -9.91 -11.05 -1.94
Endosome 12.14 5.99 16.89 5.98 11.59 -2.29 2.73 14.36 15.51 7.66 6.61 7.11 21.63 14.55 12.33
Golgi -8.26 1.30 10.56 18.10 8.99 1.66 0.47 -16.87 -17.63 -11.32 -5.58 0.41 -4.36 0.46 -3.98
Lipid Particles -1.78 -10.46 -4.91 -3.46 6.53 -0.00 -5.16 3.93 3.43 6.77 -0.56 -10.81 -0.23 0.36 10.79
Mitochondria -2.00 4.56 -1.70 0.52 -7.21 15.79 20.32 20.43 6.99 -1.10 14.58 20.55 18.56 5.86 -6.15
Mitotic Spindle 2.60 -2.17 1.02 -2.63 3.63 -2.04 -3.18 -2.38 -0.19 2.31 0.54 -4.76 -0.96 -1.68 4.31
None -1.17 1.82 -9.73 0.55 -10.58 2.19 3.47 3.29 0.75 -0.86 -0.26 3.71 1.67 0.79 -8.47
Nuclear Periphery 1.54 -4.22 0.68 -3.31 4.51 -1.43 -4.50 0.31 1.87 4.76 -0.13 -5.30 0.66 0.95 5.52
Nuclear Periphery Foci 1.71 -5.07 -0.34 -2.41 5.00 -2.10 -3.41 -1.43 0.58 3.14 -0.15 -6.21 -1.22 -1.15 5.94
Nucleolus 0.67 1.23 0.40 -0.58 -4.16 0.86 2.22 2.22 1.36 0.42 1.13 2.25 2.23 1.34 -1.91
Nucleus -1.29 1.24 -4.93 0.95 -6.43 1.39 1.55 1.56 1.49 1.00 0.24 1.59 1.33 1.17 -6.11
Peroxisomes 1.47 4.97 -2.88 -4.10 -6.62 3.36 3.73 8.34 4.46 3.33 4.23 7.47 4.92 0.58 -2.99
Vacuole 7.61 -8.21 -1.55 -7.20 6.38 -2.42 -7.86 -6.86 -4.12 3.39 3.49 -12.23 -5.94 -8.35 7.92
Vacuole Periphery 3.34 -1.07 1.13 -3.03 2.58 -0.18 4.42 -0.77 -0.44 -3.21 2.02 0.72 -0.13 -1.70 -0.66
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Trans-golgi network aminophospholipid translocase (flippase); maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation, endocytosis, protein trafficking between the Golgi and endosomal system and the cellular response to mating pheromone; autoinhibited by its C-terminal tail; localizes to the trans-Golgi network; mutations in human homolog ATP8B1 result in liver disease
Localization
Cell Percentages Golgi (30%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Drs2

Drs2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Drs2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available