Standard name
Human Ortholog
Description HDEL receptor; an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 0 0.2 0.1 0.07 0.08 0.12 0.1 0.14 0.15 0.17 0.16 0.19 0.15 0.14 0.18 0.2 0.21 0.09 0 0.05 0.05 0.05 0
Bud – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.06 0 0.05 0 0 0 0 0 0
Bud Neck – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery – 0 0 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0.06 0 0 0 0 0 0 0
Cytoplasm – 0.22 0 0.13 0.1 0.14 0.1 0.11 0.1 0.09 0.11 0.07 0.08 0.09 0.09 0.21 0.17 0.19 0.06 0 0 0 0 0
Endoplasmic Reticulum – 0.81 0.87 0.81 0.86 0.84 0.78 0.72 0.73 0.68 0.7 0.72 0.82 0.78 0.75 0 0 0 0.77 0.88 0.84 0.8 0.81 0.84
Endosome – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi – 0 0.14 0.15 0 0 0.06 0.07 0.07 0.1 0.1 0.07 0.22 0.24 0.27 0.52 0.56 0.53 0 0 0.06 0.09 0 0
Mitochondria – 0 0 0 0 0 0 0.08 0.14 0.1 0.24 0.17 0 0 0 0.08 0.06 0.08 0.05 0 0 0 0 0
Nucleus – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane – 0 0 0 0 0 0.06 0.05 0.05 0.13 0 0.06 0 0 0 0.1 0.05 0.09 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches – 4 25 18 22 23 42 32 45 62 56 70 106 104 105 30 31 31 1 3 6 21 24 27
Bud – 0 2 1 1 2 8 1 6 6 14 14 12 9 6 10 2 7 0 0 1 0 4 5
Bud Neck – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 1
Bud Site – 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery – 2 0 1 10 11 7 15 14 18 10 16 5 17 26 3 9 5 0 0 0 0 0 3
Cytoplasm – 25 5 23 31 38 36 33 33 37 35 29 42 61 64 35 26 29 1 3 1 5 8 14
Endoplasmic Reticulum – 93 111 143 272 228 274 223 234 285 231 319 451 535 550 2 6 2 13 105 113 311 392 565
Endosome – 0 2 1 1 0 1 2 3 6 3 5 0 0 1 4 5 2 0 0 1 2 6 4
Golgi – 5 18 26 14 5 20 21 21 40 32 31 119 166 197 87 86 80 0 2 8 33 21 27
Mitochondria – 0 0 1 4 10 12 25 45 43 78 75 0 0 0 14 9 12 0 0 0 2 8 6
Nucleus – 0 0 0 0 0 1 4 0 1 0 1 0 0 0 0 1 0 0 0 0 0 0 0
Nuclear Periphery – 0 1 0 0 1 0 4 2 5 6 9 0 0 0 0 1 1 0 0 0 1 2 1
Nucleolus – 0 0 0 0 0 4 3 0 4 1 2 0 1 0 2 1 0 0 0 0 0 0 0
Peroxisomes – 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0
SpindlePole – 0 0 0 0 0 0 0 0 0 0 0 1 3 0 0 1 2 0 0 0 0 0 0
Vac/Vac Membrane – 1 1 2 5 2 22 15 15 53 11 25 13 17 17 16 8 13 0 1 0 4 8 13
Unique Cell Count 115 127 176 315 271 351 310 320 419 328 442 553 688 738 168 154 151 18 120 135 388 485 676
Labelled Cell Count 130 165 216 360 320 427 378 418 560 477 596 749 914 966 203 186 184 18 120 135 388 485 676


Endoplasmic Reticulum

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) – 36.2 22.1 22.0 21.5 21.1 18.8 18.1 17.6 16.8 16.5 16.9 26.1 28.1 28.5 24.2 27.1 27.9 30.0 30.4 32.2
Std Deviation (1e-4) – 6.5 4.7 4.6 4.4 3.8 3.9 4.3 4.2 3.5 3.5 4.1 5.5 6.1 6.0 8.1 8.0 9.6 5.8 7.4 7.2
Intensity Change (Log2) – – – -0.01 -0.04 -0.07 -0.23 -0.29 -0.33 -0.39 -0.42 -0.39 0.24 0.35 0.37 0.13 0.29 0.34 0.44 0.46 0.54


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches -2.3 -3.9 -3.2 -2.1 -2.6 -1.5 -1.3 -0.7 -1.0 -0.1 -1.3 -1.6 -0.4 0.1 0.2
Bud 0 0 0 0 0 0 0 0 0 0 0 0 1.9 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 2.7 2.1 3.0 2.2 2.3 2.2 1.8 2.3 1.1 1.5 1.9 1.8 4.2 3.4 3.9
Endoplasmic Reticulum -1.4 -0.3 -0.9 -2.3 -3.5 -3.2 -4.3 -3.8 -3.5 -1.6 -2.5 -3.2 -15.1 -14.1 -14.6
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0.1 -3.6 -4.9 -3.0 -2.5 -2.6 -1.5 -1.4 -2.5 1.9 2.5 3.0 6.7 7.2 6.7
Mitochondria 0 0 0 0 3.3 4.5 3.8 6.0 5.0 0 0 0 3.3 0 3.2
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vacuole 0 0 0 2.5 0 0 3.9 0 2.3 0 0 0 3.2 0 3.0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 17.8117 20.8255 17.6644 19.2864 16.8281 18.9095 16.6082 19.4561 19.7597 16.7384 17.9602 20.0909 19.1375 23.7088 21.847 21.3437 11.3155 23.2393
Actin 0.0143 0.0255 0.0229 0.001 0.0039 0.0084 0.0188 0.0245 0.0337 0.011 0.003 0.012 0.0266 0.0069 0.0151 0.0039 0.1783 0.0103
Bud 0.0001 0.0023 0.0004 0 0.0002 0.0009 0.0004 0.0004 0.0004 0.0001 0.0001 0.0003 0.0006 0 0.0002 0 0.0012 0.0001
Bud Neck 0.0016 0.001 0.001 0.0001 0.0004 0.0014 0.0005 0.0007 0.0008 0.0004 0.0005 0.0027 0.0011 0.0004 0.0015 0.0009 0.0012 0.0011
Bud Periphery 0.0002 0.0022 0.0009 0 0.0003 0.0006 0.0004 0.0003 0.0005 0.0001 0.0004 0.0003 0.0014 0 0.0002 0.0001 0.0016 0.0001
Bud Site 0.0008 0.0127 0.0011 0 0.0008 0.0002 0.0017 0.0122 0.0006 0.0003 0 0.0009 0.0009 0.0001 0.0037 0 0.0039 0
Cell Periphery 0.0023 0.0059 0.003 0.0008 0.0016 0.001 0.0018 0.0022 0.0022 0.0009 0.0008 0.0008 0.0016 0.0031 0.0022 0.0018 0.0017 0.0009
Cytoplasm 0.0267 0.0773 0.0341 0.0061 0.0068 0.0248 0.0362 0.0395 0.0249 0.0125 0.0131 0.0311 0.0224 0.0356 0.0195 0.0098 0.008 0.0148
Cytoplasmic Foci 0.0207 0.0182 0.0211 0.0054 0.0228 0.015 0.0446 0.0439 0.0129 0.0178 0.0072 0.0135 0.0189 0.025 0.0212 0.0106 0.0299 0.0184
Eisosomes 0.0009 0.0008 0.0003 0 0.0002 0.0003 0.0005 0.0004 0.0002 0.0001 0.0002 0.0005 0.0004 0.0022 0.0003 0.0008 0.0024 0.0001
Endoplasmic Reticulum 0.66 0.6258 0.6757 0.8637 0.7172 0.66 0.5109 0.5754 0.7123 0.685 0.7316 0.6484 0.4925 0.567 0.5613 0.7172 0.3707 0.4518
Endosome 0.0626 0.0456 0.0649 0.0276 0.0499 0.0632 0.0789 0.0616 0.0487 0.0616 0.0771 0.064 0.061 0.052 0.0571 0.0607 0.08 0.0776
Golgi 0.0894 0.076 0.0978 0.0511 0.1058 0.1678 0.1648 0.1581 0.1065 0.1703 0.1339 0.1787 0.2513 0.1953 0.2383 0.1306 0.152 0.3264
Lipid Particles 0.0517 0.0907 0.0404 0.0366 0.0489 0.0232 0.0792 0.0565 0.0185 0.0247 0.009 0.0166 0.051 0.1019 0.0582 0.0359 0.1024 0.064
Mitochondria 0.0042 0.0019 0.0128 0.0006 0.0155 0.0035 0.0136 0.0017 0.0044 0.0013 0.0038 0.0065 0.0024 0.0005 0.0015 0.0009 0.0268 0.0013
None 0.0133 0.0004 0.0016 0.0001 0.0005 0.0005 0.0027 0.0076 0.0006 0.0022 0.001 0.0058 0.011 0.0002 0.0009 0.0005 0.0029 0.0002
Nuclear Periphery 0.028 0.0057 0.0082 0.0042 0.0128 0.0164 0.0216 0.0077 0.0216 0.0043 0.0098 0.0113 0.034 0.0067 0.0102 0.0203 0.015 0.0273
Nucleolus 0.0018 0.0001 0.0002 0 0.0001 0.0003 0.001 0.0001 0.0001 0.0001 0 0.0003 0.0006 0 0.0002 0 0.0003 0
Nucleus 0.0028 0.0007 0.0006 0.0001 0.0003 0.0035 0.0037 0.0005 0.0014 0.0002 0.0003 0.0011 0.0033 0.0002 0.0011 0.0004 0.0009 0.0004
Peroxisomes 0.0031 0.0004 0.0038 0.0001 0.006 0.0007 0.0036 0.001 0.0005 0.0002 0.0001 0.0004 0.0026 0.0002 0.0014 0.0001 0.0084 0.0002
Punctate Nuclear 0.0065 0.0005 0.0017 0.0001 0.0007 0.0016 0.0083 0.001 0.0024 0.0005 0.0002 0.0005 0.0077 0.0002 0.0011 0.0002 0.0015 0.0003
Vacuole 0.0054 0.0053 0.0052 0.0013 0.0025 0.0038 0.0036 0.0033 0.0036 0.0047 0.0047 0.0026 0.005 0.0015 0.003 0.0026 0.0074 0.0017
Vacuole Periphery 0.0035 0.0011 0.0024 0.0009 0.0027 0.003 0.0034 0.0013 0.0033 0.0017 0.0033 0.0019 0.0036 0.0009 0.0019 0.0025 0.0034 0.0029

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 66.873 31.3847 45.4686 55.6486 42.2681 43.4434 49.8662 58.1336 46.3165 73.2392
Translational Efficiency 1.3839 1.9865 1.2104 1.0812 1.743 2.1375 1.4207 1.1178 1.4347 1.1894

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1269 956 304 2132 1707 1870 1807 1360 2976 2826 2111 3492

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1868.48 1832.56 2592.31 2501.83 1856.72 1764.82 2096.15 2254.79 1861.73 1787.74 2167.60 2405.62
Standard Deviation 387.71 497.03 505.71 736.53 426.72 339.25 479.57 592.88 410.58 400.94 513.85 694.70
Intensity Change Log 2 — -0.028005 0.472373 0.421119 — -0.073235 0.174986 0.280237 — -0.050371 0.331796 0.352619

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.003216 0.004454 0.001848 0.008498 0.002415 0.004243 0.002172 0.004610 0.002757 0.004314 0.002125 0.006984
Bud Neck 0.000554 0.000687 0.008232 0.002078 0.000384 0.000353 0.000822 0.001514 0.000457 0.000466 0.001890 0.001858
Bud Site 0.001828 0.002068 0.003214 0.002485 0.001390 0.001608 0.001313 0.003243 0.001577 0.001764 0.001587 0.002780
Cell Periphery 0.001635 0.001719 0.012017 0.003055 0.002036 0.002156 0.003031 0.005688 0.001865 0.002008 0.004325 0.004081
Cytoplasm 0.000791 0.001261 0.000448 0.000750 0.000667 0.001294 0.001276 0.001337 0.000720 0.001283 0.001157 0.000978
Cytoplasmic Foci 0.005074 0.011748 0.002226 0.007529 0.005374 0.008135 0.006173 0.004918 0.005246 0.009357 0.005604 0.006512
Eisosomes 0.000234 0.000443 0.000429 0.000518 0.000236 0.000308 0.000350 0.000888 0.000235 0.000354 0.000361 0.000662
Endoplasmic Reticulum 0.806485* 0.615367* 0.600153* 0.485127* 0.846073* 0.806711* 0.652344* 0.494328* 0.829192* 0.741982* 0.644828* 0.488710*
Endosome 0.046631 0.076775 0.058633 0.054274 0.033001 0.045080 0.047147 0.046169 0.038813 0.055802 0.048801 0.051117
Golgi 0.042505 0.097117 0.042429 0.153137* 0.043851 0.045605 0.080519 0.146545* 0.043277 0.063031 0.075034 0.150570*
Lipid Particles 0.082281 0.159418* 0.171293* 0.254020* 0.055214 0.072853 0.186005* 0.269430* 0.066756 0.102137* 0.183887* 0.260021*
Mitochondria 0.000100 0.000227 0.000085 0.000132 0.000589 0.000657 0.000076 0.000442 0.000380 0.000512 0.000077 0.000253
Mitotic Spindle 0.000267 0.000237 0.001071 0.000368 0.000153 0.000093 0.000525 0.000091 0.000202 0.000142 0.000604 0.000260
None 0.000269 0.000703 0.000115 0.000512 0.000580 0.001821 0.000626 0.000279 0.000447 0.001443 0.000552 0.000421
Nuclear Periphery 0.000306 0.000397 0.005361 0.001192 0.000302 0.000211 0.000603 0.000753 0.000304 0.000274 0.001288 0.001021
Nuclear Periphery Foci 0.003427 0.010787 0.037635 0.008648 0.002886 0.002410 0.006041 0.004359 0.003117 0.005244 0.010591 0.006978
Nucleolus 0.000001 0.000012 0.000006 0.000004 0.000003 0.000003 0.000002 0.000195 0.000002 0.000006 0.000002 0.000079
Nucleus 0.000028 0.000064 0.000077 0.000063 0.000043 0.000040 0.000039 0.000173 0.000037 0.000048 0.000044 0.000106
Peroxisomes 0.000079 0.000441 0.000053 0.000189 0.000120 0.000501 0.000413 0.000221 0.000102 0.000481 0.000362 0.000202
Vacuole 0.003267 0.011876 0.051735 0.014237 0.003210 0.004281 0.009035 0.011669 0.003234 0.006850 0.015184 0.013237
Vacuole Periphery 0.001022 0.004198 0.002939 0.003186 0.001474 0.001639 0.001487 0.003149 0.001281 0.002504 0.001696 0.003172

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.11 1.21 -4.19 -3.14 -5.24 -1.83 0.38 -2.47 -0.35 -3.22 -2.04 1.17 -5.21 -2.94 -6.67
Bud Neck -1.16 -6.71 -6.87 -6.34 5.28 0.41 -3.03 -4.00 -4.15 -2.25 -0.14 -6.75 -8.12 -8.18 0.07
Bud Site -0.48 -1.72 -1.60 -1.31 1.07 -0.76 0.19 -2.27 -2.01 -2.39 -0.72 -0.31 -3.14 -2.83 -3.06
Cell Periphery -0.59 -6.76 -6.67 -6.11 5.81 -0.43 -4.62 -4.96 -4.65 -3.58 -0.78 -8.62 -6.99 -6.03 0.61
Cytoplasm -1.12 0.56 -0.03 1.21 -0.66 -3.32 -3.88 -0.99 -0.07 -0.13 -2.96 -3.03 -1.03 0.85 0.53
Cytoplasmic Foci -5.02 2.77 -2.57 3.69 -6.64 -2.87 -0.91 0.55 3.75 1.66 -5.28 -0.49 -1.99 4.22 -1.51
Eisosomes -1.47 -2.04 -5.43 -0.53 -0.95 -1.64 -2.44 -5.20 -4.53 -4.18 -2.10 -2.97 -7.53 -4.20 -4.77
Endoplasmic Reticulum 13.52 9.36 30.83 9.36 4.99 4.83 20.23 32.81 28.40 13.01 11.70 21.38 46.94 30.87 16.67
Endosome -7.70 -2.41 -3.22 6.30 0.95 -5.78 -7.21 -6.33 -0.48 0.50 -8.65 -5.48 -8.12 2.47 -1.29
Golgi -10.65 0.07 -24.89 -9.33 -20.90* -0.61 -10.28 -20.05 -19.82 -12.01 -7.61 -10.62 -32.23 -24.18 -19.37
Lipid Particles -8.71 -6.14 -24.34 -10.37 -5.52 -3.88 -20.17 -26.73 -23.98 -8.86 -8.07 -19.73 -38.13 -28.43 -11.09
Mitochondria -1.82 0.22 -1.06 1.31 -1.44 -0.16 1.76 0.38 0.51 -1.44 -0.47 1.80 0.63 1.03 -1.78
Mitotic Spindle 0.20 -1.75 -0.90 -1.11 1.41 0.98 -1.21 1.06 0.12 1.38 0.81 -1.46 -0.94 -1.66 1.15
None -1.53 1.54 -2.33 0.69 -4.71 -1.93 -0.24 2.05 2.45 2.67 -2.29 -0.78 0.28 2.39 1.19
Nuclear Periphery -1.96 -7.69 -8.21 -7.13 6.24 2.36 -4.49 -5.62 -7.43 -1.54 1.05 -8.59 -9.71 -10.35 1.97
Nuclear Periphery Foci -4.49 -6.05 -6.86 1.09 5.08 0.82 -3.76 -1.94 -3.63 2.21 -3.14 -7.02 -6.76 -2.58 3.25
Nucleolus -2.50 -4.15 -3.97 1.65 0.72 0.57 1.33 -1.00 -1.01 -1.01 -2.01 0.29 -1.02 -0.98 -1.03
Nucleus -2.44 -3.35 -6.74 -0.09 1.15 0.20 0.34 -1.09 -1.11 -1.13 -1.34 -1.24 -1.52 -1.26 -1.33
Peroxisomes -1.62 0.77 -3.12 1.12 -2.96 -2.09 -2.87 -1.43 1.45 1.59 -2.66 -2.99 -2.75 1.93 1.75
Vacuole -5.99 -8.92 -13.20 -1.64 6.83 -1.60 -7.98 -10.32 -7.91 -2.47 -5.49 -11.51 -16.80 -8.01 1.75
Vacuole Periphery -3.39 -4.68 -10.32 1.03 -0.66 -0.54 -0.07 -4.83 -4.70 -5.96 -3.30 -2.30 -9.42 -1.89 -8.43
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description HDEL receptor; an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins
Localization
Cell Percentages ER (98%)
Cell Cycle Regulation No
Subcompartmental Group ER-5

Erd2

Erd2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Erd2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
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