Standard name | |
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Human Ortholog | |
Description | One of two mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth; see also PTH1 |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 1 | 3 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 1 | 0 | 6 | 2 | 0 | 6 | 3 | 0 | 3 | 6 | 4 | 5 | 24 | 21 |
Bud | 1 | 4 | 3 | 4 | 3 | 3 | 9 | – | 12 | 15 | 22 | 15 | 8 | 2 | 3 | 1 | 0 | 0 | 0 | 3 | 0 | 1 | 5 | 5 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 9 | 7 |
Bud Site | 1 | 1 | 0 | 1 | 0 | 2 | 2 | – | 2 | 6 | 6 | 9 | 0 | 0 | 0 | 0 | 0 | 1 | – | – | – | – | – | – |
Cell Periphery | 6 | 11 | 6 | 11 | 3 | 1 | 6 | – | 5 | 4 | 1 | 2 | 6 | 4 | 3 | 3 | 7 | 1 | 0 | 1 | 0 | 1 | 1 | 0 |
Cytoplasm | 6 | 31 | 17 | 24 | 26 | 14 | 25 | – | 20 | 10 | 16 | 18 | 34 | 77 | 138 | 5 | 1 | 6 | 0 | 2 | 4 | 1 | 5 | 4 |
Endoplasmic Reticulum | 5 | 27 | 0 | 0 | 0 | 0 | 0 | – | 1 | 2 | 2 | 3 | 10 | 2 | 1 | 2 | 4 | 2 | 1 | 3 | 1 | 2 | 3 | 8 |
Endosome | 16 | 2 | 14 | 39 | 39 | 6 | 53 | – | 6 | 14 | 13 | 8 | 42 | 46 | 96 | 2 | 1 | 2 | 28 | 19 | 6 | 24 | 35 | 42 |
Golgi | 7 | 7 | 6 | 0 | 4 | 0 | 0 | – | 0 | 0 | 0 | 1 | 4 | 2 | 5 | 16 | 18 | 11 | 15 | 19 | 5 | 9 | 18 | 19 |
Mitochondria | 206 | 200 | 39 | 101 | 53 | 121 | 156 | – | 175 | 210 | 290 | 299 | 163 | 139 | 129 | 7 | 3 | 1 | 181 | 209 | 109 | 205 | 221 | 199 |
Nucleus | 0 | 2 | 0 | 1 | 2 | 7 | 9 | – | 4 | 2 | 6 | 6 | 4 | 4 | 2 | 1 | 1 | 4 | 0 | 0 | 0 | 0 | 1 | 1 |
Nuclear Periphery | 7 | 3 | 0 | 0 | 0 | 0 | 3 | – | 5 | 1 | 4 | 2 | 1 | 0 | 0 | 0 | 1 | 3 | 2 | 2 | 0 | 2 | 1 | 5 |
Nucleolus | 2 | 1 | 0 | 1 | 0 | 5 | 7 | – | 3 | 3 | 14 | 6 | 1 | 0 | 1 | 1 | 2 | 0 | 1 | 0 | 0 | 0 | 2 | 3 |
Peroxisomes | 4 | 1 | 9 | 25 | 14 | 1 | 11 | – | 7 | 8 | 3 | 2 | 8 | 8 | 61 | 0 | 0 | 1 | 10 | 5 | 4 | 12 | 16 | 29 |
SpindlePole | 3 | 2 | 8 | 16 | 21 | 8 | 21 | – | 7 | 25 | 20 | 17 | 8 | 18 | 7 | 1 | 1 | 1 | 3 | 1 | 0 | 3 | 6 | 10 |
Vac/Vac Membrane | 48 | 30 | 11 | 18 | 32 | 26 | 48 | – | 26 | 27 | 18 | 17 | 27 | 61 | 60 | 13 | 10 | 9 | 8 | 20 | 1 | 9 | 13 | 18 |
Unique Cell Count | 244 | 255 | 87 | 165 | 151 | 154 | 258 | 216 | 250 | 328 | 340 | 264 | 299 | 408 | 48 | 37 | 38 | 264 | 301 | 143 | 288 | 375 | 384 | |
Labelled Cell Count | 313 | 325 | 113 | 241 | 197 | 194 | 350 | 273 | 327 | 417 | 405 | 322 | 365 | 506 | 58 | 52 | 42 | 264 | 301 | 143 | 288 | 375 | 384 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 5.3 | 5.3 | 6.8 | 6.1 | 7.0 | 5.1 | 6.0 | – | 5.3 | 5.4 | 5.3 | 5.5 | 5.6 | 6.3 | 6.1 | 8.0 | 8.7 | 8.3 | 5.2 | 5.3 | 5.6 |
Std Deviation (1e-4) | 0.9 | 0.9 | 2.4 | 2.0 | 5.2 | 2.4 | 2.0 | – | 1.6 | 1.4 | 1.3 | 1.5 | 1.1 | 2.8 | 1.5 | 1.7 | 1.5 | 1.8 | 1.7 | 1.7 | 2.2 |
Intensity Change (Log2) | – | – | – | -0.16 | 0.03 | -0.43 | -0.19 | – | -0.36 | -0.35 | -0.37 | -0.31 | -0.28 | -0.11 | -0.16 | 0.24 | 0.35 | 0.28 | -0.39 | -0.37 | -0.28 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | – | 0 | 0 | 1.1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | -0.1 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | -1.0 | -0.4 | -2.3 | -2.4 | – | -2.5 | -4.6 | -4.5 | -4.3 | -1.5 | 1.2 | 2.6 | -1.4 | -2.4 | -0.5 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 1.4 | 1.7 | -3.3 | 0.9 | – | -4.2 | -3.1 | -4.1 | 0 | 0 | -0.2 | 1.5 | -2.1 | 0 | 0 |
Golgi | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.0 | 5.4 | 3.3 |
Mitochondria | 2.5 | -1.5 | 5.3 | 2.5 | – | 6.3 | 7.2 | 8.9 | 8.8 | 2.8 | 0.3 | -2.4 | -3.5 | -4.0 | -4.7 |
Nucleus | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 1.1 | -0.3 | 0 | -2.1 | – | 0 | 0 | 0 | 0 | 0 | 0 | 1.1 | 0 | 0 | 0 |
SpindlePole | 0.1 | 1.1 | -1.2 | -0.3 | – | 0 | 0.2 | -1.0 | -1.5 | 0 | -1.0 | 0 | 0 | 0 | 0 |
Vacuole | -0.4 | 1.7 | 0.9 | 1.3 | – | -0.1 | -0.5 | -2.3 | -2.6 | -0.6 | 1.6 | 0.5 | 2.1 | 2.0 | 1.5 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 0.8769 | 0.861 | 0.6702 | 0.585 | 0.2835 | 0.8103 | 2.8328 | 2.3099 | 2.6637 | 2.3587 | 2.5379 | 2.5133 | 4.519 | 4.6134 | 4.1172 | 4.5599 | 3.6952 | 4.4764 |
Actin | 0.0251 | 0.0089 | 0.008 | 0.0058 | 0.0126 | 0.0029 | 0.0384 | 0.0097 | 0.0218 | 0.023 | 0.0053 | 0.004 | 0.0344 | 0.04 | 0.0258 | 0.0614 | 0.0374 | 0.0047 |
Bud | 0.0014 | 0.0127 | 0.0105 | 0.0019 | 0.001 | 0.0045 | 0.0016 | 0.0029 | 0.003 | 0.0066 | 0.002 | 0.0017 | 0.0021 | 0.0039 | 0.0026 | 0.0021 | 0.0005 | 0.0016 |
Bud Neck | 0.002 | 0.0017 | 0.0052 | 0.0127 | 0.001 | 0.0013 | 0.0018 | 0.0013 | 0.0021 | 0.0013 | 0.0011 | 0.0023 | 0.0027 | 0.0016 | 0.0032 | 0.0007 | 0.0015 | 0.0011 |
Bud Periphery | 0.0017 | 0.0106 | 0.0077 | 0.0043 | 0.0026 | 0.0032 | 0.0023 | 0.0043 | 0.006 | 0.0107 | 0.0031 | 0.0046 | 0.0025 | 0.0147 | 0.0051 | 0.0067 | 0.0009 | 0.0063 |
Bud Site | 0.006 | 0.0364 | 0.0106 | 0.0075 | 0.0018 | 0.0009 | 0.0132 | 0.0353 | 0.0118 | 0.007 | 0.0038 | 0.0012 | 0.0246 | 0.0501 | 0.0083 | 0.0011 | 0.0026 | 0.0008 |
Cell Periphery | 0.0008 | 0.0017 | 0.0023 | 0.0008 | 0.0006 | 0.0009 | 0.0008 | 0.001 | 0.0013 | 0.0007 | 0.0005 | 0.001 | 0.0022 | 0.0065 | 0.001 | 0.0004 | 0.0003 | 0.0018 |
Cytoplasm | 0.014 | 0.0109 | 0.0142 | 0.012 | 0.0049 | 0.0147 | 0.0173 | 0.0131 | 0.017 | 0.0224 | 0.0317 | 0.0116 | 0.0271 | 0.0174 | 0.0224 | 0.0065 | 0.0019 | 0.0144 |
Cytoplasmic Foci | 0.0434 | 0.0535 | 0.0475 | 0.0681 | 0.0509 | 0.0433 | 0.0424 | 0.0515 | 0.0411 | 0.0376 | 0.0419 | 0.027 | 0.0491 | 0.0439 | 0.0308 | 0.0195 | 0.0349 | 0.0515 |
Eisosomes | 0.0009 | 0.0003 | 0.0005 | 0.0003 | 0.0002 | 0.0003 | 0.0008 | 0.0002 | 0.0004 | 0.0004 | 0.0002 | 0.0002 | 0.0034 | 0.0021 | 0.0009 | 0.0004 | 0.0005 | 0.0004 |
Endoplasmic Reticulum | 0.0031 | 0.0009 | 0.0025 | 0.0009 | 0.0008 | 0.0018 | 0.0052 | 0.0032 | 0.0029 | 0.0252 | 0.0031 | 0.0018 | 0.0119 | 0.0017 | 0.0114 | 0.0011 | 0.0017 | 0.0042 |
Endosome | 0.1685 | 0.0811 | 0.1151 | 0.1348 | 0.0934 | 0.0726 | 0.1461 | 0.1794 | 0.1205 | 0.0886 | 0.2039 | 0.1059 | 0.0447 | 0.1213 | 0.1138 | 0.1326 | 0.0937 | 0.0965 |
Golgi | 0.0685 | 0.0868 | 0.054 | 0.0704 | 0.0577 | 0.0639 | 0.078 | 0.0947 | 0.0736 | 0.0792 | 0.0985 | 0.0661 | 0.0393 | 0.0886 | 0.0758 | 0.0725 | 0.0828 | 0.0599 |
Lipid Particles | 0.0365 | 0.0154 | 0.0143 | 0.0133 | 0.0075 | 0.0132 | 0.0251 | 0.0125 | 0.0103 | 0.0216 | 0.0361 | 0.0094 | 0.0847 | 0.0043 | 0.0118 | 0.0016 | 0.0504 | 0.0219 |
Mitochondria | 0.543 | 0.6104 | 0.6211 | 0.565 | 0.7212 | 0.7135 | 0.5383 | 0.522 | 0.6309 | 0.6064 | 0.4796 | 0.7315 | 0.5318 | 0.5468 | 0.5854 | 0.6703 | 0.6144 | 0.6831 |
None | 0.0159 | 0.0196 | 0.0335 | 0.0127 | 0.0005 | 0.0088 | 0.0075 | 0.0063 | 0.0012 | 0.0051 | 0.0058 | 0.0014 | 0.0506 | 0.0242 | 0.0508 | 0.0008 | 0.0005 | 0.0048 |
Nuclear Periphery | 0.0047 | 0.0003 | 0.0031 | 0.0007 | 0.0004 | 0.0009 | 0.0118 | 0.0018 | 0.0022 | 0.0087 | 0.0264 | 0.002 | 0.0193 | 0.0003 | 0.0047 | 0.0005 | 0.0015 | 0.0013 |
Nucleolus | 0.0042 | 0.001 | 0.0019 | 0.0087 | 0.0002 | 0.0009 | 0.0046 | 0.0009 | 0.0008 | 0.0004 | 0.0022 | 0.0003 | 0.0029 | 0.0006 | 0.0004 | 0.0002 | 0.0001 | 0.0004 |
Nucleus | 0.0067 | 0.0009 | 0.0021 | 0.0088 | 0.0002 | 0.0013 | 0.0093 | 0.0013 | 0.0014 | 0.0014 | 0.0069 | 0.0006 | 0.0139 | 0.0006 | 0.0014 | 0.0003 | 0.0002 | 0.0007 |
Peroxisomes | 0.0235 | 0.0359 | 0.0233 | 0.0346 | 0.0344 | 0.0365 | 0.0122 | 0.0206 | 0.0217 | 0.0324 | 0.0209 | 0.0123 | 0.0331 | 0.0212 | 0.0175 | 0.0086 | 0.0693 | 0.0177 |
Punctate Nuclear | 0.0054 | 0.0003 | 0.0023 | 0.0057 | 0.0002 | 0.0026 | 0.0144 | 0.0004 | 0.0007 | 0.0013 | 0.0027 | 0.0008 | 0.0103 | 0.0002 | 0.0019 | 0.0002 | 0.0006 | 0.0027 |
Vacuole | 0.016 | 0.0072 | 0.0129 | 0.022 | 0.004 | 0.0067 | 0.0185 | 0.0266 | 0.0201 | 0.0116 | 0.0115 | 0.0076 | 0.0064 | 0.0071 | 0.0149 | 0.0072 | 0.0015 | 0.0139 |
Vacuole Periphery | 0.009 | 0.0037 | 0.0075 | 0.0088 | 0.0037 | 0.0056 | 0.0104 | 0.0113 | 0.0091 | 0.0084 | 0.0128 | 0.0069 | 0.0032 | 0.0028 | 0.0099 | 0.0053 | 0.0027 | 0.0103 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 55.4342 | 47.195 | 46.6943 | 45.5339 | 54.7603 | 43.971 | 41.3563 | 37.5748 | 45.672 | 47.5288 |
Translational Efficiency | 0.9369 | 0.9661 | 0.9639 | 1.0521 | 0.6968 | 0.9674 | 1.0713 | 1.0902 | 0.9854 | 0.9245 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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