Standard name
Human Ortholog
Description Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.98 0.97 0.93 0.96 0.93 0.79 0.71 0.78 0.69 0.68 0.46 0.51 1.0 0.99 0.99 0.9 0.86 0.9 0.72 0.77 0.64 0.76 0.73 0.7
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.08 0.05 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0.24 0 0.06 0.09 0.08 0.37 0.4 0.34 0.5 0.55 0.69 0.66 0 0 0 0 0 0 0.13 0.11 0.22 0.06 0.05 0.06
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0.13 0.27 0.14 0 0 0 0.08 0.09 0.08
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 1 3 3 3 6 8
Bud 0 0 5 1 6 2 6 15 10 10 10 11 0 1 0 0 0 0 0 0 2 7 16 16
Bud Neck 0 0 1 1 1 1 1 10 5 2 0 2 0 0 0 1 0 1 0 0 0 2 2 7
Bud Site 0 0 0 0 0 1 2 0 2 2 1 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 1 0 1 1 2 2 0 0 0 0 1 1 2 0 0 1 1 0 0 1 2 4 5
Cytoplasm 45 194 169 190 246 271 285 421 217 237 121 180 387 820 765 409 228 237 67 154 117 222 419 321
Endoplasmic Reticulum 0 2 0 2 0 0 0 1 1 1 3 0 0 2 2 37 12 10 3 1 2 2 5 1
Endosome 0 0 0 0 1 0 0 2 0 0 0 0 0 0 1 8 3 3 1 3 1 0 6 3
Golgi 0 0 2 1 1 0 0 1 0 0 0 0 0 1 0 1 1 1 0 1 1 0 4 3
Mitochondria 11 5 11 17 21 129 159 185 156 191 179 234 0 1 0 12 0 0 12 22 39 18 31 28
Nucleus 0 1 0 1 0 1 1 2 2 2 1 0 1 0 1 0 0 2 0 0 0 0 0 0
Nuclear Periphery 0 1 0 1 1 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 1
Nucleolus 0 0 1 0 1 2 1 3 0 0 0 0 0 0 0 0 2 0 0 0 0 0 1 0
Peroxisomes 0 0 0 0 0 1 1 0 0 0 0 0 0 2 1 0 0 0 0 0 1 0 0 2
SpindlePole 0 0 1 0 1 5 13 21 9 5 5 7 0 0 0 0 0 0 1 1 2 3 10 9
Vac/Vac Membrane 0 1 2 0 3 1 4 2 1 2 2 5 0 1 1 61 71 36 2 4 3 24 53 37
Unique Cell Count 46 201 182 198 264 345 400 541 315 348 261 353 388 828 770 452 266 263 94 199 183 294 574 460
Labelled Cell Count 56 205 193 215 283 416 475 663 403 454 322 441 389 830 771 529 318 291 94 199 183 294 574 460


Vacuole

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 3.2 3.8 3.5 3.4 3.7 2.9 2.6 2.9 2.7 2.6 2.6 2.4 3.9 4.0 4.1 4.9 5.9 5.6 3.8 4.3 4.8
Std Deviation (1e-4) 0.5 1.0 1.4 1.4 2.1 1.1 1.1 1.0 1.1 1.6 0.9 1.1 1.3 1.4 1.5 1.2 1.5 1.2 1.1 1.9 2.0
Intensity Change (Log2) – – – -0.03 0.08 -0.28 -0.41 -0.27 -0.36 -0.45 -0.45 -0.53 0.16 0.18 0.22 0.5 0.75 0.69 0.13 0.29 0.46

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000246WT3HU80HU120HU1600246WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30246WT1AF100AF140AF1800246
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Actin – – – – – – – – – – – – – – –
Bud – – – – – – – – – – – – 0 0 0
Bud Neck – – – – – – – – – – – – 0 0 0
Bud Site – – – – – – – – – – – – 0 0 0
Cell Periphery – – – – – – – – – – – – 0 0 0
Cyto – – – – – – – – – – – – – – –
Endoplasmic Reticulum – – – – – – – – – – – – 0 0 0
Endosome – – – – – – – – – – – – 0 0 0
Golgi – – – – – – – – – – – – 0 0 0
Mitochondria – – – – – – – – – – – – 0 0 0
Nuclear Periphery – – – – – – – – – – – – 0 0 0
Nuc – – – – – – – – – – – – – – –
Nucleolus – – – – – – – – – – – – 0 0 0
Peroxisomes – – – – – – – – – – – – 0 0 0
SpindlePole – – – – – – – – – – – – 0 0 0
Vac – – – – – – – – – – – – – – –
Cortical Patches – – – – – – – – – – – – 0 0 0
Cytoplasm – – – – – – – – – – – – 0 0 0
Nucleus – – – – – – – – – – – – 0 0 0
Vacuole – – – – – – – – – – – – 4.7 7.2 4.7

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration -1.9677 -1.1532 -1.602 -1.7596 -1.9393 -1.4173 0.8915 1.015 1.1961 0.59 1.1089 1.1264 1.1417 2.0008 1.7199 1.1129 1.4298 1.9172
Actin 0.0059 0.0019 0.0027 0.0002 0.0003 0.0011 0.0271 0.0003 0.0329 0.0358 0.0169 0.0042 0.0264 0.0001 0.0256 0.0011 0.0003 0.0305
Bud 0.0036 0.0003 0.0011 0 0 0.0018 0.0013 0.0008 0.0018 0.0027 0.0019 0.0007 0.0003 0.0003 0.0002 0.0023 0.0014 0.0007
Bud Neck 0.0023 0.0001 0.0003 0.0001 0 0.0074 0.0016 0.0018 0.0012 0.0002 0.001 0.0017 0.0012 0.0002 0.0005 0.0004 0.0076 0.001
Bud Periphery 0.0013 0.0006 0.0011 0.0002 0.0001 0.0031 0.0036 0.0008 0.0042 0.0176 0.0098 0.0025 0.0004 0.0005 0.0004 0.0044 0.0014 0.0015
Bud Site 0.0116 0.0003 0.0035 0 0 0.0001 0.01 0.0096 0.0047 0.0003 0.0037 0.0002 0.0014 0.0293 0.0007 0.0005 0.0315 0.0005
Cell Periphery 0.0006 0.0001 0.0001 0.0002 0 0.0001 0.0005 0.0001 0.0003 0.0001 0.0001 0.0001 0.0002 0.0002 0.0002 0.0002 0.0004 0.0001
Cytoplasm 0.0234 0.0548 0.0224 0.0263 0.0269 0.0512 0.0202 0.0106 0.0076 0.009 0.0102 0.0211 0.0143 0.0147 0.0126 0.0226 0.0103 0.0152
Cytoplasmic Foci 0.0311 0.004 0.0076 0.0074 0.0014 0.022 0.013 0.0022 0.0212 0.0236 0.0479 0.016 0.0227 0.0017 0.0041 0.0047 0.0148 0.0019
Eisosomes 0.002 0.0005 0.0012 0.0003 0.0002 0.0002 0.0007 0.0002 0.0004 0.0002 0.0002 0.0001 0.0008 0.0003 0.001 0.0002 0.0003 0.0004
Endoplasmic Reticulum 0.0012 0.0003 0.0004 0.0004 0.0001 0.0011 0.0035 0.0002 0.0012 0.0008 0.0007 0.0003 0.0039 0.0003 0.0012 0.0007 0.0002 0.0007
Endosome 0.0099 0.0004 0.0014 0.0038 0 0.0119 0.0057 0.0001 0.0224 0.0184 0.0327 0.0062 0.0113 0.0002 0.0055 0.0004 0.0001 0.0021
Golgi 0.0017 0.0001 0.0006 0.0001 0 0.0007 0.0034 0 0.0107 0.0045 0.0268 0.0028 0.0038 0 0.0015 0.0001 0.0001 0.0018
Lipid Particles 0.0079 0.0002 0.0044 0.0004 0.0001 0.0023 0.0127 0.0002 0.0087 0.0055 0.0115 0.0011 0.0118 0.0002 0.0023 0.0006 0.0002 0.0018
Mitochondria 0.003 0.0004 0.0009 0.0003 0.0001 0.0016 0.0043 0.0003 0.0048 0.0236 0.0174 0.0119 0.0025 0.0002 0.0014 0.0005 0.0002 0.0012
None 0.8691 0.9337 0.9403 0.9552 0.9696 0.8868 0.8674 0.9706 0.8577 0.8317 0.8015 0.9207 0.8452 0.9508 0.9271 0.9532 0.9281 0.9359
Nuclear Periphery 0.0016 0.0002 0.0007 0.0004 0.0001 0.0016 0.0011 0.0002 0.0034 0.002 0.0008 0.0005 0.0196 0.0001 0.0023 0.0008 0.0001 0.0017
Nucleolus 0.0032 0.0001 0.0008 0.0003 0.0001 0.0004 0.0008 0.0002 0.0018 0.0005 0.0003 0.0007 0.0012 0.0001 0.0005 0.0009 0.0009 0.0002
Nucleus 0.0027 0.0003 0.0028 0.0004 0.0002 0.0008 0.001 0.0004 0.0017 0.0007 0.0003 0.0008 0.0104 0.0003 0.0007 0.0016 0.0004 0.0004
Peroxisomes 0.004 0.0006 0.0029 0.0001 0.0001 0.001 0.018 0.0001 0.0066 0.0168 0.0131 0.0025 0.0068 0.0001 0.0004 0.0003 0.0004 0.0009
Punctate Nuclear 0.0115 0.0006 0.0045 0.0018 0.0007 0.0018 0.0023 0.001 0.0013 0.0006 0.0008 0.0027 0.0143 0.0002 0.0094 0.0031 0.0013 0.0009
Vacuole 0.0019 0.0002 0.0004 0.0019 0 0.0024 0.0015 0.0001 0.0043 0.0039 0.0015 0.0026 0.0008 0.0003 0.0015 0.001 0.0002 0.0002
Vacuole Periphery 0.0006 0 0.0001 0.0002 0 0.0006 0.0003 0 0.001 0.0015 0.001 0.0007 0.0007 0 0.0007 0.0002 0 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 104.9177 132.0789 645.9158 423.3903 74.3837 123.3181 131.9465 284.3048 266.528 78.2584
Translational Efficiency 1.0349 0.7775 1.0498 0.9738 1.0083 0.7749 0.9441 0.9816 0.9678 0.9042

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1072 1504 304 819 1294 1182 2068 1035 2366 2686 2372 1854

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 603.93 680.48 1052.76 824.04 657.20 683.19 963.42 904.65 633.06 681.67 974.87 869.04
Standard Deviation 75.26 95.40 195.77 110.12 68.21 88.64 159.99 167.35 76.25 92.50 167.69 150.31
Intensity Change Log 2 — 0.172171 0.801723 0.448333 — 0.055954 0.551832 0.461027 — 0.112778 0.676907 0.454962

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000056 0.000293 0.001253 0.000494 0.000032 0.000349 0.000446 0.005371 0.000043 0.000318 0.000550 0.003216
Bud Neck 0.003092 0.034854 0.020934 0.024241 0.005330 0.051904 0.030620 0.024806 0.004316 0.042357 0.029378 0.024557
Bud Site 0.001402 0.013001 0.067604 0.040544 0.001051 0.017488 0.023439 0.141213 0.001210 0.014975 0.029100 0.096742
Cell Periphery 0.000182 0.000112 0.003781 0.000170 0.000143 0.000144 0.000315 0.001141 0.000161 0.000126 0.000759 0.000712
Cytoplasm 0.536156 0.387762 0.064985 0.157452 0.519886 0.344498 0.114653 0.200940 0.527258 0.368723 0.108287 0.181729
Cytoplasmic Foci 0.092254 0.257705 0.111883 0.087499 0.168913 0.272840 0.040563 0.092943 0.134180 0.264365 0.049704 0.090538
Eisosomes 0.000097 0.000126 0.000053 0.000039 0.000114 0.000182 0.000025 0.000097 0.000106 0.000151 0.000029 0.000071
Endoplasmic Reticulum 0.000289 0.000797 0.006125 0.001591 0.000319 0.000440 0.002354 0.002580 0.000305 0.000640 0.002837 0.002143
Endosome 0.001936 0.030082 0.217071 0.199180 0.003852 0.040274 0.167468 0.162460 0.002984 0.034567 0.173825 0.178681
Golgi 0.000597 0.006158 0.016655 0.003468 0.000829 0.011216 0.002182 0.016528 0.000724 0.008384 0.004037 0.010759
Lipid Particles 0.003851 0.009260 0.012038 0.004031 0.007158 0.009710 0.005110 0.006356 0.005660 0.009458 0.005998 0.005329
Mitochondria 0.001372 0.019359 0.000249 0.005666 0.002545 0.021730 0.001004 0.004216 0.002013 0.020402 0.000907 0.004857
Mitotic Spindle 0.000586 0.005761 0.011935 0.023410 0.000046 0.011832 0.010181 0.029354 0.000291 0.008433 0.010406 0.026728
None 0.014234 0.005708 0.000130 0.000910 0.006168 0.002210 0.000683 0.001620 0.009823 0.004169 0.000612 0.001307
Nuclear Periphery 0.000331 0.000596 0.000499 0.000775 0.000476 0.000386 0.001210 0.000647 0.000410 0.000504 0.001119 0.000704
Nuclear Periphery Foci 0.000419 0.000352 0.013469 0.001799 0.000162 0.000246 0.003235 0.002916 0.000278 0.000306 0.004547 0.002422
Nucleolus 0.001051 0.002862 0.000898 0.002352 0.000945 0.001814 0.003488 0.000748 0.000993 0.002401 0.003156 0.001457
Nucleus 0.332509 0.118683 0.016359 0.029493 0.259782 0.097738 0.035213 0.035868 0.292734 0.109466 0.032796 0.033052
Peroxisomes 0.000870 0.018452 0.009753 0.015205 0.002129 0.025518 0.003964 0.016977 0.001559 0.021561 0.004706 0.016195
Vacuole 0.008377 0.084646 0.410131 0.397000 0.019577 0.086832 0.545175 0.245743 0.014502 0.085608 0.527868 0.312560
Vacuole Periphery 0.000340 0.003433 0.014195 0.004682 0.000542 0.002647 0.008671 0.007476 0.000450 0.003087 0.009379 0.006242

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -6.11 -2.67 -3.52 -1.21 1.87 -8.27 -1.90 -4.05 -3.68 -3.57 -10.54 -2.66 -4.35 -3.78 -3.21
Bud Neck -14.96 -5.82 -9.19 5.14 0.06 -14.74 -13.34 -9.94 9.29 4.35 -20.66 -15.12 -13.56 10.33 4.38
Bud Site -9.46 -8.74 -9.96 -5.87 4.34 -10.55 -15.80 -17.62 -14.56 -14.00 -14.34 -17.20 -19.44 -15.48 -11.75
Cell Periphery 3.03 -1.34 1.76 -0.32 1.37 0.17 -2.19 -5.91 -5.92 -4.93 3.03 -1.58 -5.41 -5.91 0.13
Cytoplasm 14.11 37.97 29.86 16.86 -9.07 16.61 43.53 26.04 9.09 -8.76 21.33 56.36 39.08 18.19 -9.96
Cytoplasmic Foci -24.62 -1.73 5.40 27.65 4.28 -12.69 26.07 16.26 26.69 -8.25 -24.17 23.57 16.11 38.25 -6.52
Eisosomes -3.54 4.08 7.87 13.71 1.06 -5.86 15.77 2.31 6.02 -4.22 -6.47 17.99 4.77 9.14 -4.83
Endoplasmic Reticulum -3.97 -2.81 -8.09 -5.22 2.06 -2.59 -8.44 -4.85 -4.56 -0.29 -4.73 -7.18 -7.35 -5.93 1.43
Endosome -15.24 -15.31 -16.22 -12.10 5.16 -14.51 -26.83 -16.19 -9.58 3.88 -20.90 -30.55 -22.89 -15.56 4.67
Golgi -7.26 -6.77 -2.67 4.92 6.05 -7.20 -3.59 -5.95 0.61 -5.37 -10.00 -7.41 -6.40 1.66 -3.22
Lipid Particles -5.23 -2.69 0.65 6.46 2.89 -2.20 2.88 2.55 4.23 -0.54 -4.89 0.25 2.41 7.17 1.54
Mitochondria -8.67 2.07 -1.32 6.49 -2.22 -8.19 2.58 -0.40 7.96 -2.75 -11.84 2.53 -1.32 10.36 -2.95
Mitotic Spindle -4.22 -3.37 -7.05 -5.59 -2.68 -5.49 -7.41 -9.31 -5.40 -5.74 -7.02 -7.91 -11.65 -8.08 -6.59
None 4.56 8.58 7.31 3.54 -2.50 4.75 7.06 5.22 0.16 -4.55 5.61 10.53 8.88 3.44 -3.60
Nuclear Periphery -1.98 -2.23 -8.55 -5.58 -5.82 1.28 -9.52 -6.35 -7.03 1.09 -1.22 -10.62 -10.48 -8.13 -0.74
Nuclear Periphery Foci 0.48 -4.77 -5.80 -6.89 4.18 -2.28 -6.28 -4.90 -4.77 -0.51 -0.37 -7.57 -6.49 -6.51 2.40
Nucleolus -4.26 -0.25 -3.05 0.16 -2.63 -3.80 -5.67 -0.07 3.50 5.56 -5.67 -5.40 -2.95 1.98 3.19
Nucleus 24.29 34.16 31.25 9.94 -5.28 22.07 32.59 26.63 5.45 -2.86 32.03 46.40 40.54 11.03 -3.80
Peroxisomes -14.49 -4.51 -7.48 5.38 -0.30 -12.24 -3.04 -7.34 6.23 -6.39 -18.49 -6.17 -10.35 8.01 -7.25
Vacuole -23.89 -22.72 -39.59 -31.13 -1.73 -16.50 -72.28 -29.26 -20.80 18.73 -27.98 -76.02 -47.10 -35.53 14.78
Vacuole Periphery -6.82 -7.01 -4.45 0.80 5.41 -7.50 -11.92 -4.79 -2.29 2.21 -9.34 -14.00 -6.29 -1.36 5.17
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
Localization
Cell Percentages cytoplasm (28%), nucleus (3%), mixed (52%)
Cell Cycle Regulation No
Subcompartmental Group N/A

Pho3

Pho3


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Pho3-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available