Standard name
Human Ortholog
Description Alpha aminoadipate reductase; catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0.07 0.06 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0.06 0.06 0.08 – 0.16 0.13 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 1.0 0.99 0.99 0.99 0.95 0.96 0.86 0.88 0.86 – 0.82 0.78 0.99 0.98 0.98 0.96 0.96 0.98 0.97 0.97 0.97 0.93 0.94 0.91
Endoplasmic Reticulum 0 0 0 0 0.05 0 0.11 0.07 0.08 – 0.06 0.11 0 0 0 0 0.05 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0 – 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 2 8 8 – 14 14 0 0 0 1 1 0 0 0 0 0 0 2
Bud 0 9 0 0 0 0 1 1 3 – 1 2 0 1 1 3 0 1 1 4 0 7 4 11
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 6 8 4 2 9 10 16 18 20 – 31 33 7 5 13 13 6 6 0 0 0 0 0 0
Cytoplasm 365 487 369 272 329 224 233 247 228 – 159 196 449 537 584 439 321 397 344 476 367 353 430 566
Endoplasmic Reticulum 0 2 7 3 16 10 30 20 20 – 11 27 4 8 13 20 17 21 1 1 3 7 15 22
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 2 1 1 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 1 3 – 0 1 0 0 1 2 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 3 6 – 12 7 0 0 0 0 1 1 1 0 0 0 0 0
Nucleus 0 1 0 0 0 0 1 0 0 – 0 0 0 0 0 1 1 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Nucleolus 0 0 0 0 0 0 0 1 0 – 0 0 0 0 0 1 0 0 0 0 0 0 0 0
Peroxisomes 0 1 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 2 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 2 1 0 0 0 0 0 0 0
Vac/Vac Membrane 0 1 0 0 0 0 0 0 0 – 2 2 0 0 0 13 9 5 1 6 2 2 2 3
Unique Cell Count 366 491 374 276 346 234 272 280 264 195 252 454 546 598 459 333 404 356 493 377 378 459 619
Labelled Cell Count 371 509 380 277 354 244 283 299 288 230 282 460 551 612 497 358 434 356 493 377 378 459 619


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 167.3 140.7 86.5 85.9 72.7 55.1 47.2 40.6 36.4 – 30.2 30.3 105.1 96.4 83.8 122.2 132.6 125.8 118.2 129.6 124.0
Std Deviation (1e-4) 35.0 30.8 18.4 17.5 15.7 12.8 12.7 10.4 9.3 – 8.7 8.0 25.7 21.1 19.1 49.0 54.8 50.5 29.9 29.8 33.8
Intensity Change (Log2) – – – -0.01 -0.25 -0.65 -0.87 -1.09 -1.25 – -1.52 -1.51 0.28 0.16 -0.05 0.5 0.62 0.54 0.45 0.58 0.52


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 4.6 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 0 1.5 2.6 3.5 3.8 4.3 – 7.0 6.3 0 0 1.3 1.8 0 0
Cytoplasm -0.1 -2.8 -2.3 -6.5 -5.7 -6.2 – -7.5 -8.6 0.3 -0.4 -1.1 -2.5 -2.0 -0.4
Endoplasmic Reticulum 0 2.1 1.7 4.9 3.4 3.5 – 2.4 4.8 0 -0.5 0.3 2.0 2.4 2.5
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole 0 0 0 0 0 0 – 0 0 0 0 0 3.3 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 165.0464 196.2947 190.156 179.3442 181.2144 186.6416 115.8505 182.8007 164.8264 164.5933 174.1823 152.0211 154.4621 203.3966 184.6697 176.0174 163.7855 181.3395
Actin 0.0002 0.0002 0.0002 0.0001 0.0002 0.0001 0.0068 0.0005 0.0046 0.0001 0.0004 0.0005 0.0008 0.0001 0.0128 0.0002 0.0002 0.0006
Bud 0.0004 0.0005 0.0006 0.0007 0.0004 0.0004 0.0034 0.0005 0.0016 0.001 0.0005 0.0008 0.0017 0.0001 0.0017 0.0008 0.0002 0.0002
Bud Neck 0.0009 0.0014 0.0016 0.001 0.0026 0.0044 0.0006 0.0004 0.0008 0.0008 0.0013 0.002 0.0005 0.0003 0.0009 0.0007 0.0003 0.0011
Bud Periphery 0.0006 0.0006 0.0007 0.0004 0.0007 0.0002 0.0043 0.0003 0.0008 0.0005 0.0002 0.0009 0.0011 0 0.0022 0.0006 0 0.0001
Bud Site 0.0002 0.0007 0.0003 0.0002 0.0001 0 0.0016 0.0006 0.0006 0.0003 0.0001 0.0001 0.0013 0.0002 0.0027 0.0006 0.0001 0
Cell Periphery 0.055 0.0659 0.0465 0.0218 0.0428 0.0039 0.0377 0.0235 0.0319 0.0692 0.0041 0.0097 0.0152 0.0058 0.0119 0.0395 0.0005 0.0006
Cytoplasm 0.6072 0.7619 0.7166 0.7002 0.806 0.8605 0.6466 0.9296 0.834 0.7795 0.9201 0.8576 0.8474 0.9741 0.8927 0.7567 0.8587 0.9714
Cytoplasmic Foci 0.0003 0.0003 0.0004 0.0004 0.0005 0.0007 0.0323 0.0006 0.0091 0.0008 0.0014 0.0032 0.0043 0.0002 0.0043 0.0025 0.0587 0.0015
Eisosomes 0.0001 0.0004 0.0001 0 0 0 0.0008 0 0.0002 0 0 0.0001 0.0006 0 0.0001 0.0004 0.0002 0
Endoplasmic Reticulum 0.065 0.0175 0.021 0.0026 0.0052 0.0376 0.0398 0.0079 0.008 0.001 0.0022 0.0266 0.0123 0.0027 0.0048 0.0014 0.0007 0.0106
Endosome 0.0012 0.0005 0.0009 0.0015 0.0011 0.0019 0.029 0.0005 0.0018 0.0008 0.0022 0.0028 0.002 0.0002 0.0022 0.001 0.0016 0.0018
Golgi 0.0001 0.0001 0.0001 0 0 0.0001 0.0019 0.0002 0.0019 0.0001 0.0002 0.0007 0.0003 0 0.0008 0.0001 0.0002 0.0002
Lipid Particles 0.0016 0.0019 0.0016 0.0008 0.0013 0.0003 0.0102 0.0021 0.0051 0.0028 0.0009 0.0016 0.0023 0.0003 0.002 0.0027 0.0069 0.0003
Mitochondria 0.0019 0.0003 0.0002 0.0001 0.0002 0.0002 0.0098 0.0003 0.0031 0.0002 0.0001 0.0072 0.0076 0.0001 0.0038 0.0045 0.0032 0.0002
None 0.0011 0.0002 0.0003 0.0001 0.0001 0.0001 0.0153 0.0007 0.0027 0.0004 0.0004 0.0096 0.0084 0.0003 0.0033 0.0159 0.0192 0.0002
Nuclear Periphery 0.0559 0.0116 0.0181 0.0091 0.0115 0.0137 0.0333 0.0046 0.0065 0.0138 0.003 0.0108 0.0117 0.0033 0.0052 0.0094 0.0039 0.003
Nucleolus 0.0016 0.0005 0.0011 0.0005 0.0004 0.0001 0.0297 0.0003 0.0038 0.0024 0.0002 0.023 0.0109 0.0001 0.0025 0.0092 0.012 0
Nucleus 0.0112 0.0049 0.0067 0.0073 0.0068 0.0061 0.0148 0.002 0.0041 0.006 0.0023 0.0111 0.0119 0.0012 0.0033 0.0151 0.0039 0.0018
Peroxisomes 0 0 0 0 0 0 0.0013 0 0.001 0.0001 0 0.0001 0.0004 0 0.0008 0.0002 0.0007 0
Punctate Nuclear 0 0 0.0001 0 0 0 0.0021 0.0001 0.0003 0.0001 0.0001 0.0002 0.0025 0 0.0006 0.0006 0.007 0.0001
Vacuole 0.1753 0.1249 0.1648 0.225 0.1091 0.0617 0.068 0.0243 0.0708 0.1089 0.0543 0.0248 0.0442 0.0104 0.0375 0.1186 0.0164 0.0053
Vacuole Periphery 0.02 0.0057 0.0182 0.0283 0.011 0.0079 0.0105 0.001 0.0073 0.0112 0.006 0.0065 0.0126 0.0004 0.0038 0.0194 0.0054 0.0009

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 179.4121 178.912 161.3091 186.4966 214.3008 203.4587 251.6578 225.1808 206.7505 214.2114
Translational Efficiency 1.5403 1.587 1.4322 1.1878 1.2465 1.7459 1.3162 1.0771 1.0692 1.1025

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
117 1687 1587 436 249 1921 216 1692 366 3608 1803 2128

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 5875.59 9032.11 8105.12 5155.17 7153.70 8616.14 6253.53 5080.56 6745.12 8810.64 7883.30 5095.85
Standard Deviation 1436.06 2061.52 1447.35 1045.86 1696.29 2042.36 1034.11 1240.21 1723.98 2061.81 1527.57 1203.33
Intensity Change Log 2 — 0.620329 0.464100 -0.188714 — 0.268352 -0.194019 -0.493702 — 0.437767 0.140162 -0.348144

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000124 0.000076 0.000090 0.000255 0.000066 0.000047 0.000241 0.000239 0.000084 0.000060 0.000108 0.000242
Bud Neck 0.001642 0.000684 0.002134 0.002021 0.000486 0.000204 0.008113 0.001857 0.000855 0.000429 0.002851 0.001891
Bud Site 0.003743 0.002494 0.002014 0.009997 0.002455 0.001549 0.006168 0.008956 0.002867 0.001991 0.002511 0.009170
Cell Periphery 0.045670 0.008568 0.005321 0.033874 0.024699 0.005768 0.016752 0.009007 0.031402 0.007077 0.006691 0.014102
Cytoplasm 0.662292* 0.853011* 0.780227* 0.698159* 0.781032* 0.924358* 0.476037* 0.797973* 0.743074* 0.890998* 0.743785* 0.777522*
Cytoplasmic Foci 0.013847 0.006790 0.008827 0.005968 0.006710 0.003997 0.018469 0.004715 0.008992 0.005303 0.009983 0.004972
Eisosomes 0.000004 0.000001 0.000002 0.000005 0.000002 0.000001 0.000007 0.000003 0.000002 0.000001 0.000003 0.000003
Endoplasmic Reticulum 0.000321 0.000343 0.000144 0.000120 0.000442 0.000350 0.000161 0.000145 0.000404 0.000347 0.000146 0.000140
Endosome 0.000774 0.000384 0.000327 0.000295 0.000411 0.000175 0.001158 0.000773 0.000527 0.000273 0.000426 0.000675
Golgi 0.063426 0.024538 0.012694 0.008870 0.035787 0.011585 0.022733 0.008335 0.044622 0.017641 0.013897 0.008445
Lipid Particles 0.025322 0.008891 0.006421 0.028164 0.017015 0.005470 0.024297 0.008991 0.019671 0.007069 0.008563 0.012919
Mitochondria 0.000086 0.000157 0.000200 0.000065 0.000145 0.000146 0.000127 0.000653 0.000126 0.000151 0.000191 0.000533
Mitotic Spindle 0.000808 0.001757 0.001939 0.000995 0.000555 0.000956 0.002509 0.002380 0.000636 0.001331 0.002007 0.002096
None 0.002107 0.003320 0.002763 0.001635 0.002966 0.005283 0.001198 0.001888 0.002691 0.004365 0.002576 0.001836
Nuclear Periphery 0.001139 0.000628 0.001864 0.000368 0.000885 0.000196 0.001931 0.000253 0.000966 0.000398 0.001872 0.000277
Nuclear Periphery Foci 0.016701 0.011240 0.008154 0.005020 0.011756 0.004712 0.015835 0.002979 0.013337 0.007764 0.009074 0.003397
Nucleolus 0.000190 0.000054 0.000117 0.000145 0.000052 0.000045 0.000184 0.000246 0.000096 0.000049 0.000125 0.000225
Nucleus 0.021623 0.013874 0.050310 0.018877 0.012463 0.010164 0.041310 0.022292 0.015391 0.011899 0.049232 0.021592
Peroxisomes 0.000021 0.000012 0.000011 0.000090 0.000041 0.000015 0.000027 0.000082 0.000034 0.000014 0.000013 0.000084
Vacuole 0.100637 0.039094 0.096267 0.176951 0.067077 0.016754 0.336987* 0.116633 0.077806 0.027200 0.125105 0.128991
Vacuole Periphery 0.039522 0.024085 0.020174 0.008127 0.034956 0.008225 0.025755 0.011599 0.036416 0.015641 0.020842 0.010888

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin 1.78 0.74 -2.14 -4.00 -3.23 1.56 -2.70 -4.17 -4.62 1.06 1.90 -3.07 -4.30 -5.19 -2.61
Bud Neck 1.39 -0.49 0.05 -5.68 1.94 2.99 -7.56 -5.76 -6.70 6.18 1.58 -6.19 -2.57 -7.18 4.80
Bud Site 1.44 1.86 -3.28 -4.53 -4.83 1.64 -3.67 -5.61 -6.86 -0.54 1.78 -0.27 -6.21 -7.58 -6.44
Cell Periphery 5.19 5.63 2.01 -6.69 -7.75 5.81 2.66 5.13 -2.44 3.28 7.56 7.66 5.77 -5.49 -5.85
Cytoplasm -6.18 -2.39 -0.69 10.64 3.15 -7.28 11.54 0.32 20.25 -14.47 -8.69 2.45 -0.79 19.36 -6.18
Cytoplasmic Foci 3.58 1.18 3.48 0.23 4.20 2.36 -5.71 1.25 -2.48 6.46 3.55 -3.53 3.44 -0.08 9.18
Eisosomes 1.85 1.21 0.00 -5.93 -3.98 3.87 -5.37 -3.14 -6.62 4.43 2.58 -1.23 -0.92 -7.28 0.51
Endoplasmic Reticulum -0.26 1.85 2.21 3.70 1.21 0.50 2.91 3.25 1.23 0.96 0.50 3.68 3.81 2.24 0.43
Endosome 1.72 1.75 2.23 1.22 2.08 3.68 -6.40 -2.95 -5.31 3.11 2.92 0.12 -1.38 -4.25 -1.83
Golgi 3.91 5.17 5.69 9.80 3.92 5.76 3.81 6.76 4.28 6.88 6.26 7.23 8.71 11.21 7.77
Lipid Particles 3.71 4.05 -0.45 -7.04 -7.72 3.35 -2.00 2.33 -3.65 5.86 4.58 3.54 2.47 -6.07 -2.87
Mitochondria -1.03 -2.71 0.97 3.88 6.86 -0.20 -1.01 -1.85 -1.83 -1.69 -0.86 -3.47 -1.82 -1.71 -1.29
Mitotic Spindle -2.06 -4.80 -0.23 1.58 3.21 -1.37 -3.94 -2.93 -2.06 0.14 -2.62 -6.42 -2.87 -1.24 0.52
None -1.70 -1.67 0.84 2.02 1.93 -2.19 2.71 1.36 3.48 -1.38 -2.38 0.33 1.45 3.73 1.49
Nuclear Periphery 1.56 -2.43 2.47 4.36 5.22 4.85 -3.42 4.01 -1.91 5.50 3.96 -3.73 4.63 2.26 6.00
Nuclear Periphery Foci 1.51 2.24 3.63 7.13 5.98 4.32 -1.33 5.37 3.08 6.73 3.49 2.12 6.53 8.61 10.44
Nucleolus 1.47 0.61 0.63 -3.72 0.11 0.25 -8.86 -4.85 -4.84 -0.90 1.44 -1.63 -2.98 -5.21 -2.45
Nucleus 1.73 -6.13 -0.07 -4.03 10.63 0.70 -7.13 -4.91 -10.38 5.14 1.41 -12.78 -3.87 -10.49 12.48
Peroxisomes 1.31 1.29 -3.10 -4.70 -4.73 2.21 -0.08 -2.52 -5.33 -2.75 2.62 2.40 -3.53 -6.60 -6.45
Vacuole 4.28 -1.12 -4.78 -12.89 -5.66 5.65 -12.45 -6.58 -22.89 10.00 6.56 -7.36 -7.49 -24.53 0.31
Vacuole Periphery 1.50 2.00 3.26 8.42 7.09 5.30 2.58 4.87 -2.06 3.93 4.41 3.53 5.72 5.42 7.26
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Alpha aminoadipate reductase; catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p
Localization
Cell Percentages cytoplasm (100%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-1

Lys2

Lys2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Lys2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available