Standard name
Human Ortholog
Description Member of Hsp110 subclass of the heat shock protein 70 (HSP70) family; serves as nucleotide exchange factor to load ATP onto the SSA class of cytosolic Hsp70s; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0.05 0 0 0 0 0 0 – 0.05 0.05 0 0 0 0.07 0.05 0.08 0 0 0 0 0 0
Cytoplasm 1.0 0.99 0.98 0.99 0.95 0.91 0.86 0.77 0.77 – 0.68 0.62 0.99 0.99 0.99 0.95 0.95 0.92 0.98 0.95 0.92 0.92 0.93 0.92
Endoplasmic Reticulum 0 0 0 0 0 0 0.1 0 0 – 0 0.07 0 0 0 0.05 0 0.05 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0 0 0 0.09 – 0.06 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0 0 0 0.17 0.13 – 0.23 0.28 0 0 0 0 0 0.07 0 0 0.05 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 0 1 1 3 1 2 – 1 9 0 0 0 0 0 0 0 0 0 0 1 0
Bud 1 1 5 0 2 4 4 2 7 – 5 5 1 0 0 0 0 0 0 1 1 0 2 5
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 1
Bud Site 0 0 0 0 0 0 0 0 0 – 0 1 0 0 0 0 0 0 – – – – – –
Cell Periphery 1 2 15 3 14 19 19 18 15 – 26 37 2 4 5 22 8 11 0 0 0 0 0 0
Cytoplasm 220 275 294 294 400 426 451 439 328 – 323 437 183 312 342 302 138 128 210 269 287 124 283 364
Endoplasmic Reticulum 0 2 2 1 9 11 50 21 18 – 14 46 1 0 3 15 4 7 0 0 0 1 5 5
Endosome 0 0 0 0 0 0 0 1 0 – 0 0 0 0 0 0 0 0 0 2 0 0 0 0
Golgi 0 0 0 0 0 0 0 1 0 – 0 0 0 0 0 3 0 1 0 1 0 0 0 0
Mitochondria 0 1 1 0 2 21 14 2 37 – 30 14 1 0 1 7 0 0 0 1 4 1 2 4
Nucleus 0 2 6 5 4 4 4 8 7 – 5 7 0 1 0 0 1 0 0 1 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 1 – 3 2 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 1 – 0 0 0 0 0 0 0 0 0 1 0 0 0 0
Vac/Vac Membrane 0 0 1 0 6 15 22 99 54 – 111 194 0 2 0 9 6 10 0 1 14 5 4 8
Unique Cell Count 220 279 301 297 419 468 525 567 426 477 702 184 315 346 317 146 139 215 283 313 135 304 398
Labelled Cell Count 222 283 325 303 438 501 567 592 470 518 752 188 319 351 358 157 157 215 283 313 135 304 398


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 8.5 8.4 7.7 6.8 9.2 8.9 10.4 12.2 11.2 – 11.9 14.6 8.3 11.0 13.1 23.4 27.2 22.4 7.2 7.8 9.2
Std Deviation (1e-4) 2.1 2.1 1.4 1.1 2.6 2.0 2.6 3.3 3.6 – 4.2 5.3 1.8 3.3 4.0 8.4 11.3 7.7 1.3 1.6 2.0
Intensity Change (Log2) – – – -0.19 0.25 0.2 0.43 0.65 0.53 – 0.63 0.91 0.1 0.51 0.76 1.6 1.81 1.53 -0.11 0.01 0.24


Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery -2.8 -1.1 -0.6 -0.9 -1.3 -1.0 – 0.3 0.2 -2.3 -2.7 -2.6 1.0 0.2 1.2
Cytoplasm 1.3 -1.6 -3.7 -5.5 -7.8 -7.8 – -10.0 -11.6 1.5 1.3 1.1 -1.6 -1.7 -2.8
Endoplasmic Reticulum 0 0 1.8 5.0 2.7 2.9 – 2.2 4.0 0 0 0 3.1 0 0
Endosome 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0 0 3.4 2.4 0 5.0 – 4.1 0 0 0 0 0 0 0
Nucleus -0.3 0 0 0 0 -0.4 – 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole 0 0 2.7 3.2 7.5 6.2 – 8.9 10.0 0 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 1.8385 3.0759 2.262 2.3401 1.2034 3.0807 2.4917 3.4581 3.2692 2.7972 3.2115 3.5435 3.4178 4.6328 4.2298 7.7533 4.6753 3.9217
Actin 0.0142 0.0092 0.0106 0.0234 0.0241 0.024 0.0133 0.0021 0.0254 0.0142 0.0199 0.0058 0.0092 0.0057 0.0152 0.0014 0.0045 0.0009
Bud 0.0006 0.0025 0.0017 0.0006 0.0035 0.0005 0.0005 0.0006 0.0011 0.0108 0.0005 0.0009 0.0004 0.0016 0.0006 0.0018 0.0004 0.0001
Bud Neck 0.0021 0.0005 0.0036 0.0013 0.0015 0.0052 0.001 0.0002 0.0038 0.0006 0.0011 0.0011 0.0023 0.0001 0.0003 0.0013 0.0002 0.0006
Bud Periphery 0.0007 0.0022 0.0018 0.0006 0.005 0.0013 0.0005 0.0005 0.0013 0.0093 0.0005 0.0013 0.0005 0.0009 0.0006 0.0033 0.0006 0.0001
Bud Site 0.0022 0.013 0.0065 0.0017 0.003 0.0005 0.0024 0.0038 0.0073 0.0037 0.0013 0.0001 0.005 0.0011 0.001 0.0031 0.0003 0.0001
Cell Periphery 0.0002 0.0003 0.0005 0.0001 0.0002 0.0001 0.0002 0.0004 0.0003 0.0003 0.0001 0 0.0002 0.0001 0.0001 0.0001 0 0
Cytoplasm 0.7284 0.8835 0.807 0.7856 0.7009 0.8703 0.7884 0.9537 0.8678 0.8711 0.8361 0.9416 0.8702 0.9399 0.8741 0.8877 0.9405 0.9561
Cytoplasmic Foci 0.0253 0.009 0.0212 0.0641 0.0486 0.0176 0.0214 0.0026 0.0153 0.0139 0.0295 0.0096 0.0147 0.0024 0.0068 0.0251 0.0027 0.0067
Eisosomes 0.0001 0 0.0003 0.0003 0.0002 0.0001 0.0001 0 0.0001 0 0.0002 0 0.0001 0 0.0001 0 0.0001 0
Endoplasmic Reticulum 0.0105 0.0033 0.005 0.0104 0.0048 0.0029 0.0048 0.002 0.0034 0.0018 0.0029 0.0047 0.0055 0.002 0.0055 0.0021 0.0009 0.0021
Endosome 0.0341 0.0054 0.0188 0.0223 0.0293 0.0189 0.0528 0.001 0.0177 0.032 0.0381 0.0088 0.0103 0.0012 0.0147 0.0228 0.0019 0.0054
Golgi 0.0083 0.0006 0.0046 0.006 0.018 0.007 0.0166 0.0001 0.0098 0.0095 0.0193 0.0047 0.0033 0.0005 0.0156 0.0081 0.0011 0.0021
Lipid Particles 0.0039 0.0001 0.0049 0.0179 0.0147 0.0026 0.0177 0 0.0032 0.006 0.015 0.0041 0.0104 0.0001 0.0026 0.0013 0.0002 0.003
Mitochondria 0.0022 0.0006 0.0052 0.0126 0.0287 0.0021 0.0138 0.0002 0.0074 0.002 0.0037 0.0009 0.0029 0.0063 0.0176 0.0097 0.0424 0.0038
None 0.127 0.0628 0.0804 0.0116 0.0904 0.0345 0.0378 0.0299 0.0222 0.0155 0.0038 0.0079 0.045 0.0353 0.0303 0.0025 0.0014 0.0145
Nuclear Periphery 0.0196 0.0011 0.0019 0.0032 0.0022 0.0021 0.0046 0.0005 0.001 0.001 0.0021 0.0012 0.0031 0.0005 0.0046 0.0049 0.0003 0.0005
Nucleolus 0.0002 0.0002 0.0067 0.0004 0.0002 0.0001 0.0033 0 0.0002 0.0001 0.0003 0 0.0002 0 0.0003 0.0003 0 0
Nucleus 0.0108 0.0022 0.0046 0.0031 0.0024 0.0023 0.0032 0.0013 0.0014 0.0019 0.003 0.0016 0.0024 0.0008 0.0023 0.0025 0.001 0.0011
Peroxisomes 0.0019 0.0002 0.0046 0.0279 0.0166 0.003 0.0074 0 0.0083 0.001 0.0174 0.0029 0.0098 0.0003 0.0031 0.0073 0.0009 0.0019
Punctate Nuclear 0.0031 0.0006 0.0057 0.0045 0.0022 0.0012 0.0036 0.0003 0.0008 0.0011 0.0016 0.0017 0.0025 0.0001 0.0013 0.0006 0.0001 0.0003
Vacuole 0.0033 0.0025 0.0036 0.0018 0.0028 0.0029 0.0052 0.0007 0.0016 0.0027 0.0027 0.0007 0.0015 0.0007 0.0024 0.0082 0.0003 0.0005
Vacuole Periphery 0.0013 0.0003 0.0008 0.0007 0.0009 0.0008 0.0014 0.0001 0.0006 0.0015 0.0011 0.0002 0.0005 0.0001 0.0011 0.0061 0.0002 0.0002

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 16.4292 19.4243 13.7106 24.0924 17.1783 21.1872 29.3401 36.0488 38.9845 27.4153
Translational Efficiency 0.8997 1.0049 1.2889 1.0762 1.0892 1.0103 0.9934 0.9397 1.13 1.0185

Hit Data

Dataset Hit
Protein Concentration ✘
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✔

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1770 773 532 538 1444 536 1061 248 3214 1309 1593 786

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 810.42 974.08 2175.61 2197.20 901.04 894.11 1530.44 2330.59 851.13 941.33 1745.90 2239.29
Standard Deviation 130.26 174.89 503.26 716.72 136.87 198.95 420.91 763.67 140.69 189.25 543.29 734.48
Intensity Change Log 2 — 0.265370 1.424678 1.438925 — -0.011139 0.764283 1.371032 — 0.126414 1.114655 1.403579

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000234 0.000716 0.000550 0.000612 0.000108 0.000263 0.000286 0.002294 0.000178 0.000530 0.000374 0.001143
Bud Neck 0.003639 0.003638 0.004443 0.003983 0.003043 0.005451 0.001541 0.003834 0.003371 0.004380 0.002510 0.003936
Bud Site 0.010603 0.021026 0.008701 0.025167 0.007031 0.019564 0.006358 0.012191 0.008998 0.020427 0.007141 0.021073
Cell Periphery 0.000111 0.000117 0.001890 0.001344 0.000108 0.000101 0.000165 0.001612 0.000110 0.000111 0.000741 0.001428
Cytoplasm 0.728783* 0.726810* 0.785807* 0.778674* 0.686467* 0.664481* 0.799400* 0.733051* 0.709771* 0.701288* 0.794861* 0.764279*
Cytoplasmic Foci 0.134377 0.129736 0.023279 0.016784 0.139998 0.157067 0.025775 0.030814 0.136903 0.140927 0.024942 0.021211
Eisosomes 0.000040 0.000047 0.000004 0.000009 0.000036 0.000041 0.000008 0.000032 0.000038 0.000045 0.000007 0.000016
Endoplasmic Reticulum 0.001210 0.000724 0.000244 0.000793 0.002818 0.000507 0.000538 0.001103 0.001932 0.000635 0.000440 0.000891
Endosome 0.008691 0.013282 0.001029 0.010791 0.009365 0.020076 0.002247 0.012321 0.008994 0.016064 0.001841 0.011274
Golgi 0.003154 0.002365 0.002830 0.010821 0.001729 0.001794 0.000351 0.013984 0.002514 0.002131 0.001179 0.011819
Lipid Particles 0.001806 0.000926 0.006007 0.010504 0.002104 0.001993 0.001611 0.013891 0.001940 0.001363 0.003079 0.011572
Mitochondria 0.001817 0.001175 0.000110 0.000483 0.000651 0.002092 0.000078 0.000611 0.001293 0.001550 0.000089 0.000523
Mitotic Spindle 0.000910 0.002061 0.003557 0.010449 0.000696 0.000989 0.013961 0.001938 0.000814 0.001622 0.010486 0.007764
None 0.005108 0.001151 0.004941 0.001757 0.003663 0.001714 0.002604 0.001146 0.004459 0.001382 0.003385 0.001564
Nuclear Periphery 0.000118 0.000148 0.000312 0.000595 0.000246 0.000139 0.000302 0.000155 0.000175 0.000145 0.000305 0.000457
Nuclear Periphery Foci 0.001224 0.001841 0.005361 0.004945 0.001462 0.001854 0.005683 0.007514 0.001331 0.001846 0.005575 0.005755
Nucleolus 0.000651 0.000222 0.000126 0.000193 0.000369 0.001263 0.000124 0.000126 0.000524 0.000648 0.000124 0.000172
Nucleus 0.034310 0.017216 0.112530 0.018646 0.046797 0.024548 0.051809 0.025938 0.039920 0.020218 0.072087 0.020947
Peroxisomes 0.001109 0.002334 0.000088 0.001306 0.000669 0.002434 0.000137 0.000336 0.000912 0.002375 0.000120 0.001000
Vacuole 0.060490 0.073352 0.037688 0.096328 0.091301 0.090932 0.086823 0.134112 0.074333 0.080550 0.070414 0.108249
Vacuole Periphery 0.001614 0.001113 0.000503 0.005817 0.001338 0.002697 0.000199 0.002996 0.001490 0.001761 0.000301 0.004927

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -1.31 -6.40 -2.36 0.68 3.75 -3.20 -9.52 -1.45 -1.09 -0.85 -1.65 -7.84 -2.43 -0.13 -0.13
Bud Neck 0.23 -5.36 -2.48 -2.49 2.67 -2.48 0.92 -3.74 0.20 -4.48 -1.82 -2.57 -4.10 -1.48 -2.22
Bud Site -4.71 -0.21 -2.71 0.85 -2.36 -5.68 -1.84 -4.12 3.31 -3.33 -7.25 -0.65 -3.80 1.79 -3.54
Cell Periphery -0.20 -12.31 -6.03 -5.98 5.00 0.74 -5.88 -6.03 -6.08 -5.06 0.08 -12.41 -7.82 -7.80 -0.88
Cytoplasm 0.44 0.83 0.17 -0.17 -0.45 1.77 -2.00 1.99 0.67 2.98 1.28 -0.11 0.70 -0.26 0.71
Cytoplasmic Foci 0.88 25.19 29.47 19.54 4.22 -2.09 25.70 22.92 17.82 0.68 -0.64 36.54 38.09 26.67 3.97
Eisosomes -0.28 14.76 13.56 1.95 -0.79 -1.47 14.17 4.17 4.65 -0.44 -0.47 19.55 12.64 2.93 -0.08
Endoplasmic Reticulum 1.86 3.43 3.06 2.04 0.12 5.14 5.19 5.16 1.04 0.99 5.18 6.10 5.94 2.22 1.01
Endosome -2.41 12.08 3.18 4.19 -2.19 -4.93 12.22 2.72 5.59 -0.60 -5.00 16.41 4.28 6.96 -1.81
Golgi 1.83 -0.18 -0.50 -1.01 -0.46 -0.04 8.97 -0.96 -0.94 -1.57 1.49 6.49 -1.06 -1.39 -1.94
Lipid Particles 3.86 -8.90 -5.82 -6.47 -0.82 0.28 -2.31 -5.95 -5.79 -5.44 2.39 -8.40 -7.82 -8.26 -5.02
Mitochondria 0.79 3.07 2.93 1.29 -0.58 -1.19 3.53 2.63 1.62 -0.73 -0.26 3.83 3.50 2.06 -1.04
Mitotic Spindle -1.18 -5.02 -3.49 -2.83 -1.54 -0.60 -7.31 -2.09 -2.03 2.30 -1.32 -8.04 -4.08 -3.57 2.01
None 5.85 1.47 5.36 -0.94 7.00 2.47 1.89 3.07 0.97 3.92 6.02 3.16 5.99 -0.07 6.87
Nuclear Periphery -0.37 -8.71 -1.63 -1.30 0.95 1.86 -4.81 -0.28 -3.26 6.67 0.54 -9.65 -1.49 -1.67 1.78
Nuclear Periphery Foci -3.30 -12.40 -4.41 -3.33 3.80 -1.58 -11.12 -4.64 -4.11 0.53 -3.46 -16.15 -6.13 -5.01 3.07
Nucleolus 2.01 2.41 2.40 1.09 -0.05 -1.80 6.54 7.35 2.34 2.04 -0.41 3.23 3.28 2.48 0.46
Nucleus 10.32 -18.19 4.03 -4.51 19.38 7.95 -5.65 5.16 -1.45 9.05 12.95 -17.19 7.24 -3.83 20.58
Peroxisomes -3.06 7.94 1.71 3.69 -1.68 -4.63 6.62 5.05 5.88 -1.76 -5.22 10.03 2.10 5.69 -1.70
Vacuole -3.51 -0.56 -11.07 -8.47 -9.74 -0.35 -8.77 -9.05 -8.55 -4.85 -2.46 -9.92 -13.58 -11.64 -6.70
Vacuole Periphery 2.02 4.99 -0.92 -1.63 -2.35 -1.48 7.67 0.85 1.74 -1.58 -0.53 8.83 -0.73 -0.31 -2.92
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Member of Hsp110 subclass of the heat shock protein 70 (HSP70) family; serves as nucleotide exchange factor to load ATP onto the SSA class of cytosolic Hsp70s; may be involved in protein folding; localized to the cytoplasm; SSE2 has a paralog, SSE1, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (99%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-9

Sse2

Sse2


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Sse2-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available