Standard name
Human Ortholog
Description Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S232 in a TORC1/2-dependent manner by Ypk1/2/3p; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0.05 0.06 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0.05 0.05 0.05 0 0.05 0 0 – 0 0 0.07 0 0 0 0 0 0 0 0
Cytoplasm 0.98 0.98 0.95 0.91 0.87 0.83 0.73 0.64 0.57 0.59 0.49 0.53 – 0.97 0.98 0.93 0.93 0.96 0.93 0.96 0.91 0.84 0.78 0.86
Endoplasmic Reticulum 0 0 0.05 0.05 0.07 0.05 0.1 0.2 0.1 0.11 0.08 0.07 – 0 0 0 0 0 0 0 0 0.1 0.12 0.07
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.14 0.17 0.15 0.39 0.29 0.45 0.36 – 0 0 0 0 0 0 0 0 0 0.05 0
Nucleus 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 0 0 0 0.05 0 0 0 0 0.07 0 0.07 – 0 0 0 0.06 0 0 0 0 0 0 0
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 1 2 1 9 9 9 6 5 0 – 1 0 1 1 1 0 0 0 0 0 0
Bud 0 0 0 0 0 0 2 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 1 0
Bud Neck 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 – – – – – –
Cell Periphery 0 1 4 4 4 6 12 10 6 9 5 0 – 4 2 18 2 8 0 0 0 0 0 1
Cytoplasm 146 133 108 124 129 102 163 128 88 105 58 40 – 118 114 250 199 264 142 151 116 96 94 149
Endoplasmic Reticulum 3 1 6 7 10 6 23 40 15 20 9 5 – 1 4 8 8 10 3 2 5 11 14 11
Endosome 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 1
Golgi 0 0 0 1 3 2 4 2 3 3 0 2 – 0 0 2 4 0 0 0 0 0 0 0
Mitochondria 0 1 0 6 0 17 37 30 60 52 53 27 – 0 0 0 4 8 2 0 1 0 5 3
Nucleus 0 0 0 1 1 2 2 2 0 1 0 2 – 0 2 1 1 0 1 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 1 1 1 0 4 0 – 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 1 1 1 – 0 0 0 0 0 0 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 1
SpindlePole 0 0 0 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0 1 0 5 7 4 10 6 5 12 5 5 – 1 0 12 13 4 0 3 2 1 2 2
Unique Cell Count 149 136 114 137 149 123 223 199 154 179 119 75 122 116 270 213 274 153 158 128 114 121 173
Labelled Cell Count 149 137 118 149 156 140 263 228 187 209 140 82 125 122 292 232 295 153 158 128 114 121 173


Cytoplasm

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 15.8 22.8 15.4 17.0 16.6 13.4 12.9 12.7 11.8 11.9 11.1 10.8 – 18.9 18.2 24.3 24.5 25.4 18.0 15.6 18.0
Std Deviation (1e-4) 2.9 4.0 2.5 2.9 3.0 3.1 3.1 2.8 2.5 2.8 2.7 2.4 – 3.2 3.6 6.1 6.1 6.4 4.2 4.0 4.4
Intensity Change (Log2) – – – 0.14 0.11 -0.2 -0.25 -0.28 -0.38 -0.37 -0.47 -0.5 – 0.3 0.25 0.66 0.67 0.73 0.23 0.02 0.23

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP540RAP620RAP7000102030WT3HU120HU1600102030WT3rpd3Δ_1rpd3Δ_2rpd3Δ_30102030WT1AF100AF140AF1800102030
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0
Cell Periphery 0 0 0 0.8 0.6 0 0.6 0 0 – 0 0 1.2 0 0
Cytoplasm -1.3 -2.2 -2.9 -4.7 -6.0 -6.9 -6.8 -7.8 -6.8 – 0.8 1.5 -0.8 -0.5 0.7
Endoplasmic Reticulum -0.1 0.5 -0.1 1.6 3.6 1.3 1.7 0.7 0 – 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0
Mitochondria 0 0 4.1 4.6 4.4 7.6 6.3 8.1 6.9 – 0 0 0 0 0
Nucleus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0
Nuclear Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0
Nucleolus 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0
Vacuole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 26.5211 34.9736 32.25 31.2431 25.0575 32.0047 27.232 33.8451 31.8206 27.9101 29.4427 30.8481 28.2795 37.4315 32.7429 23.9491 28.6654 32.9587
Actin 0.0046 0.0015 0.0004 0.001 0.0044 0.0008 0.004 0.0011 0.0005 0.0003 0.0005 0.0016 0.0013 0.0038 0.0019 0.005 0.0022 0.0022
Bud 0.0012 0.0005 0.0006 0.0051 0.0031 0.0008 0.0008 0.0004 0.0006 0.0009 0.0009 0.0012 0.005 0.006 0.0068 0.0203 0.009 0.0044
Bud Neck 0.0011 0.0004 0.0006 0.0008 0.0009 0.0013 0.0006 0.0004 0.0007 0.0012 0.0011 0.0015 0.0014 0.0012 0.0016 0.0026 0.0028 0.0048
Bud Periphery 0.0022 0.0008 0.0004 0.0227 0.0061 0.0008 0.0011 0.0002 0.0007 0.0004 0.0008 0.0018 0.0087 0.0042 0.0092 0.0224 0.0155 0.0097
Bud Site 0.001 0.0006 0.0004 0.0007 0.002 0.0001 0.0005 0.0004 0.0003 0.0002 0.0001 0.0001 0.0024 0.0074 0.005 0.0036 0.0016 0.0005
Cell Periphery 0.0041 0.0031 0.0014 0.0018 0.0053 0.0009 0.0047 0.0006 0.0012 0.0009 0.0005 0.0022 0.0073 0.0035 0.0103 0.0048 0.0031 0.0054
Cytoplasm 0.7342 0.9292 0.8731 0.8014 0.7014 0.8285 0.7535 0.9226 0.8729 0.8707 0.8226 0.7932 0.6743 0.8527 0.727 0.5542 0.7133 0.6935
Cytoplasmic Foci 0.0073 0.0034 0.0095 0.0054 0.0257 0.0095 0.0057 0.0052 0.0066 0.0097 0.0136 0.0108 0.004 0.0031 0.0042 0.0046 0.0089 0.0068
Eisosomes 0.0001 0.0001 0 0 0.0005 0 0.0001 0 0 0 0 0 0 0.0001 0 0 0 0.0001
Endoplasmic Reticulum 0.0823 0.0244 0.0223 0.0084 0.0277 0.0707 0.1063 0.0319 0.0378 0.0175 0.0474 0.0875 0.1042 0.0397 0.045 0.0394 0.036 0.1188
Endosome 0.0367 0.0075 0.0244 0.0232 0.0536 0.0411 0.0322 0.0132 0.0221 0.0392 0.067 0.0439 0.0132 0.0072 0.0086 0.017 0.0346 0.0294
Golgi 0.0057 0.0022 0.0023 0.0028 0.0049 0.0069 0.0055 0.0046 0.0024 0.0038 0.0092 0.0132 0.0016 0.0021 0.0018 0.001 0.0035 0.0073
Lipid Particles 0.0013 0.0004 0.0014 0.0004 0.0118 0.0002 0.0006 0.0002 0.0003 0.0002 0.0001 0.0002 0.001 0.0004 0.0015 0.0009 0.0012 0.0004
Mitochondria 0.011 0.0045 0.0021 0.0126 0.0172 0.007 0.0051 0.0017 0.0016 0.0005 0.0059 0.0175 0.0032 0.001 0.0025 0.0019 0.0018 0.0113
None 0.0038 0.0015 0.003 0.0009 0.0158 0.0006 0.0008 0.0002 0.0003 0.0002 0.0003 0.0006 0.0012 0.0006 0.0016 0.0013 0.0014 0.0007
Nuclear Periphery 0.0162 0.0017 0.0042 0.0036 0.0166 0.0035 0.0113 0.0014 0.003 0.003 0.0021 0.0038 0.016 0.0054 0.0111 0.0261 0.0179 0.0095
Nucleolus 0.0013 0.0001 0.0018 0.0003 0.0022 0 0.0001 0.0001 0 0 0 0 0.001 0.0007 0.0011 0.0037 0.0021 0.001
Nucleus 0.007 0.0012 0.0044 0.0025 0.0082 0.0015 0.003 0.0018 0.0013 0.0018 0.0012 0.0012 0.0765 0.0322 0.0855 0.1284 0.0647 0.046
Peroxisomes 0.0007 0.0001 0.0002 0.0003 0.0007 0.0001 0.0006 0 0 0.0001 0.0001 0.0001 0.0007 0.0001 0.0001 0.0001 0.0001 0.0001
Punctate Nuclear 0.0022 0.0001 0.001 0.0001 0.0067 0.0004 0.0001 0 0.0001 0 0 0.0001 0.0058 0.0018 0.0101 0.0078 0.0083 0.0062
Vacuole 0.063 0.0147 0.0377 0.0911 0.0627 0.0186 0.054 0.0129 0.042 0.0436 0.0202 0.015 0.0615 0.0247 0.0591 0.141 0.0627 0.0335
Vacuole Periphery 0.0132 0.0021 0.0087 0.015 0.0225 0.0067 0.0095 0.0012 0.0057 0.0057 0.0065 0.0044 0.0094 0.0021 0.0059 0.0136 0.0093 0.0083

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 3217.099 3609.7761 4404.9848 3396.6013 4039.3161 3894.6761 3130.8397 2957.1173 3409.6389 2838.0761
Translational Efficiency 0.9071 0.9111 0.789 1.0834 0.9361 0.7032 0.8985 1.0558 0.8812 0.9719

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✘
Gene Expression ✘
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1876 137 2262 946 2007 2055 2240 206 3883 2192 4502 1152

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 1300.77 1943.60 1882.67 2108.27 1509.86 1679.91 2078.32 1963.66 1408.84 1696.39 1980.02 2082.41
Standard Deviation 229.71 328.39 322.88 350.23 245.16 326.68 321.11 376.72 259.76 332.96 336.53 359.41
Intensity Change Log 2 — 0.579365 0.533414 0.696694 — 0.153969 0.461003 0.379130 — 0.366494 0.494968 0.534819

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000101 0.000336 0.000107 0.000402 0.000111 0.000147 0.000099 0.000367 0.000106 0.000159 0.000103 0.000396
Bud Neck 0.000121 0.001582 0.000525 0.001045 0.000164 0.000166 0.000585 0.002100 0.000143 0.000254 0.000555 0.001233
Bud Site 0.012372 0.025806 0.007459 0.017139 0.010127 0.010166 0.006945 0.028378 0.011212 0.011143 0.007203 0.019149
Cell Periphery 0.000596 0.007687 0.001462 0.015554 0.000569 0.000649 0.002430 0.004629 0.000582 0.001089 0.001944 0.013600
Cytoplasm 0.793962 0.695108 0.856561 0.664887 0.751162 0.853952 0.796870 0.762942 0.771840 0.844024 0.826861 0.682421
Cytoplasmic Foci 0.098091 0.062342 0.018315 0.019352 0.104387 0.053114 0.017616 0.037744 0.101345 0.053691 0.017967 0.022641
Eisosomes 0.000002 0.000004 0.000001 0.000004 0.000001 0.000002 0.000001 0.000004 0.000002 0.000002 0.000001 0.000004
Endoplasmic Reticulum 0.004288 0.003813 0.001686 0.002710 0.006994 0.002449 0.002351 0.000875 0.005687 0.002534 0.002017 0.002382
Endosome 0.003460 0.008794 0.002908 0.003836 0.005074 0.003960 0.002773 0.007158 0.004294 0.004263 0.002841 0.004430
Golgi 0.024521 0.092304 0.031342 0.090060 0.035775 0.032421 0.043559 0.039674 0.030338 0.036164 0.037421 0.081050
Lipid Particles 0.000589 0.017281 0.003273 0.022426 0.000692 0.001429 0.004571 0.010404 0.000643 0.002420 0.003919 0.020276
Mitochondria 0.000795 0.000108 0.000158 0.000194 0.000507 0.000609 0.000171 0.000048 0.000646 0.000578 0.000164 0.000168
Mitotic Spindle 0.000723 0.002948 0.002906 0.001828 0.001542 0.002240 0.001790 0.002313 0.001146 0.002284 0.002351 0.001915
None 0.001461 0.000231 0.000401 0.000440 0.000415 0.000367 0.000393 0.000215 0.000921 0.000358 0.000397 0.000400
Nuclear Periphery 0.000024 0.000095 0.000088 0.000192 0.000048 0.000026 0.000125 0.000046 0.000037 0.000030 0.000107 0.000166
Nuclear Periphery Foci 0.001092 0.010443 0.005662 0.009638 0.001763 0.001408 0.006979 0.004058 0.001439 0.001973 0.006317 0.008640
Nucleolus 0.000097 0.000032 0.000033 0.000067 0.000017 0.000112 0.000045 0.000083 0.000055 0.000107 0.000039 0.000070
Nucleus 0.002530 0.001185 0.002081 0.002960 0.000696 0.001093 0.001893 0.003261 0.001582 0.001098 0.001987 0.003014
Peroxisomes 0.000093 0.000230 0.000042 0.000096 0.000055 0.000205 0.000044 0.000415 0.000074 0.000207 0.000043 0.000153
Vacuole 0.012593 0.030533 0.038058 0.089780 0.017704 0.010717 0.060920 0.081042 0.015235 0.011956 0.049433 0.088218
Vacuole Periphery 0.042488 0.039137 0.026932 0.057388 0.062195 0.024766 0.049841 0.014242 0.052674 0.025664 0.038331 0.049673

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -3.67 -0.65 -6.43 -0.97 -6.21 -1.54 0.20 -3.89 -3.36 -3.97 -2.69 -0.21 -7.22 -5.62 -7.19
Bud Neck -3.15 -7.86 -12.22 1.07 -5.49 -0.11 -6.18 -5.65 -5.65 -4.44 -3.28 -9.57 -11.90 -10.33 -6.68
Bud Site -3.01 5.79 -3.30 1.84 -6.70 -0.06 3.96 -3.75 -3.74 -4.37 0.07 6.88 -5.47 -5.22 -8.17
Cell Periphery -6.00 -6.59 -12.26 -4.56 -11.49 -1.13 -11.26 -4.22 -4.13 -2.11 -4.81 -12.90 -12.70 -12.14 -11.30
Cytoplasm 3.79 -8.24 10.65 1.09 16.40 -13.18 -5.31 -0.39 5.05 1.90 -11.05 -9.56 8.79 15.27 14.24
Cytoplasmic Foci 4.04 22.07 21.36 5.25 -0.65 13.59 26.83 12.21 3.14 -4.40 15.37 34.49 29.71 13.18 -3.40
Eisosomes -2.37 3.65 -5.04 -0.82 -7.12 -2.46 1.47 -3.30 -1.99 -3.57 -2.12 3.86 -6.51 -3.79 -7.90
Endoplasmic Reticulum 0.47 5.90 3.25 1.16 -2.80 5.13 5.73 7.73 3.44 5.04 5.23 7.80 6.57 0.35 -1.16
Endosome -4.18 1.55 -1.11 3.89 -2.69 2.33 7.77 -1.63 -2.45 -3.53 0.06 6.54 -0.34 -0.28 -4.68
Golgi -6.41 -4.04 -14.62 0.29 -12.72 1.65 -3.58 -0.17 -0.72 1.10 -3.17 -5.13 -12.94 -10.66 -10.84
Lipid Particles -3.93 -8.81 -10.06 -1.06 -8.71 -2.22 -11.71 -7.13 -6.40 -4.12 -4.26 -14.55 -10.89 -9.64 -8.96
Mitochondria 4.56 4.59 4.12 -1.10 -0.70 -0.53 2.54 3.48 3.82 4.89 0.40 5.03 4.65 2.88 -0.05
Mitotic Spindle -4.16 -5.13 -5.13 1.95 2.40 -1.67 -1.21 -1.50 -0.83 -1.16 -2.95 -4.83 -3.36 0.47 0.99
None 2.80 2.41 2.33 -5.73 -1.22 0.49 0.24 1.95 2.26 3.26 2.55 2.41 2.40 -0.89 -0.03
Nuclear Periphery -4.06 -10.34 -10.30 -4.12 -5.88 3.51 -7.78 -1.00 -3.94 6.40 1.36 -11.90 -9.58 -9.87 -4.00
Nuclear Periphery Foci -5.09 -11.73 -14.67 0.43 -5.65 1.82 -11.70 -3.95 -4.68 4.55 -2.84 -16.46 -14.59 -13.10 -3.90
Nucleolus 1.55 1.52 0.67 -5.20 -7.15 -1.07 -13.34 -5.36 0.30 -3.15 -0.62 0.78 -0.81 0.45 -6.96
Nucleus 2.00 0.54 -0.78 -5.29 -2.66 -1.40 -9.31 -6.21 -5.00 -3.95 1.13 -1.57 -4.11 -5.59 -4.10
Peroxisomes -1.64 4.45 -0.16 1.61 -4.45 -1.68 1.52 -5.43 -1.89 -5.60 -1.59 4.57 -4.79 0.64 -6.94
Vacuole -3.50 -13.32 -16.67 -8.77 -10.58 5.32 -16.51 -7.21 -7.96 -2.51 3.04 -21.00 -17.80 -18.46 -9.04
Vacuole Periphery 0.39 6.09 -3.70 -1.96 -8.73 12.49 3.72 14.80 4.64 12.50 11.92 6.77 1.15 -7.66 -3.65
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; phosphorylated on S233 by Ypk3p in a TORC1-dependent manner, and on S232 in a TORC1/2-dependent manner by Ypk1/2/3p; RPS6B has a paralog, RPS6A, that arose from the whole genome duplication
Localization
Cell Percentages cytoplasm (97%)
Cell Cycle Regulation No
Subcompartmental Group cytoplasm-7

Rps6b

Rps6b


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Rps6b-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available