Standard name | |
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Human Ortholog | |
Description | Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 affects multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of DNA damage checkpoint after DNA repair; chromatin dynamics during transcription; and repression of divergent noncoding transcription; Msi1p localizes to nucleus and cytoplasm and independently regulates the RAS/cAMP pathway via sequestration of Npr1p kinase |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 1 | 5 | 0 | 1 | 1 |
Bud | 0 | 0 | 1 | 0 | 2 | 3 | 16 | 12 | 12 | 23 | 17 | 18 | 0 | 0 | 0 | 0 | 0 | 1 | 3 | 1 | 2 | 1 | 4 | 6 |
Bud Neck | 0 | 0 | 1 | 0 | 0 | 1 | 3 | 2 | 5 | 3 | 1 | 4 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 2 |
Bud Site | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 4 | 1 | 10 | 11 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | – | – | – | – | – | – |
Cell Periphery | 3 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 2 | 5 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 3 | 0 | 0 | 0 |
Cytoplasm | 97 | 164 | 365 | 302 | 351 | 412 | 548 | 525 | 525 | 378 | 225 | 310 | 233 | 462 | 508 | 109 | 74 | 71 | 167 | 148 | 253 | 200 | 238 | 269 |
Endoplasmic Reticulum | 0 | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 8 | 9 | 10 | 18 | 0 | 3 | 0 | 2 | 1 |
Endosome | 0 | 0 | 1 | 1 | 3 | 5 | 0 | 5 | 6 | 0 | 0 | 2 | 0 | 1 | 1 | 11 | 10 | 9 | 9 | 2 | 3 | 1 | 4 | 3 |
Golgi | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 4 | 4 | 0 | 0 | 3 | 0 | 2 | 1 |
Mitochondria | 2 | 6 | 3 | 20 | 29 | 105 | 286 | 256 | 256 | 389 | 330 | 367 | 0 | 0 | 0 | 16 | 7 | 11 | 34 | 7 | 43 | 1 | 11 | 13 |
Nucleus | 2 | 7 | 4 | 3 | 1 | 5 | 18 | 28 | 28 | 46 | 43 | 46 | 3 | 4 | 5 | 47 | 34 | 33 | 1 | 8 | 5 | 1 | 5 | 4 |
Nuclear Periphery | 9 | 0 | 1 | 1 | 0 | 0 | 0 | 4 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Nucleolus | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3 | 3 | 5 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peroxisomes | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
SpindlePole | 0 | 0 | 0 | 0 | 2 | 4 | 4 | 13 | 20 | 13 | 4 | 8 | 0 | 0 | 1 | 1 | 1 | 1 | 7 | 4 | 5 | 3 | 6 | 8 |
Vac/Vac Membrane | 0 | 10 | 7 | 10 | 10 | 22 | 24 | 31 | 20 | 24 | 23 | 42 | 2 | 7 | 11 | 104 | 71 | 59 | 25 | 12 | 35 | 7 | 20 | 12 |
Unique Cell Count | 110 | 184 | 377 | 323 | 367 | 484 | 732 | 741 | 743 | 666 | 500 | 625 | 240 | 472 | 523 | 260 | 185 | 169 | 289 | 193 | 376 | 227 | 307 | 334 |
Labelled Cell Count | 113 | 190 | 386 | 340 | 401 | 558 | 901 | 883 | 875 | 893 | 657 | 808 | 244 | 476 | 529 | 301 | 212 | 199 | 289 | 193 | 376 | 227 | 307 | 334 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 3.3 | 3.8 | 3.8 | 3.6 | 3.6 | 3.3 | 3.1 | 3.1 | 3.1 | 2.8 | 2.7 | 2.8 | 4.9 | 4.9 | 4.8 | 5.7 | 6.0 | 5.2 | 5.0 | 5.2 | 5.4 |
Std Deviation (1e-4) | 0.8 | 0.7 | 1.2 | 1.7 | 1.5 | 1.5 | 1.3 | 1.2 | 1.2 | 0.7 | 0.8 | 0.7 | 0.8 | 0.9 | 1.0 | 1.6 | 2.0 | 1.6 | 1.4 | 1.3 | 1.7 |
Intensity Change (Log2) | – | – | – | -0.1 | -0.06 | -0.21 | -0.29 | -0.3 | -0.3 | -0.43 | -0.52 | -0.45 | 0.37 | 0.35 | 0.33 | 0.59 | 0.65 | 0.46 | 0.4 | 0.44 | 0.49 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Actin | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Bud | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Neck | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Bud Site | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cell Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cyto | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Endoplasmic Reticulum | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Endosome | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Golgi | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Mitochondria | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuclear Periphery | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nuc | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Nucleolus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Peroxisomes | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
SpindlePole | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vac | – | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
Cortical Patches | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Cytoplasm | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Nucleus | – | – | – | – | – | – | – | – | – | – | – | – | 0 | 0 | 0 |
Vacuole | – | – | – | – | – | – | – | – | – | – | – | – | 12.5 | 11.8 | 11.0 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 1.2974 | 2.0041 | 1.7907 | 1.357 | 1.2092 | 1.9093 | 0.3335 | -0.8465 | -1.011 | -1.1778 | -2.0993 | -0.8374 | -1.5455 | -0.9878 | -1.0213 | -1.3109 | -0.0514 | -1.1576 |
Actin | 0.0084 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0003 | 0.1192 | 0.0009 | 0.0221 | 0.008 | 0.0008 | 0.0056 | 0.0111 | 0.0016 | 0.0161 | 0.015 | 0.0158 | 0.0011 |
Bud | 0.0003 | 0.0003 | 0.0003 | 0 | 0.0001 | 0.0022 | 0.0015 | 0.0088 | 0.0048 | 0.0005 | 0 | 0.0003 | 0.0021 | 0.0463 | 0.0296 | 0.0074 | 0.0086 | 0.0054 |
Bud Neck | 0.0013 | 0.0002 | 0.0001 | 0.0001 | 0.0001 | 0.0016 | 0.0019 | 0.0002 | 0.0153 | 0.0004 | 0.0005 | 0.0007 | 0.0005 | 0.0002 | 0.0011 | 0.0009 | 0.0005 | 0.0048 |
Bud Periphery | 0.0003 | 0.0004 | 0.0003 | 0 | 0.0001 | 0.0021 | 0.0026 | 0.002 | 0.0015 | 0.0006 | 0 | 0.0005 | 0.001 | 0.0142 | 0.01 | 0.0056 | 0.0033 | 0.0074 |
Bud Site | 0.0083 | 0.0006 | 0.0004 | 0 | 0 | 0.0003 | 0.0157 | 0.0033 | 0.0247 | 0.0009 | 0 | 0.0004 | 0.0014 | 0.0068 | 0.013 | 0.004 | 0.0033 | 0.0011 |
Cell Periphery | 0.0002 | 0.0001 | 0.0001 | 0 | 0 | 0.0001 | 0.0011 | 0.0002 | 0.0002 | 0.0001 | 0 | 0.0001 | 0.0002 | 0.0004 | 0.0005 | 0.0007 | 0.0003 | 0.0004 |
Cytoplasm | 0.1322 | 0.1011 | 0.0882 | 0.1052 | 0.1212 | 0.1866 | 0.077 | 0.2646 | 0.303 | 0.2689 | 0.2051 | 0.3495 | 0.1204 | 0.1486 | 0.1418 | 0.2072 | 0.0642 | 0.2583 |
Cytoplasmic Foci | 0.0085 | 0.0031 | 0.0116 | 0.0023 | 0.0184 | 0.014 | 0.0775 | 0.0089 | 0.0522 | 0.0106 | 0.0152 | 0.0285 | 0.0532 | 0.0094 | 0.0186 | 0.0151 | 0.0264 | 0.0277 |
Eisosomes | 0.0001 | 0.0001 | 0.0002 | 0.0001 | 0 | 0.0001 | 0.0017 | 0.0001 | 0.0002 | 0.0001 | 0 | 0.0001 | 0.0002 | 0.0002 | 0.0002 | 0.0002 | 0.0004 | 0 |
Endoplasmic Reticulum | 0.0025 | 0.0015 | 0.0015 | 0.0015 | 0.0019 | 0.0033 | 0.0097 | 0.0026 | 0.0025 | 0.003 | 0.0023 | 0.0036 | 0.0053 | 0.0021 | 0.0028 | 0.0015 | 0.0011 | 0.0024 |
Endosome | 0.0073 | 0.0009 | 0.0045 | 0.0018 | 0.044 | 0.0064 | 0.0758 | 0.0087 | 0.0303 | 0.0067 | 0.0021 | 0.0251 | 0.0381 | 0.0041 | 0.0108 | 0.005 | 0.0958 | 0.012 |
Golgi | 0.0005 | 0 | 0.0001 | 0 | 0.0006 | 0.0003 | 0.0242 | 0.0019 | 0.0166 | 0.0106 | 0.0001 | 0.0207 | 0.0108 | 0.0005 | 0.0064 | 0.0042 | 0.0196 | 0.0018 |
Lipid Particles | 0.0013 | 0.0003 | 0.0012 | 0.0001 | 0.0009 | 0.0016 | 0.0687 | 0.0014 | 0.0029 | 0.0064 | 0.0002 | 0.0283 | 0.0127 | 0.002 | 0.0137 | 0.0008 | 0.0327 | 0.0036 |
Mitochondria | 0.0003 | 0.0004 | 0.0005 | 0.0004 | 0.0013 | 0.0008 | 0.05 | 0.0097 | 0.0107 | 0.0148 | 0.0001 | 0.0227 | 0.0099 | 0.0026 | 0.0122 | 0.0105 | 0.1265 | 0.002 |
None | 0.7653 | 0.8303 | 0.8574 | 0.8395 | 0.796 | 0.6725 | 0.2479 | 0.637 | 0.4613 | 0.583 | 0.7112 | 0.4245 | 0.569 | 0.6586 | 0.5742 | 0.5192 | 0.4696 | 0.4953 |
Nuclear Periphery | 0.0027 | 0.0046 | 0.0019 | 0.0104 | 0.0022 | 0.0048 | 0.0323 | 0.0023 | 0.0034 | 0.0046 | 0.0036 | 0.0057 | 0.0192 | 0.0081 | 0.0072 | 0.0054 | 0.0076 | 0.0062 |
Nucleolus | 0.0007 | 0.0009 | 0.001 | 0.0006 | 0.0003 | 0.0018 | 0.0033 | 0.0006 | 0.0006 | 0.0008 | 0.0002 | 0.0005 | 0.0024 | 0.0016 | 0.0033 | 0.0046 | 0.0102 | 0.0024 |
Nucleus | 0.0377 | 0.0482 | 0.0181 | 0.0259 | 0.0035 | 0.0739 | 0.0931 | 0.0301 | 0.0232 | 0.0682 | 0.0532 | 0.0535 | 0.1193 | 0.0734 | 0.1051 | 0.1084 | 0.0484 | 0.1138 |
Peroxisomes | 0.0012 | 0.0001 | 0.0003 | 0.0001 | 0.0003 | 0.0006 | 0.0317 | 0.0005 | 0.0039 | 0.0056 | 0.0002 | 0.0127 | 0.0029 | 0.0009 | 0.0073 | 0.0005 | 0.0417 | 0.0033 |
Punctate Nuclear | 0.011 | 0.0055 | 0.0076 | 0.0105 | 0.0012 | 0.0227 | 0.0493 | 0.0039 | 0.0117 | 0.0042 | 0.0048 | 0.0106 | 0.0109 | 0.0155 | 0.0233 | 0.0804 | 0.0141 | 0.0348 |
Vacuole | 0.009 | 0.0011 | 0.0043 | 0.001 | 0.0057 | 0.0037 | 0.0115 | 0.0109 | 0.0072 | 0.0015 | 0.0004 | 0.0052 | 0.0065 | 0.0023 | 0.0018 | 0.0024 | 0.0058 | 0.0127 |
Vacuole Periphery | 0.0009 | 0.0002 | 0.0003 | 0.0003 | 0.0021 | 0.0004 | 0.0042 | 0.0014 | 0.0016 | 0.0006 | 0.0001 | 0.0013 | 0.0029 | 0.0006 | 0.0012 | 0.0008 | 0.004 | 0.0033 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 11.7383 | 14.7684 | 4.0375 | 11.2099 | 10.1462 | 8.6903 | 9.2345 | 9.8131 | 10.1063 | 12.9437 |
Translational Efficiency | 1.1587 | 0.6308 | 2.3392 | 0.7619 | 1.0229 | 1.5811 | 0.9851 | 0.7215 | 0.914 | 0.8824 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✘ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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