Standard name
Human Ortholog
Description Component of the Mcm2-7 hexameric helicase complex; MCM2-7 primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex
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Micrographs

ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0.07 0.09 0.12 0.07 0 0
Bud Neck 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Cytoplasm 0.33 0.25 0.4 0.28 0.43 0.32 0.28 0.25 0.2 – 0.18 0.19 0.09 0.17 0.21 0.44 0.41 0.43 0.18 0.13 0.21 0.06 0 0
Endoplasmic Reticulum 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Endosome 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0.05 0 0 0 0 0 0 0 0 0.06
Golgi 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Mitochondria 0 0 0 0 0 0.08 0.06 0 0.21 – 0.25 0.12 0 0 0 0 0 0 0 0 0 0 0 0
Nucleus 0.45 0.6 0.48 0.58 0.38 0.42 0.5 0.49 0.49 – 0.51 0.55 0.77 0.54 0.44 0.41 0.42 0.4 0.47 0.59 0.48 0.59 0.39 0.31
Nuclear Periphery 0 0 0 0 0 0 0 0.05 0.05 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Nucleolus 0.12 0.09 0 0.07 0.1 0.16 0.15 0.15 0.22 – 0.22 0.2 0.1 0.21 0.21 0 0.05 0 0.13 0.09 0.05 0.16 0.33 0.32
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
Vac/Vac Membrane 0.09 0.06 0.12 0.05 0.09 0.05 0 0.06 0 – 0 0 0.07 0.09 0.14 0.12 0.13 0.17 0 0 0 0.06 0.17 0.18
ensLOC DeepLoc
Localization WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 WT1 WT2 WT3 AF100 AF140 AF180
Cortical Patches 0 0 1 0 2 0 1 1 0 – 1 0 0 0 1 0 0 0 0 0 0 0 0 0
Bud 4 1 4 3 6 5 9 10 14 – 9 9 0 0 0 0 0 0 15 22 30 20 7 9
Bud Neck 0 0 0 0 2 3 2 8 2 – 2 3 1 0 0 0 0 0 2 2 2 1 4 3
Bud Site 0 0 0 0 1 3 1 0 6 – 5 5 0 0 0 0 0 0 – – – – – –
Cell Periphery 0 1 1 1 0 2 4 8 2 – 2 3 0 1 1 6 4 6 0 0 0 0 0 0
Cytoplasm 61 58 97 69 172 117 125 123 80 – 54 69 33 90 115 181 99 97 39 31 53 18 3 1
Endoplasmic Reticulum 0 1 0 0 0 0 1 0 0 – 0 1 0 1 1 12 6 5 0 0 0 1 0 1
Endosome 7 5 3 6 12 12 8 10 4 – 0 1 6 18 28 4 7 5 8 3 6 2 15 37
Golgi 0 0 0 2 0 0 0 1 0 – 0 0 0 0 0 2 1 1 1 1 0 0 4 3
Mitochondria 7 2 1 1 4 31 26 21 84 – 73 42 3 1 3 3 0 1 1 0 2 0 4 10
Nucleus 82 139 117 143 151 157 226 239 191 – 150 200 288 281 240 169 102 92 104 143 121 167 205 204
Nuclear Periphery 1 1 0 1 5 14 17 24 21 – 4 5 0 5 12 3 0 1 0 0 0 0 2 13
Nucleolus 22 21 5 18 38 59 68 72 86 – 66 74 39 111 118 14 11 5 29 21 13 43 172 210
Peroxisomes 0 0 0 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 2 3 3 4 11 2 – 0 0 0 1 0 2 2 1 4 9 8 7 10 23
Vac/Vac Membrane 17 14 28 12 35 17 17 31 10 – 9 13 26 47 76 51 32 38 8 7 8 16 88 119
Unique Cell Count 184 232 242 245 397 371 452 490 393 297 363 373 523 551 412 241 228 220 245 252 281 526 649
Labelled Cell Count 201 243 257 258 431 423 509 559 502 375 425 396 556 595 447 264 252 220 245 252 281 526 649


Cytoplasm, Nucleus

(Huh et al. Nature 2003 425:686)
Screen WT1 WT2 WT3 RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3 AF100 AF140 AF180
Mean Cell GFP Intensity (1e-4) 11.8 12.3 10.1 9.9 9.2 7.6 7.5 8.2 6.7 – 6.3 6.5 13.2 13.4 13.0 15.5 16.0 15.0 11.2 11.3 11.7
Std Deviation (1e-4) 3.5 3.2 2.0 2.2 1.9 1.9 1.9 2.0 1.9 – 1.8 1.6 3.1 2.9 2.8 4.6 4.9 4.7 2.7 2.3 2.1
Intensity Change (Log2) – – – -0.03 -0.13 -0.41 -0.43 -0.3 -0.59 – -0.69 -0.63 0.39 0.41 0.37 0.62 0.66 0.57 0.15 0.16 0.21

WT3RAP60RAP140RAP220RAP300RAP380RAP460RAP620RAP70005101520WT3HU80HU120HU16005101520WT3rpd3Δ_1rpd3Δ_2rpd3Δ_305101520WT1AF100AF140AF18005101520
rapamycinhydroxy-urearpd3 knockoutalpha-factorMultiple Condition Time-Course Intensity PlotsGFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)GFP Intensity (1e-4)

Localization RAP60 RAP140 RAP220 RAP300 RAP380 RAP460 RAP540 RAP620 RAP700 HU80 HU120 HU160 rpd3Δ_1 rpd3Δ_2 rpd3Δ_3
Cortical Patches 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud 0 0 0 0 0 1.4 – 1.0 0.7 0 0 0 0 0 0
Bud Neck 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Bud Site 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cell Periphery 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Cytoplasm -2.8 0.8 -2.2 -3.3 -4.2 -5.4 – -5.6 -5.7 -9.3 -6.8 -5.6 1.0 0.2 0.5
Endoplasmic Reticulum 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Endosome 0 1.4 1.6 0 0 0 – 0 0 0 1.7 2.6 0 0 0
Golgi 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Mitochondria 0 0 4.3 3.5 2.9 7.5 – 8.1 5.2 0 0 0 0 0 0
Nucleus 2.2 -2.6 -1.5 0.4 0.1 0.1 – 0.5 1.6 7.4 1.4 -1.2 -1.8 -1.3 -1.7
Nuclear Periphery 0 0 3.1 3.1 3.5 3.7 – 0 0 0 0 0 0 0 0
Nucleolus 2.7 3.7 5.5 5.3 5.2 6.9 – 6.9 6.6 3.9 6.9 6.9 1.0 1.5 0
Peroxisomes 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
SpindlePole 0 0 0 0 0 0 – 0 0 0 0 0 0 0 0
Vacuole -2.7 -1.1 -3.2 -4.0 -2.5 -4.7 – -3.9 -3.8 -2.0 -1.1 0.9 0.3 0.6 1.6

Images

Circle plot not available

Protein Concentration and Protein Localization Data

R1 R2 R3
G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Pre-START G1 Post-START S/G2 Metaphase Anaphase Telophase
Concentration 9.9669 9.373 8.5317 7.3051 6.9124 9.5968 7.0106 8.1753 6.1015 4.4311 5.0125 7.8467 8.1131 9.637 7.2308 5.5732 5.225 8.792
Actin 0.0022 0.001 0.0125 0.0031 0.0062 0.0026 0.0305 0.0118 0.0097 0.0081 0.0192 0.0004 0.0118 0.003 0.0076 0.0465 0.006 0.0144
Bud 0.0012 0.0206 0.0466 0.0673 0.0422 0.0121 0.001 0.0322 0.0596 0.0496 0.0411 0.0006 0.0004 0.0112 0.034 0.0427 0.0451 0.0014
Bud Neck 0.0013 0.0043 0.0063 0.0071 0.0155 0.0114 0.0005 0.0016 0.0034 0.0055 0.008 0.0061 0.0008 0.0016 0.0048 0.0067 0.0024 0.0045
Bud Periphery 0.0025 0.0131 0.0405 0.0646 0.0443 0.0123 0.001 0.0142 0.0327 0.0333 0.0174 0.0009 0.0005 0.0047 0.0201 0.044 0.0408 0.0014
Bud Site 0.0043 0.0626 0.0296 0.0392 0.0197 0.0052 0.002 0.0383 0.0204 0.0114 0.0353 0.0008 0.0068 0.0139 0.0129 0.0093 0.003 0.0004
Cell Periphery 0.0009 0.0022 0.0027 0.0038 0.0024 0.0007 0.0002 0.0014 0.0014 0.0024 0.0018 0.0007 0.0002 0.0005 0.0013 0.0015 0.0005 0.0002
Cytoplasm 0.0122 0.0708 0.3499 0.6163 0.6386 0.053 0.0192 0.1562 0.4001 0.6208 0.525 0.0764 0.0097 0.0797 0.3823 0.45 0.2583 0.0581
Cytoplasmic Foci 0.0021 0.0177 0.0085 0.0091 0.0089 0.0028 0.009 0.0025 0.0192 0.0236 0.0127 0.0013 0.0253 0.002 0.0208 0.0446 0.0298 0.001
Eisosomes 0 0 0.0001 0 0 0 0.0002 0 0 0 0.0002 0 0.0004 0 0.0003 0.0002 0.0002 0
Endoplasmic Reticulum 0.0018 0.0015 0.0126 0.0121 0.0067 0.0009 0.0048 0.0012 0.0046 0.0044 0.002 0.0005 0.0026 0.0014 0.0055 0.0074 0.0021 0.0016
Endosome 0.0035 0.0066 0.0079 0.0154 0.0067 0.0026 0.0266 0.0018 0.022 0.0424 0.0388 0.0014 0.0133 0.0011 0.0113 0.022 0.0152 0.0058
Golgi 0.001 0.0006 0.0011 0.0012 0.0007 0.0009 0.008 0.0007 0.004 0.0495 0.0197 0.0003 0.007 0.0002 0.002 0.0066 0.0105 0.0009
Lipid Particles 0.0034 0.0007 0.0018 0.0006 0.0005 0.0038 0.0067 0.0002 0.0019 0.003 0.0063 0.0003 0.0213 0.0001 0.0087 0.0111 0.1064 0.0013
Mitochondria 0.0014 0.0006 0.0041 0.0025 0.0015 0.0013 0.0066 0.0011 0.0063 0.0068 0.0161 0.0091 0.0131 0.0011 0.008 0.0059 0.1518 0.0167
None 0.001 0.001 0.0034 0.0026 0.0283 0.0015 0.0043 0.0006 0.0024 0.0039 0.0012 0.0003 0.0028 0.004 0.0087 0.0159 0.0133 0.0004
Nuclear Periphery 0.0193 0.0142 0.0337 0.008 0.0119 0.0059 0.0209 0.0201 0.0235 0.0122 0.0024 0.007 0.0082 0.0103 0.0206 0.0164 0.0066 0.007
Nucleolus 0.031 0.0342 0.0284 0.011 0.0034 0.1439 0.0201 0.0168 0.026 0.0108 0.0868 0.1412 0.0287 0.0109 0.0163 0.0035 0.0092 0.0822
Nucleus 0.8944 0.7085 0.3553 0.0777 0.1361 0.7206 0.8073 0.6861 0.3229 0.0703 0.1391 0.7416 0.8088 0.8253 0.3946 0.2285 0.231 0.7984
Peroxisomes 0.0078 0.0003 0.0059 0.0004 0.0004 0.0008 0.0054 0.0003 0.0007 0.0016 0.0021 0.0001 0.0047 0.0002 0.0035 0.0071 0.0383 0.0003
Punctate Nuclear 0.0014 0.0258 0.0199 0.0084 0.0038 0.0121 0.0191 0.0063 0.0228 0.0057 0.0014 0.0054 0.0312 0.0227 0.0207 0.0096 0.0092 0.0016
Vacuole 0.0055 0.0127 0.0273 0.0447 0.0198 0.0048 0.004 0.0057 0.0134 0.0298 0.0199 0.0052 0.0014 0.0055 0.0129 0.0174 0.0136 0.0015
Vacuole Periphery 0.0016 0.0009 0.0022 0.0049 0.0023 0.0007 0.0025 0.0009 0.0031 0.0047 0.0035 0.0006 0.001 0.0007 0.0031 0.0034 0.0068 0.0009

Sequencing Data

R1 R2
G1 Post-START S/G2 Metaphase Anaphase Telophase G1 Post-START S/G2 Metaphase Anaphase Telophase
Gene Expression 15.6511 12.0479 63.7342 69.9933 20.856 20.4221 27.2122 55.1656 58.0073 35.4332
Translational Efficiency 0.5524 0.7554 0.8925 0.8534 0.8932 0.7713 0.8169 0.7416 0.7951 0.7289

Hit Data

Dataset Hit
Protein Concentration ✔
Protein Localization ✔
Gene Expression ✔
Translational Efficiency ✘

Micrographs

Cell Count

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
1311 727 1574 811 1028 1493 953 614 2339 2220 2527 1425

Protein Abundance

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Mean 921.20 1184.98 1705.32 1550.90 1110.48 1178.37 1483.56 1452.66 1004.39 1180.53 1621.69 1508.57
Standard Deviation 163.53 242.13 326.49 299.27 210.76 233.45 256.18 336.86 208.17 236.35 320.46 319.74
Intensity Change Log 2 — 0.363276 0.888456 0.751519 — 0.085609 0.417880 0.387514 — 0.218160 0.650377 0.564000

Localization Score (DeepLoc)

R1 R2 R1 & R2
WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14 WT UBP2 UBP14 UBP2UBP14
Actin 0.000602 0.000988 0.000662 0.000655 0.000920 0.000961 0.000959 0.000468 0.000742 0.000970 0.000774 0.000574
Bud Neck 0.016181 0.040745 0.046182 0.010423 0.029511 0.042000 0.029060 0.013144 0.022040 0.041589 0.039725 0.011595
Bud Site 0.011736 0.013885 0.006795 0.016916 0.012579 0.014310 0.010113 0.018222 0.012106 0.014171 0.008046 0.017479
Cell Periphery 0.001010 0.000607 0.000373 0.000806 0.000789 0.000664 0.000486 0.000454 0.000913 0.000646 0.000416 0.000654
Cytoplasm 0.133269 0.146871 0.126502 0.636998 0.124010 0.123510 0.259202 0.592063 0.129200 0.131160 0.176547 0.617637
Cytoplasmic Foci 0.016877 0.011019 0.004927 0.022932 0.017835 0.015881 0.016174 0.021046 0.017298 0.014289 0.009168 0.022119
Eisosomes 0.000049 0.000035 0.000026 0.000008 0.000047 0.000046 0.000030 0.000009 0.000048 0.000043 0.000028 0.000009
Endoplasmic Reticulum 0.002382 0.001747 0.000703 0.000423 0.002715 0.002552 0.000961 0.000337 0.002528 0.002288 0.000800 0.000386
Endosome 0.003885 0.002182 0.000585 0.002524 0.004455 0.003495 0.001414 0.001549 0.004135 0.003065 0.000898 0.002104
Golgi 0.001495 0.000758 0.000464 0.004402 0.001052 0.002224 0.000508 0.000763 0.001300 0.001744 0.000481 0.002834
Lipid Particles 0.000490 0.000392 0.000558 0.003369 0.000551 0.000875 0.000793 0.001044 0.000517 0.000717 0.000647 0.002367
Mitochondria 0.001730 0.001847 0.002384 0.000854 0.001804 0.003468 0.002001 0.000872 0.001762 0.002937 0.002240 0.000862
Mitotic Spindle 0.007306 0.017165 0.016489 0.034825 0.007147 0.019441 0.028019 0.039862 0.007236 0.018696 0.020837 0.036995
None 0.011169 0.004737 0.003663 0.005806 0.005575 0.005185 0.004545 0.007485 0.008710 0.005038 0.003996 0.006529
Nuclear Periphery 0.000455 0.000773 0.000832 0.001619 0.000684 0.001232 0.000822 0.000583 0.000556 0.001082 0.000829 0.001173
Nuclear Periphery Foci 0.004263 0.003047 0.000892 0.005428 0.004257 0.003371 0.003336 0.002273 0.004260 0.003265 0.001814 0.004069
Nucleolus 0.196762 0.123366 0.012627 0.003234 0.157074 0.138762 0.019209 0.003796 0.179319 0.133720 0.015110 0.003476
Nucleus 0.577700 0.619886 0.768651 0.214318 0.615828 0.611425 0.600494 0.278470 0.594458 0.614196 0.705234 0.241960
Peroxisomes 0.001713 0.001465 0.000464 0.000366 0.001808 0.001631 0.000737 0.000471 0.001755 0.001576 0.000567 0.000411
Vacuole 0.009285 0.007196 0.005837 0.029956 0.009611 0.007192 0.020758 0.016643 0.009428 0.007193 0.011464 0.024219
Vacuole Periphery 0.001639 0.001287 0.000383 0.004137 0.001748 0.001776 0.000378 0.000446 0.001687 0.001616 0.000381 0.002546

Localization Changes (T-score)

R1 R2 R1 & R2
UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14 UBP2_WT UBP14_WT UBP2UBP14_WT UBP2UBP14_UBP2 UBP2UBP14_UBP14
Actin -4.39 -7.10 -7.89 -0.98 -4.17 -0.82 -3.57 0.02 0.77 3.23 -4.66 -6.59 -6.17 -0.81 -1.70
Bud Neck -9.39 -17.59 -7.34 2.35 5.74 -4.56 -3.58 -0.82 2.93 2.26 -11.17 -14.84 -5.83 3.68 6.11
Bud Site -2.61 3.31 -5.66 -2.38 -8.90 -1.54 1.54 -3.05 -2.06 -4.15 -3.14 3.79 -6.16 -3.44 -9.31
Cell Periphery 2.66 5.37 1.98 -1.26 -5.82 1.15 2.80 2.19 1.44 -1.13 2.87 5.97 2.88 -0.28 -5.04
Cytoplasm -0.25 3.40 -16.44 -14.80 -19.60 0.16 -5.23 -14.37 -15.00 -10.34 0.31 -0.74 -21.85 -22.02 -21.86
Cytoplasmic Foci 2.70 6.06 -1.93 -4.66 -8.50 0.89 2.42 -0.11 -1.11 -2.92 1.94 6.33 -1.58 -3.61 -8.75
Eisosomes 5.02 6.84 10.42 5.94 5.23 0.22 3.74 10.26 10.77 7.42 2.78 7.85 14.51 12.40 8.69
Endoplasmic Reticulum 1.52 5.92 3.85 3.56 -4.21 0.08 5.58 6.34 6.87 2.09 0.27 8.28 6.90 7.38 -2.19
Endosome 3.46 9.42 4.41 1.04 -3.56 1.57 5.32 4.51 4.20 -0.21 2.73 10.01 6.29 4.12 -3.00
Golgi 1.62 2.53 -0.43 -1.24 -1.64 -2.10 2.57 1.38 3.03 -1.64 -0.78 3.30 -0.20 0.30 -1.80
Lipid Particles -0.32 -1.33 -6.78 -6.49 -6.30 -0.75 -1.96 -4.40 -2.74 -3.55 -0.97 -2.08 -7.99 -6.24 -7.20
Mitochondria -0.88 -4.38 -1.68 -1.19 5.45 -2.24 -3.83 -1.38 1.74 3.14 -2.40 -5.80 -2.15 1.46 6.35
Mitotic Spindle -3.87 -5.46 -10.12 -6.93 -7.83 -4.94 -6.98 -9.10 -7.12 -4.65 -6.53 -8.79 -13.60 -10.08 -9.06
None 5.83 7.35 4.40 -2.65 -5.96 0.37 0.80 -2.06 -3.14 -3.73 5.20 6.85 2.45 -4.00 -6.89
Nuclear Periphery -4.18 -8.22 -6.92 -5.38 -4.69 -2.21 -5.01 -6.97 -3.88 -3.50 -3.62 -8.96 -9.41 -5.85 -5.91
Nuclear Periphery Foci -0.35 3.50 -1.45 -0.94 -5.29 0.42 1.98 0.94 0.58 -0.82 0.07 4.17 -0.68 -0.76 -5.02
Nucleolus 7.87 27.21 27.02 14.87 1.37 1.96 17.70 21.00 22.66 4.90 7.23 32.42 34.09 27.17 4.21
Nucleus -2.10 -16.04 14.64 14.68 27.89 0.97 -0.37 12.70 12.63 12.41 -0.98 -12.29 19.39 19.96 29.27
Peroxisomes 1.25 7.63 6.45 4.40 -1.00 0.77 5.93 6.30 4.22 1.65 1.02 9.81 9.03 5.60 0.36
Vacuole 1.07 -0.94 -10.64 -11.14 -10.23 0.97 -7.09 -7.50 -7.92 -1.76 1.26 -6.00 -12.98 -13.57 -9.05
Vacuole Periphery 1.48 6.84 -0.05 -0.56 -1.79 0.14 5.06 4.90 5.73 0.30 0.59 8.32 1.30 1.00 -1.75
Protein Complexes26S Proteasome complex37S mitochondrial small ribosomal subunit54S mitochondrial large ribosomal subunit60S cytosolic large ribosomal subunitAar2-U5 snRNPAnaphase-Promoting Complex variant 1Anaphase-Promoting Complex variant 2Anaphase-Promoting Complex variant 3Anaphase-Promoting Complex variant 4Arp2/3 complexATG1 kinase complexBLOC-1 complexCcr4-Not complexCentral kinetochore CTF19 complexCleavage and polyadenylation specificity factorcomplexCMG helicase complexCMG-Pol epsilon complexCOMPASS complexCOP9 signalosome COPI vesicle coat complexCoQ6 biosynthesis complexCore mediator complexCORVET complexCTF18-RFC complexCURI complex variant 1CURI complex variant 2CURI complex variant 3Cytoplasmic exosome complex, DIS3 variantDASH complexDNA-directed RNA Polymerase I complexDNA-directed RNA polymerase II complexDNA-directed RNA polymerase III complexDNA replication factor C complexEGO complexELG1-RFC complex Elongator holoenzyme complexEndoplasmic Reticulum Membrane ComplexEukaryotic translation initiation factor 2BcomplexEukaryotic translation initiation factor 3core complexExocystExomer complexFAR complexGeneral transcription factor complex TFIIDGeneral transcription factor complex TFIIHGET4-GET5 transmembrane domain recognition complexGID ubiquitin ligase complexGin4 complexGolgi transport complexGSE complexHMC complexHOPS complexINO80 chromatin remodeling complexLSM1-7 complexLsm1-7-Pat1 complexLSM2-7 complexLSM2-8 complexMCM complexMICOS complexMitochondrial electron transport complex IIIMitochondrial inner membrane pre-sequence translocasecomplexMitochondrial outer membrane translocase holocomplexMitochondrial proton-transporting ATP synthase complexMitochondrial pyruvate dehydrogenase complexNineTeen complexNOP8 60s ribosome pre-assembly complexNuA3 histone acetyltransferase complexNuA4 histone acetyltransferase complexNuclear condensin complexNuclear/nucleolar exosome complex, DIS3-RRP6 variantNuclear pore complexNucleolar ribonuclease MRP complexNucleolar ribonuclease P complexOligosaccharyl transferase complex variant 1Oligosaccharyl transferase complex variant 2PAF1 complexPAS complexPhosphatidylinositol 3-kinase complex IPolarisomePrefoldin complexPRP19-associated complexRad17 RFC-like complexRetromer complexRPD3L histone deacetylase complexRPD3S histone deacetylase complexRQC complexRSC complex variant RSC1RSC complex variant RSC2SAGA complexSCF-Met30 ubiquitin ligase complexSCF-Ufo1 ubiquitin ligase complexSEA complexSeptin complexSET3C histone deacetylase complexSignal recognition particleSLIK (SAGA-like) complexSmall ribosomal subunit processome, variant1Small ribosomal subunit processome, variant2Small ribosomal subunit processome, variant3SMC5-SMC6 SUMO ligase complexSm complexSpliceosomal commitment complexSPOTS complexSWI/SNF chromatin remodelling complexSwr1 chromatin remodelling complexTHO complexTranscription factor TFIIIC complexTranslocon complexTRAPPIII protein complexTRAPPII protein complexTRAPPI protein complexTREX complexU1 snRNPU2 snRNPU4 snRNPU4/U6 snRNPU4/U6.U5 tri-snRNP complexU5 snRNPU6 snRNP complexUTP-A complexUTP-B complexUTP-C complex variant 1UTP-C complex variant 2UTP-C complex variant 3Vacuolar proton translocating ATPase complex,Golgi variantVacuolar proton translocating ATPase complex,vacuole variantCellular Components••••••••••••••••actinbud neckcell peripherycytoplasmendosomeERGolgimitochondrionmixednuclear peripherynucleolusnucleusperoxisomespindle polevacuolar membranevacuole
Standard name
Human Ortholog
Description Component of the Mcm2-7 hexameric helicase complex; MCM2-7 primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex
Localization
Cell Percentages nucleus (84%), cytoplasm (8%), mixed (6%)
Cell Cycle Regulation Yes
cytoplasm - MA (4e-10)
nucleus - T/G1 (1.1e-13)
Subcompartmental Group N/A

Mcm7

Mcm7


Nearest neighbours ( genes)

correlation threshold

0.6

1.0

0.80


Biological Process (Gene Ontology)
Molecular Function (Gene Ontology)
Cellular Component (Gene Ontology)

Endocytosis
Temp Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Vph1-GFP)
37℃
RT
Cell Cycle Omics

CYCLoPs (Mcm7-GFP)
Gene / Allele Actin Patch (Sac6-tdTomato) Cortical Patch (Sla1-GFP) Late Endosome (Snf7-GFP) Vacuole (Sac6-tdTomato)
Gene Images
Gene Images
Images are not yet available
Images are not yet available