Standard name | |
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Human Ortholog | |
Description | Mitochondrial serine hydroxymethyltransferase; converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine |
ensLOC | DeepLoc | |||||||||||||||||||||||
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Localization | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | WT1 | WT2 | WT3 | AF100 | AF140 | AF180 |
Cortical Patches | 0 | 2 | 1 | 6 | 5 | 2 | 6 | – | 1 | 3 | 0 | 1 | 5 | 5 | 2 | 3 | 4 | 12 | 8 | 9 | 4 | 3 | 6 | 3 |
Bud | 5 | 3 | 2 | 1 | 4 | 3 | 4 | – | 4 | 4 | 10 | 4 | 1 | 0 | 0 | 1 | 2 | 4 | 1 | 0 | 1 | 0 | 0 | 1 |
Bud Neck | 0 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 1 | 0 | 0 | 0 | 0 | 0 | 0 | – | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | – | – | – | – | – | – |
Cell Periphery | 2 | 3 | 4 | 7 | 2 | 1 | 1 | – | 3 | 2 | 1 | 2 | 5 | 3 | 5 | 2 | 3 | 5 | 0 | 1 | 0 | 0 | 0 | 0 |
Cytoplasm | 1 | 1 | 0 | 3 | 10 | 3 | 13 | – | 4 | 4 | 8 | 6 | 2 | 8 | 4 | 5 | 3 | 7 | 0 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0 | 2 | 0 | 0 | 1 | 2 | 0 | – | 3 | 2 | 0 | 4 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 4 | 1 | 5 | 3 | 4 | 7 | 5 | – | 5 | 5 | 1 | 1 | 0 | 2 | 2 | 1 | 2 | 1 | 6 | 6 | 5 | 0 | 5 | 6 |
Golgi | 2 | 19 | 66 | 26 | 78 | 20 | 24 | – | 13 | 19 | 4 | 20 | 38 | 77 | 113 | 36 | 38 | 27 | 13 | 26 | 8 | 10 | 24 | 27 |
Mitochondria | 258 | 161 | 91 | 166 | 193 | 330 | 366 | – | 288 | 388 | 364 | 471 | 140 | 173 | 164 | 17 | 13 | 9 | 238 | 172 | 165 | 44 | 79 | 69 |
Nucleus | 0 | 0 | 1 | 0 | 2 | 0 | 2 | – | 1 | 2 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Nuclear Periphery | 11 | 2 | 4 | 1 | 5 | 32 | 35 | – | 30 | 29 | 14 | 26 | 5 | 1 | 5 | 4 | 1 | 1 | 3 | 1 | 1 | 0 | 1 | 0 |
Nucleolus | 24 | 9 | 14 | 5 | 19 | 57 | 84 | – | 57 | 47 | 48 | 64 | 5 | 6 | 3 | 13 | 11 | 8 | 0 | 2 | 0 | 1 | 1 | 0 |
Peroxisomes | 20 | 7 | 8 | 10 | 9 | 4 | 9 | – | 1 | 11 | 6 | 5 | 3 | 10 | 16 | 6 | 6 | 10 | 18 | 6 | 14 | 0 | 3 | 3 |
SpindlePole | 2 | 1 | 3 | 0 | 1 | 1 | 0 | – | 4 | 1 | 1 | 6 | 0 | 1 | 2 | 2 | 0 | 1 | 2 | 1 | 1 | 0 | 0 | 2 |
Vac/Vac Membrane | 14 | 18 | 29 | 5 | 25 | 29 | 14 | – | 20 | 22 | 6 | 21 | 24 | 17 | 17 | 11 | 15 | 20 | 4 | 5 | 1 | 3 | 10 | 14 |
Unique Cell Count | 286 | 189 | 160 | 187 | 262 | 404 | 465 | 352 | 447 | 402 | 547 | 164 | 220 | 233 | 86 | 86 | 88 | 300 | 238 | 208 | 69 | 139 | 132 | |
Labelled Cell Count | 344 | 229 | 228 | 233 | 358 | 491 | 563 | 434 | 539 | 464 | 632 | 228 | 304 | 333 | 104 | 99 | 109 | 300 | 238 | 208 | 69 | 139 | 132 |
Screen | WT1 | WT2 | WT3 | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 | AF100 | AF140 | AF180 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mean Cell GFP Intensity (1e-4) | 13.2 | 18.5 | 16.7 | 17.8 | 19.9 | 18.6 | 18.9 | – | 17.7 | 17.5 | 16.7 | 17.1 | 18.9 | 19.1 | 18.1 | 21.8 | 23.9 | 22.0 | 13.8 | 18.7 | 19.7 |
Std Deviation (1e-4) | 3.4 | 4.5 | 3.5 | 4.1 | 5.2 | 4.4 | 5.0 | – | 4.9 | 5.0 | 5.3 | 5.1 | 5.2 | 4.3 | 3.8 | 6.1 | 7.6 | 6.8 | 3.8 | 5.5 | 6.4 |
Intensity Change (Log2) | – | – | – | 0.09 | 0.25 | 0.16 | 0.18 | – | 0.08 | 0.07 | 0.0 | 0.04 | 0.18 | 0.19 | 0.12 | 0.39 | 0.52 | 0.4 | -0.27 | 0.17 | 0.24 |
Localization | RAP60 | RAP140 | RAP220 | RAP300 | RAP380 | RAP460 | RAP540 | RAP620 | RAP700 | HU80 | HU120 | HU160 | rpd3Δ_1 | rpd3Δ_2 | rpd3Δ_3 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cortical Patches | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Neck | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bud Site | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cell Periphery | 0.7 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cytoplasm | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endoplasmic Reticulum | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Endosome | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Golgi | -5.8 | -2.4 | -10.8 | -11.2 | – | -10.9 | -11.6 | -13.0 | -12.8 | -3.5 | -1.2 | 1.4 | 0.1 | 0.4 | -1.6 |
Mitochondria | 6.8 | 3.6 | 6.1 | 5.4 | – | 6.0 | 8.0 | 9.2 | 8.1 | 5.7 | 4.5 | 2.8 | -5.6 | -6.3 | -7.2 |
Nucleus | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nuclear Periphery | 0 | 0 | 2.4 | 2.3 | – | 2.5 | 1.9 | 0.6 | 1.2 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolus | -2.5 | -0.6 | 1.7 | 2.8 | – | 2.3 | 0.6 | 1.1 | 1.0 | -2.2 | -2.6 | -3.6 | 1.5 | 1.0 | 0.1 |
Peroxisomes | 0.1 | -0.8 | 0 | 0 | – | 0 | -1.6 | 0 | 0 | -1.6 | -0.2 | 0.8 | 0 | 0 | 1.8 |
SpindlePole | 0 | 0 | 0 | 0 | – | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vacuole | -4.8 | -2.6 | -3.9 | -6.5 | – | -4.4 | -5.2 | -7.4 | -6.2 | -0.8 | -3.1 | -3.3 | -1.1 | -0.1 | 0.9 |
R1 | R2 | R3 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Pre-START | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Concentration | 24.0747 | 24.7297 | 24.2742 | 22.6459 | 18.7563 | 24.2827 | 21.7509 | 23.9929 | 22.2718 | 18.6888 | 20.5748 | 23.8177 | 23.7742 | 26.5395 | 24.2529 | 25.2641 | 23.6177 | 27.2965 |
Actin | 0.0025 | 0.0074 | 0.003 | 0 | 0.016 | 0.0002 | 0.0177 | 0.0126 | 0.003 | 0.0011 | 0.001 | 0.0027 | 0.039 | 0.0104 | 0.0214 | 0.0002 | 0.001 | 0.0003 |
Bud | 0.0001 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0 | 0 | 0.0004 | 0 | 0.0003 | 0 | 0.0002 | 0.0001 | 0.0002 | 0 |
Bud Neck | 0 | 0 | 0.0001 | 0 | 0.0001 | 0 | 0.0001 | 0.0001 | 0 | 0 | 0.0002 | 0 | 0.001 | 0 | 0.0004 | 0 | 0 | 0 |
Bud Periphery | 0.0001 | 0.0001 | 0.0003 | 0 | 0.0001 | 0 | 0.0003 | 0.0001 | 0.0001 | 0.0001 | 0.0006 | 0 | 0.0005 | 0.0001 | 0.0003 | 0.0003 | 0.0002 | 0 |
Bud Site | 0.0004 | 0.0001 | 0.0015 | 0 | 0.0001 | 0 | 0.0003 | 0.0003 | 0.0004 | 0.0001 | 0.0049 | 0 | 0.0013 | 0.0001 | 0.0021 | 0 | 0.0004 | 0 |
Cell Periphery | 0.0003 | 0.0001 | 0.0003 | 0 | 0.0001 | 0 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0.0001 | 0 | 0.0005 | 0.0002 | 0.0002 | 0.0002 | 0.0001 | 0 |
Cytoplasm | 0.0002 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.0014 | 0 | 0.0004 | 0 | 0.0003 | 0 |
Cytoplasmic Foci | 0.0077 | 0.0007 | 0.001 | 0 | 0.0057 | 0.003 | 0.0016 | 0.001 | 0.0046 | 0.0012 | 0.0028 | 0.0001 | 0.0147 | 0.0004 | 0.0113 | 0.0001 | 0.0112 | 0 |
Eisosomes | 0.0004 | 0.0003 | 0.0006 | 0.0001 | 0.0005 | 0.0002 | 0.0006 | 0.0002 | 0.0003 | 0.0001 | 0.0002 | 0.0005 | 0.0015 | 0.0004 | 0.0004 | 0.0001 | 0.0002 | 0.0002 |
Endoplasmic Reticulum | 0.0001 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0.0001 | 0 | 0 | 0.0013 | 0 | 0.0005 | 0 | 0.0003 | 0 |
Endosome | 0.0018 | 0.0014 | 0.0013 | 0 | 0.0007 | 0.0004 | 0.0011 | 0.0001 | 0.0004 | 0.0083 | 0.0004 | 0.0003 | 0.0113 | 0.001 | 0.0097 | 0.0003 | 0.021 | 0.0002 |
Golgi | 0.0019 | 0.012 | 0.0066 | 0.0001 | 0.0022 | 0.0066 | 0.0032 | 0.0007 | 0.0014 | 0.0193 | 0.0008 | 0.0039 | 0.0067 | 0.003 | 0.0044 | 0.0008 | 0.0061 | 0.0017 |
Lipid Particles | 0.0152 | 0.0093 | 0.0031 | 0.0025 | 0.0192 | 0.0037 | 0.0136 | 0.0077 | 0.0106 | 0.0314 | 0.0066 | 0.0033 | 0.0358 | 0.01 | 0.017 | 0.0062 | 0.0333 | 0.0022 |
Mitochondria | 0.942 | 0.9515 | 0.9659 | 0.9932 | 0.9433 | 0.9829 | 0.9439 | 0.9675 | 0.9703 | 0.9249 | 0.9571 | 0.9865 | 0.8193 | 0.9612 | 0.9143 | 0.9764 | 0.9008 | 0.9833 |
None | 0.0003 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0.0001 | 0.0002 | 0 | 0.0078 | 0 | 0.0003 | 0 | 0.0006 | 0 |
Nuclear Periphery | 0.0005 | 0.0001 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0 | 0.0005 | 0.0001 | 0.0001 | 0.0025 | 0 | 0.0008 | 0 | 0.0012 | 0.0001 |
Nucleolus | 0.0048 | 0.0001 | 0.0001 | 0 | 0.0001 | 0.0006 | 0.0003 | 0.0009 | 0.0002 | 0.0003 | 0.0132 | 0 | 0.0176 | 0.0001 | 0.0007 | 0.0001 | 0.0007 | 0.0001 |
Nucleus | 0.0004 | 0 | 0 | 0 | 0 | 0 | 0.0001 | 0 | 0.0001 | 0.0002 | 0.0016 | 0 | 0.0014 | 0 | 0.0003 | 0.0001 | 0.0003 | 0 |
Peroxisomes | 0.0117 | 0.0041 | 0.0092 | 0.0004 | 0.0105 | 0.0003 | 0.0122 | 0.0065 | 0.0058 | 0.0009 | 0.0071 | 0.001 | 0.0128 | 0.0036 | 0.0089 | 0.0008 | 0.0062 | 0.0004 |
Punctate Nuclear | 0.0017 | 0 | 0 | 0 | 0.0002 | 0 | 0.0001 | 0 | 0.0005 | 0.0001 | 0.0017 | 0 | 0.0041 | 0 | 0.0011 | 0 | 0.0026 | 0 |
Vacuole | 0.0018 | 0.0006 | 0.001 | 0.0002 | 0.0002 | 0.0002 | 0.0006 | 0.0002 | 0.0003 | 0.0015 | 0.0003 | 0.0001 | 0.0029 | 0.0013 | 0.0017 | 0.0033 | 0.0013 | 0.0003 |
Vacuole Periphery | 0.0061 | 0.0121 | 0.0059 | 0.0032 | 0.0011 | 0.0019 | 0.0037 | 0.002 | 0.0017 | 0.0098 | 0.0006 | 0.0014 | 0.0166 | 0.0081 | 0.0036 | 0.0109 | 0.0118 | 0.0113 |
R1 | R2 | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | G1 Post-START | S/G2 | Metaphase | Anaphase | Telophase | |
Gene Expression | 216.8605 | 235.7124 | 194.2879 | 221.4804 | 231.6368 | 193.1573 | 210.738 | 204.04 | 192.5002 | 195.0637 |
Translational Efficiency | 1.0888 | 1.0644 | 1.3181 | 1.045 | 1.0279 | 1.096 | 1.0289 | 1.0193 | 1.1059 | 1.0497 |
Dataset | Hit |
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Protein Concentration | ✘ |
Protein Localization | ✘ |
Gene Expression | ✘ |
Translational Efficiency | ✔ |
Temp | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Vph1-GFP) |
---|---|---|---|---|
37℃ | ||||
RT |
Gene / Allele | Actin Patch (Sac6-tdTomato) | Cortical Patch (Sla1-GFP) | Late Endosome (Snf7-GFP) | Vacuole (Sac6-tdTomato) |
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Gene | Images |
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Gene | Images |
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